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Topic Review
Collagen in Wound Healing
Collagens are the most abundant protein found throughout the body. In the healing wound, these collagens are synthesized by cells such as fibroblasts and modified into complex morphologies . The type, amount and organization of collagen changes in the healing wound and determines the tensile strength of the healed skin. Collagen III is the first to be synthesized in the early stages of wound healing and is replaced by collagen I, the dominant skin collagen. The initial random deposition of collagen during the granulation tissue formation is further enhanced by lysyl oxidase enzyme-induced covalent cross-linking. This process matures the collagen into complex structures that are reoriented for tensile strength restoration. Collagen remodeling continues for months after wound closure and the tensile strength of the repaired tissue increases to about 80–85% of normal tissue if all processes proceed without any perturbations.In the skin, the fibrillar collagens types I, III and V are the most common, followed by fibril-associated collagens type XII, XIV, XVI, and VI. The non-fibrillar collagens type IV, XVIII are found in the basement membrane of the skin
  • 2.0K
  • 23 Jun 2021
Topic Review
Pinus
The pine (Pinus L.) is the largest and most heteromorphic plant genus of the pine family (Pinaceae Lindl. ), which grows almost exclusively in the northern hemisphere. The demand for plant-based remedies, supplements and functional food is growing worldwide.
  • 2.0K
  • 17 Jan 2022
Topic Review
Dr. Dipankar Chakraborti: A Legend of Arsenic Research
This encyclopedia provides a brief biography of a legendary scientist Dr. Dipankar Chakraborti. Dr. Chakraborti pioneered arsenic research in the Ganga Meghna Brahmaputra Basin and dedicated his entire life to researching and serving arsenic-affected communities in India and Bangladesh. 
  • 2.0K
  • 22 Feb 2022
Topic Review
Fat-tailed Gerbil
The fat-tailed gerbil (Pachyuromys duprasi), also called the duprasi gerbil, is a rodent belonging to subfamily Gerbillinae. It is the only member of the genus Pachyuromys. These rodents are the most docile species of the gerbil subfamily. They have fluffy and soft fur. Fat-tailed gerbils have been available on the pet market for decades, but in the 21st century breeders can be hard to find. They are sometimes considered as pocket pets. Other common English names are: fat-tailed jird, fat-tailed rat, and beer mat gerbil. Names in other languages are: abu lya (أبو ليه) in Egyptian Arabic, and adhal alyan (عضل أليان) in Standard Arabic, souris à grosse queue (French), Fettschwanzrennmaus (German), fedthale mus (Danish), rasvahäntägerbiili (Finnish), and dikstaartgerbil (Dutch).
  • 2.0K
  • 08 Oct 2022
Topic Review
Modulation of the Nrf2 pathways
The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that acts through antioxidant-responsive elements (ARE) in the promoter region of deoxyribonucleic acid (DNA) and it transcriptionally promotes the expression of Phase 2 metabolism/antioxidant enzymes, such as glutathione S-transferase (GST), nicotinamide adenine dinucleotide (phosphate)  (NAD(P)H) quinone oxidoreductase-1 (NQO-1), and heme oxygenase-1 (HO-1).  The Nrf2-mediated pathway is now recognized to occupy a central position in cell defense mechanisms. Here, we discuss the historical discovery of Nrf2 and the regulatory mechanism of the Nrf2-mediated pathway, focusing on the interacting proteins and post-translational modifications. 
  • 2.0K
  • 05 Sep 2020
Biography
Margaret Hamilton
Margaret Heafield Hamilton (born Heafield on August 17, 1936)[1] is an American computer scientist, systems engineer, and business owner. She is credited with coining the term, "software engineering". Hamilton was Director of the Software Engineering Division[2] of the MIT Instrumentation Laboratory, which developed on-board flight software for the Apollo space program.[3] In 1986, she became th
  • 2.0K
  • 10 Nov 2022
Topic Review
Goose Bumps
Goose bumps, goosebumps or goose-pimples are the bumps on a person's skin at the base of body hairs which may involuntarily develop when a person is tickled, cold or experiencing strong emotions such as fear, euphoria or sexual arousal. The formation of goose bumps in humans under stress is considered to be a vestigial reflex. Its function in other apes is to raise the body's hair, and would have made human ancestors appear larger to scare off predators or to increase the amount of air trapped in the fur to make it more insulating. The reflex of producing goose bumps is known as piloerection or the pilomotor reflex, or, more traditionally, horripilation. It occurs in many mammals; a prominent example is porcupines, which raise their quills when threatened, or sea otters when they encounter sharks or other predators.
  • 2.0K
  • 29 Nov 2022
Topic Review Peer Reviewed
Main Carotenoids Produced by Microorganisms
Carotenoids are the pigments present in plants, animals, and microorganisms which are responsible for a broad variety of colors found in nature. Their capacity as antioxidants mainly established their marketable success as health, food, and feed supplements, and cosmetics components. Currently, chemical synthesis dominates the worldwide market; however, due to the high biological value of natural carotenoids, the production scheme is moving towards microbial production as a profitable alternative. 
  • 2.0K
  • 13 Apr 2022
Topic Review
Cellular Senescence in Cancer
Cellular senescence is a state of stable cell cycle arrest that can be triggered in response to various insults and is characterized by distinct morphological hallmarks, gene expression profiles, and the senescence-associated secretory phenotype (SASP). Importantly, cellular senescence is a key component of normal physiology with tumor suppressive functions.
  • 2.0K
  • 14 Feb 2021
Topic Review
Synechocystis sp.: A Model Microorganism
Synechocystis sp. is a unicellular, spherical, non-nitrogen-fixing cyanobacterium with 0.7–8 µm in diameter and no or fine and colorless mucilage layer . The cell envelop of Synechocystis sp. contains the outer membrane, a peptidoglycan layer, and cytoplasmic membrane. The thylakoid membranes, derived from the cytoplasmic membrane, cover the peripheral region of the cell . From cyanobacteria to higher plants, thylakoid membranes are the site of photosynthesis converged near the cytoplasmic membrane. Thylakoid centers, fibrous coated cylindrical structures, 40–50 nm in diameter and 50–1000 nm in length, establish and maintain thylakoid membrane organization
  • 2.0K
  • 15 Apr 2022
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