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Topic Review
Hydrogen Sulfide in Mammalian Cells
Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric oxide (-NO) and carbon monoxide (CO). It's important to provide an overview of the formation of hydrogen sulfide (H2S) in the human body. H2S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE), cysteine aminotransferase (CAT), 3-mercaptopyruvate sulfurtransferase (3MST) and D-amino acid oxidase (DAO). The physiological and pathological effects of hydrogen sulfide (H2S) on various systems in the human body have led to extensive research efforts to develop appropriate methods to deliver H2S under conditions that mimic physiological settings and respond to various stimuli. These functions span a wide spectrum, ranging from effects on the endocrine system and cellular lifespan to protection of liver and kidney function. The exact physiological and hazardous thresholds of hydrogen sulfide (H2S) in the human body are currently not well understood and need to be researched in depth. 
  • 241
  • 18 Dec 2023
Topic Review
Smart Agriculture Based on Internet of Things
The Internet of Things (IoT) is a transformative technology that is reshaping industries and daily life, leading us towards a connected future that is full of possibilities and innovations. IoT technologies are widely used in the agriculture sector in many developed countries to increase production and meet the demand for food supply in the market. IoT in agriculture can reduce production costs and time by providing precision agriculture.
  • 208
  • 18 Dec 2023
Topic Review
Modelling Meningioma Using Organoids
Meningiomas are the most common tumours of the central nervous system. According to the World Health Organization (WHO), this disease is classified into three different grades: 80% of meningioma patients present with benign grade I tumours, while less than 2% present with malignant grade III meningiomas. Despite affecting thousands of people worldwide, much remains unknown about this disease, and the development of systemic treatments is still far behind in comparison to other types of tumours. Therefore, forming 3D structures (spheroids and organoids) could facilitate research on the mechanisms of formation, proliferation, migration, and invasion of these, for the most part, benign tumours, while also helping in the process of drug development. To date, there are three published methods for the formation of meningioma organoids primarily derived from patient tissue samples. Organoids offer many advantages in the development of treatments because they recapitulate the cellular complexity within tumours. These new methodological advances could open a substantial number of possibilities for the further characterisation and treatment of meningiomas.
  • 330
  • 18 Dec 2023
Topic Review
Bronchial Asthma as a Precursor of Lung Fibrosis
Bronchial asthma is a heterogeneous disease characterized by persistent respiratory system inflammation, airway hyperreactivity, and airflow obstruction. Lung fibrosis is a common occurrence in the pathogenesis of fatal and long-term asthma, and it is associated with disease severity and resistance to therapy.
  • 137
  • 18 Dec 2023
Topic Review
Antifungal Resistance in Pathogenic Candida Species
Candidiasis is a highly pervasive infection posing major health risks, especially for immunocompromised populations. Pathogenic Candida species have evolved intrinsic and acquired resistance to a variety of antifungal medications.
  • 178
  • 18 Dec 2023
Topic Review
Prokaryotic Argonaute Proteins in Point-of-Care Viral Diagnostics
Point-of-care (POC) technologies, which offer immediate and accurate testing at or near the site of patient care, have become a cornerstone of modern medicine. Prokaryotic Argonaute proteins (pAgo), proficient in recognizing target RNA or DNA with complementary sequences, have emerged as potential game-changers. pAgo present several advantages over the currently popular CRISPR/Cas systems-based POC diagnostics, including the absence of a protospacer adjacent motif (PAM) sequence requirement, the use of shorter nucleic acid molecules as guides, and a smaller protein size. 
  • 112
  • 18 Dec 2023
Topic Review
Alpha-Glucosidase Inhibitory Peptides
With the change in people’s lifestyle, diabetes has emerged as a chronic disease that poses a serious threat to human health, alongside tumor, cardiovascular, and cerebrovascular diseases. α-glucosidase inhibitors, which are oral drugs, have proven effective in preventing and managing this disease. Studies have suggested that bioactive peptides could serve as a potential source of α-glucosidase inhibitors. These peptides possess certain hypoglycemic activity and can effectively regulate postprandial blood glucose levels by inhibiting α-glucosidase activity, thus intervening and regulating diabetes.
  • 171
  • 18 Dec 2023
Topic Review
Pharmacotherapeutic Approaches to Treatment of Muscular Dystrophies
Muscular dystrophies are a heterogeneous group of genetic muscle-wasting disorders that are subdivided based on the region of the body impacted by muscle weakness as well as the functional activity of the underlying genetic mutations. A common feature of the pathophysiology of muscular dystrophies is chronic inflammation associated with the replacement of muscle mass with fibrotic scarring. With the progression of these disorders, many patients suffer cardiomyopathies with fibrosis of the cardiac tissue. Anti-inflammatory glucocorticoids represent the standard of care for Duchenne muscular dystrophy, the most common muscular dystrophy worldwide; however, long-term exposure to glucocorticoids results in highly adverse side effects, limiting their use. Thus, it is important to develop new pharmacotherapeutic approaches to limit inflammation and fibrosis to reduce muscle damage and promote repair.
  • 539
  • 18 Dec 2023
Topic Review
Platelets and Red Blood Cells with SARS-CoV-2
Interaction of platelets and red blood cells with SARS-CoV-2, their mechanisms, consequences, and pathological significance.
  • 121
  • 18 Dec 2023
Topic Review
CRISPR Variants for Gene Editing in Plants
CRISPR-based technology has been used to enhance the characteristics of different plants, offering a promising approach to improving plant genetics. The CRISPR–Cas system is an exact and efficient tool for targeted gene editing in plants. This system comprises RNA-guided Cas enzymes, including Cas9, Cpf1, and Cas12a, which recognize specific target sequences within the plant genome and introduce site-specific DNA breaks.
  • 161
  • 18 Dec 2023
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