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Topic Review
Biography
Topic Review
Pathophysiology of Secondary Acute Myeloid Leukemia
Secondary acute myeloid leukemia (sAML) is a heterogeneous malignant hematopoietic disease that arises either from an antecedent hematologic disorder (AHD) including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), aplastic anemia (AA), or as a result of exposure to genotoxic chemotherapeutic agents or radiotherapy (therapy related AML, tAML). sAML is diagnosed when the number of blasts is ≥20% in the bone marrow or peripheral blood, and it is characterized by poor prognosis, resistance to therapy and low overall survival rate.
124
15 Mar 2024
Topic Review
Common Genet
The Common Genet, also known as Genetta genetta, is a small carnivorous mammal native to Europe and parts of North Africa. Recognizable by its slender body, long tail, and distinctive facial markings, the Common Genet is a nocturnal hunter, preying on small mammals, birds, reptiles, and insects. Despite its name, the Common Genet is not closely related to cats but belongs to the family Viverridae, making it a unique and intriguing member of the carnivore community.
233
15 Mar 2024
Topic Review
Antarctic Fur Seal
The Antarctic Fur Seal, scientifically known as Arctocephalus gazella, is a charismatic marine mammal native to the subantarctic and Antarctic regions. Recognized for its dense fur coat, robust build, and distinctive facial features, this species is a top predator in its icy habitat. Antarctic Fur Seals play a vital role in marine ecosystems, influencing prey populations and contributing to the overall health of polar environments.
277
15 Mar 2024
Topic Review
Galapagos Fur Seal
The Galapagos Fur Seal, scientifically known as Arctocephalus galapagoensis, is a marine mammal endemic to the Galapagos Islands. With its dense, dark brown fur and slender physique, this species is well-adapted to its coastal habitat. Despite its name, the Galapagos Fur Seal is not a true seal but rather belongs to the fur seal family, Otariidae, distinguishing it by its ability to rotate its hind flippers forward for efficient movement on land.
303
15 Mar 2024
Topic Review
Glypican-Regulated Transport and Gradient Formation in Drosophila
Glypicans (Glps) are a family of heparan sulphate proteoglycans that are attached to the outer plasma membrane leaflet of the producing cell by a glycosylphosphatidylinositol anchor. Glps are involved in the regulation of many signalling pathways, including those that regulate the activities of Wnts, Hedgehog (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), among others. In the Hh-signalling pathway, Glps have been shown to be essential for ligand transport and the formation of Hh gradients over long distances, for the maintenance of Hh levels in the extracellular matrix, and for unimpaired ligand reception in distant recipient cells.
93
15 Mar 2024
Topic Review
Gambian Mongoose
The Gambian Mongoose, scientifically known as Mungos gambianus, is a species of mongoose native to the African continent. Recognizable by its sleek, reddish-brown fur and long, tapering tail, this mongoose species inhabits a variety of habitats including forests, savannas, and agricultural areas. Highly adaptable and social animals, Gambian Mongooses are known for their cooperative hunting behavior and tight-knit family groups.
166
15 Mar 2024
Topic Review
Pure Mycelial Materials
Modern efforts to influence materials science with principles of biology have allowed fungal mycelial materials to take a foothold and develop novel solutions for the circular bioeconomy of tomorrow. However, recent studies have shown that the value of tomorrow’s green materials is not determined simply by their environmental viability, but rather by their ability to make the polluting materials of today obsolete. With an inherently strong structure of chitin and β-glucan, the ever-adaptable mycelia of fungi can compete at the highest levels with a litany of materials from leather to polyurethane foam to paper to wood. There are significant efforts to optimize pure mycelial materials (PMMs) through the entire process of species and strain selection, mycelial growth, and fabrication.
286
15 Mar 2024
Topic Review
Long-tailed Weasel
The Long-tailed Weasel (Mustela frenata) is a slender and agile carnivore found across North and Central America, characterized by its distinctive long body and tail. With a keen sense of smell and excellent hunting skills, the Long-tailed Weasel primarily preys on small mammals such as rodents, rabbits, and voles. Its adaptable nature allows it to thrive in a variety of habitats, including forests, grasslands, and agricultural areas, where it plays a vital role in controlling rodent populations.
360
15 Mar 2024
Topic Review
Malagasy Civet
The Malagasy Civet (Fossa fossana) is a unique carnivore endemic to the island of Madagascar, characterized by its slender body, short legs, and distinctive facial markings. Despite its name, the Malagasy Civet is not closely related to true civets and belongs to its own taxonomic family, Eupleridae. This elusive nocturnal mammal inhabits a variety of forested habitats across Madagascar, where it plays a vital role in controlling insect populations and contributing to ecosystem dynamics.
229
15 Mar 2024
Topic Review
Beech Marten
The Beech Marten (Martes foina) is a slender and agile carnivore native to Europe and parts of Asia. With its distinctive cream-colored throat patch and bushy tail, this medium-sized mustelid is known for its adaptability to various habitats, including forests, woodlands, and urban areas. As a versatile predator, the Beech Marten preys on a variety of small mammals, birds, insects, and fruits, playing a vital role in ecosystem dynamics across its range.
218
15 Mar 2024
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