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Topic Review
Anomalocaridid
The Anomalocaridids comprise a group of very early marine animals known primarily from fossils found in Cambrian deposits in China , United States , Canada , Poland and Australia . They were long thought to be restricted to this Cambrian time range, but the discovery of large Ordovician specimens has extended this somewhat. The later Devonian Schinderhannes shows many anomalocaridid features. Although originally interpreted as an anomalocaridid-like arthropod, some recent studies suggest that it may represent an anomalocaridid: if so it would extend the group's record by some hundred million years: the non-mineralised anomalocaridid structure means they are absent from the intermediate fossil record. Anomalocaridids are the largest Cambrian animals known—some Chinese forms may have reached 2 m (7 ft) in length—and most of them were probably active carnivores.
  • 1.2K
  • 31 Oct 2022
Topic Review
Biological Functions of Coffee
Coffee is a Rubiaceae coffee plant ranked as the first of the three most important beverages in the world, with effects including lowering blood sugar, protecting the liver, and protecting the nerves. Coffee contains many chemical components, including alkaloids, phenolic acids, flavonoids, terpenoids, and so on. Chemical components in coffee are the basis of its biological function and taste.
  • 1.2K
  • 20 Apr 2022
Topic Review
Oral Melanosis
Oral melanosis is a benign pigmented lesion arising in the oral cavity. Oral pigmentation is asymptomatic and does not usually cause any alteration to the texture or thickness of the affected area. The colour can be uniform or speckled and can appear solitary or as multiple lesions. Depending on the site, depth, and quantity of pigment, the appearance can vary considerably. Oral pigmentation is found in the following places: Oral pigmentation affects about 3% of the population and is most likely seen in those with dark skin; however people with light skin have, on average, 30 local pigmented areas and in some circumstances will present intra-orally. They are more often found in females than males and the typical age at presentation is 40 years although they can appear at any age. Diagnosis of oral pigmentation is by a complete history taken by the clinican followed by a thorough clinical examination. Management of such lesions is typically by close clinical monitoring, photographs and measuring tools. A biopsy may be indicated where the following features are present: large or new-pigmented lesions and those with a papular appearance or irregular colouration.
  • 1.2K
  • 11 Nov 2022
Topic Review
Major Cell Death Pathways
Programmed cell death (PCD) or apoptosis is an important form of cell-autonomous immune control over intracellular pathogens. PCD is mainly responsible for regulating animal development and tissue homeostasis, which regularly occurs in a broad range of human diseases, including immunological, developmental problems, neurodegeneration, and cancer.
  • 1.2K
  • 05 Jul 2022
Topic Review
Milk Proteins
Milk and colostrum have high biological potential, and due to their natural origin and non-toxicity, they have many uses in cosmetics and dermatology. Research is ongoing on their potential application in other fields of medicine, but there are still few results; most of the published ones are included in this entry. These natural products are especially rich in proteins, such as casein, β-lactoglobulin, α-lactalbumin, lactoferrin, immunoglobulins, lactoperoxidase, lysozyme, and growth factors, and possess various antibacterial, antifungal, antiviral, anticancer, antioxidant, immunomodulatory properties, etc. 
  • 1.2K
  • 22 Jun 2021
Topic Review
Modes of Nanofertilizer Application
There are three primary methods of nanofertilizer application: foliar, seed nanopriming, and soil treatment. The appropriate method of nanofertilizer application is crucial for optimal plant growth, as it varies depending on the soil and climate type. The choice depends on soil quality, nutrient availability, and climate, which affect nutrient uptake and utilization. Understanding these factors and selecting the appropriate method can improve crop yield, reduce environmental impact, and create more sustainable agricultural practices.
  • 1.2K
  • 30 Jun 2023
Topic Review
TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system. TRL4 expressing cells are myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS. It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein. Palmitic acid is also a TLR4 agonist. TLR4 has also been designated as CD284 (cluster of differentiation 284). The molecular weight of TLR4 is approximately 95 kDa.
  • 1.2K
  • 29 Nov 2022
Topic Review
Coriandrum sativum L.
Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects.
  • 1.2K
  • 13 Jan 2022
Topic Review
Hypermethioninemia
Hypermethioninemia is an excess of a particular protein building block (amino acid), called methionine, in the blood. This condition can occur when methionine is not broken down (metabolized) properly in the body.
  • 1.2K
  • 23 Dec 2020
Topic Review
Vitamin D Deficiency
Vitamin D was found to counteract insulin resistance via  participation in the maintenance of normal resting reactive oxygen species level and regulation of Ca2+ level in many cell types. Both genomic and non-genomic action of vitamin D is directed to insulin signaling. Thereby, vitamin D  reduces the extent of pathologies associated with insulin resistance such as oxidative stress and inflammation. Therefore, the beneficial actions of vitamin D include an improvement of glucose and lipid metabolism in insulin-sensitive tissues, and in consequence the diminish of insulin resistance.
  • 1.2K
  • 30 Sep 2020
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