Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Klebsiella pneumoniae
Klebsiella pneumoniae is an opportunistic pathogen that causes nosocomial and community-acquired infections. The spread of resistant strains of K. pneumoniae represents a growing threat to human health, due to the exhaustion of effective treatments. K. pneumoniae releases outer membrane vesicles (OMVs). OMVs are a vehicle for the transport of virulence factors to host cells, causing cell injury. Previous studies have shown changes of gene expression in human bronchial epithelial cells after treatment with K. pneumoniae OMVs. These variations in gene expression could be regulated through microRNAs (miRNAs), which participate in several biological mechanisms. Thereafter, miRNA expression profiles in human bronchial epithelial cells were evaluated during infection with standard and clinical K. pneumoniae strains. Microarray analysis and RT-qPCR identified the dysregulation of miR-223, hsa-miR-21, hsa-miR-25 and hsa-let-7g miRNA sequences. Target gene prediction revealed the essential role of these miRNAs in the regulation of host immune responses involving NF-ĸB (miR-223), TLR4 (hsa-miR-21), cytokine (hsa-miR-25) and IL-6 (hsa-let-7g miRNA) signalling pathways. The current study provides the first large scale expression profile of miRNAs from lung cells and predicted gene targets, following exposure to K. pneumoniae OMVs. Our results suggest the importance of OMVs in the inflammatory response.
  • 1.3K
  • 29 Dec 2020
Topic Review
Insect-Specific Viruses (ISVs)
Unlike arboviruses, which have a dual-host tropism by cycling between vertebrate hosts and arthropod vectors, ISVs replicate exclusively in arthropod populations, causing a persistent viral infection, as such they are mainly maintained in nature by vertical transmission route. ISVs are also refereed to as mosquito-specific viruses as they are generally identified and discovered in mosquitoes. They are nonetheless an important part of the mosquito microbiome. The first ISV identified is cell-fusing agent virus (CFAV), which was isolated from an Aedes aegypti (Ae. aegypti) cell culture.
  • 1.3K
  • 10 Sep 2020
Topic Review
Casein Micelles for Bioactives
Caseins and casein micelles are the most prevalent amphiphilic proteins that are widely used to make stabilised emulsions. Caseins can adsorb at the oil–water interface, thus having a high surface activity during homogenisation, processing and storage by preventing coalescence in emulsions under different conditions, such as pH, temperature, structure elasticity and aggregation. Because of these properties, casein is now used to deliver different hydrophobic bioactive in emulsion-based drug delivery systems.
  • 1.3K
  • 16 Sep 2021
Topic Review
Cyclops (Genus)
Cyclops is one of the most common genera of freshwater copepods, comprising over 400 species. Together with other similar-sized non-copepod fresh-water crustaceans, especially cladocera, they are commonly called water fleas. The name Cyclops comes from the Cyclops of Greek mythology which shares the quality of having a single large eye, which may be either red or black in Cyclops.
  • 1.3K
  • 14 Oct 2022
Topic Review
Mammalian Na+/H+ Exchanger
The mammalian Na+/H+ exchanger (NHE1, isoform 1) is a ubiquitously expressed membrane protein of mammalian cells. It removes one intracellular proton in exchange for a single extracellular sodium ion. NHE1 has several important physiological functions. It maintains intracellular pH (pHi) while protecting cells from acidification as a result of metabolism. It also regulates cell volume in response to osmotic challenge. There are ten isoforms of NHE that are different gene products. In human pathology, NHE1 is critical in several diseases, including myocardial heart hypertrophy and ischemia reperfusion damage . NHE1 is also important in breast cancer, where it acts as a trigger for metastasis.
  • 1.3K
  • 09 Nov 2020
Topic Review
Entosis and Cell Adhesion
Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.
  • 1.3K
  • 08 Sep 2020
Topic Review
Foodborne Diseases
Foodborne diseases (FBDs) comprise a broad spectrum of illnesses that result from the ingestion of contaminated foodstuffs or water. FBDs can occur at any stage, from production to food consumption, and contamination may be the result of environmental contamination, such as pollution of water, soil, or air [1]. FBDs represent one of the most critical public health problems in the world, especially in developing countries that present serious shortcomings in infrastructure and basic sanitation [2–5]. With the knowledge to prevent FBDs, and the concerns about the increase in FBD cases arising in households, it is essential to evaluate homes’ good food preparation practices.
  • 1.3K
  • 10 Nov 2020
Topic Review Video
Bee Nutritional Demands
For all bee species, the pollen quality determines the overall quality of the larval food, influences the development of individuals and shapes their populations. However, not all plants produce pollen that fully satisfies the nutritional requirements of bees. Lack of understanding of the nutritional requirements of wild bees may lead to unintended negative effects of conservation efforts. Ecological stoichiometry provides an approach to better understand the nutritional constraints on growing and developing organisms and their colonies and populations. It makes reference to elements that, if scarce in the environment, prevent the construction of biologically important organic molecules. The least understood aspect of the nutritional requirements of bees concerns stoichiometric balancing and the need for adequate ratios of nutritional elements in consumed food. This text provides theoretical foundation for the project aiming at determining the likely limitations imposed on wild bees by the lack of nutritionally balanced pollen. The following hypotheses may be tested: 1. Pollen stoichiometry vary among plant species and populations but will differ more widely among species than within different populations of the same species.2. The stoichiometry of bees will vary substantially among bee species and between sexes within a species, which suggests the existence of different nutritional demands. Therefore, it is expected that the stoichiometric mismatches experienced by bees will vary in a species-specific and sex-specific manner.3. For a given bee species, specific pollen species allow the overcoming of stoichiometric mismatches and will balance the diet. Accordingly, it is expected expect that flora diversity and, thus, pollen diversity matches the stoichiometric niches of bees. I predict that the occurrence of specific key host plant species that produce stoichiometrically desirable pollen allows bees to stoichiometrically balance their diets. The project may ask if and how floral diversity, particularly the accessibility of nutritionally desirable key species, may influence bee populations. The obtained data will allow the parameterization of a conceptual model of nutritional limitations (to be developed in the future), which will enable to predict how floral community influences wild bee populations via supply and demand of nutrients.
  • 1.3K
  • 05 Nov 2020
Topic Review
Hydrogen Sulfide in Rumen
Hydrogen sulfide is a Janus-faced molecule with many beneficial and toxic effects on the animal health. In ruminants, rumen fermentation plays a vital role in the digestion and absorption of nutrients. During rumen fermentation, the production of hydrogen sulfide can occur, and it can be rapidly absorbed into the body of the animals through the intestinal wall. If the production of hydrogen sulfide concentration is higher in the rumen, it can cause a toxic effect on ruminants known as poliomyelitis. The production of hydrogen sulfide depends on the population of sulfate-reducing bacteria in the rumen. In rodents, H2S maintains the normal physiology of the gastrointestinal tract and also improves the healing of the chronic gastric ulcer. In the gut, H2S regulates physiological functions such as inflammation, ischemia–reperfusion injury and motility. In this review article, we summarize the toxicity occurrence in the body of animals due to high levels of hydrogen sulfide production and also recent progress in the studies of physiological function of H2S in the gut, with a special emphasis on bacteria-derived H2S is discussed in this review.
  • 1.3K
  • 28 Sep 2020
Topic Review
Oxidative Stress Biomarkers
Oxidative stress biomarkers can be used to detect oxidative damages occurring concomitantly in many cellular structures, which may cause a deterioration of function, including apoptosis and necrosis. There is an intimate relationship between oxidative stress, inflammation, and functional impairment, resulting in various diseases affecting the entire human body.
  • 1.3K
  • 20 Aug 2021
  • Page
  • of
  • 1815
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback