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Topic Review
Quetiapine-Related Deaths
Quetiapine is a second-generation antipsychotic drug available for two and half decades. Due to increased misuse, prescription outside the approved indications, and availability on the black market, it is being encountered in medicolegal autopsies more frequently. For instance, it has been linked to increased mortality rates, most likely due to its adverse effects on the cardiovascular system. 
  • 136
  • 10 Jan 2024
Topic Review
B Cells and B-Cell Receptor Signaling
B-cell receptor (BCR) is a B cell hallmark surface complex regulating multiple cellular processes in normal as well as malignant B cells. Igα (CD79a)/Igβ (CD79b) are essential components of BCR that are indispensable for its functionality, signal initiation, and signal transduction. CD79a/CD79b-mediated BCR signaling is required for the survival of normal as well as malignant B cells via a wide signaling network. Studies identified the great complexity of this signaling network and revealed the emerging role of CD79a/CD79b in signal integration.
  • 166
  • 09 Jan 2024
Topic Review
Na+ Uptake and Accumulation under Salt Stress
High concentrations of sodium (Na+), chloride (Cl−), calcium (Ca2+), and sulphate (SO42−) are frequently found in saline soils. Crop plants cannot successfully develop and produce because salt stress impairs the uptake of Ca2+, potassium (K+), and water into plant cells. Different intracellular and extracellular ionic concentrations change with salinity, including those of Ca2+, K+, and protons. These cations serve as stress signaling molecules in addition to being essential for ionic homeostasis and nutrition. Maintaining an appropriate K+:Na+ ratio is one crucial plant mechanism for salt tolerance, which is a complicated trait. 
  • 170
  • 09 Jan 2024
Topic Review
Role of Neutrophils in Immune-Related Diseases
Neutrophils are the most abundant of the circulating immune cells and are the first to be recruited to sites of inflammation. Neutrophils are a heterogeneous group of immune cells from which are derived extracellular traps (NETs), reactive oxygen species, cytokines, chemokines, immunomodulatory factors, and alarmins that regulate the recruitment and phenotypes of neutrophils, macrophages, dendritic cells, T cells, and B cells. In addition, cytokine-stimulated neutrophils can express class II major histocompatibility complex and the internal machinery necessary for successful antigen presentation to memory CD4+ T cells. This may be relevant in the context of vaccine memory. Neutrophils thus emerge as orchestrators of immune responses that play a key role in determining the outcome of infections, vaccine efficacy, and chronic diseases like autoimmunity and cancer.
  • 145
  • 09 Jan 2024
Topic Review
Imaging Techniques Used in Fish Bioimages
Detecting skeletal or bone-related deformities in model and aquaculture fish is vital for numerous biomedical studies. In biomedical research, model fish with bone-related disorders are potential indicators of various chemically induced toxins in their environment or poor dietary conditions. In aquaculture, skeletal deformities are affecting fish health, and economic losses are incurred by fish farmers. 
  • 168
  • 09 Jan 2024
Topic Review
Oral Microbes in Oral Squamous Cell Carcinoma
Microorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. 
  • 160
  • 09 Jan 2024
Topic Review
Antifungal Activity of Silver Nanoparticles against Candida Species
Silver nanoparticles have long been known for their antibacterial properties. Increasing numbers of studies confirm that they have antifungal properties as well.
  • 183
  • 09 Jan 2024
Topic Review
Digital Horizon of Smart Agriculture
Agriculture is essential to the existence of the human race, as well as the foundation of our civilization, because it provides food, fuel, fiber, and other resources necessary for survival; however, it is facing critical challenges due to anthropogenic climate change, which hampers food and nutritional security. Several measures have been implemented to enhance agricultural productivity, including plant breeding, genetic engineering, and precision agriculture. The world has witnessed the burgeoning development of novel scientific innovations and technological advancements enabled by drones, smart sensors, robotics, and remote sensing, resulting in a plethora of revolutionary methods that can be applied to real-time crop modeling, high-throughput phenotyping, weather forecasting, yield prediction, fertilizer application, disease detection, market trading, farming practices, and other environmental practices vital to crop growth, yield, and quality. Digitalization is the most significant technological advancement of our time, and it profoundly affects agriculture and other industries. Delivering a comprehensive view of how technology could help in tackling critical issues like environmental degradation and threatened world biodiversity, this perspective emphasizes the perks of digitalization.
  • 334
  • 09 Jan 2024
Topic Review
Biomaterials for Dry Eye Diseases Treatment
Dry eye disease (DED) is an emerging health issue affecting millions of individuals annually. Ocular surface disorders, such as DED, are characterized by inflammation triggered by various factors. This condition can lead to tear deficiencies, resulting in the desiccation of the ocular surface, corneal ulceration/perforation, increased susceptibility to infections, and a higher risk of severe visual impairment and blindness. The history of ophthalmic biomaterials is relatively short. The primary objective of advancing successive generations of biomaterials is to address the shortcomings of previous versions and enhance safety, effectiveness, and comfort. Innovations have been made to elevate quality standards and production efficiency, ultimately reducing costs. Market demands to enhance competitiveness and accessibility have further intensified the pressure to cut expenses. Ophthalmic biomaterials have evolved into highly sophisticated devices, significantly increasing their utility in recent years. These materials must fulfill several crucial requirements, such as delivering oxygen to tissues, managing refractive changes, safeguarding tissues during surgery, facilitating tissue integration, and modulating the healing process. The recent advancements in biomaterials for treating DED include scaffolds, nanosystems, hydrogels, and drug-eluting contact lenses.
  • 221
  • 09 Jan 2024
Topic Review
Microbiota-Induced Epigenetic Alterations in Depressive Disorders
Major depressive disorder (MDD) is a complex disorder and a leading cause of disability in 280 million people worldwide. Many environmental factors, such as microbes, drugs, and diet, are involved in the pathogenesis of depressive disorders.
  • 228
  • 09 Jan 2024
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