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All Topic Review Biography
Topic Review
Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw
The pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is multifactorial and there is a substantial consensus on the role of antiresorptive drugs (ARDs), including bisphosphonates (BPs) and denosumab (Dmab), as one of the main determinants. The time exposure, cumulative dose and administration intensity of these drugs are critical parameters to be considered in the treatment of patients, as cancer patients show the highest incidence of MRONJ. BPs and Dmab have distinct mechanisms of action on bone, but they also exert different effects on immune subsets which interact with bone cells, thus contributing to the onset of MRONJ.
  • 263
  • 17 May 2023
Topic Review
Oral Complications in Children with Acute Lymphoblastic Leukemia
Acute lymphocytic leukemia (ALL) is the most frequent form of all childhood leukemias, mostly affecting children between 2 and 4 years old. Oral symptoms, such as mouth ulcers, mucositis, xerostomia, Herpes or Candidiasis, gingival enlargement and bleeding, petechiae, erythema, mucosal pallor and atrophic glossitis, are very common symptoms of ALL and can be early signs of the disease.
  • 259
  • 05 Sep 2023
Topic Review
Dental Implants Materials
The development of dental implantology is based on the detailed study of the interaction of implants with the surrounding tissues and methods of osteogenesis stimulation around implants, which has been confirmed by the increasing number of scientific publications presenting the results of studies related to both the influence of the chemical composition of dental implant material as well as the method of its surface modification on the key operational characteristics of implants.
  • 258
  • 06 Dec 2023
Topic Review
Sports Mouthguards
Mouthguards are classified into three groups according to their fabrication: stock, boil and bite, and custom-made. Additionally, they can be fabricated from various materials that can influence their effectiveness. Among the most commonly used materials for producing this device are polyvinyl acetate–polyethylene or ethylene vinyl acetate (EVA) copolymer, polyvinyl chloride, latex, acrylic resin, and polyurethane. Although using a mouthguard in sports activities is essential for preventing or reducing orofacial injuries, impacts affecting the rigid structure while using this device remain significant, especially in the anterior region of the maxilla.
  • 257
  • 30 Oct 2023
Topic Review
Dysregulated Phosphate Metabolism, Periodontal Disease, and Cancer
Phosphate, an essential dietary micronutrient, is dysregulated in chronic kidney disease, and both cancer and periodontal disease are associated with chronic kidney disease. Reviewed evidence includes the association between phosphate toxicity and cancer development, and the association between periodontal disease and chronic kidney disease-mineral and bone disorder includes conditions such as ectopic calcification and bone resorption, which may be indirectly related to periodontal disease. Dental calculus in periodontal disease contains calcium phosphate crystals that are deposited from excess calcium and phosphate in saliva. Alveolar bone resorption may be linked systemically to release of parathyroid hormone in response to hypocalcemia induced by hyperphosphatemia. 
  • 255
  • 13 Mar 2024
Topic Review
Oral Microbiome in Systemic Pathologic Conditions
The human being is defined as a ‘superorganism’ since it is made up of its own cells and microorganisms that reside inside and outside the human body. Commensal microorganisms, which are even ten times more numerous than the cells present in the body, perform very important functions for the host, as they contribute to the health of the host, resist pathogens, maintain homeostasis, and modulate the immune system. In the mouth, there are different types of microorganisms, such as viruses, mycoplasmas, bacteria, archaea, fungi, and protozoa, often organized in communities. Normal microbial flora was present in the oral cavity both in physiological conditions and in local pathological conditions and in the most widespread systemic pathologies. Furthermore, the therapeutic precautions that the clinician can follow in order to intervene on the change in the microbiome.
  • 250
  • 23 Nov 2023
Topic Review
Applications of 3D Printing in Dentistry
3D printing technologies include stereolithography, digital light processing, fused deposition modeling, selective laser sintering/melting, photopolymer jetting, powder binder, and 3D laser bioprinting. The main categories of 3D printing materials are polymers, metals, and ceramics. Despite limitations in printing accuracy and quality, 3D printing technology is now able to offer people a wide variety of potential applications in different fields of dentistry, including prosthodontics, implantology, oral and maxillofacial, orthodontics, endodontics, and periodontics. Understanding the existing spectrum of 3D printing applications in dentistry will serve to further expand its use in the dental field. Three-dimensional printing technology has brought about a paradigm shift in the delivery of clinical care in medicine and dentistry. 
  • 250
  • 08 Jan 2024
Topic Review
Periodontitis in Pregnant Women
Periodontitis develops in 11% of pregnant women, and it is independently linked to severe complications during pregnancy such as preterm birth, low birth weight, and gestational diabetes. Periodontal disease appears to be associated with adverse events in pregnancy due to the transport of biofilm bacteria into the bloodstream and into placental tissue; what would cause adverse events is the body’s immune response to infection.
  • 249
  • 29 May 2023
Topic Review
Oral Health and Schizophrenia in Advanced Age
Schizophrenia is a psychiatric disorder that makes patients incompetent to perform day-to-day activities due to their progressing mental illness. In addition to disturbances with thoughts, behavioral changes, and impaired cognitive functions, oro-systemic health also becomes compromised. 
  • 246
  • 17 Nov 2023
Topic Review
Factors That Influence the Accuracy of Intraoral Scanners
Intraoral scanners (IOSs) have become increasingly popular in the field of dentistry for capturing accurate digital impressions of patients’ teeth and oral structures. The accuracy of intraoral scanning is influenced by various factors such as scanner selection, operator skill, calibration, patient’s oral anatomy, ambient conditions, and scanning aids. Maintaining updated software and understanding factors beyond scanner resolution are crucial for optimal accuracy. Conversely, smaller IOS tips, fast scanning speeds, and specific scanning patterns compromise the accuracy and precision. By understanding these factors, dental professionals can make more informed decisions and enhance the accuracy of IOSs, leading to improved final dental restorations.
  • 243
  • 08 Dec 2023
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