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Topic Review
Mammalian Zona Pellucida Glycoproteins
Zona pellucida (ZP) plays an important role in the oocyte lifespan providing mechanical protection and defense against polyspermic fertilization by directly modulating sperm function.
  • 1.4K
  • 27 May 2021
Topic Review
Macrophage Polarization in Atherosclerosis
Macrophages (Macs) are one of the major cell types of the innate immune system. They regulate inflammation and clear infection through antigen presentation, polarization, and phagocytosis. Macs release cytokines to regulate other immune cells.
  • 1.4K
  • 24 Jun 2022
Topic Review
The Wavy Liquid Film
Two-phase annular flow in vertical pipes is one of the most common and important flow regimes in fluid mechanics, particularly in the field of building drainage systems where discharges to the vertical pipe are random and the flow is unsteady. With the development of experimental techniques and analytical methods, the understanding of the fundamental mechanism of the annular two-phase flow has been significantly advanced, such as liquid film development, evolution of the disturbance wave, and droplet entrainment mechanism. 
  • 1.4K
  • 16 Nov 2022
Topic Review
Bigels
Bigels have been mainly applied in the pharmaceutical sector for the controlled release of drugs or therapeutics. However, these systems, with their intricate structures, hold great promise for wider application in food products. Besides their classical role as carrier and target delivery vehicles for molecules of interest, bigels may also be valuable tools for building complex food structures. In the context of reducing or even eliminating undesirable (but often highly functional) food components, current strategies often critically affect food structure and palatability. The production of solid fat systems that are trans-fat-free and have high levels of unsaturated fatty acids is one of the challenges the food industry currently faces. 
  • 1.4K
  • 13 Nov 2023
Topic Review
DHH Gene
Desert Hedgehog
  • 1.4K
  • 24 Dec 2020
Topic Review
Machine Learning in Agriculture
Big Data and ML have appeared as high-performance informatics technologies for creating new opportunities to unravel, quantify and understand data-intensive processes in the environment of farm operations
  • 1.4K
  • 11 Mar 2021
Topic Review
Friction Stir Welding of Polymers
Friction Stir Welding (FSW) is one of the welding methods within the category of friction welding, as it uses the friction between the base material and the tool to generate the heat necessary to soften the material of the joint. The FSW process was developed, demonstrated and patented by “The Welding Institute (TWI)” in England for the first time by Thomas et al.. The principle of the conventional process is illustrated in, as well as its main variables.
  • 1.4K
  • 30 Jun 2021
Topic Review
Asset Management, Complex System Governance
Asset management (AsM) has emerged from engineering as a structured approach to organizing complex organizations to realize the value of assets while balancing performance, risks, costs, and opportunities. Complex system governance (CSG) is an emerging field encompassing a framework for system performance improvement through the purposeful design, execution, and evolution of essential metasystem functions.
  • 1.4K
  • 04 Aug 2021
Topic Review
Oligodendroglial Cells
Oligodendrocytes (OLs) are ramified glial cells within the central nervous system (CNS) whose terminal processes generate myelin and enwrap neuronal axons. 
  • 1.4K
  • 04 Aug 2021
Topic Review
Digital Economy
With the development of digital technologies such as the Internet and digital industries such as e-commerce, the digital economy has become a new form of economic and social development, which has brought forth a new perspective for environmental governance, energy conservation, and emission reduction. 
  • 1.4K
  • 18 Aug 2021
Topic Review
Art of Material Jetting
Material jetting (MJ) technology is an additive manufacturing method that selectively cures liquid photopolymer to build functional parts.
  • 1.4K
  • 02 Sep 2021
Topic Review
Gut-Brain Axis in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by speech and language disorders, intellectual impairment, learning and motor dysfunctions. Several genetic and environmental factors are suspected to affect the ASD phenotype including air pollution, exposure to pesticides, maternal infections, inflammatory conditions, dietary factors or consumption of antibiotics during pregnancy.  Many children with ASD shows abnormalities in gastrointestinal (GI) physiology, including increased intestinal permeability, overall microbiota alterations, and gut infection. Moreover, they are “picky eaters” and the existence of specific sensory patterns in ASD patients could represent one of the main aspects in hampering feeding. GI disorders are associated with an altered composition of the gut microbiota. Gut microbiome is able to communicate with brain activities through microbiota-derived signaling molecules, immune mediators, gut hormones as well as vagal and spinal afferent neurons. Since the diet induces changes in the intestinal microbiota and in the production of molecules, such as the SCFA, we wanted to investigate the role that nutritional intervention can have on GI microbiota composition and thus on its influence on behavior, GI symptoms and microbiota composition and report which are the beneficial effect on ASD condition.
  • 1.4K
  • 23 Nov 2021
Topic Review
Nucleolar and Ribosomal Dysfunction
Ageing is a complex and unavoidable process that can be defined as the functional decline after a period of maturity. In this respect, maturity is understood as the endpoint of development and the condition of maximal functional performance capability.  The nucleolus organizes around the sites of transcription by RNA polymerase I (RNA Pol I). rDNA transcription by this enzyme is the key step of ribosome biogenesis and most of the assembly and maturation processes of the ribosome occur co-transcriptionally. Therefore, disturbances in rRNA transcription and processing translate to ribosomal malfunction. Nucleolar malfunction has recently been described in the classical progeria of childhood, Hutchinson–Gilford syndrome (HGPS), which is characterized by severe signs of premature aging, including atherosclerosis, alopecia, and osteoporosis. A deregulated ribosomal biogenesis with enlarged nucleoli is not only characteristic for HGPS patients, but it is also found in the fibroblasts of “normal” aging individuals. Cockayne syndrome (CS) is also characterized by signs of premature aging, including the loss of subcutaneous fat, alopecia, and cataracts. It has been shown that all genes in which a mutation causes CS, are involved in rDNA transcription by RNA Pol I. 
  • 1.4K
  • 27 Apr 2022
Topic Review
Privacy-Preserving and Explainable AI
The industrial environment has gone through the fourth revolution, also called “Industry 4.0”, where the main aspect is digitalization. Each device employed in an industrial process is connected to a network called the industrial Internet of things (IIOT). With IIOT manufacturers being capable of tracking every device, it has become easier to prevent or quickly solve failures. Specifically, the large amount of available data has allowed the use of artificial intelligence (AI) algorithms to improve industrial applications in many ways (e.g., failure detection, process optimization, and abnormality detection).
  • 1.4K
  • 01 Jul 2022
Topic Review
Unmanned Aerial Vehicles and Federated Learning
Unmanned aerial vehicles (UAVs) have gained increasing attention in boosting the performance of conventional networks due to their small size, high efficiency, low cost, and autonomously nature. The amalgamation of UAVs with both distributed/collaborative Deep Learning (DL) algorithms, such as Federated Learning (FL), and Blockchain technology have ushered in a new paradigm of Secure Multi-Access Edge Computing (S-MEC). Indeed, FL enables UAV devices to leverage their sensed data to build local DL models. The latter are then sent to a central node, e.g., S-MEC node, for aggregation, in order to generate a global DL model. Therefore, FL enables UAV devices to collaborate during several FL rounds in generating a learning model, while avoiding to share their local data, and thus ensuring UAVs’ privacy.
  • 1.4K
  • 22 Jul 2022
Topic Review
Adsorption Effect Modification of Lithium–Sulfur Batteries
Lithium–sulfur batteries (LSBs) have high theoretical specific capacity (1675 mAh g−1) and high energy density (2600 Wh kg−1), and the cathode sulfur is low cost, abundant, and environmentally friendly. The “shuttle effect” refers to the phenomenon that Li2Sx (4 ≤ x ≤ 8) produced by the positive electrode diffuses to the negative electrode during the charging and discharging process, and is reduced to solid Li2S2/Li2S on the negative electrode surface and attached to the negative electrode.
  • 1.4K
  • 30 Aug 2022
Topic Review
Temperature Record of the Past 1000 Years
The temperature record of the past 1,000 years or longer is reconstructed using data from climate proxy records in conjunction with the modern instrumental temperature record which only covers the last 170 years at a global scale. Large-scale reconstructions covering part or all of the 1st millennium and 2nd millennium have shown that recent temperatures are exceptional: the Intergovernmental Panel on Climate Change Fourth Assessment Report of 2007 concluded that "Average Northern Hemisphere temperatures during the second half of the 20th century were very likely higher than during any other 50-year period in the last 500 years and likely the highest in at least the past 1,300 years." The curve shown in graphs of these reconstructions is widely known as the hockey stick graph because of the sharp increase in temperatures during the last century. As of 2010 this broad pattern was supported by more than two dozen reconstructions, using various statistical methods and combinations of proxy records, with variations in how flat the pre-20th-century "shaft" appears. Sparseness of proxy records results in considerable uncertainty for earlier periods. Individual proxy records, such as tree ring widths and densities used in dendroclimatology, are calibrated against the instrumental record for the period of overlap. Networks of such records are used to reconstruct past temperatures for regions: tree ring proxies have been used to reconstruct Northern Hemisphere extratropical temperatures (within the tropics trees do not form rings) but are confined to land areas and are scarce in the Southern Hemisphere which is largely ocean. Wider coverage is provided by multiproxy reconstructions, incorporating proxies such as lake sediments, ice cores and corals which are found in different regions, and using statistical methods to relate these sparser proxies to the greater numbers of tree ring records. The "Composite Plus Scaling" (CPS) method is widely used for large-scale multiproxy reconstructions of hemispheric or global average temperatures; this is complemented by Climate Field Reconstruction (CFR) methods which show how climate patterns have developed over large spatial areas, making the reconstruction useful for investigating natural variability and long-term oscillations as well as for comparisons with patterns produced by climate models. During the 1,900 years before the 20th century, it is likely that the next warmest period was from 950 to 1100, with peaks at different times in different regions. This has been called the Medieval Warm Period, and some evidence suggests widespread cooler conditions during a period around the 17th century known as the Little Ice Age. In the hockey stick controversy, contrarians have asserted that the Medieval Warm Period was warmer than at present, and have disputed the data and methods of climate reconstructions.
  • 1.4K
  • 29 Nov 2022
Topic Review
Pathological Conditions with Excessive Hepatic Glycogen Accumulation
The liver is a major store of glycogen and is essential in maintaining systemic glucose homeostasis. In healthy individuals, glycogen synthesis and breakdown in the liver are tightly regulated. Abnormal glycogen metabolism results in prominent pathological changes in the liver, often manifesting as hepatic glycogenosis or glycogen inclusions. This can occur in genetic glycogen storage disease or acquired conditions with insulin dysregulation such as diabetes mellitus and non-alcoholic fatty liver disease or medication effects. Excessive glycogen accumulation within hepatocytes occurs in diseases caused or accompanied by the dysregulation of carbohydrate metabolism, as well as in conditions not primarily driven by altered carbohydrate metabolism. In these pathological conditions, the excess glycogen is distinctly visible on H&E; the hepatocytes usually exhibit cytoplasmic pallor and rarefaction or may show cytoplasmic-glycogen-filled inclusion bodies. Some hepatocytes may also demonstrate glycogen-filled nuclear vacuoles without a delimiting membrane (“glycogenated nuclei”); these are frequently seen in patients with diabetes and obesity, although they can also be seen in other liver conditions such as Wilson’s disease.
  • 1.4K
  • 06 Apr 2023
Topic Review
Reactive Oxygen Species and Oxidative Stress in Stroke
Stroke is one of the leading causes of morbidity and mortality worldwide. A main cause of brain damage by stroke is ischemia-reperfusion (IR) injury due to the increased production of reactive oxygen species (ROS) and energy failure caused by changes in mitochondrial metabolism. Reverse electron transfer (RET) has been implicated in excessive ROS production during IR injury in stroke and new insights into the mechanism of RET gained from various systems in recent studies will help understand stroke pathophysiology and inform therapy.
  • 1.4K
  • 18 Apr 2023
Topic Review
Kappa-2 Carrageenans
Hybrid carrageenans, also called kappa-2 (K2) or weak kappa, are a class of sulfated polysaccharides with thermo-reversible gelling properties in water and are extracted from a specific family of red seaweeds. K2 are known in the industry for their texturizing properties which are intermediate between those of kappa-carrageenans (K) and iota-carrageenans (I). As such, K2 are gaining industrial interest, as they can replace blends of K and I (K + I) in some niche applications. 
  • 1.4K
  • 22 Sep 2023
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