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Topic Review
In Vitro Lung Models
In vitro lung models are used to faithfully model basic human pathology and the complexity and diversity of human respiratory tissues and to study emerging viral respiratory pathogens and diseases. These models include conventional cell lines, primary human airway epithelial cell (hAEC) cultures, lung organoids, lung-on-a-chip technology, ex vivo lung perfusion (EVLP) models and human lung tissue explants.
  • 1.7K
  • 23 Jun 2021
Topic Review
Bacterial Signal Transduction Systems
Bacteria possess a large number of signal transduction systems that sense and respond to different environmental cues. Most frequently these are transcriptional regulators, two-component systems and chemosensory pathways. A major bottleneck in the field of signal transduction is the lack of information on signal molecules that modulate the activity of the large majority of these systems. 
  • 1.7K
  • 23 Apr 2021
Topic Review
Nuclear Pore Complex
The import and export of proteins requires interaction with the components of the nuclear envelope (NE), which is formed by a double membrane that harbor protein channels called nuclear pore complexes (NPCs). NPCs are formed by multiple copies of Nups that participate in the bi-directional nucleus–cytoplasmic transport of macromolecules, ribosomal subunits, viral proteins and RNAs (mRNAs, rRNAs, tRNAs, miRNAs) from both cellular and viral origin.
  • 1.7K
  • 28 Apr 2021
Topic Review
Glucosinolates
Glucosinolates (GSLs) are secondary plant metabolites abundantly found in plant order Brassicales. GSLs are constituted by an S-β-d-glucopyrano unit anomerically connected to O-sulfated (Z)-thiohydroximate moiety. The side-chain of the O-sulfate thiohydroximate moiety, which is derived from a different amino acid, contributes to the diversity of natural GSL, with more than 130 structures identified and validated to this day. Both the structural diversity of GSL and their biological implication in plants have been biochemically studied. While intact GSLs are biologically inactive, various products, including isothiocyanates, nitriles, epithionitriles, and cyanides obtained through enzyme-catalyzed hydrolysis of GSLs, exhibit many different biological activities, among which several therapeutic benefits have been suggested. 
  • 1.7K
  • 12 Oct 2020
Topic Review
Clinical Manifestations of Arthropod Bites
Arthropod blood feeders are vectors of several human pathogenic agents, including viruses (e.g., yellow fever, chikungunya, dengue fever), parasites (e.g., malaria, leishmaniasis, lymphatic filariasis...), or bacteria (e.g., plague...). Besides their role as a vector of pathogens, their biting activities cause a nuisance to humans. We document herein, clinical symptoms associated with the biting of ten clusters of hematophagous arthropods, including mosquitoes, biting midges and sandflies, lice, ticks, tsetse flies, blackflies, horse flies, fleas, triatomine and bed bugs. Within the framework of clinical history and entomo-epidemiological information, we propose a  discriminative key that can be helpful for practicing physicians in identifying hematophagous arthropods biting humans and delivering treatment for the associated clinical disorders.
  • 1.7K
  • 04 Jun 2020
Topic Review
The Toxic Impact of Honey Adulteration
Honey is characterized as a natural and raw foodstuff that can be consumed not only as a sweetener but also as medicine due to its therapeutic impact on human health. It is prone to adulterants caused by humans that manipulate the quality of honey. Honey adulterants are any substances that are added to the pure honey. 
  • 1.7K
  • 09 Jan 2023
Topic Review
Stingless Bee-Collected Pollen
Stingless Bee-collected pollen is a mixture of bee pollen, bee salivary enzymes, and regurgitated honey, fermented by indigenous microbes during storage in the cerumen pot. This review provides knowledge on stingless bee collected pollen, its nutrient and microbes for application in the food and pharmaceutical industries 
  • 1.7K
  • 12 Apr 2021
Topic Review
CD19-CAR-T Cells
CD19-targeted chimeric antigen receptor (CAR) T (CD19-CAR-T) cell therapy usually causes B cell aplasia because of “on-target off-tumor” toxicity. The aim of the study was to assess the concept that the introduction of an inhibitory CAR (iCAR) into CAR-T cells could alleviate the side effect of CD19-CAR-T cell therapy. The results showed that CD19-CAR-T cells with a novel KIR/PD-1-based inhibitory CAR (iKP-19-CAR-T) exhibited more naïve, less exhausted phenotypes and preserved a higher proportion of central memory T cells (TCM). Furthermore, iKP-19-CAR-T cells exerted the similar level of cytotoxicity on CD19+HLA-C1- Burkitt’s lymphoma cells compared to CD19-CAR-T cells while sparing CD19+HLA-C1+ healthy human B cells both in vitro and in the xenograft model. Our data demonstrates that the KIR/PD-1-based inhibitory CAR can be a promising strategy to avoid B cell aplasia caused by CD19-CAR-T cell therapy.  
  • 1.7K
  • 26 Oct 2020
Topic Review
Crop Domestication
In agriculture, domestication is the process of a selection of the best trait with increased adaptation or acclimatization of the plant. Driven by human activities, the domestication of plants has dramatically changed the development of the ecological condition. Domestication is the outcome of both phenotypic and genomics changes of a species conferred with classical plant breeding. Gradually, a wild plant changed to an elite high yielding cultivar. Domestication of orphan or underutilized crop plants using recently developed frontier technologies such as genome editing based on current and emerging knowledge generated by genomics and postgenomics approaches are thought to be one of the promising ways for the improvement of the smart crop for the future smart agriculture
  • 1.7K
  • 22 Dec 2020
Topic Review
Chromothripsis
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020). The phenomenon of chromothripsis was discovered in 2011 and changed the concept of genome variability, mechanisms of oncogenic transformation, and hereditary diseases.
  • 1.7K
  • 27 May 2021
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