Topic Review
Microfluidic Systems and Breast Cancer Metastasis
Microfluidic devices are useful tools in studying biological phenomena involving fluid flow, thin tissue culture, and cell mobility; each of these aspects make microfluidic techniques attractive for studying human breast cancer, which is the most commonly occurring cancer in women and the second most common cancer overall worldwide.
  • 946
  • 15 Feb 2022
Topic Review
Nanofiber Polymers for Biomedical Applications
The features of the nanofibers (NFs) that are used to coat biomedical Ti-based implants are predominantly dependent on the type of polymer employed. Applicable polymers are categorized as either natural or synthetic based on their source and composition. Natural polymers, namely cellulose, collagen, gelatin, chitosan, chitin, dextrose and silk fibroin, have been electrospun into NF scaffolds.
  • 945
  • 13 May 2022
Topic Review
Advances in Translational Nanotechnology
       The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.
  • 943
  • 30 Oct 2020
Topic Review
Exosomes and Glioma Treatment
More than 40 years ago, vesicle structures, similar to “cytoplasmic fragments” physiologically released, were identified in the cellular matrix. Their peculiarity was their ability to contain various materials, including ribosomes, which are involved in several pathological and physiological activities.These systems were defined as extracellular vesicles (EVs), and they include a wide variety of vesicles (from 30 nm to 5 μm) released from the plasma membrane (PM) of many different cell types into several bodily fluids. All EVs present a lipid bilayer membrane that surrounds a pool of genetic material, cytosolic proteins, or cellular debris. However, they significantly differ in terms of size, biogenesis, mechanisms, and function. Among these membrane vesicles, the most well-studied EVs are exosomes.  Exosomes have sizes ranging between 30 and 150 nm and represent a homogenous population of EVs released from cells when multivesicular bodies (MVBs) are fused with the membrane through inward budding in a highly regulated process. As natural carrier systems, exosomes present low immunogenicity, low toxicity, stability in the bloodstream, and efficient cell uptake due to their endogenous cellular tropism. Furthermore their ability to mediate intercellular communication allows their use as a promising therapeutic and diagnostic tool.
  • 931
  • 24 Nov 2020
Topic Review
SBA-15 synthesis variables
SBA-15 synthetized at different values of time and temperature of the hydrothermal treatment were mixture with tobacco in order to determine the capacity of reduction of toxic and carcirogenic compounds on tobacco smoke. The effect of temperature is not significative but time presents a remarked effect. And a parameter not frequently studied, the aparent density, has been shown the most relevant relation with the results on smoking experimentos. Finally, the effect of reduce the supernatant liquor also has been studied and the results have shown that the material properties remain practically unchanged.
  • 930
  • 01 Nov 2020
Topic Review
Glucose Monitoring
Glucose monitoring is essential to control diabetes and avoid long-term complications. Diabetics suffer on a daily basis with the traditional glucose monitors currently in use, which are invasive, painful, and cost-intensive. Therefore, the demand for non-invasive, painless, economical, and reliable approaches to monitor glucose levels is increasing.
  • 928
  • 30 Oct 2021
Topic Review
Speech Features for Schizophrenia
It is known that speech and language provide unique and essential information about human thought. Speech in subjects with schizophrenia is perceived as a negative symptom because it is mainly reflected in a lack of emotion (blunted affect) and poor speech (alogia). Other speech symptoms in schizophrenia include slow speech, reduced pitch variability, more pauses, and less synchronization in syllable variability. Speech production in patients with schizophrenia is usually stimulated via clinical interviews, free speech activities, image description or reading. Free speech can be compromised in people with a diagnosis of schizophrenia. Therefore, techniques such as asking patients to report activities or plans for the future, tasks done the previous day, and dreams can be implemented. Narrative of Emotions Tasks can also be used during medical consultation.
  • 917
  • 09 May 2023
Topic Review
Artificial Intelligence and Machine Learning for Biocatalysis
Biocatalysis is currently a workhorse used to produce a wide array of compounds, from bulk to fine chemicals, in a green and sustainable manner. The success of biocatalysis is largely thanks to an enlargement of the feasible chemical reaction toolbox. This materialized due to major advances in enzyme screening tools and methods, together with high-throughput laboratory techniques for biocatalyst optimization through enzyme engineering. Therefore, enzyme-related knowledge has significantly increased. To handle the large number of data now available, computational approaches have been gaining relevance in biocatalysis, among them machine learning methods (MLMs). MLMs use data and algorithms to learn and improve from experience automatically. 
  • 915
  • 14 Jun 2023
Topic Review
Photolyase Current Applications
The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct can lead to multiple affections such as cellular apoptosis and mutagenesis that can evolve into skin cancer. The development of integrated applications to prevent the negative effects of prolonged sunlight exposure, usually during outdoor activities, is imperative. 
  • 911
  • 26 Sep 2022
Topic Review
Algae-Based Biofuels
Microalgal biomass has gained a significant role in the development of dif-ferent high-end (nutraceuticals, colorants, food supplements, and pharmaceuticals) and low-end products (biodiesel, bioethanol, and biogas) due to its rapid growth and high carbon-fixing effi-ciency. Therefore, microalgae are considered a useful and sustainable resource to attain energy security while reducing our current reliance on fossil fuels. From the technologies available for obtaining biofuels using microalgae biomass, thermochemical processes (pyrolysis, Hydrothermal Liquefaction (HTL), gasification) have proven to be processed with higher viability, because they use all biomass. However, due to the complex structure of the biomass (lipids, carbohydrates, and proteins), the obtained biofuels from direct thermochemical conversion have large amounts of heteroatoms (oxygen, nitrogen, and sulfur). As a solution, catalyst-based processes have emerged as a sustainable solution for the increase in biocrude production. 
  • 906
  • 11 Jan 2021
Topic Review
Camera-Imaging-Based Measurement of Vital Signs
Techniques for noncontact measurement of vital signs using camera imaging technologies have been attracting increasing attention. For noncontact physiological assessments, computer vision-based methods appear to be an advantageous approach that could be robust, hygienic, reliable, safe, cost effective and suitable for long distance and long-term monitoring. In addition, video techniques allow measurements from multiple individuals opportunistically and simultaneously in groups.
  • 903
  • 07 Sep 2020
Topic Review
Wet Nanotechnology
Wet nanotechnology (also known as wet nanotech) involves working up to large masses from small ones. Wet nanotechnology requires water in which the process occurs. The process also involves chemists and biologists trying to reach larger scales by putting together individual molecules. While Eric Drexler put forth the idea of nano-assemblers working dry, wet nanotech appears to be the likely first area in which something like a nano-assembler may achieve economic results. Pharmaceuticals and bioscience are central features of most nanotech start-ups. Richard A.L. Jones calls nanotechnology that steals bits of natural nanotechnology and puts them in a synthetic structure biokleptic nanotechnology. He calls building with synthetic materials according to nature's design principles biomimetic nanotechnology. Using these guiding principles could lead to trillions of nanotech robots, that resemble bacteria in structural properties, entering a person's blood stream to do medical treatments.
  • 894
  • 29 Sep 2022
Topic Review
Polymeric Platforms and Delivery Systems of Probiotics
The selection of optimal material for probiotic encapsulation and the appropriate processing route are key parameters to ensure an efficient delivery strategy, where early degradation by GIT stimuli and harsh conditions are largely avoided. Nevertheless, selecting the materials for superior performance in complex physiological environments such as the GIT is a task made challenging not only by the obstacles to be overcome to reach the target site but also by the need to maintain high biological activities and positive responses to the changing surroundings. The fast-growing notion that encapsulates can be composed of active biomaterials should be driven by matching the material’s properties with expected responses through the GIT. Particularly, polymers exhibit versatile molecular moieties that have been widely exploited to fabricate chemical and physical delivery platforms with properties that can be finely tuned by adjusting interchain interactions. Chemical polymeric scaffolds are formed by covalent bonds between adjacent chains, while the physical ones are maintained together by charged polyvalent surfactants or ion interactions. Moreover, their versatile processability schemes facilitate obtaining different morphologies, functionalities, and the possibility to form composites with nanostructured materials in search of an enhanced response when subjected to a stimulus. Typical polymeric encapsulates comprise microparticles, microspheres, microcapsules, hydrogels, and, more recently, nanocomposite 3D matrices.
  • 891
  • 17 Mar 2022
Topic Review
Visual pH Sensors
The pH sensors are gaining widespread attention as non-destructive tools, visible to the human eye, and are capable of real-time and in-situ response.
  • 890
  • 31 May 2021
Topic Review
Hydroxyapatite in Oral Care Products
Calcium phosphate compounds form the inorganic phases of our mineralised tissues such as bone and teeth, playing an important role in hard tissue engineering and regenerative medicine. In dentistry and oral care products, hydroxyapatite (HA) is a stable and biocompatible calcium phosphate with low solubility being used for various applications such as tooth remineralisation, reduction of tooth sensitivity, oral biofilm control, and tooth whitening. 
  • 890
  • 08 Sep 2021
Topic Review
Electroencephalography in Schizophrenia
Electroencephalography (EEG) provides a non-invasive tool for the study of the brain’s temporal and spatial register of electric activity. Schizophrenia is a complex and heterogeneous disease, manifesting deficits that underlie many overlapping pathological mechanisms distributed across multiple brain regions. Patients with schizophrenia have sensory processing deficits and high-level attention-dependent cognitive deficits. These deficits can be assessed by the time-locked EEG activity in stimuli called ERPs and extracting the features. EEG oscillations are considered biomarkers or features of complex states in health and schizophrenia persons. The oscillatory activity of the EEG in schizophrenia patients indicates abnormal temporal integration and interregional connectivity of brain networks during neurocognitive function. EEG signal analysis can be performed in the time, frequency, and time–frequency domains.
  • 885
  • 09 May 2023
Topic Review
Preclinical Cold Atmospheric Plasma Cancer Treatment
Cold atmospheric plasma (CAP) is generated in a rapid yet low-energy input streamer-discharge process under atmospheric pressure conditions and environment. CAP is an ionized gas with a low ionization degree and plenty of reactive species and radicals. These reactive components, and their near-room temperature nature, make CAP a powerful tool in medical applications, particularly cancer therapy. Here, researchers systematically introduced the research status of the preclinical application of CAP in cancer therapy, particularly in vivo studies.
  • 884
  • 22 Jul 2022
Topic Review
Antisense Peptide Technology
Antisense peptide technology (APT) is based on a useful heuristic algorithm for rational peptide design. It was deduced from empirical observations that peptides consisting of complementary (sense and antisense) amino acids interact with higher probability and affinity than the randomly selected ones. This phenomenon is closely related to the structure of the standard genetic code table, and at the same time, is unrelated to the direction of its codon sequence translation.
  • 883
  • 11 Oct 2021
Topic Review
Smartphone-Based Biosensor Devices for Healthcare
Electrochemical biosensors are undoubtedly the most popular among POC devices due to their high sensitivity, simplicity, low cost, and reliability. The development of these electrochemical devices has continued to grow exponentially since Clark designed the first enzymatic glucose biosensor, which was then improved and became the most commercialized healthcare biosensor. Electrochemical biosensors that use smartphones received great attention as they use a friendly semi-automated user interface with minimum extra tailored hardware. They can also be used at home, offering an interesting, cost-effective alternative.
  • 880
  • 11 Mar 2022
Topic Review
Biomedical Applications of Microfluidic Devices
Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). 
  • 876
  • 02 Dec 2022
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