Topic Review
Baddeley's Model of Working Memory
Baddeley's model of working memory is a model of human memory proposed by Alan Baddeley and Graham Hitch in 1974, in an attempt to present a more accurate model of primary memory (often referred to as short-term memory). Working memory splits primary memory into multiple components, rather than considering it to be a single, unified construct. Baddeley & Hitch proposed their three-part working memory model as an alternative to the short-term store in Atkinson & Shiffrin's 'multi-store' memory model (1968). This model is later expanded upon by Baddeley and other co-workers to add a fourth component, and has become the dominant view in the field of working memory. However, alternative models are developing, providing a different perspective on the working memory system. The original model of Baddeley & Hitch was composed of three main components: the central executive which acts as a supervisory system and controls the flow of information from and to its slave systems: the phonological loop and the visuo-spatial sketchpad. The phonological loop stores verbal content, whereas the visuo-spatial sketchpad caters to visuo-spatial data. Both the slave systems only function as short-term storage centers. In 2000, Baddeley added a third slave system to his model, the episodic buffer. Baddeley & Hitch's argument for the distinction of two domain-specific slave systems in the older model was derived from experimental findings with dual-task paradigms. Performance of two simultaneous tasks requiring the use of two separate perceptual domains (i.e. a visual and a verbal task) is nearly as efficient as performance of the tasks individually. In contrast, when a person tries to carry out two tasks simultaneously that use the same perceptual domain, performance is less efficient than when performing the tasks individually. A fourth component of Baddeley's model was added 25 years later to complement the central executive system. The third slave system was designated as episodic buffer. It is considered a limited-capacity system that provides temporary storage of information by conjoining information from the subsidiary systems, and long-term memory, into a single episodic representation.
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  • 04 Nov 2022
Topic Review
Fabrication of Organ-on-Chip
Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ biomimetic systems. OOC technology brings numerous advantages in the current landscape of preclinical models, capable of recapitulating the multicellular assemblage, tissue–tissue interaction, and replicating numerous human pathologies.
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  • 26 Apr 2022
Topic Review
Chitosan Biopolymer on Plant Growth
The chitosan (CHT) biopolymer is a de-acetylated chitin derivative derived from the outer shell of shrimp, shellfish, lobster, or crabs, as well as the cell wall of fungi. Because of its biodegradability, environmental non-toxicity, and biocompatibility, it is an ideal resource for sustainable agriculture. The CHT emerged as a promising agent used as a plant growth promoter. It induces plant growth by influencing plant physiological processes like nutrient uptake, cell division, cell elongation, enzymatic activation, and synthesis of protein that can eventually lead to increased yield. It also alters plant defense responses by triggering multiple useful metabolic pathways. Depending on the structures, chitosan is useful for industrial and agricultural applications.
  • 1.4K
  • 21 Dec 2020
Topic Review
Citrus Canker
Xanthomonas citri subsp. citri, a causative agent of the citrus canker (CC) disease, belongs to one of the essential groups of the bacterial phytopathogen family, Xanthomonadaceae. It has been a potential threat to the globally significant citrus fruit crop, which has remained under investigation for disease management and epidemiology since the 1980s. In Pakistan, the average yield of citrus is 11 t/ha, which is lower than other countries, including China, Brazil, and India, having average productions of 27, 26, and 22 tons/hectare, respectively. Citrus canker is one of the most devastating diseases, posing a significant threat to crop yield and fruit quality. To date, five distinct types (or forms) of the citrus canker have been recognized; the Asiatic (Canker A) form is most destructive and affects most citrus cultivars. Severe infection outcomes include dieback, defoliation, severely blemished fruit, premature fruit drop, and reduced fruit quality. The infection increases under humid, warm, cloudy climate, wind, and heavy rainfall.
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  • 20 May 2022
Topic Review
Forest Volatile Organic Compounds
This article provides a biochemical description of forest Biogenic Volatile Organic Compounds (BVOCs), namely any organic substance, except carbon dioxide and monoxide, mostly emitted by plants and having vapor pressure high enough to be vaporized in relevant amounts into the forest air. An estimation of the average contribution of forests to the atmospheric composition is mentioned. Additionally, a brief analysis of functional roles that BVOCs play for plant physiology and forest ecology is reported, including the importance of non-tree-derived BVOCs. Finally, biochemical pathways leading to the natural production of most forest BVOCs are described.
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  • 02 Feb 2021
Topic Review
3D-LC
Three-dimensional liquid chromatography (3D-LC) is the consecutive combination of 3 independent LC techniques to decrease the complexity of proteome digest samples. 3D-LC systems can be performed in an online or offline manner. Ideally, each dimension in a 3D-LC system is completely orthogonal to the others.
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  • 27 Oct 2020
Topic Review
Traditional Bulgarian Dairy Products
Dairy products are nutritionally indispensable, consumed daily and one of the most desired foods by a large part of the world population. 
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  • 01 Jun 2021
Topic Review
Cannabis and Male Reproductive Health
Cannabis sativa is a cheap hallucinating agent used in different parts of the world from time unknown as a part of various religious as well as social practices. Cannabis which is a special type of Marijuana can provide temporary relief from analgesia, body pain and in some other clinical conditions. But, impacts of Cannabis on reproductive health of males and females are multi-faceted and differentially fatal. In males, Cannabis can cause changes in testicular morphology, sperm parameters (in terms of semen quality, sperm morphology, sperm mortality and sperm motility), male reproductive hormones and finally causing reduced libido. In females, Cannabis can reduce female fertility by disrupting hypothalamic release of gonadotropin releasing hormone (GnRH), leading to reduced estrogen and progesterone production and anovulatory menstrual cycles.  Current research suggest that cannabis may negatively impact on male and female fertility conditions. However, male sterility considering the Cannabis impact is totally lacking in human as well as in sub-human primates. However, very limited studies are available on Cannabis effect on primate female reproduction considering Rhesus monkeys. Hence, further studies are needed to validate that robust findings in animal models will carry over into human experience.
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  • 18 Sep 2021
Topic Review
Fluorescence Polarization-Based Bioassays
Fluorescence polarization holds considerable promise for bioanalytical systems because it allows the detection of selective interactions in real time and a choice of fluorophores, the detection of which the biosample matrix does not influence; thus, their choice simplifies and accelerates the preparation of samples. For decades, these possibilities were successfully applied in fluorescence polarization immunoassays based on differences in the polarization of fluorophore emissions excited by plane-polarized light, whether in a free state or as part of an immune complex. However, the results of recent studies demonstrate the efficacy of fluorescence polarization as a detected signal in many bioanalytical methods.
  • 1.4K
  • 17 Dec 2020
Topic Review
Classification of Polyphenols
Polyphenols are the secondary metabolites synthesized by the plants as a part of defense machinery. Owing to their antioxidant, anti-inflammatory, anticancerous, antineoplastic, and immunomodulatory effects, natural polyphenols have been used for a long time to prevent and treat a variety of diseases. Polyphenols are plant secondary metabolites, with over 8000 polyphenolic compounds discovered to date, and have a variety of complicated structures. The most common and abundant polyphenols are phenolic acids, phenolic alcohols, flavonoids, lignans, and stiblins, which are available in the plant kingdom.
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  • 04 May 2023
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