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Topic Review
Borrelia burgdorferi in Ixodidae Tick around Asia
Lyme disease (LD) is a common arthropod-borne inflammatory disorder prevalent in the northern hemisphere. LD is caused by a spirochete named Borrelia burgdorferi s.l., which is transmitted to humans by ticks. Climate, environment, and other factors affect land use; recreational-behavior changes affect human contact with infected ticks. Ixodes, Haemaphysalis and Dermacentor may be the most common tike of B. burgdorferi-positive in Asia. 
  • 478
  • 13 Apr 2022
Topic Review
Borreliaceae Diagnostics
The acceleration of climate change has been associated with an alarming increase in the prevalence and geographic range of tick-borne diseases (TBD), many of which have severe and long-lasting effects—particularly when treatment is delayed principally due to inadequate diagnostics and lack of physician suspicion. Moreover, there is a paucity of treatment options for many TBDs that are complicated by diagnostic limitations for correctly identifying the offending pathogens. 
  • 587
  • 30 Sep 2022
Topic Review
C9orf72-Associated Toxic Dipeptide Repeats
Protein homeostasis is essential for neuron longevity, requiring a balanced regulation between protein synthesis and degradation. The clearance of misfolded and aggregated proteins, mediated by autophagy and the ubiquitin–proteasome systems, maintains protein homeostasis in neurons, which are post-mitotic and thus cannot use cell division to diminish the burden of misfolded proteins. When protein clearance pathways are overwhelmed or otherwise disrupted, the accumulation of misfolded or aggregated proteins can lead to the activation of ER stress and the formation of stress granules, which predominantly attempt to restore the homeostasis by suppressing global protein translation. Alterations in these processes have been widely reported among studies investigating the toxic function of dipeptide repeats (DPRs) produced by G4C2 expansion in the C9orf72 gene of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
  • 135
  • 26 Jan 2024
Topic Review
Caenorhabditis elegans as an In Vivo Model
Antimicrobial resistance (AMR) due to the prevalence of multidrug-resistant (MDR) pathogens is rapidly increasing worldwide, and the identification of new antimicrobial agents with innovative mechanisms of action is urgently required. Medicinal plants that have been utilised for centuries with minor side effects may hold great promise as sources of effective antimicrobial products. The free-living nematode Caenorhabditis elegans (C. elegans) is an excellent live infection model for the discovery and development of new antimicrobial compounds. However, while C. elegans has widely been utilised to explore the effectiveness and toxicity of synthetic antibiotics, it has not been used to a comparable extent for the analysis of natural products.
  • 278
  • 11 Aug 2023
Topic Review
Caenorhabditis elegans Models Established for Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease characterised by the selective and gradual loss of motor neurons in the spinal, bulbar and cortical regions. C. elegans has established itself as a favoured model organism in the field of neurodegenerative disease research. Through analysis of gene mutations pertinent to these disease, it provides a unique opportunity to identify pathogenic molecular pathways and explore promising therapeutic options. 
  • 195
  • 10 Jan 2024
Topic Review
Caenorhabditis elegans Models in Amyotrophic Lateral Sclerosis Mechanism
Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative condition characterized by the progressive degeneration of motor neurons. Despite extensive research in various model animals, the cellular signal mechanisms of ALS remain elusive, impeding the development of efficacious treatments. Among these models, a well-characterized and diminutive organism, Caenorhabditis elegans (C. elegans), has emerged as a potent tool for investigating the molecular and cellular dimensions of ALS pathogenesis. 
  • 96
  • 10 Jan 2024
Topic Review
Camelina sativa
Camelina sativa (L.) Crantz, also called gold-of-pleasure, false flax, or linseed dodder, is an oilseed crop belonging to the tribe Camelineae of the mustard family (Brassicaceae). Camelina is a hardy plant that adapts very well to different types of soil and grows best in cool semi-arid climates. The great potential of this crop is also being exploited to obtain a sustainable feedstock for its different applications, and to improve dryland agriculture. Camelina can be used to improve the quality of foods, such as dairy products and meat, and the consumption of its oil has potential benefits for human health.
  • 504
  • 23 May 2023
Topic Review
Camelina sativa as an Allelopathic Potential Cover Crop
Camelina sativa, known for its high oil content and adaptability to diverse climatic conditions, exhibits allelopathic potential by releasing chemical compounds that inhibit weed growth. The crop’s vigorous growth and canopy architecture contribute to effective weed suppression, reducing the prevalence and spread of associated pathogens. Furthermore, the chemical compounds released by camelina through the solubilization of compounds from leaves by rain, root exudation, or deriving from microbial-mediated decay of camelina’s tissues interfere with the growth of neighbouring plants, indicating allelopathic interactions. The isolation and identification of benzylamine and glucosinolates as allelochemicals in camelina highlight their role in plant–plant interactions. 
  • 325
  • 31 Aug 2023
Topic Review
Campylobacter Upsaliensis
Campylobacter upsaliensis is a gram negative bacteria in the Campylobacter genus. C. upsaliensis is found worldwide, and is a common cause of Campylobacteriosis in humans, as well as gastroenteritis in dogs. Human infections are primarily associated with raw or undercooked meat and contaminated water sources, however there is some zoonotic risk associated with the spread from dogs. C. upsaliensis primarily affects the gastrointestinal tract as it damages gastrointestinal epithelial cells. There are many methods for detecting C.upsaliensis including PCR and ELISA, however there is no current gold standard in detection techniques. Infection is typically self limiting, however there is antimicrobial therapy available.
  • 1.1K
  • 30 Sep 2022
Topic Review
Carcino-Evo-Devo
The term “carcino-evo-devo” was used for the first time as a name for the theory of the evolutionary role of tumors. The new term was coined from two other terms: “carcinoembryonic” and “evo-devo”.
  • 268
  • 18 May 2023
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