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Topic Review
Centromere Flexibility
Centromeres are the complex structures responsible for the proper segregation of chromosomes during cell division. Structural or functional alterations of the centromere cause aneuploidies and other chromosomal aberrations that can induce cell death with consequences on health and survival of the organism as a whole. Because of their essential function in the cell, centromeres have evolved high flexibility and mechanisms of tolerance to preserve their function following stress, whether it is originating from within or outside the cell.Despite the differences in DNA sequences, protein composition and centromere size, all of these diverse centromere structures promote efficient chromosome segregation, balancing genome stability and adaptability, and ensuring faithful genome inheritance at each cellular generation.
  • 1.1K
  • 03 Aug 2020
Topic Review
Endogenous Opioid Peptides
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta opioid receptor (DOR) and kappa opioid receptor (KOR), and play important roles not only in analgesia, but also many other biological processes such as reward, stress response, feeding and emotion. 
  • 1.1K
  • 08 May 2021
Topic Review
Polyphenols in Apple-Processing By-Products
Polyphenols of plant origin are a broad family of secondary metabolites that range from basic phenolic acids to more complex compounds such as stilbenes, flavonoids, and tannins, all of which have several phenol units in their structure. Considerable health benefits, such as having prebiotic potential and cardio-protective and weight control effects, have been linked to diets based on polyphenol-enriched foods and plant-based products, indicating the potential role of these substances in the prevention or treatment of numerous pathologies. The most representative phenolic compounds in apple pomace are phloridzin, chlorogenic acid, and epicatechin, with major health implications in diabetes, cancer, and cardiovascular and neurocognitive diseases. 
  • 1.1K
  • 01 Dec 2022
Biography
Harvey Fletcher
Harvey Fletcher (September 11, 1884 – July 23, 1981) was an American physicist.[1] Known as the "father of stereophonic sound," he is credited with the invention of the 2-A audiometer[2] and an early electronic hearing aid.[3][4] He was an investigator into the nature of speech and hearing, and made contributions in acoustics, electrical engineering, speech, medicine, music, atomic physics, so
  • 1.1K
  • 25 Nov 2022
Topic Review
Pancreatic β-Cell Dysfunction
Under healthy conditions, pancreatic β-cells produce and secrete the insulin hormone in response to blood glucose levels. Under diabetic conditions, however, β-cells are compelled to continuously secrete larger amounts of insulin to reduce blood glucose levels, and thereby, the β-cell function is debilitated in the long run.
  • 1.1K
  • 30 Dec 2020
Topic Review
Fusarium oxysporum
Fon has four recognized races: 0, 1, 2, and 3. Each subsequent race is determined by its ability to cause infection on previously resistant cultivars, with race 3 having the largest range of pathogenicity. Although the specific avirulence gene responsible for overcoming cultivar resistance is not known in most races, the ability to cause infection should be characterized as virulence rather than pathogenicity as their differentiation rests on a 1–9 scale of disease rating.
  • 1.1K
  • 24 Sep 2021
Topic Review
AMP-activated Protein Kinase
We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. If this is the case, then aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between a wide variety of conditions associated with metabolic disorder.
  • 1.1K
  • 10 May 2021
Topic Review
Tetrahydrofuran Biodegradation
Tetrahydrofuran (THF) is widely used as a precursor for polymer syntheses and a versatile solvent in industries. THF is an environmental hazard and carcinogenic to humans. We characterized the THF degradation potential of a number of THF-degrading bacteria reported before and a new isolated filamentous fungus Pseudallescheria boydii ZM01. Two different microbial THF degradation pathways have been proposed here. In addition, The initial key metabolic intermediate 2-hydroxytetrahydrofuran was detected and identified by gas chromatography (GC) analyses for the first time during the THF degradation process.
  • 1.1K
  • 10 Nov 2020
Topic Review
Computational Modeling of Human Microbiome
The human microbiome has been identified as a potentially significant contributor to human health, but the composition and role that the microbiome plays varies across body sites.  Technological improvements have enabled large-scale studies of the human microbiome and this review focuses on the data and health impacts that have been analyzed to date associated with the skin, oral, gut, and vaginal microbiomes.  One major challenge in this area that remains is to gain a better mechanistic understanding of the microbial consortium function and dynamics and how it impacts the human host.  Computational approaches can help analyze some of the interactions and complexity of the microbiome-host interactions and thus, discussion on relevant computational studies associated with the human microbiome are also presented.
  • 1.1K
  • 01 Nov 2020
Topic Review Peer Reviewed
CRISPR Towards a Sustainable Agriculture
Climate change and the need to feed an increasing population undermines food production and safety, representing the reasons behind the development of a new agriculture that is much more sustainable, productive and accessible worldwide. Genome editing and, in particular, clustered regularly interspaced palindromic repeats/CRISPR-associated protein (CRISPR/Cas) tools will play a major role in plant breeding to address these concerns. CRISPR/Cas includes a series of genome editing tools relying on the recognition and cleavage of target DNA/RNA sequences to introduce specific mutations.
  • 1.1K
  • 13 Apr 2022
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