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Topic Review
Protein conformational changes induced by Pulsed electric fields
Pulsed power is the technology of accumulating energy during a relatively long period of time and of releasing the accumulated energy in an extremely short period of time as a high-power pulse composed of a high voltage and a large current but moderately low energy. The food processing applications of pulsed power technologies, such as intense pulsed electric fields and time-modulated discharge plasmas, have been studied worldwide. Pulsed electric fields (PEFs), which are generated by pulsed power technologies, are being tested for their applicability in food processing through protein conformational change and the poration of cell membranes.
  • 1.4K
  • 03 Nov 2021
Topic Review
Head and Neck Cancer in Germany
Analysis of Diagnosis Related Groups (DRG) data of the treatment of head and neck cancer in Germany from 2005 to 2018
  • 1.4K
  • 03 Dec 2021
Topic Review
Trends of Crimes on LGTBI People in Spain
Respect for different sexual options and orientations prevents the occurrence of hate crimes against lesbian, gay, bisexual, trans and intersex (LGTBI) persons for this reason. In Spain there is an upward trend in the number of hate crime victimizations motivated by sexual identity or orientation. The effectiveness of data collection, thanks to better training and awareness of police forces regarding hate crimes and the processes of data cleansing and consolidation contributes to a greater visibility of hate crimes against LGTBI people.
  • 1.4K
  • 27 Mar 2022
Topic Review
Effects of Oxysterols on Immune Cells
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on several cells, organs, and systems in the body. Oxysterols also have an influence on the physiology of the immune system, from immune cell maturation and migration to innate and humoral immune responses. 
  • 1.4K
  • 21 Apr 2022
Topic Review
Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut
Gut microorganisms are comprised of thousands of species and play an important role in the host’s metabolism, overall health status, and risk of disease. Cyanobacteria are the oldest organisms on earth, and their fossil record possibly tracked back to ~3.5 billion years ago. The emergence of the oxygenic photosynthesis of cyanobacteria was associated with the rise of oxygen in the earth’s atmosphere (also known as the Great Oxygenation Event) ~2.1 billion years ago.
  • 1.4K
  • 22 Apr 2022
Topic Review
Preparation of Organosiloxane Telechelics by Cationic Ring-Opening Polymerization
Polydimethylsiloxanes (PDMS) telechelics are important both in industry and in academic research. They are used both in the free state and as part of copolymers and cross-linked materials. The most important, practically used, and well-studied method for the preparation of such PDMS is diorganosiloxane ring-opening polymerization (ROP) in the presence of nucleophilic or electrophilic initiators. Cationic ROP is also of interest for the preparation of functional PDMS. The advantage of this process is that it can be carried out at a relatively low temperature, the catalyst can be easily deactivated, and the process can also be used to synthesize polysiloxanes having base-sensitive substituents such as Si–H or Si–(CH2)3–SH.
  • 1.4K
  • 24 Jun 2022
Topic Review
PIXE and XRF in Heritage Science
Analytical techniques play a fundamental role in heritage science (HS). Among them, Particle Induced X-ray Emission (PIXE) and X-ray Fluorescence (XRF) techniques are widely used in many laboratories for elemental composition analysis. Although they are well-established, a strong effort is put on their upgrade, making them suitable for more and more applications. 
  • 1.4K
  • 11 Jul 2022
Topic Review
H-BIM Workflow for Interventions on Heritage Building Elements
Intervention projects for heritage buildings depend on the quality of multidisciplinary data sets; their collection, structure, and semantics. Building information model (BIM) based workflows for heritage buildings accumulate some of the data sets in a shared information model that contains the building’s geometry assemblies with associated attributes (such as material). A BIM model of any building can be a source of data for different engineering assessments, for example, solar and wind exposure and seismic vulnerability, but for historic buildings it is particularly important for interventions like conservation, rehabilitation, and improvements such as refurbishment and retrofitting. Semantic technologies, such as ontologies, enhance the quality of information on interventions in historical buildings. 
  • 1.4K
  • 31 Aug 2022
Topic Review
Overview of Fucoidan
The marine macroalgae produce a collection of bioactive polysaccharides, of which the sulfated heteropolysaccharide fucoidan produced by brown algae of the class Phaeophyceae has received worldwide attention because of its particular biological actions that confer nutritional and health benefits to humans and animals. The biological actions of fucoidan are determined by their structure and chemical composition, which are largely influenced by the geographical location, harvest season, extraction process, etc. 
  • 1.4K
  • 08 Oct 2022
Topic Review
Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Wound Healing
Mesenchymal stem cell-derived exosomes (MSC Exos) may favorably impact intercellular signaling and immunomodulation, promoting neoangiogenesis, collagen synthesis, and neoepithelization. Stem cell-derived extracellular vesicles (EVs) can build up a pro-healing environment by activating intercellular signaling, angiogenesis, proliferation, and the regional differentiation of the various cell types in tissue regeneration. In addition, the development of 3D printing technologies can help to fabricate size-specific functional scaffolds to be used in the treatment of chronic non-healing wounds. Continued advances in controlled drug delivery using MSC EVs should allow for the development of new highly effective loco-regional antibiotic delivery strategies.
  • 1.4K
  • 25 Nov 2022
Topic Review
Seismic Rehabilitation Techniques for Cultural Heritage
Increased awareness of the importance of preserving old masonry structures of cultural heritage has turned to the development of sustainable strategies for their reconstruction and seismic strengthening. Strengthening the fabric and structure of the building are the only means by which it is possible to reduce the effects of an earthquake. Repair and reconstruction techniques must be properly selected in accordance with the structure and characteristics of the material. Historical buildings do not have their cultural significance exclusively as relics from the past, and the value of architectural heritage is not only in its appearance, but also in the integrity of all its components as a unique product of the specific construction technology of its time. 
  • 1.4K
  • 16 Dec 2022
Topic Review Peer Reviewed
Impacts of Climate Change on Rural Communities: Vulnerability and Adaptation in the Global South
Climate change has resulted in negative impacts upon rural communities, notably in the Global South; these impacts expose vulnerabilities that exist on individual and societal levels, necessitating consideration of adaptive capacity given the climate change threat, as well as the role of government in responding to hazards, and encouraging resilience and sustainability.
  • 1.4K
  • 22 Jul 2026
Topic Review Peer Reviewed
Cushion Gas Consideration for Underground Hydrogen Storage
Due to the increasing world population and environmental considerations, there has been a tremendous interest in alternative energy sources. Hydrogen plays a major role as an energy carrier due to its environmentally benign nature. The combustion of hydrogen releases water vapor while it also has a vast industrial application in aerospace, pharmaceutical, and metallurgical industries. Although promising, hydrogen faces storage challenges. Underground hydrogen storage (UHS) presents a promising method of safely storing hydrogen. The selection of the appropriate cushion gas for UHS is a critical aspect of ensuring the safety, efficiency, and reliability of the storage system. Cushion gas plays a pivotal role in maintaining the necessary pressure within the storage reservoir, thereby enabling consistent injection and withdrawal rates of hydrogen. One of the key functions of the cushion gas is to act as a buffer, ensuring that the storage pressure remains within the desired range despite fluctuations in hydrogen demand or supply. This is achieved by alternately expanding and compressing the cushion gas during the injection and withdrawal cycles, thereby effectively regulating the overall pressure dynamics within the storage facility. Furthermore, the choice of cushion gas can have significant implications on the performance and long-term stability of the UHS system. Factors such as compatibility with hydrogen, cost-effectiveness, availability, and environmental impact must be carefully considered when selecting the most suitable cushion gas. The present study provides a comprehensive review of different types of cushion gases commonly used in UHS, including nitrogen, methane, and carbon dioxide. By examining the advantages, limitations, and practical considerations associated with each option, the study aims to offer valuable insights into optimizing the performance and reliability of UHS systems. Ultimately, the successful implementation of UHS hinges not only on technological innovation but also on strategic decisions regarding cushion gas selection and management. By addressing these challenges proactively, stakeholders can unlock the full potential of hydrogen as a clean and sustainable energy carrier, thereby contributing to the global transition towards a low-carbon future.
  • 1.4K
  • 15 May 2024
Topic Review
Oxidative Stress in Cancer Cell Metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which activates pro-tumorigenic signaling, enhances cell survival and proliferation and drives DNA damage and genetic instability. However, higher ROS levels have been found to promote anti-tumorigenic signaling by initiating oxidative stress-induced tumor cell death. Tumor cells develop a mechanism where they adjust to the high ROS by expressing elevated levels of antioxidant proteins to detoxify them while maintaining pro-tumorigenic signaling and resistance to apoptosis. Therefore, ROS manipulation can be a potential target for cancer therapies as cancer cells present an altered redox balance in comparison to their normal counterparts.
  • 1.4K
  • 11 May 2022
Topic Review
Green Infrastructure in Spatial Planning
Adaptation to climate change is becoming one of the main paradigms for how cities function and develop. The significant role of green infrastructure (GI) as a tool for cities to adapt to climate change is increasingly emphasized among practitioners of spatial planning and in the research literature. Green infrastructure should be understood as "a strategically planned network of natural and semi-natural areas with other environmental features designed and managed to deliver a wide range of ecosystem services. It incorporates green spaces (or blue if aquatic ecosystems are concerned) and other physical features in terrestrial (including coastal) and marine areas".
  • 1.4K
  • 12 Jun 2023
Topic Review
Tumor Cells with Macrophages
The biological nature of the various populations of circulating tumor cells (CTCs) within the blood is still not well understood. Tumor cell fusion with immune cells is a longstanding hypothesis that has caught more attention in recent times. Specifically, fusion of tumor cells with macrophages might lead to the development of metastasis by acquiring features such as genetic and epigenetic heterogeneity, chemotherapeutic resistance, and immune tolerance. A unique circulating cell population has been identified as being potential fusions cells, characterized by distinct, large, polymorphonuclear cancer-associated cells with a dual epithelial and macrophage phenotype. Artificial fusion of tumor cells with macrophages leads to migratory, invasive, and metastatic phenotypes. Further studies might investigate whether these have a potential impact on the immune response towards the cancer. Such fusion cells could be a key component in cancer metastasis, and therefore, evolve as a diagnostic and therapeutic target in cancer precision medicine.
  • 1.4K
  • 27 Oct 2020
Topic Review
Wall Mosaics: on-site non-invasive diagnostics
This entry concerns the challenges and perspectives of on-site non-invasive measurements applied to valuable wall mosaics. The choice of the appropriate technique or combination of different techniques depends on a variety of factors: the depth of investigation, the resolution, the possibility to have direct contact with the surfaces or, on the contrary, limited accessibility of the wall mosaics due to their location (e.g., vaults), as well as deterioration problems, (e.g., voids, detachments, or humidity effects). This entry illustrates briefly the current state of the art in the field of non-invasive diagnostic methodsavailable for the study of wall mosaics (IRT, GPR, DHSPI, DHSPI-SIRT, SLDV, HSR), considering their potentials, limitations and future development frontiers. 
  • 1.4K
  • 10 Nov 2020
Topic Review
Catalysts Used in Pollutant Ozonation
The objective of this study was to summarize the results obtained in a wide research project carried out for more than 15 years on the catalytic activity of di erent catalysts (activated carbon, metal–carbon xerogels/aerogels, iron-doped silica xerogels, ruthenium metal complexes, reduced graphene oxide-metal oxide composites, and zeolites) in the photooxidation (by using UV or solar radiation) and ozonation of water pollutants, including herbicides, naphthalenesulfonic acids, sodium para-chlorobenzoate, nitroimidazoles, tetracyclines, parabens, sulfamethazine, sodium diatrizoate, cytarabine, and surfactants. All catalysts were synthesized and then texturally, chemically, and electronically characterized using numerous experimental techniques, including N2 and CO2 adsorption, mercury porosimetry, thermogravimetric analysis, X-ray di raction, Fourier-transform infrared spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, di use reflectance UV–vis spectroscopy, photoluminescence analysis, and transmission electron microscopy. The behavior of these materials as photocatalysts and ozonation catalysts was related to their characteristics, and the catalytic mechanisms in these advanced oxidation processes were explored. Investigations were conducted into the e ects on pollutant degradation, total organic carbon reduction, and water toxicity of operational variables and the presence of di erent chemical species in ultrapure, surface, ground, and wastewaters. Finally, a review is provided of the most recent and relevant published studies on photocatalysis and catalyzed ozonation in water treatments using similar catalysts to those examined in our project.
  • 1.4K
  • 04 Jan 2021
Topic Review
Hypofractionation for Localized Prostate Cancer
Prostate cancer is the most commonly diagnosed cancer among men around the world. Radiotherapy is a standard of care treatment option for men with localized prostate cancer. Over the years, radiation delivery modalities have contributed to increased precision of treatment, employing radiobiological insights to shorten the overall treatment time, improving the control of the disease without increasing toxicities.
  • 1.4K
  • 16 Aug 2021
Topic Review
Development of Organic Food Sector
Our study aimed to explore the factors limiting the development of the organic food sector in Poland from the perspective of processing, distributing, and retailing companies. We used a qualitative approach with in-depth semi-structured interviews with the management board representatives of 17 large- and medium-sized enterprises and the owners of 10 small and medium companies. The potential limiting factors, including legal, economic, technological, and environmental factors, were identified by reviewing the corporate and market reports of processing and retailing companies operating in the Polish organic sector.
  • 1.4K
  • 28 Sep 2021
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