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Topic Review
Principles of Immunology Relevant to Oral Vaccination
Vaccines continue to play an enormous role in the progression of aquaculture industries worldwide. Though preventable diseases cause massive economic losses, injection-based vaccine delivery is cost-prohibitive or otherwise impractical for many producers. Most oral vaccines, which are much cheaper to administer, do not provide adequate protection relative to traditional injection or even immersion formulas. Research has focused on determining why there appears to be a lack of protection afforded by oral vaccines. The basic immunological principles is reviewed associated with oral vaccination before discussing the recent progress and current status of oral vaccine research. This knowledge is critical for the development and advancement of efficacious oral vaccines for the aquaculture industry.
  • 219
  • 14 Dec 2023
Topic Review
The Molecular Identity of Plant Callus Tissues
In response to different degrees of mechanical injury, certain plant cells re-enter the division cycle to provide cells for tissue replenishment, tissue rejoining, de novo organ formation, and/or wound healing. The intermediate tissue formed by the dividing cells is called a callus. Callus formation can also be induced artificially in vitro by wounding and/or hormone (auxin and cytokinin) treatments. The callus tissue can be maintained in culture, providing starting material for de novo organ or embryo regeneration and thus serving as the basis for many plant biotechnology applications. Due to the biotechnological importance of callus cultures and the scientific interest in the developmental flexibility of somatic plant cells, the initial molecular steps of callus formation have been studied in detail. It was revealed that callus initiation can follow various ways, depending on the organ from which it develops and the inducer, but they converge on a seemingly identical tissue. However, the common molecular signature that the various pathways converge on and define calli, regardless of their variable origin, as the same tissue has not yet been revealed.
  • 161
  • 13 Dec 2023
Topic Review
Pathophysiology and Treatment of Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition characterized by the sudden onset of respiratory failure, pulmonary edema, dysfunction of endothelial and epithelial barriers, and the activation of inflammatory cascades. Despite the increasing number of deaths attributed to ARDS, a comprehensive therapeutic approach for managing patients with ARDS remains elusive. To elucidate the pathological mechanisms underlying ARDS, numerous studies have employed various preclinical models, often utilizing lipopolysaccharide as the ARDS inducer. Accumulating evidence emphasizes the pivotal role of reactive oxygen species (ROS) in the pathophysiology of ARDS. Both preclinical and clinical investigations have asserted the potential of antioxidants in ameliorating ARDS. 
  • 231
  • 13 Dec 2023
Topic Review
Conditioned Media from Radioresistant and Chemoresistant Cancer Cells
Chemoradiation therapy (CRT) is a commonly indicated treatment in the case of cancer. In combination with surgery or alone, it offers a relief of condition or even a cure for some patients. Resistance to chemo- or radiotherapy is the main obstacle to consistent treatment outcomes in oncology patients.
  • 111
  • 13 Dec 2023
Topic Review
Smart Responsive Hydrogel Design for Chronic Wound Treatment
Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves low pH, high levels of reactive oxygen species, and specific enzyme expression. Therefore, smart responsive hydrogels that can sense and respond to these stimuli are needed. 
  • 274
  • 13 Dec 2023
Topic Review
Interaction and Collaboration of SP1, HIF-1, and MYC
Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates diverse yet distinct biological activities; MYC is a master regulator of all key cellular activities including cell metabolism and proliferation; and HIF-1, whose protein level is rapidly increased when the local tissue oxygen concentration decreases, functions as a mediator of hypoxic signals. Systems analyses of the regulatory networks in cancer have shown that SP1, HIF-1, and MYC belong to a group of TFs that function as master regulators of cancer. Therefore, the contributions of these TFs are crucial to the development of cancer. SP1, HIF-1, and MYC are often overexpressed in tumors, which indicates the importance of their roles in the development of cancer. Thus, proper manipulation of SP1, HIF-1, and MYC by appropriate agents could have a strong negative impact on cancer development. Under these circumstances, these TFs have naturally become major targets for anticancer drug development. Accordingly, there are many SP1 or HIF-1 inhibitors available; however, designing efficient MYC inhibitors has been extremely difficult. Studies have shown that SP1, HIF-1, and MYC modulate the expression of each other and collaborate to regulate the expression of numerous genes.
  • 127
  • 13 Dec 2023
Topic Review
Probiotics in Aquaculture
The Food and Agriculture Organization (FAO) of the United Nations and the World Health Organization (WHO) define probiotics as “Live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. Possible action modes of probiotics in aquaculture include the regulation of amino and fatty acid metabolisms, the excretion of digestive enzymes and vitamins or cofactors, the production of antagonistic compounds that inhibit bacteria, the enhancement of immune responses, the disruption of the quorum-sensing processes of pathogenic organisms, stress improvement, and heavy-metal detoxification.
  • 584
  • 13 Dec 2023
Topic Review
Mycotoxin Occurrence in Foodstuffs
Mycotoxins are toxic substances produced as secondary fungal metabolites that can cause harmful effects on humans and animals. These compounds considerably affect the food industry and public health. The occurrence and levels of many mycotoxins have been studied in the overall food system, in which such toxins are more notable in the most nutritious and largely consumed foods like cereals and nuts.
  • 135
  • 13 Dec 2023
Topic Review
Fungal Toxins in Cereal Grains and Flours—Mycotoxins
Cereal grains serve as the cornerstone of global nutrition, providing a significant portion of humanity’s caloric requirements. Mycotoxins originate from the Greek word “μύκητας-mykitas”, which means fungus, and the Latin word “toxicum”, meaning poison. They are low molecular weight compounds, naturally present in cereals, which also act as secondary metabolites produced mainly by mycelial structures of filamentous fungi that do not exhibit any biochemical meaning to fungus growth and development.
  • 165
  • 13 Dec 2023
Topic Review
Exosomal miRNAs as Biomarkers of Ischemic Stroke
Exosomes are small lipid bilayer membrane particles released from all living cells into the extracellular environment. They carry several molecules and have a critical role in cell–cell communication under physiological and pathological conditions. Ischemic stroke due to cerebral vascular occlusion is the most common form, while hemorrhagic stroke due to cerebral bleeding accounts for about 12% of cases.
  • 189
  • 12 Dec 2023
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