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Topic Review
Notch Signaling
Roles of Notch signaling in human development and cancer are reviewed herein. The four Notch paralogs along with the five Notch ligands are described. Their structures, mode of activation, and functions are briefly summarized based on published works.
  • 1.0K
  • 21 Oct 2020
Biography
Joseph A. Walker
Joseph Albert Walker (February 20, 1921 – June 8, 1966) flew the world's first two spaceplane flights in 1963, thereby becoming the United States' seventh man in space. Walker was a Captain in the United States Air Force , an American World War II pilot, an experimental physicist, a NASA test pilot, and a member of the U.S. Air Force Man In Space Soonest spaceflight program. His two X-15 exper
  • 1.0K
  • 15 Nov 2022
Topic Review
Mycoplasma pneumoniae Infections
Mycoplasma pneumoniae is a major causative agent of community-acquired pneumonia which can lead to both acute upper and lower respiratory tract inflammation, and extrapulmonary syndromes. 
  • 1.0K
  • 28 Sep 2021
Biography
William Thomson, Baron Kelvin
William Thomson, Baron Kelvin, OM, GCVO, PC, PRS, FRSE (26 June 1824 – 17 December 1907) was a British[1] mathematical physicist and engineer who was born in Belfast in 1824. At the University of Glasgow he did important work in the mathematical analysis of electricity and formulation of the first and second laws of thermodynamics, and did much to unify the emerging discipline of physics in it
  • 1.0K
  • 01 Dec 2022
Topic Review
Applications of Machine Learning Algorithms in Food Industry
Machine learning assists with food process optimization techniques by developing a model to predict the optimal solution for given input data. Machine learning includes unsupervised and supervised learning, data pre-processing, feature engineering, model selection, assessment, and optimization methods. Various problems with food processing optimization could be resolved using these techniques. Machine learning is increasingly being used in the food industry to improve production efficiency, reduce waste, and create personalized customer experiences. Machine learning may be used to improve ingredient utilization and save costs, automate operations such as packing and labeling, and even forecast consumer preferences to develop personalized products. Machine learning is also being used to identify food safety hazards before they reach the consumer, such as contaminants or spoiled food. The usage of machine learning in the food sector is predicted to rise as more businesses understand the potential of this technology to enhance customer experience and boost productivity.
  • 1.0K
  • 15 Jun 2023
Topic Review
OTOF-Associated Hearing Impairment
Otoferlin, an essential synaptic protein in the auditory sensory inner hair cells, is encoded by the gene OTOF. Biallelic variants in OTOF are associated with autosomal recessive auditory neuropathy or synaptopathy (DFNB9). Since its discovery in 1996, roughly 220 causally-associated variants have been uncovered. The prevalence of OTOF-associated hearing loss varies according to population. A higher molecular genetic diagnostic yield has been reported in patients with prelingual auditory synaptopathy, making this very specific clinical feature a useful criterion for OTOF diagnostic testing. Apart from this clinical hallmark, genotype-phenotype correlations are rather complex and include a variant that causes temperature-sensitive auditory neuropathy (p.Ile515Thr) and three variants that have so far been associated with progressive hearing impairment. Several founder variants have been reported in the Asian and European populations. A complete landscape of genomic variation at the DFNB9 locus remains to be determined and improvements in genomics technologies may eventually uncover novel insights into possible missing variants. A complete understanding of OTOF variants is essential for the success of current and future therapies.
  • 1.0K
  • 13 Jan 2021
Topic Review
Microalgae Encapsulation
Microalgae are microorganisms with a singular biochemical composition, including several biologically active compounds with proven pharmacological activities, such as anticancer, antioxidant and anti-inflammatory activities, among others. These properties make microalgae an interesting natural resource to be used as a functional ingredient, as well as in the prevention and treatment of diseases, or cosmetic formulations. Nevertheless, natural bioactives often possess inherent chemical instability and/or poor solubility, which are usually associated with low bioavailability. As such, their industrial potential as a health-promoting substance might be severely compromised. In this context, encapsulation systems are considered as a promising and emerging strategy to overcome these shortcomings due to the presence of a surrounding protective layer.
  • 1.0K
  • 23 Apr 2021
Biography
Mathias Jucker
Mathias Jucker, born 7 July 1961 in Zürich, Switzerland , is a Swiss neuroscientist, Professor, and a Director at the Hertie Institute for Clinical Brain Research of the University of Tübingen, Germany . He is also a Group Leader at the German Center for Neurodegenerative Diseases (German: Deutsches Zentrum für Neurodegenerative Erkrankungen, (DZNE)) in Tübingen. Jucker is known for his rese
  • 1.0K
  • 30 Dec 2022
Topic Review
Epigenetics for Forest Trees
Epigenetics refers to a scientific domain studying all the processes affecting the expression of genes and/or the activity of transposable elements (TEs) without altering the DNA sequence that may be heritable by mitosis (during development) and/or meiosis (across generations). Forest trees are sessile, perennial, and modular organisms with complex life cycles that are often challenged by environmental variations such as actual climate changes during their long-lifespan. Surviving tree populations can respond to these environmental changes through complex and interacting mechanisms and notably using epigenetics. 
  • 1.0K
  • 21 Sep 2020
Topic Review
Root Rot Disease in Agriculture
Root rot diseases remain a major global threat to the productivity of agricultural crops. They are usually caused by more than one type of pathogen and are thus often referred to as a root rot complex.
  • 1.0K
  • 19 Mar 2021
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