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Topic Review
Clinical Communication Skills in Dental Education
Effective communication skills, that is, accurate listening or observation and focused verbal or non-verbal response, enhances efficiency of diagnoses, ethical clinical decision making, positive clinical outcomes, promotes patient use of services, and patient–clinician satisfaction. It also helps to decrease patient anxiety and pain perception.
  • 1.4K
  • 19 Apr 2022
Topic Review
Traditional Computer-Vision Methods Implemented in Sports
Automatic analysis of video in sports is a possible solution to the demands of fans and professionals for various kinds of information. Analyzing videos in sports has provided a wide range of applications, which include player positions, extraction of the ball’s trajectory, content extraction, and indexing, summarization, detection of highlights, on-demand 3D reconstruction, animations, generation of virtual view, editorial content creation, virtual content insertion, visualization and enhancement of content, gameplay analysis and evaluations, identifying player’s actions, referee decisions and other fundamental elements required for the analysis of a game. Recent developments in video analysis of sports have a focus on the features of computer vision techniques, which are used to perform certain operations for which these are assigned, such as detailed complex analysis such as detection and classification of each player based on their team in every frame or by recognizing the jersey number to classify players based on their team will help to classify various events where the player is involved. In higher-level analysis, such as tracking the player or ball, many more such evaluations are to be considered for the evaluation of a player’s skills, detecting the team’s strategies, events and the formation of tactical positions such as midfield analysis in various sports such as soccer, basketball, and also various sports vision applications such as smart assistants, virtual umpires, assistance coaches. A higher-level semantic interpretation is an effective substitute, especially in situations when reduced human intervention and real-time analysis are desired for the exploitation of the delivered system outputs.
  • 1.4K
  • 19 May 2022
Topic Review
Antibiotic Residues in Food
The usage of antibiotics has been, and remains, a topic of utmost importance; on the one hand, for animal breeders, and on the other hand, for food safety. Although many countries have established strict rules for using antibiotics in animal husbandry for the food industry, their misuse and irregularities in compliance with withdrawal periods are still identified. In addition to animal-origin foods that may cause antibiotic residue problems, more and more non-animal-origin foods with this type of non-compliance are identified. 
  • 1.4K
  • 31 May 2022
Topic Review
Biotechnological Approaches Applied for Marine Hydrocarbon Spills Remediation
Biological and physico-chemical remediation technologies can be efficient in terms of spill cleanup and microorganisms—mainly bacteria—are the main ones responsible for petroleum hydrocarbons (PHCs) degradation such as crude oil. Biodegradation is considered as one of the most sustainable and efficient techniques for the removal of PHCs. 
  • 1.4K
  • 18 Jul 2022
Topic Review
Nanoparticles-Based Platforms Targeting the PD-1/PD-L1 Pathway
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis showed remarkable improvements in overall response and patient survival, which changed the treatment landscape for multiple cancer types. PD-1/PD-L1-targeted agents encapsulated in nanoparticles have emerged as novel drug delivery systems for improving the delivery efficacy, enhancing immune response and minimizing side effects in cancer treatment. Nanocarriers targeting the PD-1/PD-L1 axis showed enhanced functionalities and improved technical weaknesses based on their reduced off-target effects, biocompatible properties, multifunctional potential and biomimetic modifications. 
  • 1.4K
  • 24 Aug 2022
Topic Review
Performance Indicator
A performance indicator or key performance indicator (KPI) is a type of performance measurement. KPIs evaluate the success of an organization or of a particular activity (such as projects, programs, products and other initiatives) in which it engages. Often success is simply the repeated, periodic achievement of some levels of operational goal (e.g. zero defects, 10/10 customer satisfaction), and sometimes success is defined in terms of making progress toward strategic goals. Accordingly, choosing the right KPIs relies upon a good understanding of what is important to the organization. What is deemed important often depends on the department measuring the performance – e.g. the KPIs useful to finance will differ from the KPIs assigned to sales. Since there is a need to understand well what is important, various techniques to assess the present state of the business, and its key activities, are associated with the selection of performance indicators. These assessments often lead to the identification of potential improvements, so performance indicators are routinely associated with 'performance improvement' initiatives. A very common way to choose KPIs is to apply a management framework such as the balanced scorecard. The importance of such performance indicators is evident in the typical decision-making process (e.g. in management of organisations). When a decision-maker considers several options, they must be equipped to properly analyse the status quo to predict the consequences of future actions. Should they make their analysis on the basis of faulty or incomplete information, the predictions will not be reliable and consequently the decision made might yield an unexpected result. Therefore, the proper usage of performance indicators is vital to avoid such mistakes and minimise the risk.
  • 1.4K
  • 10 Oct 2022
Biography
Wesley A. Brown
Wesley Anthony Brown (April 3, 1927 – May 22, 2012) was the first African-American graduate of the United States Naval Academy (USNA) in Annapolis, Maryland.[1] He served in the United States Navy from May 2, 1944, until June 30, 1969. He was involved in both the Korean and Vietnam wars. Wesley Brown was born on April 3, 1927, in Baltimore, Maryland. He graduated from Dunbar High School in
  • 1.4K
  • 15 Nov 2022
Topic Review
Electromechanics
In engineering, electromechanics combines processes and procedures drawn from electrical engineering and mechanical engineering. Electromechanics focuses on the interaction of electrical and mechanical systems as a whole and how the two systems interact with each other. This process is especially prominent in systems such as those of DC or AC rotating electrical machines which can be designed and operated to generate power from a mechanical process (generator) or used to power a mechanical effect (motor). Electrical engineering in this context also encompasses electronics engineering. Electromechanical devices are ones which have both electrical and mechanical processes. Strictly speaking, a manually operated switch is an electromechanical component due to the mechanical movement causing an electrical output. Though this is true, the term is usually understood to refer to devices which involve an electrical signal to create mechanical movement, or vice versa mechanical movement to create an electric signal. Often involving electromagnetic principles such as in relays, which allow a voltage or current to control another, usually isolated circuit voltage or current by mechanically switching sets of contacts, and solenoids, by which a voltage can actuate a moving linkage as in solenoid valves. Before the development of modern electronics, electromechanical devices were widely used in complicated subsystems of parts, including electric typewriters, teleprinters, clocks, initial television systems, and the very early electromechanical digital computers. Solid-state electronics have replaced electromechanics in many applications.
  • 1.4K
  • 17 Nov 2022
Topic Review
Insulitis in Human Type 1 Diabetic Pancreas
Type 1 diabetes (T1D) is an autoimmune disease with immune cells’ islet infiltration (called “insulitis”), which leads to beta cell loss. Despite being the critical element of T1D occurrence and pathogenesis, insulitis is often present in a limited percentage of islets, also at diagnosis. Therefore, it is needed to define reproducible methods to detect insulitis and beta-cell decline, to allow accurate and early diagnosis and to monitor therapy. This goal is still far due to the morphological aspect of islet microvasculature, which is rather dense and rich, and is considerably rearranged during insulitis. More studies on microvasculature are required to understand if contrast-enhanced ultrasound sonography measurements of pancreatic blood-flow dynamics may provide a clinically deployable predictive marker to predict disease progression and therapeutic reversal in pre-symptomatic T1D patients. It is needed to clarify the relation between insulitis and the dynamics of β cell loss and with coexisting mechanisms of dysfunction, according to clinical stage, as well as the micro vessels’ dynamics and microvasculature reorganization. The ideal cell-based therapy of T1D should start from an early diagnosis allowing a sufficient isolation of specific Procr+ progenitors, followed by the generation and expansion of islet organoids, which could be transplanted coupled to an immune-regulatory therapy which will permit the maintenance of pancreatic islets and an effective and long-lasting insulitis reversal.
  • 1.4K
  • 14 Dec 2022
Topic Review
Steroid Oximes
Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N−OH and they exist as colorless crystals and are poorly soluble in water. Oximes can be easily obtained through the condensation of aldehydes or ketones with various amine derivatives, making them a very interesting chemical group in medicinal chemistry for the design of drugs as potential treatments for several diseases. A large number of steroid oximes exhibit important biological activities, such as anticancer, anti-inflammatory, antibacterial, antifungal and antiviral, among others, through different mechanisms of action. Several steroid oximes are used clinically as drugs and many others are in clinical trials.
  • 1.4K
  • 20 Feb 2023
Topic Review
Models and Tools for Developing Serious Games
Serious games (SG), (video games with an educational purpose), provide teachers with tools to strengthen their students’ knowledge. Developing a SG requires knowledge, time, and effort. As a result, specialized tools to aid in the development process are needed.
  • 1.4K
  • 31 Oct 2023
Topic Review
Fall Risk Assessment Using Wearable Sensors
Fall risk assessment based on wearable sensors can be performed from a long-term perspective, in which sensor data is used to predict subject’s long-term fall risk based on clinical scale scores, or from a short-term approach, where data collected is used to detect pre-fall/unbalanced situations in real-time and consequently identify fall risk events.
  • 1.4K
  • 24 Feb 2022
Topic Review
Sources and Absorption of Resveratrol
Polyphenols are secondary metabolites produced by plants and also found in many natural products, such as fruit and vegetables, and their derivatives, such as tea, coffee, olive oil, and wine. Polyphenols are well known for their antioxidant properties, which confer to them health-beneficial effects. Among them, resveratrol is probably one of the most investigated molecules. It was first described in 1940 by Michio Takaoka, a Japanese student who was investigating extracts from traditional medicinal plants and called it “resveratrol” because the molecule had been extracted from the roots of Veratrum grandiflorum (white hellebore) and presented the skeleton of resorcinol in its molecular structure. The extract from this plant was exploited for treating several allergic and inflammatory diseases, among others. However, this molecule did not attract much interest until 1997, when Jang and colleagues published an article regarding its cancer chemopreventive activity. Resveratrol is the common name for 3,5,4′-trihydroxy-trans-stilbene, a natural phytoalexin derived from phenylpropanoids, that is synthesized in plants under stress conditions, such as infections or UV exposure. 
  • 1.4K
  • 14 Dec 2021
Topic Review
Gemtuzumab ozogamicin
       Gemtuzumab ozogamicin (GO) is a humanized anti-CD33 monoclonal antibody conjugated to calicheamicin, a cytotoxic antitumor antibiotic. GO is indicated for the treatment of newly-diagnosed or relapsed/refractory CD33-positive acute myeloid leukemia (AML).
  • 1.4K
  • 30 Oct 2020
Topic Review
Phosphodiesterases in Cirrhotic Portal Hypertension
Here, we review the role of phosphodiesterases in regulation of portal pressure in healthy liver and in liver cirrhosis and we present data, that inhibitors of phosphodiesterase-5 (PDE-5) might be a promising novel therapeutic approach in cirrhotic portal hypertension.
  • 1.4K
  • 13 Sep 2020
Topic Review
Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a leading cause of severe visual loss among the elderly. AMD patients are tormented by progressive central blurring/loss of vision and have limited therapeutic options to date. Drusen accumulation causing retinal pigment epithelial (RPE) cell damage is the hallmark of AMD pathogenesis, in which oxidative stress and inflammation are the well-known molecular mechanisms.
  • 1.4K
  • 26 Oct 2020
Topic Review
High-Density Lipoproteins as Homeostatic Nanoparticles
It is well known that blood lipoproteins (LPs) are multimolecular complexes of lipids and proteins that play a crucial role in lipid transport. High-density lipoproteins (HDL) are a class of blood plasma LPs that mediate reverse cholesterol transport (RCT)—cholesterol transport from the peripheral tissues to the liver. Due to this ability to promote cholesterol uptake from cell membranes, HDL possess antiatherogenic properties. This function was first observed at the end of the 1970s to the beginning of the 1980s, resulting in high interest in this class of LPs. It was shown that HDL are the prevalent class of LPs in several types of living organisms (from fishes to monkeys) with high resistance to atherosclerosis and cardiovascular disorders. Lately, understanding of the mechanisms of the antiatherogenic properties of HDL has significantly expanded. Besides the contribution to RCT, HDL have been shown to modulate inflammatory processes, blood clotting, and vasomotor responses. These particles also possess antioxidant properties and contribute to immune reactions and intercellular signaling.
  • 1.4K
  • 30 Nov 2020
Topic Review
MXenes
Recent progress in the application of new 2D-materials—MXenes—in the design of biosensors, biofuel cells and bioelectronics is overviewed and some advances in this area are foreseen. Recent developments in the formation of a relatively new class of 2D metallically conducting MXenes opens a new avenue for the design of conducting composites with metallic conductivity and advanced sensing properties. Advantageous properties of MXenes suitable for biosensing applications are discussed. Frontiers and new insights in the area of application of MXenes in sensorics, biosensorics and in the design of some wearable electronic devices are outlined. Some disadvantages and challenges in the application of MXene based structures are critically discussed.
  • 1.4K
  • 08 Jan 2021
Topic Review
Structural Class of ARS Inhibitors
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that ligate amino acids to tRNAs and translate the genetic code during protein synthesis. Their function in pathogen-derived infectious diseases has been well established, which has led to the development of small molecule therapeutics. The applicability of ARS inhibitors for other human diseases, such as fibrosis, has recently been explored in the clinical setting. There are active studies to find small molecule therapeutics for cancers.
  • 1.4K
  • 13 Jan 2021
Topic Review
Colistin Resistance in Bacteria
Colistin is an old polypeptide antibiotic of the group E, discovered in 1947 by Y. Koyama from Paenibacillus polymyxa subspecies colistinus cultures. It is a bactericidal, narrow-spectrum molecule directed against most GNB, but ineffective against Gram-positive bacteria, anaerobic bacteria, and mycoplasmas.
  • 1.4K
  • 21 Mar 2021
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