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Topic Review
Targeted Cytokines as Cancer Therapeutics in Glioblastoma
Cytokines are secreted proteins that engage the extracellular domains of cell surface receptors and regulate immune response and homeostasis. Cytokines can be classified based on their roles as pro- or anti-inflammatory cytokines or on cellular origin.
  • 192
  • 15 Sep 2023
Topic Review
Techniques of Making Edible Coatings
Edible coatings are made from natural food-grade materials, such as hydrocolloids (polysaccharides, proteins), lipids, and emulsifiers, produced with different techniques, such as dipping (immersing), spraying, spreading, brushing, pressing them/thermoforming, or extrusion. The most used method for coating is immersing, where food is dipped in a liquid containing food matrices, forming a film around the food and protecting all the components present.
  • 1.2K
  • 15 Sep 2023
Topic Review
Detection of Antibiotic and Multi-Drug Resistant Salmonella
Antibiotic and multi-drug resistant (MDR) Salmonella poses a significant threat to public health due to its ability to colonize animals (cold and warm-blooded) and contaminate freshwater supplies. Monitoring antibiotic resistant Salmonella is traditionally costly, involving the application of phenotypic and genotypic tests over several days.
  • 254
  • 15 Sep 2023
Topic Review
Great Video Abstract
In today's information-rich landscape, the art of scientific communication is evolving, with video abstracts emerging as a dynamic tool. This comprehensive guide explores the power of video abstracts to engage a diverse audience. It dissects key components, including narration, visuals, music, structure, and accessibility. Practical tips, examples, and case studies highlight best practices. Researchers are encouraged to plan, practice, and promote their video abstracts while considering legal and ethical considerations. By mastering this skill, scientists can bridge the gap between their research and a global audience, advancing knowledge dissemination and fostering scientific understanding.
  • 434
  • 15 Sep 2023
Topic Review
Anoikis in Brief
Anoikis, a term rooted in the Greek word "anoikos," meaning homelessness. Anoikis is a fundamental process in cellular biology, orchestrating programmed cell death when cells lose their anchorage by detaching from the extracellular matrix (ECM) or surrounding tissue. Beyond its crucial role in maintaining tissue homeostasis, anoikis is deeply intertwined with the complex landscape of cancer biology, metastasis, and tissue regeneration. We embark on a journey through the molecular mechanisms governing anoikis, highlighting its significance in normal physiological processes. However, when it comes to cancer, anoikis dysregulation emerges as a harbinger of disease progression. Cancer cells acquire the ability to evade anoikis, empowering them to navigate the challenges of metastasis by surviving in the bloodstream and colonizing distant organs. They exhibit invasive capabilities, infiltrating neighboring tissues and fueling local tumor expansion. Moreover, this resistance extends to therapeutic interventions, making cancer cells resilient to conventional treatments like chemotherapy and radiation therapy. We also explore the mechanisms behind cancer cells' evasion of anoikis, shedding light on alterations in apoptotic pathways, activation of survival signaling, epithelial-mesenchymal transition (EMT), and the role of autophagy in promoting survival during detachment. The promising realm of targeting anoikis resistance in cancer treatment is unveiled, with approaches including apoptosis inducers, inhibitors of survival signaling, anti-EMT therapies, and autophagy inhibitors. These strategies hold potential to restore anoikis sensitivity in cancer cells and curb metastasis, offering hope to patients battling this relentless disease. Comprehending anoikis and its dysregulation in cancer is a pivotal step toward developing innovative therapeutic interventions. By targeting anoikis resistance, we aim to improve treatment outcomes, overcome therapy resistance, and ultimately provide renewed hope to cancer patients facing this formidable adversary.
  • 329
  • 15 Sep 2023
Topic Review
Yeasts on Fermentation Quality and Human Health-Promoting Compounds
Non-Saccharomyces are important during wine fermentation once they influence wine composition. In the early stages of wine fermentation, and with indigenous or commercial Saccharomyces cerevisiae strains, non-Saccharomyces can transform grape-must sugars into ethanol, CO2, and other important secondary metabolites. A better understanding of yeast biochemistry will allow the selection of yeast strains that have defined specific influences on fermentation efficiency, wine quality, and the production of human health-promoting compounds. Yeast metabolism produces compounds derived from tryptophan, melatonin, and serotonin found in fermented beverages, such as wine and beer. Melatonin is a neurohormone secreted from the pineal gland and has a wide-ranging regulatory and neuroprotective role, while serotonin, as well as being a precursor of melatonin synthesis, is also a neurotransmitter. 
  • 286
  • 14 Sep 2023
Topic Review
Nanoparticles in Eliminating Contamination and Seed Germination
Owing to their minuscule size, nanoparticles (NPs) acquire novel and unique properties that differ from their bulkier counterparts, giving rise to breakthrough technology with application-based solutions in many sectors of agriculture and plant biotechnology. 
  • 256
  • 14 Sep 2023
Topic Review
Microglia Phenomics in Alzheimer’s Disease
Phenomics, the complexity of microglia phenotypes and their related functions compels the continuous study of microglia in disease animal models to find druggable targets for neurodegenerative disorders. Activation of microglia was long considered detrimental for neuron survival, but it has become apparent that the real scenario of microglia morphofunctional diversity is far more complex.
  • 332
  • 14 Sep 2023
Topic Review
Collagen Hydrolysates
Collagen hydrolysates (CHs) are products with low molecular weight (MW) peptides, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. 
  • 390
  • 14 Sep 2023
Topic Review
Gut–Brain Axis and the Microbiome Physiology
Human microbiome has not been at the center of scientific research until recent years, when the scientific approach to the gut–brain axis and its medical involvement in multiple pathologies has revealed the decisive role of the intestinal flora.
  • 252
  • 14 Sep 2023
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