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Topic Review
Solanum aethiopicum
Solanum aethiopicum is a very important vegetable for both rural and urban communities in Africa. The crop is rich in both macro-and micronutrients compared with other vegetables and is suitable for ensuring food and nutritional security.
  • 1.6K
  • 18 Jun 2021
Biography
Venkatraman Ramakrishnan
Venkatraman "Venki" Ramakrishnan (born 1952)[1] is an American and British structural biologist of Indian origin. He was elected President of the Royal Society in November 2015; Presidents serve for five years.[2] In 2009 he shared the Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath, "for studies of the structure and function of the ribosome".[3][4][5][6][7] Since 1999, he has wor
  • 1.5K
  • 21 Nov 2022
Topic Review
Diversity of Allanblackia parviflora A. Chev. in Ghana
Allanblackia parviflora A. Chev. is an indigenous tree species that are found in West African rainforest zones. It is an underutilized fruit tree species that have been targeted for improvement as part of efforts to domesticate high-value indigenous multi-purpose trees for fruit and seed production in Africa. Allanblackia has several benefits, such as providing shade, timber, and medicine; however, the production of edible oil from its seeds is the economically most important use. There is evidence that the Allanblackia seed oil, which is used for cooking, the production of margarine and the manufacturing of ointments and soap, is being developed as a new agri-business in Ghana, Nigeria, Cameroon, and Tanzania. Despite the nutritional and socio-economic importance of A. parviflora, it is still at the early stages of its domestication process.
  • 1.5K
  • 08 Jan 2022
Topic Review
HiPSC-Derived Cardiac Tissue
Relevant, predictive normal, or disease model systems are of vital importance for drug development. The difference between nonhuman models and humans could contribute to clinical trial failures despite ideal nonhuman results. As a potential substitute for animal models, human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) provide a powerful tool for drug toxicity screening, modeling cardiovascular diseases, and drug discovery.
  • 1.5K
  • 14 Dec 2020
Topic Review
Diospyros kaki L. (Persimmon)
Persimmon (Diospyros kaki L.) is a member of the Ebenaceae family and is a very popular and important fruit in East Asian countries, being widely produced in China, South Korea, and Japan. The name “persimmon” (Diospyros) originates from the Greek dióspuron, which means “food of Zeus”, while “kaki” comes from the Japanese kaki (柿).
  • 1.5K
  • 08 Oct 2021
Topic Review Peer Reviewed
Bagnoli Urban Regeneration through Phytoremediation
The Bagnolidistrict in Naples has needed urban redevelopmentfor many years. The area is not only affected by pollution caused by many industries but also by environmental pollutants, according togeognostic surveys that have found numerous contaminantsin the subsoil and water.Currently, the combination of an urban rehabilitation processwith the phytodepuration technique may represent a successful idea for obtaining bothurban regenerationand environmental remediation. Phytoremediation, a biologically based technology, has attracted the attention of both thepublic and scientists as a low-cost alternative for soil requalification. The use of plants as well as the microorganisms present in their root systems plays an important role in the ecological engineering field in controlling and reducing pollutants present in theair, water and soil.The result is efficient, sustainable and cost-effective environmental recovery compared to conventional chemical–physical techniques. In this way, not only the environmental recovery of SIN Bagnoli-Corogliocan be obtained, but also the regeneration of its landscape.
  • 1.5K
  • 27 Apr 2022
Topic Review
Bile Acid Signaling
Bile acids are digestive agents synthesized in the liver and released into the gastrointestinal track during normal physiological conditions to aid in the emulsification of lipids and fat-soluble vitamins. These bile acids are highly regulated via enterohepatic circulation, a process which minimizes bile acid loss through a wide network of organs and bile acid transporters. Beyond this, bile acids and the activation of bile acid receptors has been observed in extrahepatic tissues, in particular the central nervous system. Certain bile acids, through the use of specific bile acid transporters, can also gain entry into the brain via the blood brain barrier. Furthermore, there has been an increase in recent literature highlighting bile acids and the presence of bile acid signaling in the brain and neural cells. This entry is a current overview of these topics.
  • 1.5K
  • 21 Aug 2020
Topic Review
COVID-19 Treatment
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable economic distress globally and a significant loss of life. Sadly, the vulnerable and immunocompromised in our societies seem to be more susceptible to severe COVID-19 complications. Notably, there are several significant risk factors for severe COVID-19 infection. These include the presence of poor nutritional status and pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular diseases (CVD), obesity, and various other diseases that render the patient immunocompromised. These diseases are characterized by systemic inflammation, which may be a common feature of these NCDs, affecting patient outcomes against COVID-19. As a result, various antiviral treatments and anti-inflammatory agents are under investigation for their potential therapeutic value. The section presented below originates from the following article [1].
  • 1.5K
  • 06 Nov 2020
Topic Review
NLRP3 Inflammasome Regulatory Mechanisms
The inflammasome is an intracellular molecular complex, which is mainly involved in innate immunity. Inflammasomes are formed in response to danger signals, associated with infection and injury, and mainly regulate the secretion of interleukin-1β and interleukin-18. Inflammasome dysregulation is known to be associated with various diseases and conditions, and its regulatory mechanisms have become of great interest in recent years. In the colon, inflammasomes have been reported to be associated with autophagy and the microbiota, and their dysregulation contributes to colitis and. However, the detailed role of inflammasomes in inflammatory bowel disease is still under debate because the mechanisms that regulate the inflammasome are complex and the inflammasome components and cytokines show seemingly contradictory multiple effects. 
  • 1.5K
  • 18 Jan 2021
Topic Review
Bradykinin
Bradykinin (BK) (Greek brady-, slow; -kinin, kīn(eîn) to move) is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids. A class of drugs called angiotensin converting enzyme inhibitors (ACE inhibitors) increase bradykinin levels by inhibiting its degradation, thereby increasing its blood pressure lowering effect. ACE inhibitors are FDA approved for the treatment of hypertension and heart failure.
  • 1.5K
  • 04 Nov 2022
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