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Topic Review
Scalindua
"Candidatus Scalindua" is a bacterial genus, and a proposed member of the order Planctomycetes. These bacteria lack peptidoglycan in their cell wall and have a compartmentalized cytoplasm. They are ammonium oxidizing bacteria found in marine environments.
  • 1.4K
  • 25 Nov 2022
Topic Review
Drought in Chickpea
Chickpea productivity has been found to be around 995 kg ha−1 on a global scale, which is quite low. Drought, terminal heat, excessive salt, and cold are abiotic variables. Several factors are responsible for complexity of drought stress, including severity of drought, stage of crop, and duration of drought stress.
  • 1.4K
  • 29 Nov 2022
Topic Review
The Role of Ocular Fundus in Systemic Infections
Examining the ocular fundus demonstrates significant clinical relevance in systemic infections among inpatients. The necessity of such evaluations is not universal for all infectious cases but critical when systemic infections, notably those demonstrating a potential for ocular involvement. The utilization of a collaborative decision tree is proposed to guide clinicians in identifying patients who may derive substantial benefit from fundus examinations, thereby enhancing diagnostic accuracy and tailoring therapeutic interventions. A well-structured, interdisciplinary approach, combining systemic and ocular assessments, is crucial to establish diagnostic clarity and refine therapeutic approaches, especially in the complex clinical scenarios often presented by inpatients with systemic infections. Ultimately, adopting this strategic framework aims to promote better patient outcomes through informed and timely intervention strategies.
  • 1.4K
  • 22 Dec 2023
Topic Review
Oriental Small-clawed Otter
The Oriental Small-clawed Otter (Aonyx cinerea) is the smallest otter species in the world, native to freshwater and coastal habitats across South and Southeast Asia. Distinguished by its diminutive size and unique feature of partially webbed claws, this otter species exhibits a highly social nature, often living in extended family groups and engaging in cooperative hunting and grooming behaviors. As a skilled hunter of fish, crustaceans, and mollusks, the Oriental Small-clawed Otter plays a vital ecological role in maintaining the health of aquatic ecosystems throughout its range.
  • 1.4K
  • 28 Feb 2024
Topic Review
HGF/MET
Unlike in normal epithelium, dysregulated overactivation of various proteases have been reported in cancers. Degradation of pericancerous extracellular matrix leading to cancer cell invasion by matrix metalloproteases is well known evidence. On the other hand, several cell-surface proteases, including type II transmembrane serine proteases (TTSPs), also induce progression through activation of growth factors, protease activating receptors and other proteases. Hepatocyte growth factor (HGF) known as a multifunctional growth factor that upregulates cancer cell motility, invasiveness, proliferative, and anti-apoptotic activities through phosphorylation of MET (a specific receptor of HGF). HGF secreted as inactive zymogen (pro-HGF) from cancer associated stromal fibroblasts, and the proteolytic activation by several TTSPs including matriptase and hepsin is required. The activation is strictly regulated by HGF activator inhibitors (HAIs) in physiological condition. However, downregulation is frequently observed in cancers. Indeed, overactivation of MET by upregulation of matriptase and hepsin accompanied by the downregulation of HAIs in urological cancers (prostate cancer, renal cell carcinoma, and bladder cancer) are also reported, a phenomenon observed in cancer cells with malignant phenotype, and correlated with poor prognosis.
  • 1.4K
  • 29 Oct 2020
Topic Review
FAK Family Kinases
In various vascular diseases, extracellular matrix (ECM) and integrin expression are frequently altered, leading to FAK or Pyk2 activation. In addition to the major roles of FAK and Pyk2 in regulating adhesion dynamics via integrins, recent studies have shown a new role of nuclear FAK in gene regulation in various vascular cells. In particular, FAK primarily localizes within the nuclei of vascular smooth muscle cells (VSMCs) of healthy arteries. However, vessel injury increased FAK localization back to adhesions and elevated FAK activity, leading to VSMC hyperplasia. The study suggested that abnormal FAK or Pyk2 activation in vascular cells may cause pathological condition in vascular diseases. Here we will review several studies of FAK and Pyk2 associated with integrin signaling in vascular diseases including restenosis, atherosclerosis, heart failure, pulmonary arterial hypertension, aneurysm, and thrombosis. Despite the importance of FAK family kinases in vascular diseases, comprehensive reviews are scarce. Therefore, we summarized animal models involving FAK family kinases in vascular diseases
  • 1.4K
  • 27 Oct 2020
Topic Review
Glass Fiber Coated Sol–Gel Poly-Diphenylsiloxane
A novel simple and sensitive, time-based flow injection solid phase extraction system was developed for the automated determination of metals at low concentration. The potential of the proposed scheme, coupled with flame atomic absorption spectrometry (FAAS), was demonstrated for trace lead and chromium(VI) determination in environmental water samples. The new sorptive extraction system, consisted of an online microcolumn packed with glass fiber coated with sol–gel poly (diphenylsiloxane) (sol–gel PDPS), which is presented here for the first time.
  • 1.4K
  • 13 Jan 2021
Topic Review
β-Amyloid Vaccination
β-amyloid (Aβ) is a peptide, 38 to 43 amino acids long, that derives from the proteolytic processing of amyloid precursor protein (APP) by the γ-secretase; Aβ40 and Aβ42 are the most studied Aβ peptide species.
  • 1.4K
  • 20 Apr 2021
Topic Review
Multi-Walled Carbon Nanotubes-Based Sensors
Extensive use of multi-walled carbon nanotube (MWCNT) has been done for the fabrication and implementation of flexible sensors due to their enhanced electrical, mechanical, and thermal properties. These nanotubes have been deployed both in pure and composite forms for obtaining highly efficient sensors in terms of sensitivity, robustness, and longevity.
  • 1.4K
  • 17 Mar 2021
Topic Review
Applying CADD for Neurodegenerative Diseases
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. 
  • 1.4K
  • 07 May 2021
Topic Review
Octopus Biological Studies
Increasing effort in research involving octopuses with a greater number of journals reporting research on these animals, as well as countries, institutions, and researchers involved. Some research themes lost importance over time, while some new themes appeared recently. Current data provide significant insight into the evolving trends in octopuses studies.
  • 1.4K
  • 30 Jun 2021
Topic Review
Sustainability in Universities
It was found that universities have hardly incorporated sustainability in their academic areas, as can be seen in the evaluation systems of the global academic rankings, although some measurements were made from an institutional rather than an academic perspective. There is a need for universities to incorporate elements related to sustainability in their programs, not only in response to the new trends in the countries but also as a factor in responding to the emerging needs of the world in terms of efficient resource management, improving the education and the formation of an integral and responsible professional.
  • 1.4K
  • 20 Apr 2022
Topic Review
Performance and Modelling of AC Transmission
Performance modelling is the abstraction of a real system into a simplified representation to enable the prediction of performance. The creation of a model can provide insight into how a proposed or actual system will or does work. This can, however, point towards different things to people belonging to different fields of work. Performance modelling has many benefits, which includes: A model will often be created specifically so that it can be interpreted by a software tool that simulates the system's behaviour, based on the information contained in the performance model. Such tools provide further insight into the system's behaviour and can be used to identify bottlenecks or hot spots where the design is inadequate. Solutions to the problems identified might involve the provision of more physical resources or change in the structure of the design. Performance modelling is found helpful, in case of: Modelling of a transmission line is done to analyse its performance and characteristics. The gathered information vis simulating the model can be used to reduce losses or to compensate these losses. Moreover, it gives more insight into the working of transmission lines and helps to find a way to improve the overall transmission efficiency with minimum cost.
  • 1.4K
  • 01 Nov 2022
Topic Review
Disruptive Mood Dysregulation Disorder
Disruptive mood dysregulation disorder (DMDD) is a mental disorder in children and adolescents characterized by a persistently irritable or angry mood and frequent temper outbursts that are disproportionate to the situation and significantly more severe than the typical reaction of same-aged peers. DMDD was added to the DSM-5 as a type of depressive disorder diagnosis for youths. The symptoms of DMDD resemble those of attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), anxiety disorders, and childhood bipolar disorder. DMDD first appeared as a disorder in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) in 2013 and is classified as a mood disorder. Treatments include medication to manage mood symptoms as well as individual and family therapy to address emotion-regulation skills. Children with DMDD are at risk for developing depression and anxiety later in life.
  • 1.4K
  • 01 Dec 2022
Topic Review
Eastern Equine Encephalitis
Eastern equine encephalitis (EEE), commonly called Triple E or sleeping sickness (not to be confused with African trypanosomiasis), is a disease caused by a zoonotic mosquito vectored Togavirus that is present in North, Central, and South America, and the Caribbean. EEE was first recognized in Massachusetts , United States, in 1831, when 75 horses died mysteriously of viral encephalitis. Epizootics in horses have continued to occur regularly in the United States. It can also be identified in donkeys and zebras. Due to the rarity of the disease, its occurrence can cause economic impact beyond the cost of horses and poultry. EEE is found today in the eastern part of the United States and is often associated with coastal plains. It can most commonly be found in East Coast and Gulf Coast states. In Florida, about one to two human cases are reported a year, although over 60 cases of equine encephalitis are reported. In years in which conditions are favorable for the disease, the number of equine cases is over 200. Diagnosing equine encephalitis is challenging because many of the symptoms are shared with other illnesses and patients can be asymptomatic. Confirmations may require a sample of cerebral spinal fluid or brain tissue, although CT scans and MRI scans are used to detect encephalitis. This could be an indication that the need to test for EEE is necessary. If a biopsy of the cerebral spinal fluid is taken, it is sent to a specialized laboratory for testing. Eastern equine encephalitis virus (EEEV) is closely related to Venezuelan equine encephalitis virus and western equine encephalitis virus.
  • 1.4K
  • 05 Dec 2022
Topic Review
Differentiation of Genes Encoding Peroxisome Proliferator-Activated Receptors
The heritability of the tendency to obesity is estimated to vary widely (from 5% to 90%), depending on the research method and the hypotheses being tested. Genetic components may play an important role, both in regulating metabolism and influencing behavioral aspects-in the presence of certain critical genetic variants, the dysregulation of energy metabolism can undoubtedly lead to an increased risk of obesity. Genes code for protein products that are directly involved in the processes of digestion, assimilation, and physiological utilization of nutrients supplied to the body. There are also genes whose products are important factors that influence the activation and regulation of various metabolic pathways and also determine the maintenance of the balance of metabolic changes and the shift of this balance in a specific direction. Finally, there are the genes that code for factors that influence human behavior, eating habits, dietary preferences and so on. Systemic regulation of metabolism takes place in human cells at many levels. At the deepest molecular level, metabolic flexibility depends on the configuration of many different metabolic pathways regulated by key transcription factors, many of which interact closely with each other. From this point of view, transcription factors are considered very important elements of metabolic regulatory networks. In this group, genes encoding peroxisome proliferator-activated receptors (PPARs) are among the best studied. PPARs provide balance in nutrient and energy metabolism and maintain metabolic flexibility important for lipid metabolism, glucose homeostasis, cholesterol metabolism, and other important metabolic networks. Differentiation of PPAR genes may affect the efficacy of reduction diets and post-exercise weight loss.
  • 1.4K
  • 06 Jan 2023
Topic Review
Electrocatalytic CO2 Reduction to Formate and Formic acid
The electrocatalytic CO2 reduction reaction (CO2RR) to formic acid has gained significant attention as a potential environmentally friendly approach to reducing CO2 emissions and producing carbon-neutral liquid fuels. However, several challenges must be addressed to achieve the production of high-purity and high-concentration formic acid through CO2RR. One major challenge is the formation of a formate mixture instead of pure formic acid in conventional reactors. This requires costly downstream purification and concentration processes to obtain pure formic acid. 
  • 1.4K
  • 19 Jun 2023
Topic Review
PCSK6 in Cardiovascular Biology and Disease
Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins. In the cardiovascular system, PCSK6 acts as a key modulator in heart formation, lipoprotein metabolism, body fluid homeostasis, cardiac repair, and vascular remodeling. To date, dysregulated PCSK6 expression or function has been implicated in major cardiovascular diseases.
  • 1.4K
  • 02 Aug 2023
Topic Review
Role of Melatonin in Directing Plant Physiology
Melatonin (MT), a naturally occurring compound, is found in various species worldwide. In 1958, it was first identified in the pineal gland of dairy cows. MT is an “old friend” but a “new compound” for plant biology. It brings experts and research minds from the broad field of plant sciences due to its considerable influence on plant systems. The MT production process in plants and animals is distinct, where it has been expressed explicitly in chloroplasts and mitochondria in plants. Tryptophan acts as the precursor for the formation of phyto-melatonin, along with intermediates including tryptamine, serotonin, N-acetyl serotonin, and 5-methoxy tryptamine. It plays a vital role in growth phases such as the seed germination and seedling growth of crop plants. MT significantly impacts the gas exchange, thereby improving physio-chemical functions in plant systems. During stress, the excessive generation and accumulation of reactive oxygen species (ROS) causes protein oxidation, lipid peroxidation, nucleic acid damage, and enzyme inhibition. Because it directly acts as an antioxidant compound, it awakens the plant antioxidant defense system during stress and reduces the production of ROS, which results in decreasing cellular oxidative damage. MT can enhance plant growth and development in response to various abiotic stresses such as drought, salinity, high temperature, flooding, and heavy metals by regulating the antioxidant mechanism of plants.
  • 1.4K
  • 17 Oct 2023
Topic Review
Mental Imagery
Mental imagery is a term used to describe the cognitive process of simulating sensations, actions, or other types of experiences through generating and using mental images, including metaphors.
  • 1.4K
  • 18 Mar 2021
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