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Topic Review
Properties of Claudin-2
Claudin-2 is a member of the claudin family of epithelial tight junction proteins expressed mostly in the kidneys and gastrointestinal tract. Its role as a cation-selective and water permeable paracellular channel is well studied. In addition, newly emerging strong evidence also shows that it can modulate proliferation, migration, and cell fate determination. These effects appear to be due to its interactions with cytosolic adapters, that connect it to key signaling pathways. A multitude of new data document dysregulated claudin-2 expression in many pathologies including cancer, inflammation, and fibrosis. Thus, changes in claudin-2 expression may contribute to the generation, maintenance, and/or progression of diseases through both permeability-dependent and -independent mechanisms. Based on this, efforts are underway to develop therapies targeting claudin-2 with the hope of benefiting patients with a variety of disease. 
  • 1.5K
  • 30 Oct 2020
Topic Review
Cannabinoid Receptors
Spermatogenesis is a highly coordinated process that begins with division of spermatogonia, followed by meiosis to produce haploid spermatids, and finally the differentiation of haploid spermatids into mature spermatozoa. Several stages of male germ cell development are regulated by epigenetic mechanisms that are important for correct gamete development and functions.  The use of  Cannabis sativa has been demonstrated to induce spermatogenesis dysfunctions. Cannabis sativa (Marijuana) exerts its effect by binding to and activating  cannabinoid receptors CB1 and CB2 . In males, both the receptors CB1 and CB2, are involved in male germ cell development.  Here we will discuss on the importance of cannabinoid receptors signaling in the regulation of several stages of male germ cell development and their role in mediating epigenetic modifications that may be transmitted to the next generation by sperm.
  • 1.5K
  • 31 Jul 2020
Topic Review
Semantic Memory
Semantic memory refers to general world knowledge that we have accumulated throughout our lives. This general knowledge (facts, ideas, meaning and concepts) is intertwined in experience and dependent on culture. Semantic memory is distinct from episodic memory, which is our memory of experiences and specific events that occur during our lives, from which we can recreate at any given point. For instance, semantic memory might contain information about what a cat is, whereas episodic memory might contain a specific memory of petting a particular cat. We can learn about new concepts by applying our knowledge learned from things in the past. Semantic memory and episodic memory are both types of explicit memory (or declarative memory), that is, memory of facts or events that can be consciously recalled and "declared". The counterpart to declarative or explicit memory is nondeclarative memory or implicit memory.
  • 1.5K
  • 22 Nov 2022
Topic Review
Probiotics in Poultry Nutrition
Probiotics are live bacteria, fungi, or yeasts that supplement the gastrointestinal flora and help to maintain a healthy digestive system, thereby promoting the growth performance and overall health of poultry.
  • 1.5K
  • 06 Nov 2020
Topic Review
Poultry Parasitic Diseases
Parasitic infections are a major public health concern affecting millions of people universally. The medicinal importance of natural herbs depends upon their bioactive ingredients, which are originated from crude plants, consequently leading to the specific action on the body. Due to the limited availability of effective drugs and high cost, the development of drug resistance in several harmful parasites and microbes leads to huge economic losses in the poultry industry.
  • 1.5K
  • 19 Apr 2022
Topic Review
Strategies to Cope with Late Wilt of Maize
Zea mays L. (maize, corn) is one of the world’s leading crops for food, feed, and fuel and as a raw material for different industrial products. Control of maize late wilt disease (LWD) has been at the forefront of research efforts since the discovery of the disease in the 1960s. The disease has become a major economic restraint in highly affected areas such as Egypt and Israel and is of constant concern in other counties. LWD causes dehydration and collapsing at a late stage of maize cultivation, starting from the male flowering phase. The disease causal agent, Magnaporthiopsis maydis, is a seed- and soil-borne phytoparasitic fungus, penetrating the roots at sprouting, colonizing the vascular system without aboveground symptoms, and spreading upwards in the xylem, eventually blocking the water supply to the plant’s upperparts. Nowadays, the disease’s control relies mostly on identifying and developing resistant maize cultivars. Still, host resistance can be limited because M. maydis undergoes pathogenic variations, and virulent strains can eventually overcome the host immunity. This alarming situation is driving researchers to continue to seek other control methods. The current entry will summarize the various strategies tested over the years to minimize the disease damage. These options include agricultural (crop rotation, cover crop, no-till, flooding the land before sowing, and balanced soil fertility), physical (solar heating), allelochemical, biological, and chemical interventions. Some of these methods have shown promising success, while others have contributed to our understanding of the disease development and the environmental and host-related factors that have shaped its outcome. The most updated global knowledge about LWD control will be presented, and knowledge gaps and future aims will be discussed.
  • 1.5K
  • 10 Jan 2022
Topic Review
Sustainable Viticulture Method
The goal of sustainable viticulture is to determine appropriate varieties and suitable cultivation modes for different ecological types to achieve optimal land and scientific management. The quality and yield of plants should be selected to ensure the sustainable use of ecological resources and the life of vine plants. Sustainable viticulture should aim to produce high-quality vines and wine, respect people and the environment, and ensure long-term economic benefits of vines and wine.
  • 1.5K
  • 25 Jun 2021
Topic Review
Transplacental Gene Delivery
Transplacental gene delivery (TPGD) is a technique for delivering nucleic acids to fetal tissues via tail-vein injections in pregnant mice. After transplacental transport, administered nucleic acids enter fetal circulation and are distributed among fetal tissues. In 1995, TPGD was established by Tsukamoto et al., and its mechanisms, and potential applications have been further characterized since. In 2019, Nakamura et al. demonstrated that intravenous injection of plasmid DNA containing genome editing component (CRISPR/Cas9 system) produced indels in fetal myocardial cells. In the future, this unique technique will allow manipulation of fetal cell functions in basic studies of fetal gene therapy.
  • 1.5K
  • 31 Jul 2020
Topic Review
New Uses of Common Vetch for Sustainable Agriculture
Common vetch (Vicia sativa L.) is a grain legume used in animal feed. It is rich in protein, fatty acid and minerals content, therefore is a very suitable component for feed enrichment. Furthermore, important pharmacological properties in humans have been described. Like other legumes, common vetch has the ability to fix atmospheric nitrogen, an important characteristic in sustainable agricultural systems. These characteristics enhance the usage of vetch as a cover crop and its use in intercropping systems. In addition, several studies have highlighted the potential of vetch in the phytoremediation of polluted soils. These features make common vetch an appropriate crop to address for various potential improvements. Comparative analyzes have allowed the identification of varieties with different flowering time, shattering resistance, yield, nutrient content and composition, drought response, rhizobacteria associations, nitrogen fixation capacity, and other agronomically relevant traits.
  • 1.5K
  • 16 Mar 2023
Topic Review
Oligodendrocyte (OL) Differentiation and Differentiation
Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. OL myelination is critical to the vertebrate central nervous system (CNS) function. It supports not only the myelinating cell in the CNS but also provides metabolic and trophic support to the myelinated axon. The myelin sheath is essential insulation surrounding axons for conduction in the nervous system. Hypermyelination or hypomyelination interferes with saltatory nerve conduction, causing neurological disabilities.
  • 1.5K
  • 18 May 2022
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