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Topic Review
The Local Neuropeptide System of Keratinocytes
The synthesis and activity of neuropeptides and their receptors in epithelial cells of the skin and mucous membranes. Note that the term "neuropeptide" was originally coined to indicate small protein molecules that are contained in neurons, however it is now known that the synthesis of this class of peptides is not restricted to neurons.
  • 353
  • 04 Jan 2022
Topic Review
Dental Implants in AUBB and ALBBs
The Implant survival rates were negatively affected in sub-entities linked to more extensive augmentation procedures such as bone donor site and dentition status. The inclusion and pooling of literature with a low level of evidence, the absence of randomized controlled clinical trials (RCTs) comparing AUBB and ALBB and the limited count of comparative studies with short follow-ups increases the risk of bias and complicates data interpretation.
  • 353
  • 08 Feb 2022
Topic Review
Topical Agents for Nonrestorative Management of Dental Erosion
A nonrestorative approach to the management of dental erosion is the foremost option: controlling dental erosion. Nonrestorative approaches to dental erosion commonly include dietary analysis and counselling, oral health education and topical use of anti-erosive agents. Topical anti-erosive agents can be broadly categorised as fluorides, calcium phosphate-based agents, organic compounds and other anti-erosive agents. In the presence of saliva, fluorides promote the formation of fluorapatite on teeth through remineralisation.
  • 353
  • 11 Aug 2022
Topic Review
Regenerative Materials in Furcations of Patients with Periodontitis
Periodontitis is a chronic, multi-factorial inflammatory disease, caused by an inflammatory reaction by the host to a dysbiotic subgingival microflora, which can be modified by genetic and lifestyle factors, and it results in the loss of tooth-supporting apparatus, the connective tissue attachment and alveolar bone. Worldwide, periodontitis affects about 20–50% of the global population. Regeneration of lost tissues around the teeth remains a clinical challenge, especially in furcation defects of molar teeth. This research will give an overview of the outcomes of the use of different regenerative materials in the treatment of class II furcation defects in patients with periodontitis. 
  • 351
  • 19 May 2022
Topic Review
Home Oral Care of Children
Tooth decay remains one of the most common diseases in children. The oral health status of children can be influenced by many different factors related to their oral health practices, but also to parental factors.
  • 350
  • 26 Aug 2022
Topic Review
Bisphosphonates and Their Influence on the Implant Failure
The use of bisphosphonate (BP) may impair the osseointegration. It is a class of drugs that are frequently selected when there is an alteration in the bone metabolism, which are utilized to prevent bone loss. It can be administered orally (e.g., daily, weekly, or monthly) for treatment of osteoporosis and Paget’s disease, or intravenously (every 3 months or annually) to treat malignant skeletal oncological diseases.
  • 351
  • 17 Mar 2023
Topic Review
Implant Treatment by Guided Surgery Supporting Overdentures
This study aimed to show the clinical outcomes of implants inserted by guided surgery supporting mandibular overdentures in edentulous patients. Patients and methods: Mandibular edentulous patients were diagnosed with an oral examination, cone-beam computerized tomography, and diagnostic casts for intermaxillary relations and treated with overdentures over two implants by guided surgery. After flapless surgery, implants were early loaded with an overdenture at 6 weeks.
  • 349
  • 18 Nov 2021
Topic Review
The Making of Surgical Guide for TADs
A temporary anchorage devices (TADs)  surgical guide is a guide that allows a dental surgeon to place TAD in a precise, pre-planned location to give the ideal depth, angulation, and screw size to fit the area for anchorage purposes. The purpose of anchorage in orthodontics is to move a tooth or teeth for dental and alveolar orthopedic purposes. The TAD number of the screw that can be placed using the surgical guide may range from one to multiple, depending on the purpose of the anchorage needed. The surgical guide is made from hard materials like acrylic or metal. The TAD surgical guide is positioned over the adjacent teeth to maintain stability during the maneuver. The surgical guide is created using CAD/CAM technology and a 3D printer.
  • 348
  • 01 Dec 2023
Topic Review
Melatonin and Periodontitis-Related Systemic Diseases
Periodontitis has become the main reason for tooth loss/edentulism in adults worldwide. It is also linked closely with other systemic diseases such as cardiovascular disease, Alzheimer’s disease, diabetes, and cancer, thus profoundly impairing people’s quality of life. As the most common chronic inflammatory disease of humans, periodontitis has brought about huge socioeconomic impacts and healthcare costs. Periodontitis as a highly prevalent chronic infection/inflammatory disease can eventually lead to tooth loss and masticatory dysfunction. It also has a negative impact on general health and largely impairs quality of life. The tissue destruction during periodontitis is mainly caused by the excessive immune–inflammatory response; hence, how to modulate the host’s reaction is of profound importance for effective periodontal treatment and tissue protection. Melatonin, as an endogenous hormone exhibiting multiple biological functions such as circadian rhythm regulation, antioxidant, and anti-inflammation, has been widely used in general healthcare. The application of melatonin as an adjunctive approach in the treatment of periodontitis and periodontitis-related systemic comorbidities is witnessed. 
  • 347
  • 02 Dec 2022
Topic Review
Molecular, Cellular and Genetic Aspects of Peri-Implantitis
Peri-implantitis is a multi-factorial disease with an inflammatory background that occurs in both soft and hard tissues surrounding implants. A wide array of cells stands behind peri-implantitis, as well as cytokines and their genetic variations that take part in the process. Recently, growing interest in this topic has led to the introduction of specific new diagnostic tools to enable a better understanding of patients’ responses to treatment and, in turn, to even enable prediction of the risk of developing peri-implant disease.
  • 348
  • 21 Jul 2023
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