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Topic Review
Psilocybin
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. Psilocybin was marketed by Sandoz as Indocybin for basic psychopharmacological and therapeutic clinical research, rising in popularity during the 1960s and classified as a Schedule I drug in 1970. Psilocybin is a naturally occurring tryptamine known for its psychedelic properties. Recent research indicates that psilocybin may constitute a valid approach to treat depression and anxiety associated to life-threatening diseases. 
  • 1.1K
  • 23 Sep 2020
Topic Review
Post-Traumatic Stress Disorder in Caregivers
Post-traumatic stress disorder (PTSD) is a mental disorder typically occurring after the exposure, both direct and indirect, to a traumatic event, and is characterized by the onset and persistence of a series of clinical symptoms that can often be profoundly incapacitating and tendentially chronic. In the past decades, increasing attention has been deserved to PTSD among caregivers of patients affected by severe medical conditions characterized by a risk for life, a severe impairment or a chronic course (e.g. cancer, severe injuries, type 1 diabetes and neurologic disorders) highlighting the potential traumatic role of such experiences.
  • 1.1K
  • 22 Sep 2020
Topic Review
Noninvasive Vagal Nerve Stimulation
Neuromodulation is a promising new area with treatment applications for psychiatry. Electrical stimulation of the vagus nerve is associated with a reduction in peripheral sympathetic and inflammatory function and modulation of brain areas mediating fear and the stress response, and thus has potential applications to patients with stress-related psychiatric disorders, including posttraumatic stress disorder (PTSD) and depression. Non-invasive Vagal Nerve Stimulation (nVNS) can be applied to vagus nerve locations at the neck (transcutaneous cervical, or tcVNS) or ear (transcutaneous auricular, or taVNS), intervening at the level of the underlying psychobiology with potential beneficial treatment effects.   
  • 875
  • 18 Sep 2020
Topic Review
Green Purchase
   Green purchase refers to the green product purchase activities conducted by consumers to save resources and protect the environment.    Green marketing refers to the marketing activities (including price, plan, process, production, promotion, and personnel) designed by enterprises for all consumers. The purpose of these activities is to minimize the environmental impact of the company's products and service.    Many companies have changed their production strategies to actively respond to environmental problems and changes in consumers' environmental attitudes. They abandoned products that are relatively polluting to the environment or harmful to human health and turned to environmental protection products. Although manufacturers have produced environmentally friendly products, many consumers are not interested in their products due to their consumption values, resistance to new technologies, or their resistance to the premium prices charged for these new products, which leads to sales obstacles for these products. Therefore, it is of great practical significance to understand the influencing factors of consumers' green product purchase behavior for green marketing.
  • 2.2K
  • 16 Sep 2020
Topic Review
Maternal-Autoantibody-Related Autism
Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related (MAR) autism and some have described attempts to define the antigenic targets. This entry describes evidence on MAR autism and the various autoantibodies that have been implicated. Among other possibilities, antibodies to neuronal surface protein Contactin Associated Protein 2 (CASPR2) have been found more frequently in mothers of children with neurodevelopmental disorders or autism, and two independent experimental studies have shown pathogenicity in mice. The N-methyl-D-aspartate receptor (NMDAR) is another possible target for maternal antibodies as demonstrated in mice. Here, we discuss the growing evidence, discuss issues regarding biomarker definition, and summarise the therapeutic approaches that might be used to reduce or prevent the transfer of pathogenic maternal antibodies.
  • 831
  • 03 Sep 2020
Topic Review
Concurrent Disorder
Concurrent disorder refers to a diverse set of combinations of substance use disorders and mental disorders simultaneously in need of treatment. Concurrent disorders are underdiagnosed, undertreated, and more complex to manage, practicing the best recommendations can support better outcomes. The purpose of this work is to systematically assess the quality of the current concurrent disorders’ clinical recommendation management guidelines. Literature searches were performed by two independent authors in electronic databases, web, and gray literature. The inclusion criteria were English language clinical management guidelines for adult concurrent disorders between 2000 and 2020. The initial search resulted in 8841 hits. A total of 24 guidelines were identified and assessed with the standardized guidelines assessment tool: AGREE II (Appraisal of Guidelines for Research and Evaluation). Most guidelines had acceptable standards, however, only the NICE guidelines had all detailed information on all AGREE II Domains. Guidelines generally supported combinations of treatments for individual disorders with a very small evidence base for concurrent disorders, and they provided little recommendation for further structuring of the field, such as level of complexity or staging, or evaluating dierent models of treatment integration.
  • 1.1K
  • 01 Sep 2020
Topic Review
Career Adaptability
With the rapid development of society and technology, personal adaptability is becoming more and more important. Learning how to adapt to a changing world is becoming one of the necessary conditions for success. Career adaptability can help individuals to smoothly adapt to changes when coping with their career roles, and maintain their ability to balance their career roles, which will affect their important psychological resources for career development and achieve more meaning in life. In recent years, career adaptability has gradually attracted the attention of researchers. Therefore, in order to explore the main factors, such as research focus, the main researchers, its evolution, and the important results of career adaptability in the last ten years, this study used the scientific knowledge mapping software CiteSpace as a research tool, and select related articles from the Web of Science between 2010 to 2020 under the theme of “career adaptability” for data analysis, which can help future researchers to understand current and future career adaptability research and control the research direction of career adaptability. The results of this research indicate that there are direct or indirect connections between different themes, such as the career adaptability scale, career construction, positive personalities, and so on, but few articles integrate multiple research topics. At the same time, the main researchers, research frontiers and network relationships were also obtained. Based on the above findings, the correlative main concept, theoretical structure, evolution, and research progress of career adaptability in the past ten years are discussed. Super and Knasel argued that career adaptability is a state of readiness which is required to cope with tasks that can be predicted by current or future job roles and to adapt to unpredictable work or changes in the work environment (Super & Knasel, 1981). Savickas modified it to be the individual’s state of readiness for predictable career tasks, the career roles involved, and career problems that are unpredictable in career changes or career situations, which is also a quality that allows for change without much difficulty to conform to the new environment (Savivkas, 1997). Later, Savickas made a more concise definition and supplement to the concept that was the state of preparation and resources needed to respond to current and anticipated career development tasks, including the attitudes, abilities, and behaviors individuals need to match them with work that suits them, which are psychological resources for managing career change, new tasks, and job trauma (Savickas, 2005; Savickas, 2002).
  • 9.5K
  • 27 Aug 2020
Topic Review
Delirium
Delirium is a set of neuropsychiatric symptoms, including qualitative disturbances of consciousness and attention, which may be accompanied by cognitive deficits and psychotic symptoms. The incidence of delirium varies from several percent in patients hospitalized in general wards up to 80% in patients with multi-organ failure treated in intensive care units. Delirium worsens the prognosis, extends hospitalization time, and may increase mortality.
  • 1.1K
  • 27 Aug 2020
Topic Review
Epigenomic Dysregulation in Schizophrenia
       Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms that causes very significant disability in young people. While schizophrenia has a strong genetic component, with heritability around 80%, there is also a very significant range of environmental exposures and stressors that have been implicated in disease development and neuropathology, such as maternal immune infection, obstetric complications, childhood trauma and cannabis exposure. It is postulated that epigenetic factors, as well as regulatory non-coding RNAs, mediate the effects of these environmental stressors. In this review, we explore the most well-known epigenetic marks, including DNA methylation and histone modification, along with emerging RNA mediators of epigenomic state, including miRNAs and lncRNAs, and discuss their collective potential for involvement in the pathophysiology of schizophrenia implicated through the postmortem analysis of brain tissue. Given that peripheral tissues, such as blood, saliva, and olfactory epithelium have the same genetic composition and are exposed to many of the same environmental exposures, we also examine some studies supporting the application of peripheral tissues for epigenomic biomarker discovery in schizophrenia. Finally, we provide some perspective on how these biomarkers may be utilised to capture a signature of past events that informs future treatment.
  • 753
  • 27 Aug 2020
Topic Review
Rural Livelihood Climate Vulnerability
Rural livelihood vulnerability to climate change impacts is one of the major policy challenges for sustainable development. Rural socio-economic systems are different from urban and peri-urban systems because of high dependence on climate sensitive natural resources for livelihood practices, access to which is significantly influenced by context-specific socio-cultural and political properties. Rural livelihood vulnerability, therefore, needs to be understood considering both climatic and non-climatic factors. By articulating the Vulnerability Assessment (VA) Framework and the Sustainable Rural Livelihoods (SRL) Framework into a shared conceptual framing, this entry defines the rural livelihood vulnerability and outlines its assessment process. In so doing, the framing borrows three vulnerability components (i.e., exposure, sensitivity and adaptive capacity) for its structural outline and derives analytical variables from the SRL framework.
  • 1.2K
  • 21 Aug 2020
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