Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Bone Marrow Aspirate Concentrate
Human bone marrow (BM) has been highlighted as a promising source of mesenchymal stromal cells (MSCs) containing various growth factors and cytokines that can be potentially utilized in regenerative procedures involving cartilage and bone.
  • 1.5K
  • 15 Feb 2022
Topic Review
Development of Organ Specificity among Endothelial Cells
Endothelial cells have a mesodermal origin; during vasculogenesis, a “first draft” of the vascular system is laid down to support the growing embryo. Vascular endothelial cells line the entire circulatory system and show remarkable heterogeneity. Even though endothelial cells originate from the same progenitor cells during development, they eventually contribute to different subtypes of endothelia. Based on morphology, the microvasculature consists of three main phenotypes: discontinuous, fenestrated, and non-fenestrated endothelium.
  • 1.5K
  • 21 Feb 2022
Topic Review
First-and Second-Line Therapies for Primary Biliary Cholangitis
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by the progressive destruction of the intrahepatic bile ducts. Currently, the first line drug for PBC is ursodeoxycholic acid characterized by anti-apoptotic, anti-inflammatory and protective actions on cholangiocytes. 
  • 1.5K
  • 21 Mar 2022
Topic Review
Senescence-Associated Cell Transition and Interaction
Aging is a broad process that occurs as a time-dependent functional decline and tissue degeneration in living organisms. On a smaller scale, aging also exists within organs, tissues, and cells. As the smallest functional unit in living organisms, cells “age” by reaching senescence where proliferation stops. Such cellular senescence is achieved through replicative stress, telomere erosion and stem cell exhaustion. It has been shown that cellular senescence is key to tissue degradation and cell death in aging-related diseases (ARD). However, senescent cells constitute only a small percentage of total cells in the body, and they are resistant to death during aging. This suggests that ARD may involve interaction of senescent cells with non-senescent cells, resulting in senescence-triggered death of non-senescent somatic cells and tissue degeneration in aging organs.
  • 1.5K
  • 06 Apr 2022
Topic Review
Vincent Stomatitis
Acute necrotizing ulcerative gingivitis (ANUG) is a common, non-contagious infection of the gums with sudden onset. The main features are painful, bleeding gums, and ulceration of inter-dental papillae (the sections of gum between adjacent teeth). This disease, along with necrotizing (ulcerative) periodontitis (NP or NUP) is classified as a necrotizing periodontal disease, one of the seven general types of gum disease caused by inflammation of the gums (periodontitis). The often severe gum pain that characterizes ANUG distinguishes it from the more common chronic periodontitis which is rarely painful. If ANUG is improperly treated or neglected, it may become chronic and/or recurrent. The causative organisms are mostly anaerobic bacteria, particularly Fusobacteriota and spirochete species. Predisposing factors include poor oral hygiene, smoking, poor nutrition, psychological stress, and a weakened immune system. When the attachments of the teeth to the bone are involved, the term NUP is used. Treatment of ANUG is by removal of dead gum tissue and antibiotics (usually metronidazole) in the acute phase, and improving oral hygiene to prevent recurrence. Although the condition has a rapid onset and is debilitating, it usually resolves quickly and does no serious harm. The informal name trench mouth arose during World War I as many soldiers developed the disease, probably because of the poor conditions and extreme psychological stress.
  • 1.5K
  • 21 Nov 2022
Topic Review
Peach Palm (Bactris gasipaes Kunth.)
A pre-Columbian staple, Bactris gasipaes Kunth. is a palm tree domesticated around 4000 years ago, so appreciated that a Spanish chronicler wrote in 1545, “only their wives and children were held in higher regard” by the Mesoamerican natives. The peach palm is an integral part of the foodways and gastronomy of Ecuador, Colombia, Bolivia, Peru, Brazil, and other tropical American countries; meanwhile, it is almost unknown in the rest of the world, except for hearts of palm. Although abundant, the species faces anthropogenic threats. 
  • 1.5K
  • 24 Nov 2022
Topic Review Peer Reviewed
Improving Compliance with Medical Treatment Using Eye Drop Aids
Achieving optimal treatment outcomes in glaucoma requires patients to adhere to their medication regimens. Possible barriers to patients’ cooperation include the misunderstanding of a treatment’s importance or errors in applying instructions, forgetfulness, financial constraints and others. Due to the fact that glaucoma usually causes no apparent symptoms or pain, on the one hand, and the significant inconvenience that the eye drops used for glaucoma treatment can cause due to local irritation, on the other, patient compliance is a challenge. To address this challenge, we require strategies for improving adherence to glaucoma treatment. The importance of proper eye drop administration techniques cannot be overstated, particularly for vulnerable populations such as the elderly, the sick and the visually handicapped. Studies have shown that failure to comply with glaucoma treatment is a significant factor affecting disease progression, emphasizing the need for interventions that improve patient compliance. Educational interventions, medication reminders and the use of assistive devices such as eye drop aids have been shown to improve adherence to glaucoma treatment. By promoting strategies that can be used to enhance treatment adherence, healthcare providers can ensure that glaucoma patients receive the full benefits of their treatment plans, reducing the risk of disease progression. Many patients struggle with the complexity of their treatment regimens and the challenges of administering eye drops. This entry provides a comprehensive overview of the different barriers to patient adherence to glaucoma eye drop treatment, emphasizing the difficulties associated with eye drop instillation. This entry examines a range of eye drop aids available to patients, evaluating their modes of action, benefits, drawbacks and effectiveness in improving patient compliance. By providing detailed information on the barriers to adherence and the range of eye drop aids available, this entry aims to support healthcare providers in helping glaucoma patients to achieve better treatment adherence and outcomes.
  • 1.5K
  • 19 Oct 2023
Topic Review
Sensorial Impact of Alcohol in Wine
The quality of grapes and wine quality, flavor, stability, and sensory characteristics depend on the content and composition of several different groups of compounds from grapes. One of these groups of compounds is sugars and, consequently, the alcohol content quantified in wines after alcoholic fermentation. During grape berry ripening, sucrose transported from the leaves is accumulated in the berry vacuoles as glucose and fructose. The wine alcohol content continues to be a challenge in enology, as it is also the study of the role of chemosensory factors in alcohol intake and consumer preferences. Several technical and scientific advances have occurred, such as identifying receptors and other essential molecules involved in the transduction mechanisms of flavor. In addition, consumers know that wines with high alcohol content can cause a gustatory disequilibrium affecting wine sensory perceptions, leading to unbalanced wines.
  • 1.5K
  • 13 Sep 2023
Topic Review
Dermatophyte Infections Worldwide
The increase in the incidence of superficial fungal infections combined with the emergence of antifungal resistance represents both a global health challenge and a considerable economic burden. Dermatophytes, the main culprit causing superficial fungal infections, have started to exhibit antifungal resistance. This can be observed in some of the most common species, such as Trichophyton rubrum and Trichophyton mentagrophytes. Importantly, the new subspecies, known as Trichophyton indotineae, has been reported to show high resistance to terbinafine, a first-line treatment for dermatophyte infections. Compounding these issues is the realization that diagnosing the causative infectious agents requires using molecular analysis that goes beyond the conventional macroscopic and microscopic methods. 
  • 1.5K
  • 09 Jan 2024
Topic Review
Discrimination
Discrimination is the unjust or prejudicial treatment of individuals or groups based on certain characteristics such as race, gender, age, religion, sexual orientation, or other distinguishing features. It involves the act of making distinctions or differentiating between people in a way that results in unequal opportunities, privileges, or access to resources. Discrimination can manifest in various forms, including direct actions, policies, or practices that may intentionally or unintentionally disadvantage certain individuals or communities based on perceived differences. It is a social issue that contributes to systemic inequalities and can have significant consequences for the well-being, opportunities, and overall experiences of those who are targeted. Legal frameworks and human rights initiatives aim to address and prevent discrimination, promoting principles of equality, justice, and inclusivity in societies around the world.
  • 1.5K
  • 25 Jan 2024
Topic Review
Coastal Dune
This work analyzes the evolution of the large shifting dune included in the Corrubedo Natural Park from 1956 until the present day. The analysis was carried out using aerial images, orthophotographs, topographic surveys and LiDAR (Light Detection and Ranging) data. Variations were analyzed in terms of four different aspects: evolution of pathways in each period, changes in the position of the mobile dune front and the degree of vegetation cover, all between 1956 and 2017; and variations in elevation and volume of the dune system between 2001 and 2015. To analyze these aspects, geospatial and geostatistical techniques were employed, which revealed that the dune front had undergone two different phases: one until the 1980s, with a mean seaward advance of 32 m and another one between the 1980 s and 2017, when the front prograded to the continent, with an approximate mean advance of 82 m. Loss of volume, related to the expansion of the mobile dune towards the north, was confirmed in this sector. It is evident that these changes are closely linked to anthropic influence, due to sand extraction until the early 1990s and, more recently, due to an increase in the number of visitors to the Natural Park. The results obtained highlight the need to carry out detailed studies to understand the evolution of this system and to prevent further damage in the future. Moreover, based on these analyses, a strategy to improve coastal and environmental management in the Corrubedo Natural Park could be designed.
  • 1.5K
  • 06 Jan 2021
Topic Review
Pectobacterium Brasiliense
Pectobacterium brasiliense (Pbr) is a worldwide-distributed bacterial plant pathogen causing soft rot of a wide range of economically important crops.
  • 1.5K
  • 04 Feb 2021
Topic Review
Terrorist and Built Environment
Terrorist impacts have been increasing over time in many countries, being one of the most significant threats for the Built Environment (BE), intended as a network of open spaces (streets, squares) and facing buildings, and their users. Due to the relevance of the perpetrator “will” and the quickness of actions, Terrorism is assimilable to Sudden Onset Disasters (SUOD). BE and its morpho-technological features can be inherently prone or resilient to terrorism risk. The analysis of Risk Mitigation and Reduction Strategies (RMRSs) can support the safety of BE from a sustainable point of view, above all when they transform the existing urban environments.
  • 1.5K
  • 28 Sep 2021
Topic Review
Moderate Consumption of Beer
There is growing interest in the potential health-related effects of moderate alcohol consumption and, specifically, of beer. This entry provides an assessment of beer-associated effects on cardiovascular and metabolic risk factors to identify a consumption level that can be considered “moderate”. It introduced all prospective clinical studies and systematic reviews that evaluated the health effects of beer published between January 2007 and April 2020. Five of six selected studies found a protective effect of moderate alcohol drinking on cardiovascular disease (beer up to 385 g/week) vs. abstainers or occasional drinkers. Four out of five papers showed an association between moderate alcohol consumption (beer intake of 84 g alcohol/week) and decreased mortality risk. We concluded that moderate beer consumption of up to 16 g alcohol/day (1 drink/day) for women and 28 g/day (1–2 drinks/day) for men is associated with decreased incidence of cardiovascular disease and overall mortality, among other metabolic health benefits. 
  • 1.5K
  • 09 Apr 2021
Topic Review
Quercetin in Prostate Cancer Therapy
Prostate cancer is the second most leading and prevalent malignancy around the world, following lung cancer. Prostate cancer is characterized by the uncontrolled growth of cells in the prostate gland. Prostate cancer morbidity and mortality have grown drastically, and intensive prostate cancer care is unlikely to produce adequate outcomes. The synthetic drugs for the treatment of prostate cancer in clinical practice face several challenges. Quercetin is a natural flavonoid found in fruits and vegetables. Apart from its beneficial effects, its plays a key role as an anti-cancer agent. Quercetin has shown anticancer potential, both alone and in combination. 
  • 1.5K
  • 13 May 2021
Topic Review
Cephalaria (Caprifoliaceae) Genus
The genus Cephalaria, belonging to the Caprifoliaceae family, is a rich source of interesting secondary metabolites, including mainly saponins which display a variety of biological activities, such as immunomodulatory, antimicrobial and hemolytic effects.
  • 1.5K
  • 02 Jul 2021
Topic Review
Seaweeds and Gut Health Benefits
Macroalgae, or seaweeds, are a rich source of components which may exert beneficial effects on the mammalian gut microbiota through the enhancement of bacterial diversity and abundance. An imbalance of gut bacteria has been linked to the development of disorders such as inflammatory bowel disease, immunodeficiency, hypertension, type-2-diabetes, obesity, and cancer. This review outlines current knowledge from in vitro and in vivo studies concerning the potential therapeutic application of seaweed-derived polysaccharides, polyphenols and peptides to modulate the gut microbiota through diet. Polysaccharides such as fucoidan, laminarin, alginate, ulvan and porphyran are unique to seaweeds. Several studies have shown their potential to act as prebiotics and to positively modulate the gut microbiota. Prebiotics enhance bacterial populations and often their production of short chain fatty acids, which are the energy source for gastrointestinal epithelial cells, provide protection against pathogens, influence immunomodulation, and induce apoptosis of colon cancer cells. The oral bioaccessibility and bioavailability of seaweed components is also discussed, including the advantages and limitations of static and dynamic in vitro gastrointestinal models versus ex vivo and in vivo methods. Seaweed bioactives show potential for use in prevention and, in some instances, treatment of human disease. 
  • 1.5K
  • 06 Jul 2021
Topic Review
Organosulfur Compounds from Allium cepa
Species belonging to the genus Allium contain many organosulfur compounds (OSCs) that have been widely studied showing their biological properties and beneficial effects on intestinal health and gut microbiota (GM). 
  • 1.5K
  • 03 Sep 2021
Topic Review
Liquid Biopsy of Brain Tumors
Direct biopsies obtain tissue material from the primary tumor, either via neurosurgical removal of all or most parts of a tumor or via stereotactic tissue biopsy. In contrast, a liquid biopsy uses body fluids collected distant to the brain tumor, such as venous blood from the arm or cerebrospinal fluid (CSF) via lumbar or cisternal puncture.
  • 1.5K
  • 25 Dec 2025
Topic Review
Methods of Thermal Treatment of Radioactive Waste
Nuclear power is generated by a small amount of fuel, as related to other non-renewable energy sources. The volume of waste formed in this process is comparably small. Thermal treatment of waste is a term given to any treatment technology that involves high temperatures in the processing of the waste feedstock. All the thermal treatment methods used for normal waste have been applied to radioactive waste.  
  • 1.5K
  • 24 Jan 2022
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback