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Topic Review
Anticancer Profile of Rhodanines
The rhodanine derivatives are small compounds with a broad spectrum of biological activities; they are used as antimicrobial, antiviral, antitubercular, anti-inflammatory, antidiabetic, and antitumor agents. In the pharmaceutical market, epalrestat (rhodanine-3-acetic acid) has been marketed in Japan since 1992 for treatment of diabetic complications (peripheral neuropathy). Epalrestat is an inhibitor of aldose reductase, the key enzyme in the polyol pathway of glucose metabolism under hyperglycemic conditions. The good clinical safety profile of epalrestat justified the interest of the researchers in rhodanines as potential drug candidates.
  • 1.5K
  • 20 Jun 2022
Topic Review
Cation–pi Interaction
Cation–π interaction is a noncovalent molecular interaction between the face of an electron-rich π system (e.g. benzene, ethylene, acetylene) and an adjacent cation (e.g. Li+, Na+). This interaction is an example of noncovalent bonding between a monopole (cation) and a quadrupole (π system). Bonding energies are significant, with solution-phase values falling within the same order of magnitude as hydrogen bonds and salt bridges. Similar to these other non-covalent bonds, cation–π interactions play an important role in nature, particularly in protein structure, molecular recognition and enzyme catalysis. The effect has also been observed and put to use in synthetic systems.
  • 1.5K
  • 15 Nov 2022
Topic Review
Management of Bacterial Diseases of Hazelnut
The cultivation of hazelnut (Corylus avellana) has expanded in several areas of Europe, Asia, Africa, and North and South America following the increased demand for raw materials by the food industry. Bacterial diseases caused by Xanthomonas arboricola pv. corylina and Pseudomonas avellanae are threats of major concern for hazelnut farmers. These pathogens have been controlled with copper-based products, which are being phased out in the European Union. Following the need for alternative practices to manage these diseases, some progress has been achieved through the exploitation of the plant’s systemic acquired resistance mechanisms, nanoparticle technology, as well as preventive measures based on hot water treatment of the propagation material.
  • 1.5K
  • 06 Jan 2023
Topic Review
Cryptocyanine Dye, NK-4
NK-4 plays a key role in the treatment of various diseases, such as in hay fever to expect anti-allergic effects, in bacterial infections and gum abscesses to expect anti-inflammatory effects, in scratches, cuts, and mouth sores from bites inside the mouth for enhanced wound healing, in herpes simplex virus (HSV)-1 infections for antiviral effects, and in peripheral nerve disease that causes tingling pain and numbness in hands and feet, while NK-4 is used also to expect antioxidative and neuroprotective effects.
  • 1.5K
  • 08 Mar 2023
Topic Review
Chaotic Intermittency
Chaotic intermittency is characterized by a signal that alternates aleatory between long regular (pseudo-laminar) phases and irregular bursts (pseudo-turbulent or chaotic phases).
  • 1.5K
  • 16 Jun 2023
Topic Review
Water Photo-Oxidation over TiO2
Photocatalytic splitting of water is a direct and attractive approach for the utilization of solar energy by producing the most-prospective clean hydrogen fuel. In photocatalytic water splitting, oxidation of water to molecular oxygen, or oxygen evolution reaction (OER), is the most difficult process because it needs the transfer of four electrons, while the hydrogen evolution reaction (HER) is a two-electron transfer reaction.
  • 1.5K
  • 16 Jan 2023
Topic Review
Impact of Climate Change on Grapevines, Berries, Wine
Grapevine and wine production is vulnerable to the effect of climate change. Heat and water stress related to climate change can affect vine phenology, pest and disease pressure, crop yield, and berry and wine composition.
  • 1.5K
  • 27 Apr 2023
Topic Review
Walking Recognition in Mobile Devices
Presently, smartphones are used more and more for purposes that have nothing to do with phone calls or simple data transfers. One example is the recognition of human activity, which is relevant information for many applications in the domains of medical diagnosis, elderly assistance, indoor localization, and navigation. The information captured by the inertial sensors of the phone (accelerometer, gyroscope, and magnetometer) can be analyzed to determine the activity performed by the person who is carrying the device, in particular in the activity of walking. Nevertheless, the development of a standalone application able to detect the walking activity starting only from the data provided by these inertial sensors is a complex task. This complexity lies in the hardware disparity, noise on data, and mostly the many movements that the smartphone can experience and which have nothing to do with the physical displacement of the owner. In this work, we explore and compare several approaches for identifying the walking activity. We categorize them into two main groups: the first one uses features extracted from the inertial data, whereas the second one analyzes the characteristic shape of the time series made up of the sensors readings. Due to the lack of public datasets of inertial data from smartphones for the recognition of human activity under no constraints, we collected data from 77 different people who were not connected to this research. Using this dataset, which we published online, we performed an extensive experimental validation and comparison of our proposals.
  • 1.5K
  • 01 Nov 2020
Topic Review
GLUT-5 in Chicken Duodenal Epithelium
Although patterns of glucose transporter expression and notes about diseases leading to adaptive changes in intestinal fructose transport have been well-characterized, the connection between infection and fructose transportation has been lightly investigated. Up to now only few studies on GLUT-5 expression and function under pathological conditions in bird intestines have been carried out. In the current study we immunolocalized GLUT-5 in one-week-old chicken (Gallus gallus domesticus) duodenal epithelium in norm and during T-2 mycotoxicosis using polyclonal primary antibody Rabbit anti-GLUT-5 (Abcam, UK). The study revealed strong expression of GLUT-5 in the apical parts of the duodenal epithelial cells in the control group chickens and weak staining for GLUT-5 in the intestinal epithelium in the T-2 mycotoxicosis group indicating to the decreased expression of GLUT-5 in the duodenal epithelium during T-2 mycotoxicosis.
  • 1.5K
  • 05 Nov 2020
Topic Review
Antimicrobial Resistance in Escherichia coli
Public healthcare systems all over the world are faced with a great challenge in this respect. Obviously, there are many bacteria that can cause infections in humans and animals alike, but somehow it seems that the greatest threat nowadays comes from the Enterobacteriaceae members, especially Escherichia coli.
  • 1.5K
  • 08 Feb 2021
Topic Review
Oral Health and Gastro-intestinal Diseases
Various bi-directional associations exist between oral health and gastro-intestinal diseases. The oral microbiome plays a role in the gastro-intestinal carcinogenesis and fusobacteria are the most investigated bacteria involved. The salivary microbiota can affect the development of the intestinal microbiota, as saliva flows through the gastrointestinal tract, allowing the bacteria present in it to easily reach the intestine. The DNA of bacteria belonging to the salivary microbiota is detectable in the gut even in low concentrations.
  • 1.5K
  • 01 Jun 2021
Topic Review
Nrf2-Keap1-ARE Signaling and IRI
Ischemia/reperfusion (I/R) injury is associated with substantial clinical implications, including a wide range of organs such as the brain, kidneys, lungs, heart, and many others. I/R injury (IRI) occurs due to the tissue injury following the reestablishment of blood supply to ischemic tissues, leading to enhanced aseptic inflammation and stimulation of oxidative stress via reactive oxygen and nitrogen species (ROS/RNS). Since ROS causes membrane lipids’ peroxidation, triggers loss of membrane integrity, denaturation of proteins, DNA damage, and cell death, oxidative stress plays a critical part in I/R pathogenesis. Therefore, ROS regulation could be a promising therapeutic strategy for IRI. In this context, Nrf2 (NF-E2-related factor 2) is a transcription factor that regulates the expression of several factors involved in the cellular defense against oxidative stress and inflammation, including heme oxygenase-1 (HO-1). 
  • 1.5K
  • 01 Jun 2021
Topic Review
Tetrasubstituted α-Aminophosphonic Acid Derivatives
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the biological activity of chiral molecules into their absolute configuration, the synthesis of α-aminophosphonates bearing tetrasubstituted carbons in an asymmetric fashion has grown in interest in the last decades. In the following lines, the existing literature for the synthesis of optically active tetrasubstituted α-aminophosphonates are summarized, comprising diastereoselective and enantioselective approaches.
  • 1.5K
  • 19 Jun 2021
Topic Review
Genetic Susceptibility to AKI
Acute kidney injury (AKI) is a widely held concern related to a substantial burden of morbidity, mortality and expenditure in the healthcare system. AKI is not a simple illness but a complex conglomeration of syndromes that often occurs as part of other syndromes in its wide clinical spectrum of the disease. Genetic factors have been suggested as potentially responsible for its susceptibility and severity.
  • 1.5K
  • 27 Jul 2021
Topic Review
Food Science's Chemical Element Compositions
In recent years, many analyses have been carried out to investigate the chemical components of food data. However, studies rarely consider the compositional pitfalls of such analyses. This is problematic as it may lead to arbitrary results when non-compositional statistical analysis is applied to compositional datasets. In this study, compositional data analysis (CoDa), which is widely used in other research fields, is compared with classical statistical analysis to demonstrate how the results vary depending on the approach and to show the best possible statistical analysis. For example, honey and saffron are highly susceptible to adulteration and imitation, so the determination of their chemical elements requires the best possible statistical analysis. Our study demonstrated how principle component analysis (PCA) and classification results are influenced by the pre-processing steps conducted on the raw data, and the replacement strategies for missing values and non-detects. Furthermore, it demonstrated the differences in results when compositional and non-compositional methods were applied. Our results suggested that the outcome of the log-ratio analysis provided better separation between the pure and adulterated data and allowed for easier interpretability of the results and a higher accuracy of classification. Similarly, it showed that classification with artificial neural networks (ANNs) works poorly if the CoDa pre-processing steps are left out. From these results, we advise the application of CoDa methods for analyses of the chemical elements of food and for the characterization and authentication of food products.
  • 1.5K
  • 24 Nov 2021
Topic Review
Gut–Lung Axis Communication in COVID-19
The ecosystem of the human gastrointestinal tract, named gut microbiota, represents the most thoroughly mapped ecosystem. Perturbations on bacterial populations cause dysbiosis, a condition correlated to a wide range of autoimmune, neurological, metabolic, cardiovascular, and respiratory diseases. The lungs have their flora, which are directly related to the gut flora via bidirectional communication allowing the transport of microbial metabolites and toxins produced by intestinal bacteria through the circulation and lymphatic system. This mutual microbial cross-talk communication called the gut–lung axis modulates the immune and inflammatory response to infections. COVID-19 causes dysbiosis, altered intestinal permeability, and bacterial translocation. Dysbiosis, through the gut–lung axis, promotes hyper-inflammation, exacerbates lung damage, and worsens clinical outcomes.
  • 1.5K
  • 08 Sep 2022
Topic Review
D0 Experiment
The DØ experiment (sometimes written D0 experiment, or DZero experiment) consists of a worldwide collaboration of scientists conducting research on the fundamental nature of matter. DØ was one of two major experiments (the other is the CDF experiment) located at the world's second highest-energy accelerator, the Tevatron Collider at the Fermilab in Batavia, Illinois, USA. The research is focused on precise studies of interactions of protons and antiprotons at the highest available energies. It involves an intense search for subatomic clues that reveal the character of the building blocks of the universe.
  • 1.5K
  • 11 Oct 2022
Topic Review
Firewall
A black hole firewall is a hypothetical phenomenon where an observer falling into a black hole encounters high-energy quanta at (or near) the event horizon. The "firewall" phenomenon was proposed in 2012 by physicists Ahmed Almheiri, Donald Marolf, Joseph Polchinski, and James Sully as a possible solution to an apparent inconsistency in black hole complementarity. The proposal is sometimes referred to as the AMPS firewall, an acronym for the names of the authors of the 2012 paper. The potential inconsistency pointed out by AMPS had been pointed out earlier by Samir Mathur who used the argument in favour of the fuzzball proposal. The use of a firewall to resolve this inconsistency remains controversial, with physicists divided as to the solution to the paradox.
  • 1.5K
  • 07 Nov 2022
Topic Review
Learning Analytics of Students' Academic Performance
Learning analytics, understood as the use of data about students to improve their learning, is an approach through which teachers can understand education, help them to be student conscious and better capitalize teaching resources. Educational data mining, such as learning analytics, may guide educational institutions in providing suitable learning environments that promote academic success.
  • 1.5K
  • 21 Nov 2022
Topic Review
Hydrogen Generation
Hydrogen generation is the process of producing hydrogen gas from various sources, such as fossil fuels, water, or biomass. Hydrogen gas is a clean and versatile energy carrier that can be used in a wide range of applications, including fuel cells, transportation, and industrial processes. Hydrogen generation can be achieved through various methods, including steam methane reforming, electrolysis, and coal gasification. The use of hydrogen as a fuel offers a clean and sustainable alternative to traditional fossil fuels, with applications in transportation, power generation, industrial processes, heating systems, and energy storage. The development of sustainable hydrogen generation technologies is crucial for achieving a low-carbon economy and combating climate change. However, the technology still faces challenges such as high cost and lack of infrastructure. This entry provides an overview of the different methods and applications of hydrogen generation, and discusses the potential benefits and challenges associated with this technology.
  • 1.5K
  • 23 Mar 2023
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