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Topic Review
EPR Effect for Cancer Treatment
The EPR effect was first discovered by Maeda and colleagues in solid murine tumors. The polymer-drug conjugates were i.v. administered, and 10-to-100-fold higher concentrations were achieved relative to free drug administration. The concentration of nanodrugs builds up in tumors due to the EPR effect, reaching several times higher than that of plasma due to the lack of lymphatic drainage. 
  • 1.1K
  • 23 Jun 2021
Topic Review
Histone Deacetylase Inhibitors
Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.
  • 1.1K
  • 11 Dec 2020
Topic Review
Microglial Staining
Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system. Accurate identification of microglia and their reactivity state is therefore essential to further understanding of CNS pathophysiology. Many staining techniques have been used to visualise microglia in rodent and human tissue, and immunostaining is currently the most frequently used.
  • 1.1K
  • 29 Apr 2022
Topic Review
Neuropharmacological Effects of Terpenoids
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disorders.
  • 1.1K
  • 28 Sep 2022
Topic Review
Endocrine Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.
  • 1.1K
  • 27 Oct 2020
Topic Review
ESKAPE Bacteria in the Dog
ESKAPE bacteria (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are a group of common opportunistic pathogens associated mainly with nosocomial infections.
  • 1.1K
  • 30 Oct 2020
Topic Review
Nutritional Composition of Flaxseeds
Flaxseed (Linum usitatissimum L.) has gained worldwide recognition as a health food because of its abundance in diverse nutrients and bioactive compounds such as oil, fatty acids, proteins, peptides, fiber, lignans, carbohydrates, mucilage, and micronutrients. These constituents attribute a multitude of beneficial properties to flaxseed that makes its use possible in various applications, such as nutraceuticals, food products, cosmetics, and biomaterials.
  • 1.1K
  • 25 Oct 2022
Topic Review
Thousand-Year Rose
The Thousand-year Rose (German: Tausendjähriger Rosenstock, literally: Thousand-year-old Rosebush) is also known as the Rose of Hildesheim. It grows on the apse of the Hildesheim Cathedral, a Catholic cathedral in Hildesheim, Germany, that is dedicated to the Assumption of Mary. The cathedral and the adjacent St. Michael's Church have been on the UNESCO list of World Heritage Sites since 1985. The rose that climbs on the wall of the cathedral's apse is believed to be the oldest living rose in the world. A Rosa canina, commonly known as a wild dog rose, grows against the eastern apse of the cathedral, which is around 21 metres (69 ft) high and 9 metres (30 ft) wide. The rose bush reaches a height of around 10 metres (33 ft) and documentation verifies its age at approximately 700 years. Slight variations arise in the tale of the establishment of the diocese by King Louis the Pious at Hildesheim in 815 but the rose bush is a common theme in all versions. The cathedral was destroyed by Allied bombers in 1945 during the Second World War, but the roots of the rose bush survived and it blossomed again among the ruins. According to legend, while the rose bush flourishes, Hildesheim will prosper. A poem about the rose was published in 1896. In the early twentieth century, after visiting the cathedral and seeing the rose, author Mabel Wagnalls was inspired to write a book, which went on to form the basis of a silent film.
  • 1.1K
  • 08 Nov 2022
Topic Review
Salicylic Acid in Plants Exposed to Heavy Metals
Salicylic acid (SA) is a very simple phenolic compound (a C7H6O3 compound composed of an aromatic ring, one carboxylic and a hydroxyl group) and this simplicity contrasts with its high versatility and the involvement of SA in several plant processes either in optimal conditions or in plants facing environmental cues, including heavy metal (HM) stress. 
  • 1.1K
  • 29 Jul 2022
Topic Review
Fibroblasts
Fibroblasts, the most abundant cells in the connective tissue, are key modulators of the extracellular matrix (ECM) composition.
  • 1.1K
  • 18 Jan 2021
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