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Topic Review
The Two-Component Systems of Helicobacter pylori
Numerous studies of Helicobacter pylori, a human pathogen responsible for various stomach diseases, have focused on elucidating the mechanisms that regulate gene transcription to attempt to understand the physiological changes of the bacterium during infection and adaptation to the environmental conditions it encounters. The number of regulatory proteins inferred from genome sequence analyses responsible for properly orchestrating gene expression appears limited to three sigma factors and 14 regulators, including four Two-Component Systems and two orphan Response Regulators.
  • 383
  • 02 Dec 2022
Topic Review
The Tumor-Intrinsic NLRP3-HSP70 Signaling Axis in Immune Evasion
The tumor-intrinsic NLRP3 inflammasome is a newly recognized player in the regulation of tumor-directed immune responses and promises to provide fresh insight into how tumors respond to immunotherapy. 
  • 442
  • 29 Mar 2022
Topic Review
The Tumor Heterogeneity in Sézary Syndrome
Sézary syndrome (SS) is an aggressive variant of cutaneous t-cell lymphoma characterized by the accumulation of neoplastic CD4+ lymphocytes—the SS cells—mainly in blood, lymph nodes, and skin. The tumor spread pattern of SS makes this lymphoma a unique model of disease that allows a concurrent blood and skin sampling for analysis.
  • 464
  • 28 Jun 2022
Topic Review
The Tubulin Code in Mitosis
Mitosis relies on the critical contribution of microtubules, as well as several microtubule-associated proteins (MAPs) and motors, to regulate several key mechanisms underlying the faithful segregation of the genetic material during cell division. The mitotic spindle is an anisotropic and highly heterogeneous structure, with dynamic astral microtubules essentially tyrosinated, in contrast with more stable microtubule subpopulations, such as kinetochore and a fraction of interpolar microtubules, which accumulate detyrosinated, Δ2, acetylated and polyglutamylated tubulin.
  • 943
  • 06 Jan 2023
Topic Review
The TRPM2 Cation Channel
The transient receptor potential melastatin (TRPM) family belongs to the superfamily of TRP ion channels. It consists of eight family members that are involved in a plethora of cellular functions. TRPM2 is a homotetrameric Ca2+-permeable cation channel activated upon oxidative stress and is important, among others, for body heat control, immune cell activation and insulin secretion. Invertebrate TRPM2 proteins are channel enzymes; they hydrolyze the activating ligand, ADP-ribose, which is likely important for functional regulation. Since its cloning in 1998, the understanding of the biophysical properties of the channel has greatly advanced due to a vast number of structure–function studies. The physiological regulators of the channel have been identified and characterized in cell-free systems. In the wake of the recent structural biochemistry revolution, several TRPM2 cryo-EM structures have been published. These structures have helped to understand the general features of the channel, but at the same time have revealed unexplained mechanistic differences among channel orthologues. 
  • 369
  • 11 May 2021
Topic Review
The Transition Period of Dairy Cows
Considerable literature exists on the severe challenges faced by dairy cows at their transition from calving to lactation. Most studies focus on the transition period (TP) phase, which begins three weeks before calving and spans the first three weeks of lactation. Typically, this physiological phase implies severe alterations in the metabolic asset of dairy cows. These alterations are driven by sudden changes in hormonal trends and nutrient partitioning as well as by the adaptation of the animal’s metabolism to the negative energy and protein balance conditions driven by late pregnancy and early lactation requirements.
  • 387
  • 19 Nov 2021
Topic Review
The Transcriptomics of Sesame
Transcriptome is an inevitable link between genomic genetic information and biological function, and is one of the most active disciplines in the post genomic era. The transcriptome sequencing technology has been widely utilized in basic research fields, such as medicine, drug development and agricultural science. Researchers in plant science have been focusing on the application of RNA sequencing technology to study gene expression patterns under different environmental conditions or different growth and development stages, in order to understand the regulatory mechanism of gene expression and explore candidate genes related to specific traits. In fact, sesame is an oil crop with a large planting area in China. As an important food and medicine, it plays a vital role in human life. Therefore, studying the gene expression pattern of sesame under specific conditions is very important for the development and utilization of sesame germplasm resources.
  • 301
  • 05 May 2023
Topic Review
The Toxicity of Zearalenone
Zearalenone (ZEA) is one of the top five agriculturally important and of greatest concern mycotoxins. Its toxicity is mainly manifested in the following aspects: reproductive toxicity, hepatotoxicity, immunotoxicity, genotoxicity, and carcinogenicity. Several acute toxicity studies have given oral LD50s of ZEA, which are above 2000, 4000, and 5000 mg/kg bw in mice, rats, and Guinea pigs, respectively. The no-observed-effect level (NOEL) of ZEA in pigs and rats shown by 90-day sub-chronic oral toxicity studies were 40 and 100 μg/kg bw, respectively. Since ZEA has an estrogen-like structure, it binds to various estrogen receptors (ERs). Therefore, low-dose ZEA interferes with the physiological–metabolic response and affects the vital functions of the body. Reproductive toxicity is one of ZEA’s main toxic effects, which causes reproductive disorders in various animals. Besides, ZEA is a potential carcinogen. The International Agency for Research on Cancer (IARC) classifies ZEA as the first Class 3 carcinogen. Existing studies indicate that ZEA induces genotoxicity by DNA fragmentation, micronucleus formation, DNA adduct formation, chromosomal aberrations, and apoptosis. Additionally, ZEA induces liver lesions accompanied by cancer development. Moreover, ZEA is immunotoxic and nephrotoxic. It causes changes in immune parameters and chronic progressive nephropathy both in vivo and vitro.
  • 602
  • 13 Jun 2022
Topic Review
The Toxic Impact of Honey Adulteration
Honey is characterized as a natural and raw foodstuff that can be consumed not only as a sweetener but also as medicine due to its therapeutic impact on human health. It is prone to adulterants caused by humans that manipulate the quality of honey. Honey adulterants are any substances that are added to the pure honey. 
  • 1.8K
  • 09 Jan 2023
Topic Review
The Three Rs (Animals)
The Three Rs (3Rs) in relation to science are guiding principles for more ethical use of animals in testing. They were first described by W. M. S. Russell and R. L. Burch in 1959. The 3Rs are: Replacement: methods which avoid or replace the use of animals in research Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain more information from the same number of animals. Refinement: use of methods that alleviate or minimize potential pain, suffering or distress, and enhance animal welfare for the animals used. The 3Rs have a broader scope than simply encouraging alternatives to animal testing, but aim to improve animal welfare and scientific quality where the use of animals cannot be avoided. In many countries, these 3Rs are now explicit in legislation governing animal use. It is usual to capitalise the first letter of each of the three 'R' principles (i.e. 'Replacement' rather than 'replacement') to avoid ambiguity and clarify reference to the 3Rs principles.
  • 582
  • 21 Oct 2022
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