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Topic Review
Osteoclast Multinucleation
       Osteoclasts  are derived from hemopoietic progenitors of the monocyte-macrophage lineage. They differentiate upon exposure to macrophage colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL), which are presented by osteoblasts and osteocytesare. Multinucleation in a late phase of osteoclastogenesis is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border that enable efficient bone resorption.  The process of osteoclast multinucleation is dynamic, complicated and finely controlled by multiple entangled factors. At the beginning of the 21st century, two master fusogens, DC-STAMP and OC-STAMP, had been identified that directly regulate osteoclast multinucleation.
  • 1.2K
  • 17 Aug 2020
Topic Review
Appendage Regeneration in Vertebrates
Appendage regeneration in vertebrates means the ability to regenerate amputated or injured tissues and organs, which is a fascinating property shared by several invertebrates and, interestingly, some vertebrates.
  • 1.2K
  • 01 Jun 2021
Topic Review
Arbuscular Mycorrhizal Fungi Symbiosis to Enhance Plant–Soil Interaction
Arbuscular mycorrhizal fungi (AMF) form a symbiotic relationship with plants; a symbiotic relationship is one in which both partners benefit from each other. Fungi benefit plants by improving uptake of water and nutrients, especially phosphorous, while plants provide 10–20% of their photosynthates to fungus. AMF tend to make associations with 85% of plant families and play a significant role in the sustainability of an ecosystem. Plants’ growth and productivity are negatively affected by various biotic and abiotic stresses. AMF proved to enhance plants’ tolerance against various stresses, such as drought, salinity, high temperature, and heavy metals.
  • 1.2K
  • 15 Jul 2022
Topic Review
Techniques of Making Edible Coatings
Edible coatings are made from natural food-grade materials, such as hydrocolloids (polysaccharides, proteins), lipids, and emulsifiers, produced with different techniques, such as dipping (immersing), spraying, spreading, brushing, pressing them/thermoforming, or extrusion. The most used method for coating is immersing, where food is dipped in a liquid containing food matrices, forming a film around the food and protecting all the components present.
  • 1.2K
  • 15 Sep 2023
Topic Review
Photorespiration: The Futile Cycle?
Photorespiration, or C2 photosynthesis, is generally considered a futile cycle that potentially decreases photosynthetic carbon fixation by more than 25%. Nonetheless, many essential processes, such as nitrogen assimilation, C1 metabolism, and sulfur assimilation, depend on photorespiration. Most studies of photosynthetic and photorespiratory reactions are conducted with magnesium as the sole metal cofactor despite many of the enzymes involved in these reactions readily associating with manganese. Indeed, when manganese is present, the energy efficiency of these reactions may improve. 
  • 1.2K
  • 19 May 2021
Topic Review
Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
Thrombocytopenia is a clinical manifestation that refers to the low platelet count, i.e., <150 × 103/μL, of blood, resulting in imbalanced hemostasis, which leads to several fatal complications. The causative factors vary greatly, but, as a consequence, they interfere with platelet production and promote destruction, leading to death. Carica papaya leaf has unique therapeutic and medicinal characteristics against thrombocytopenia, and this is supported by scientific studies. Secondary metabolites and minerals in the leaf, such as carpaine and quercetin, promote platelet production, inhibit platelet destruction, and maintain platelet membrane through gene expression activity and the ceasing of viral proteases, respectively. Phytochemical profiles of C. papaya leaf revealed the presence of flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins, which impart therapeutic potential to the leaf. The therapeutic benefits of the leaf include immunomodulatory, antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antibacterial, and antioxidant activities. Several conducted scientific research studies have proved the efficacy of C. papaya leaf against thrombocytopenia, expanding the implication of natural sources to eradicate numerous ailments.
  • 1.2K
  • 24 May 2022
Topic Review
Atomic Force Microscopy
Atomic force microscopy (AFM) is one of the microscopic techniques with the highest lateral resolution. It can usually be applied in air or even in liquids, enabling the investigation of a broader range of samples than scanning electron microscopy (SEM), which is mostly performed in vacuum. Since it works by following the sample surface based on the force between the scanning tip and the sample, interactions have to be taken into account, making the AFM of irregular samples complicated, but on the other hand it allows measurements of more physical parameters than pure topography.
  • 1.2K
  • 06 Apr 2022
Topic Review
Litsea cubeba
Litsea cubeba is a special woody oil plant resource in China, which is mainly distributed in provinces and regions in the south of the Yangtze River. For the past several decades, Litsea cubeba essential oil has been the only product for trading, which can be extracted from its whole plant, including leaves, flowers, fruits, trunks, and even roots. Based on the zero-waste biorefinery concept, residues generated from Litsea cubeba essential oil processing have recently been found as potential sources for various plant-based products with added values, i.e., kernel oil with a high content of medium chain fatty acids might be used for the sustainable production of surfactants or even biofuels, pomace including protein might be used as a good source for feeding.
  • 1.2K
  • 12 Jul 2021
Topic Review
T Helper Cells in IBD
Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn’s disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector or regulatory phenotypes is controlled by cytokine networks and transcriptional regulators. Distinct polarized T helper cells are able to alter their phenotypes to adapt to diverse and fluctuating physiological environments. T helper cells exhibit intrinsic instability and flexibility to express cytokines of other lineages or transdifferentiate from one T helper cell type to another in response to various perturbations from physiological cytokine milieu as a means of promoting local immunity in response to injury or ensure tissue homeostasis. Furthermore, functional plasticity and diversity of T helper cells are associated with pathogenicity and are critical for immune homeostasis and prevention of autoimmunity. In this review, we provide deeper insights into the combinatorial extrinsic and intrinsic signals that control plasticity and transdifferentiation of T helper cells and also highlight the potential of exploiting the genetic reprogramming plasticity of T helper cells in the treatment of IBD.
  • 1.2K
  • 28 Oct 2020
Topic Review
Proteomics in Forensic Analysis
Proteomics is in the early stages of development for forensic applications. It has been used in forensics for identification of tissue and body fluid, identification and quantification of protein toxins, human individualization, detection of protein drugs and hormones in sports, and estimation of post-mortem intervals.
  • 1.2K
  • 19 Apr 2021
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