Topic Review
Human Endogenous Retrovirus in Neurodegeneration
Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation is mainly achieved by epigenetic mechanisms, which can be altered by environmental factors, e.g., viral infections, leading to HERV activation. This review summarizes the recent advances on the epigenetic mechanisms controlling HERV expression and the pathogenic effects triggered by HERV de-repression leading to neurological diseases, inflammatory processes and neurodegeneration.
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  • 04 Jun 2021
Biography
Marcia Moore
Marcia Moore (May 22, 1928 – January 14, 1979[1]) was an American writer, astrologer and yoga teacher brought to national attention in 1965 through Jess Stearn's book Yoga, Youth, and Reincarnation. She was an advocate and researcher of the dissociative properties of the drug ketamine. Moore disappeared in 1979, and although her remains were found in 1981, the cause and circumstances of her de
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  • 16 Dec 2022
Topic Review
Antimicrobial Potential of Curcumin
Curcumin is a bioactive compound that is extracted from Curcuma longa and that is known for its antimicrobial properties. Curcuminoids are the main constituents of curcumin that exhibit antioxidant properties. It has a broad spectrum of antibacterial actions against a wide range of bacteria, even those resistant to antibiotics. Curcumin has been shown to be effective against the microorganisms that are responsible for surgical infections and implant-related bone infections, primarily Staphylococcus aureus and Escherichia coli. The efficacy of curcumin against Helicobacter pylori and Mycobacterium tuberculosis, alone or in combination with other classic antibiotics, is one of its most promising antibacterial effects. Curcumin is known to have antifungal action against numerous fungi that are responsible for a variety of infections, including dermatophytosis. Candidemia and candidiasis caused by Candida species have also been reported to be treated using curcumin. Life-threatening diseases and infections caused by viruses can be counteracted by curcumin, recognizing its antiviral potential.
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  • 16 Mar 2022
Topic Review
Bioinformatics in Plant Breeding and Disease Resistance
In the context of plant breeding, bioinformatics can empower genetic and genomic selection to determine the optimal combination of genotypes that will produce a desired phenotype and help expedite the isolation of these new varieties. Bioinformatics is also instrumental in collecting and processing plant phenotypes, which facilitates plant breeding. Robots that use automated and digital technologies to collect and analyze different types of information to monitor the environment in which plants grow, analyze the environmental stresses they face, and promptly optimize suboptimal and adverse growth conditions accordingly, have helped plant research and saved human resources.
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  • 02 Dec 2022
Topic Review
Hydrogen Sulfide
Hydrogen sulfide is a colorless gas with a characteristic smell like rotten eggs. It is flammable and corrosive at very high concentrations. It has been always considered a toxic molecule, but more recently, it has been proved it is a metabolite and signaling molecule in biological tissues that regulates many physiological processes.
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  • 08 Nov 2020
Topic Review
Xanthomonas campestris
Xanthomonas campestris pv. campestris (Xcc) is a Gram-negative, aerobic, vascular, and motile bacterium with a single flagellum, which causes the disease identified as black rot in Brassica crops.
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  • 30 Aug 2021
Topic Review
Lambari
Lambari is a group of small native fish from Brazil common in natural freshwater. They have gained visibility and good acceptance in very profitable market niches, such as human food and live bait for sport fishing.
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  • 15 Sep 2021
Topic Review
Green Synthesis of Gold Nanoparticles (AuNPs) from Plants
Gold nanoparticles (AuNPs) are becoming promising cancer therapeutic and diagnostic metal NPs that attract researchers due to their unique physiochemical properties such as stability, biocompatibility, high thermal activity, optical, electrical, high surface area to volume ratio surface chemistry, and multifunctionalization, etc. By fine tuning the components and concentrations, AuNPs can be easily manufactured into various forms and sizes. AuNPs have also shown significant advancement in treating inflammatory diseases and bacterial infections.
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  • 02 Nov 2021
Topic Review
Rapid Nontranscriptional Effects of Calcifediol and Calcitriol
Classically, a secosteroid hormone, vitamin D, has been implicated in calcium and phosphate homeostasis and has been associated with the pathogenesis of rickets and osteomalacia in patients with severe nutritional vitamin D deficiency. The spectrum of known vitamin D-mediated effects has been expanded in recent years. However, the mechanisms of how exactly this hormone elicits its biological function are still not fully understood. The interaction of this metabolite with the vitamin D receptor (VDR) and, subsequently, with the vitamin D-responsive element in the region of specific target genes leading to the transcription of genes whose protein products are involved in the traditional function of calcitriol (known as genomic actions). Moreover, in addition to these transcription-dependent mechanisms, it has been recognized that the biologically active form of vitamin D3, as well as its immediate precursor metabolite, calcifediol, initiate rapid, non-genomic actions through the membrane receptors that are bound as described for other steroid hormones. So far, among the best candidates responsible for mediating rapid membrane response to vitamin D metabolites are membrane-associated VDR (VDRm) and protein disulfide isomerase family A member 3 (Pdia3). 
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  • 29 Jun 2022
Topic Review
Ethylene
Salinity stress is one of the major threats to agricultural productivity across the globe. Research in the past three decades, therefore, has focused on analyzing the effects of salinity stress on the plants. Evidence gathered over the years supports the role of ethylene as a key regulator of salinity stress tolerance in plants. This gaseous plant hormone regulates many vital cellular processes starting from seed germination to photosynthesis for maintaining the plants’ growth and yield under salinity stress. Ethylene modulates salinity stress responses largely via maintaining the homeostasis of Na+/K+, nutrients, and reactive oxygen species (ROS) by inducing antioxidant defense in addition to elevating the assimilation of nitrates and sulfates. Moreover, a cross-talk of ethylene signaling with other phytohormones has also been observed, which collectively regulate the salinity stress responses in plants.
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  • 09 Jul 2021
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