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Topic Review
Gestational Diabetes Mellitus (GDM)
Gestational Diabetes Mellitus (GDM) is a transient condition characterized by carbohydrate intolerance, hyperglycemia, peripheral insulin resistance, insufficient insulin secretion or activity, endothelial dysfunction, and low-grade inflammation during pregnancy, frequently with the first onset between 24 and 28 weeks of gestation.
  • 1.3K
  • 28 Sep 2021
Topic Review
Poultry Litter
Poultry litter is a combination of aviary excreta and bedding materials such as wood shavings, sawdust, peanut hulls, shredded sugar cane, straw, or other dry, absorbent, uneaten feed, broken eggs, dead birds, bird feathers and low-cost organic material [1].
  • 1.3K
  • 27 Dec 2020
Topic Review Video
Bee Nutritional Demands
For all bee species, the pollen quality determines the overall quality of the larval food, influences the development of individuals and shapes their populations. However, not all plants produce pollen that fully satisfies the nutritional requirements of bees. Lack of understanding of the nutritional requirements of wild bees may lead to unintended negative effects of conservation efforts. Ecological stoichiometry provides an approach to better understand the nutritional constraints on growing and developing organisms and their colonies and populations. It makes reference to elements that, if scarce in the environment, prevent the construction of biologically important organic molecules. The least understood aspect of the nutritional requirements of bees concerns stoichiometric balancing and the need for adequate ratios of nutritional elements in consumed food. This text provides theoretical foundation for the project aiming at determining the likely limitations imposed on wild bees by the lack of nutritionally balanced pollen. The following hypotheses may be tested: 1. Pollen stoichiometry vary among plant species and populations but will differ more widely among species than within different populations of the same species.2. The stoichiometry of bees will vary substantially among bee species and between sexes within a species, which suggests the existence of different nutritional demands. Therefore, it is expected that the stoichiometric mismatches experienced by bees will vary in a species-specific and sex-specific manner.3. For a given bee species, specific pollen species allow the overcoming of stoichiometric mismatches and will balance the diet. Accordingly, it is expected expect that flora diversity and, thus, pollen diversity matches the stoichiometric niches of bees. I predict that the occurrence of specific key host plant species that produce stoichiometrically desirable pollen allows bees to stoichiometrically balance their diets. The project may ask if and how floral diversity, particularly the accessibility of nutritionally desirable key species, may influence bee populations. The obtained data will allow the parameterization of a conceptual model of nutritional limitations (to be developed in the future), which will enable to predict how floral community influences wild bee populations via supply and demand of nutrients.
  • 1.3K
  • 05 Nov 2020
Topic Review
Induction of heme oxygenase-1 Expression
Heme oxygenase-1 (HO-1) catalyzes the degradation of heme molecules releasing equimolar amounts of biliverdin, iron and carbon monoxide. Its expression is induced in response to stress signals such as reactive oxygen species and inflammatory mediators with antioxidant, anti-inflammatory and immunosuppressive consequences for the host. Interestingly, several intracellular pathogens responsible for major human diseases have been shown to be powerful inducers of HO-1 expression in both host cells and in vivo. Studies have shown that this HO-1 response can be either host detrimental by impairing pathogen control or host beneficial by limiting infection induced inflammation and tissue pathology. These properties make HO-1 an attractive target for host-directed therapy (HDT) of the diseases in question, many of which have been difficult to control using conventional antibiotic approaches.
  • 1.3K
  • 10 Dec 2020
Topic Review
Histone deacetylase (HDAC)
Histone deacetylase (HDAC) enzymes play crucial roles in epigenetic gene expression and are an attractive therapeutic target. Five HDAC inhibitors have been approved for cancer treatment to date, however clinical applications have been limited due to poor single agent drug efficacy and side effects associated with a lack of HDAC isoform or complex selectivity. An emerging strategy aiming to address these limitations is the development of bifunctional HDAC therapeutics – single molecules comprising a HDAC inhibitor conjugated to another specificity targeting moiety. There has been many recent advancements in novel types of dual-targeting HDAC modulators, including PROTACs, often achieving high HDAC isoform selectivity, as well as some dual inhibitor examples affording HDAC complex selectivity. Such bifunctional molecules have future potential in achieving enhanced drug efficacy and therapeutic benefits in treating disease.
  • 1.3K
  • 12 Oct 2020
Topic Review
Larval Feeding Guilds
Larval feeding guilds may affect pollinator ecology, evolution and diversity. I propose to evaluate the nutritional demands of pollinating insects from different larval feeding guilds and the nutrient supplies offered by their host plants/other larval food to explore the nutritional dimension of the ecology and evolution of pollinators and their host plants.
  • 1.3K
  • 05 Nov 2020
Topic Review
Drought Stress
Drought is one of the most important factors restricting agricultural production, which seriously affects crop yield.
  • 1.3K
  • 18 May 2021
Topic Review
The Principles and Characteristics of NIR Spectroscopy
Spectroscopy technology is a popular method for quantitative and qualitative analysis in fields such as agricultural products and foods by combining with various chemometric methods. In fact, this is the application basis for spectroscopy and spectral imaging techniques in other fields such as genetics and transgenic monitoring. There has been considerable research using spectroscopy (especially near infrared (NIR) spectroscopy) for the effective identification of agricultural products and foods. The principles and characteristics of NIR spectroscopy and its applications in the detection of transgenic agricultural products and foods are described.
  • 1.3K
  • 03 Mar 2023
Topic Review
Alignment-Free Approaches
Alignment-free (AF) methodologies have increased in popularity in the last decades as alternative tools to alignment-based (AB) algorithms for performing comparative sequence analyses. They have been especially useful to detect remote homologs within the twilight zone of highly diverse gene/protein families and superfamilies. The most popular alignment-free methodologies, as well as their applications to classification problems, have been described in previous reviews. Despite a new set of graph theory-derived sequence/structural descriptors that have been gaining relevance in the detection of remote homology, they have been omitted as AF predictors when the topic is addressed. Here, we first go over the most popular AF approaches used for detecting homology signals within the twilight zone and then bring out the state-of-the-art tools encoding graph theory-derived sequence/structure descriptors and their success for identifying remote homologs.
  • 1.3K
  • 29 Oct 2020
Topic Review
CD38: T Cell Immuno-Metabolic Modulator
CD38 is a major mammalian NAD+ glycohydrolase (NADase), expresses on T cells following activation and appears to be an essential modulator of intracellular NAD+ levels. The enzymatic activity of CD38 in the process of generating the second messenger cADPR utilizes intracellular NAD+, and thus limits its availability to differentNAD+ consuming enzymes (PARP, ART, and sirtuins) inside the cells.
  • 1.3K
  • 27 Oct 2020
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