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Topic Review
Self-Assembled Nanocomposites and Nanostructures
Self-assembled nanocomposites and nanostructures are a class of molecules that spontaneously assemble directly through specific interactions or indirectly through their environment without any human intervention. The benefits of self-assembled nanocomposites or nanostructures have been reported several times for their prominent applications.
  • 587
  • 01 Mar 2022
Topic Review
New Horizons in Structural Biology of Membrane Proteins
A third of both pro- and eukaryotic proteomes consist of membrane proteins. Housed in a milieu of hydrophobic molecules, they serve as crucial contacts of communication between the cytoplasm and non-cytosolic environments, making them essential pharmaceutical targets. While membrane proteins are notoriously difficult to investigate at any level, high-resolution structures of these targets only became feasible at the very end of the twentieth century. It was not until robust technological developments in the fields of X-ray crystallography, NMR spectroscopy and cryo-EM, that the scientific community at large, finally gained access to an ever-increasing number of atomic resolution structures, and began to rationalize how membrane proteins accommodate their function. As if the lack of structural information wasn’t enough to hamper progress, a higher level of complexity arose from the modern understanding of “one structure—one function” paradigm, a primitive simplification useful at the dawn of the scientific era, that has promptly lost credence to the complex maneuvers of membrane proteins.
  • 586
  • 26 Apr 2022
Topic Review
Factors Affecting NCGs Removal
Bast fiber plants require a post-harvest process to yield useable natural cellulosic fibers, denoted as retting or degumming. It encompasses the degradation of the cell wall’s non-cellulosic gummy substances (NCGs), facilitating fibers separations, setting the fiber’s quality, and determining downstream usages. Due to the inconvenience of traditional retting practices, bacterial inoculum and enzyme applications for retting gained attention. Therefore, concurrent changes of agroclimatic and socioeconomic conditions, the conventional water retting confront multiple difficulties, bast industries become vulnerable, and bacterial agents mediated augmented bio-retting processes trying to adapt to sustainability. However, this process’s success demands a delicate balance among substrates and retting-related biotic and abiotic factors. These critical factors were coupled to degrade bast fibers NCGs in bacterial retting while holistically disregarded in basic research. In this study, a set of factors were defined that critically regulates the process and requires to be comprehended to achieve optimum retting without failure. 
  • 575
  • 24 Aug 2021
Topic Review
Bioremediation of Heavy Metals by the Genus Bacillus
Bioremediation agents include bacteria of the genus Bacillus, among others. The best-described species in terms of the bioremediation potential of Bacillus spp. Are B. subtilis, B. cereus, or B. thuringiensis. This bacterial genus has several bioremediation strategies, including biosorption, extracellular polymeric substance (EPS)-mediated biosorption, bioaccumulation, or bioprecipitation. Due to the above-mentioned strategies, Bacillus spp. strains can reduce the amounts of metals such as lead, cadmium, mercury, chromium, arsenic or nickel in the environment. 
  • 573
  • 27 Sep 2023
Topic Review
Magnetic Elements for Neuromorphic Computing
Neuromorphic computing is also called cognitive or adaptive computing. Brain-inspired computers could work like neuronal networks, be more energy-efficient, and could learn and solve special mathematical problems faster than recent computers. It is assumed to be significantly more energy efficient than, and at the same time expected to outperform, conventional computers in several applications, such as data classification, since it overcomes the so-called von Neumann bottleneck. Artificial synapses and neurons can be implemented into conventional hardware using new software, but also be created by diverse spintronic devices and other elements to completely avoid the disadvantages of recent hardware architecture.
  • 571
  • 01 Dec 2021
Topic Review
Pseudomonas Lipopeptides
The Pseudomonas genus is ubiquitous and comprises species which are well known phytopathogens, such as P. syringae, or opportunistic human pathogens, such as P. aeruginosa, but also host members associated with water, soil and plant surfaces. Pseudomonas spp. are well adapted to growing in the rhizosphere and are well suited for biocontrol and growth promotion. Pseudomonas lipopeptides (Ps-LPs) play crucial roles in bacterial physiology, host–microbe interactions and plant disease control.
  • 570
  • 09 Feb 2022
Topic Review
Polyphenols in Dental Applications
Polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials.
  • 565
  • 29 Mar 2022
Topic Review
Metal Nanoparticles against Viruses
This study is an actual review about of recent studies using metal nanocomposites as antivirals against coronavirus and structurally similar viruses. We wrote this review in a new perspective, within the scope of nanomaterials, the purpose of the review is to demonstrate the potential of nanoparticles in combating the COVID-19 pandemic.
  • 565
  • 28 Jan 2022
Topic Review
Applications of Valuable Compounds from Fermented Residues
Significant amounts of fermented food waste are generated worldwide, promoting an abundance of residual biomass that can be used as raw material to extract bioactive peptides, fermentable sugars, polyphenols, and valuable compounds for synthesizing bioproducts. Therefore, generating these high-value-added products reduces the environmental impact caused by waste disposal and increases the industrial economic value of the final products. The fermentation process favors the synthesis of products with high added value. However, the use of fermentation also leads to the production of fermentative residues containing metabolites, extracellular enzymes, and other byproducts generated by microbiological metabolism. 
  • 562
  • 04 Nov 2023
Topic Review
Supercritical Fluid Applications in Novel Antimicrobial Materials
The extraordinary properties of supercritical fluids such as high density, near-zero surface tension, and high diffusivities enable the uniqueness and numerous advantages of the materials obtained.  The application of supercritical fluids is a powerful tool in the development of novel materials with antimicrobial activity desperately needed in the time of increasing bacterial resistance to antibiotics and the dramatic appearance and spread of not only multidrug-resistant (MDR) but also pandrug-resistant (PDR) bacterial strains. MDR is defined as the resistance to at least one antibiotic from at least three different categories, while PDR is defined as non-susceptibility to all drugs in all antimicrobial categories.
  • 560
  • 06 Dec 2021
Topic Review
Mitochondria-Targeting Probes
Sulfane sulfurs, which include hydropersulfides (RSSH), hydrogen polysulfides (H2Sn, n > 1), and polysulfides (RSnR, n > 2), play important roles in cellular redox biology and are closely linked to hydrogen sulfide (H2S) signaling. While most studies on sulfane sulfur detection have focused on sulfane sulfurs in the whole cell, increasing the recognition of the effects of reactive sulfur species on the functions of various subcellular organelles has emerged, such as mitochondria. This has driven a need for organelle-targeted detection methods.
  • 560
  • 08 Mar 2023
Topic Review
Structure and Immobilization of Aptamers
Aptamers are synthetically produced via a process known as systematic evolution of ligands by exponential enrichment (SELEX).
  • 553
  • 29 Apr 2022
Topic Review
Artificial Super-Wettable Surfaces
Inspired by nature, significant research efforts have been made to discover the diverse range of biomaterials for various biomedical applications such as drug development, disease diagnosis, biomedical testing, therapy, etc. Polymers as bioinspired materials with extreme wettable properties, such as superhydrophilic and superhydrophobic surfaces, have received considerable interest in the past due to their multiple applications in anti-fogging, anti-icing, self-cleaning, oil–water separation, biosensing, and effective transportation of water. Apart from the numerous technological applications for extreme wetting and self-cleaning products, recently, super-wettable surfaces based on polymeric materials have also emerged as excellent candidates in studying biological processes. 
  • 549
  • 17 Jan 2022
Topic Review
Silver Cluster Interactions with Tyrosine
Tyrosine (Tyr) is involved in the synthesis of neurotransmitters, catecholamines, thyroid hormones, etc. Multiple pathologies are associated with impaired Tyr metabolism. Silver nanoclusters (Ag NCs) can be applied for colorimetric, fluorescent, and surface-enhanced Raman spectroscopy (SERS) detection of Tyr.
  • 542
  • 14 Mar 2022
Topic Review
Complexes with Antibiofilm Activity
Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3d ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. 
  • 542
  • 28 Mar 2022
Topic Review
SPR Biosensing of SARS-CoV-2 Entry Inhibitors
This work compiles recent advancements on the discovery of SARS-CoV2 inhibitors by SPR analysis. One of the major benefits of SPR biosensing is the possibility of easily investigating molecular interactions. Owing to this quality, SPR biosensor technology has become a first-line tool for analyzing the binding properties of potential drug candidates against COVID-19. Overall, SPR biosensors seem to offer a single methodology for attaining full kinetic profiles while providing the screening of fragment libraries and the validation of fragment hits.
  • 540
  • 06 Dec 2021
Topic Review
Acyl-Homoserine Lactones Improve Growth of Ginseng Seedlings
Panax ginseng is a well-known medicinal plant that achieves strong resistance against plant pathogens while growing in the wild. Due to the high market demand for ginseng as a health food source, ginseng cultivation is prevalent in South Korea. However, continuous monocropping creates problems like irregular growth or vulnerability to crop diseases. Quorum sensing (QS) deals with the intracellular communication of bacteria and plays a role in dynamic changes in the soil microbiome. Here, we investigated how acyl-homoserine lactone (AHL) signaling molecules in QS (C8, C10, and C12) improve plant growth and induce shifts in the soil microbiome. To assess the effects, we recorded root and shoot growth of ginseng seedlings and checked the changes in the soil microbiome during different time points (0, 2, 4, and 8) after 8 weeks of growth. We observed that soils treated with N-decanoyl-L-homoserine lactone (C10) showed the most pronounced effects. Very striking was that C10 had the lowest alpha diversity. Using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2), we observed a high number of QS-related functional genes, with the highest count occurring in the untreated planted soil (W). Together with the known direct and beneficial effects of AHLs on plant development, AHLs treated mono-cropped soil showed trends in the microbiome community. 
  • 538
  • 10 Nov 2021
Topic Review
MS-Based Metabolomic Workflows in Marine Natural Products Analysis
Marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention.
  • 534
  • 20 May 2022
Topic Review
Crystal-storing Histiocytosis
Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. 
  • 533
  • 01 Jun 2021
Topic Review
Carbohydrates/Matrix Lignin in Mechanically Graded Bamboo Culms
The mechanical performance of bamboo is highly dependent on its structural arrangement and the properties of biomacromolecules within the cell wall. Along the radius of bamboo culms, the concentration of xylan within the fiber sheath increased, while that of cellulose and lignin decreased gradually. At cellular level, although the consecutive broad layer (Bl) of fiber revealed a relatively uniform cellulose orientation and concentration, the outer Bl with higher lignification level has higher elastic modulus (19.59–20.31 GPa) than that of the inner Bl close to the lumen area (17.07–19.99 GPa). Comparatively, the cell corner displayed the highest lignification level, while its hardness and modulus were lower than that of fiber Bl, indicating the cellulose skeleton is the prerequisite of cell wall mechanics. The obtained cytological information is helpful to understand the origin of the anisotropic mechanical properties of bamboo.
  • 512
  • 12 Jan 2022
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