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Topic Review
Nematophagous Fungi
Plant-parasitic nematodes significantly threaten agriculture and forestry, causing various diseases. They cause annual losses of up to 178 billion dollars worldwide due to their parasitism. Nematophagous fungi (NF) are valuable in controlling or reducing parasitic nematode diseases by killing nematodes through predatory behavior.
  • 400
  • 09 Nov 2023
Topic Review
Nanoparticles in Brief
Nanoparticles, materials at the nanoscale, have revolutionized various fields. Their unique properties, ranging from size-dependent characteristics to high reactivity, have enabled diverse applications in medicine, electronics, materials science, and environmental protection. This review explores the world of nanoparticles, encompassing their properties, synthesis methods, and applications, underscoring their significance across industries. Additionally, it addresses the challenges associated with nanoparticles, such as toxicity and environmental concerns, emphasizing the need for responsible utilization. The world of nanoparticles promises innovation and solutions but requires cautious exploration to maximize benefits while minimizing risks.
  • 133
  • 23 Oct 2023
Topic Review
Pancreatic Cancer-Secreted Proteins in Tumor Microenvironment
Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the tumor microenvironment (TME). The role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies is discussed here.
  • 208
  • 13 Oct 2023
Topic Review
Detection of Pancreatic Cancer
The pancreas is a vital organ with exocrine and endocrine functions. Pancreatitis is an inflammation of the pancreas caused by alcohol consumption and gallstones. This condition can heighten the risk of pancreatic cancer (PC), a challenging disease with a high mortality rate. Genetic and epigenetic factors contribute significantly to PC development, along with other risk factors. Early detection is crucial for improving PC outcomes. Diagnostic methods, including imagining modalities and tissue biopsy, aid in the detection and analysis of PC. In contrast, liquid biopsy (LB) shows promise in early tumor detection by assessing biomarkers in bodily fluids. Understanding the function of the pancreas, associated diseases, risk factors, and available diagnostic methods is essential for effective management and early PC detection. The current clinical examination of PC is challenging due to its asymptomatic early stages and limitations of highly precise diagnostics. Screening is recommended for high-risk populations and individuals with potential benign tumors. Among various PC screening methods, the N-NOSE plus pancreas test stands out with its high AUC. Compared to other commercial products, the N-NOSE plus pancreas test offers a cost-effective solution for early detection. However, additional diagnostic tests are required for confirmation. Further research, validation, and the development of non-invasive screening methods and standardized scoring systems are crucial to enhance PC detection and improve patient outcomes. This review outlines the context of pancreatic cancer and the challenges for early detection.
  • 284
  • 11 Oct 2023
Topic Review
Evolution of Domestic Goats
Goat evolution is the process by which domestic goats came to exist through evolution by natural selection. Wild goats — medium-sized mammals which are found in noticeably harsh environments, particularly forests and mountains, in the Middle East and Central Asia — were one of the first species domesticated by modern humans, with the date of domestication generally considered to be 8,000 BCE. Goats are part of the family Bovidae, a broad and populous group which includes a variety of ruminants such as bison, cows and sheep. Bovids all share many traits, such as hooves and a herbivorous diet and all males, along with many females, have horns. Bovids began to diverge from deer and giraffids during the early Miocene epoch. The subfamily Caprinae, which includes goats, ibex and sheep, are considered to have diverged from the rest of Bovidae as early as the late Miocene, with the group reaching its greatest diversity in the ice ages. The tribe Caprini would subsequently develop from Caprids who arrived in the mountainous areas of Eurasia and split into goats and sheep in response to a further geographic separation. The ancestors of sheep remained in the foothills and the ancestors of goats went to higher altitudes. This divergence resulted in the adaption of the ancestors of goats to a mountainous environment, producing many of the traits considered peculiar to the species. During the ice ages a genus called Capri evolved which would then diverge into the modern goat species, along with several species of ibex. It is commonly held that the earliest domestication was of the bezoar ibex in the Zagros Mountains. These earliest domesticated goats were used to produce meat and milk for Neolithic farmers, along with providing many of the materials required to built residences and tools. Following the domestication of goats over 300 breeds have been established for a variety of purposes, including for the maximation of milk production and for meat. Domestication and the selective breeding which resulted had a significant effect on the direction of goat evolution, with goats developing behaviour which is considered to have been influenced by consistent proximity to humans. Selective breeding also significantly increased the physical diversity of modern goats, producing characteristics not seen in wild goats.
  • 1.9K
  • 08 Oct 2023
Topic Review
Electrospinning for Drug Delivery Systems
The term “drug delivery” refers to administrating the therapeutic effect of a pharmaceutical compound to humans or animals. Progress in the field of disease exploration is widely acknowledged, leading to ongoing research and development of advanced techniques for advanced drug delivery systems (DDSs). Electrospinning is a cost-effective and simple tool that is used for the preparation of drug delivery systems using natural, synthetic, and blended polymers. 
  • 210
  • 27 Sep 2023
Topic Review
The Hallmarks of Atrial Fibrillation
Atrial fibrillation (AF) is a prevalent cardiac condition predominantly affecting older adults, characterized by irregular heartbeat rhythm. The condition often leads to significant disability and increased mortality rates. 
  • 305
  • 24 Aug 2023
Topic Review
Biomedical Applications of Hybrid Nanoparticles
Organic and inorganic nanoparticles (NPs) have attracted significant attention due to their unique physico-chemical properties, which have paved the way for their application in numerous fields including diagnostics and therapy. Hybrid nanomaterials consisting of organic nanocompartments (e.g., liposomes, micelles, poly (lactic-co-glycolic acid) NPs, dendrimers, or chitosan NPs) encapsulating inorganic NPs (quantum dots, or NPs made of gold, silver, silica, or magnetic materials) have been researched for usage in vivo as drug-delivery or theranostic agents.
  • 205
  • 02 Aug 2023
Topic Review
Macropore Formation and Current Facilitation in P2X7
Macropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules. The precise mechanisms underlying macropore formation remain poorly understood, but recent evidence suggests two alternative pathways: a direct entry through the P2X7 pore itself, and an indirect pathway triggered by P2X7 activation involving additional proteins, such as TMEM16F channel/scramblase. On the other hand, current facilitation refers to the progressive increase in current amplitude and activation kinetics observed with prolonged or repetitive exposure to ATP. Various mechanisms, including the activation of chloride channels and intrinsic properties of P2X7, have been proposed to explain this phenomenon.
  • 293
  • 12 Jul 2023
Topic Review
Overview of Ocular Delivery Systems
Many disorders of the anterior region of the eye may be efficiently treated via topical administration; however, it is more challenging to target conventional therapeutic doses to the posterior of the eye in this manner. Thus, various nanocarriers have been created and investigated for the transport of drugs and genes to the anterior or the posterior portions of the eyes. Liposomes, nanoparticles, micelles, inserts, implants, hydrogel, and emulsions are some of the most frequently utilized drug delivery systems.
  • 803
  • 03 Jul 2023
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