Topic Review
Amelogenin-Derived Peptides
Amelogenins are enamel matrix proteins currently used to treat bone defects in periodontal surgery. Recent studies have highlighted the relevance of amelogenin-derived peptides, named LRAP, TRAP, SP, and C11, in bone tissue engineering. Interestingly, these peptides seem to maintain or even improve the biological activity of the full-length protein, which has received attention in the field of bone regeneration.
  • 336
  • 11 Oct 2021
Topic Review
Anterior Open Bite Treatment with Skeletal Anchorage
Anterior open bite (AOB) is still one of the most difficult and demanding clinical problems. This malocclusion relies on a reduction in the vertical relationship between the incisal edges of the upper and lower incisors.
  • 359
  • 29 Dec 2021
Topic Review
Anti-tumor Photodynamic Therapy
Anti-tumor photodynamic therapy (PDT) is a unique oxidative stress-based modality that has proven highly effective on a variety of solid malignancies. Endogenous nitric oxide (NO) has a critical role in the therapeutic outcome of this modality.
  • 264
  • 27 Apr 2021
Topic Review
Antifungals in Preventing Oropharyngeal Candidiasis among HIV-Infected Adults
Oropharyngeal candidiasis (OPC) is attributed to the overgrowth of the commensal fungi, Candida spp., in the mouth and throat. Among HIV-infected adults, there is an increased risk of developing OPC due to the loss of cell-mediated immunity. Fluconazole can be considered as an effective agent with a better safety profile for the prevention of OPC in HIV-infected adults.
  • 126
  • 22 Jun 2022
Topic Review
Antisclerostin Effect on Osseointegration and Bone
Sclerostin is a glycoprotein encoded in humans by the SOST gene. It is located on chromosome 17q12-q21, with a C-terminal cysteine knot-like (CTCK) domain. It has a similar sequence also to DAN (Differential screening-selected gene Aberrative in Neuroblastoma), an antagonist’s family of the bone morphogenetic protein (BMP). Sclerostin is primarily produced and secreted by osteocytes. Moreover, it is a negative key regulator of osteoblastic functions. It inhibits osteoblast differentiation and bone formation by inhibiting the Wnt signaling pathway after binding with LRP5 and 6 (Wnt-coreceptor). This canonical Wnt signaling (Wnt/β-catenin pathway) is essential in bone healing. It promotes pre-osteoblast proliferation and osteo-induction, enhances survival of all cells of the osteoblast lineage, inhibits differentiation of mesenchymal stem cells (MSCs) into chondrocytes and adipocytes and controls osteoclast maturation by regulating RANKL levels in osteoblast receptors.
  • 68
  • 15 Feb 2023
Topic Review
Applications for Nanotechnology in Endodontics
Nanotechnology has been utilized in several different parts of dentistry. Nanomaterials can be employed as irrigation, intracanal medicament, obturation materials and sealers.
  • 743
  • 11 Aug 2022
Topic Review
Applications of Biodegradable Magnesium-Based Materials
Reconstruction of defects in the maxillofacial region following traumatic injuries, craniofacial deformities, defects from tumor removal, or infections in the maxillofacial area represents a major challenge for surgeons. Various materials have been studied for the reconstruction of defects in the maxillofacial area. Biodegradable metals have been widely researched due to their excellent biological properties. Magnesium (Mg) and Mg-based materials have been extensively studied for tissue regeneration procedures due to biodegradability, mechanical characteristics, osteogenic capacity, biocompatibility, and antibacterial properties. 
  • 212
  • 07 Sep 2022
Topic Review
Applications of BioHPP in Prosthetic Dentistry
BioHPP is not only extremely interesting for the future, but possesses characteristics suitable for clinical application today, for endocrowns, small adhesive bridges, temporary prostheses and for immediate loads on implant restorations. The excellent aesthetics and the possibility of simple reprocessing of the restorations made with this material invite its clinical application. 
  • 628
  • 28 Mar 2022
Topic Review
Applications of Facial Scanners in Dentistry
Facial scanning accuracy has proven to be clinically acceptable for use in dental applications. Accuracy is measured by comparing the scan to a control model and measuring the deviations between the two. Scanners with deviation values less than 2 mm are considered acceptable. Deviation values for facial scanners range between 140 and 1330 μm. Reported accuracy for most facial scanners was approximately 500 μm, which is within the limits for clinical acceptability. 
  • 375
  • 06 Dec 2022
Topic Review
Applications of Nanoparticles in Dentistry
Interest in the topic of nanoparticles (NPs) and nanomaterials used in dentistry is growing in research as well as clinical settings. An increasing number of nanomaterials have been developed and tested, enabling novel solutions unavailable in dentistry before. The shape and size of these particles influences the physicochemical properties of a substance, which in turn impacts their absorption characteristics. Nanomaterials have unique structures and properties that distinguish them from other materials. In the dental field, nanoparticles have a variety of applications, such as nanocomposites, antimicrobial nanomaterials and bio-mineralization systems.
  • 152
  • 11 Jan 2023
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