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Topic Review
P-Glycoprotein Transporter Modelling
ATP-binding cassette (ABC) transporters play a critical role in both drug bioavailability and toxicity, and with the discovery of the P-glycoprotein (P-gp), this became even more evident, as it plays an important role in preventing intracellular accumulation of toxic compounds. Intensive studies have been conducted to find new therapeutic molecules to reverse the phenomenon of multidrug resistance (MDR), that research has found is often associated with overexpression of P-gp, the most extensively studied drug efflux transporter; in MDR, therapeutic drugs are prevented from reaching their targets due to active efflux from the cell. The development of P-gp inhibitors is recognized as a good way to reverse this type of MDR, which has been the subject of extensive studies over the past few decades. Despite the progress made, no effective P-gp inhibitors to reverse multidrug resistance are yet on the market, mainly because of their toxic effects. Computational studies can accelerate this process, and in silico models such as quantitative structure-activity relationship (QSAR) models that predict the activity of compounds associated with P-gp (or analogous transporters) are of great value in the early stages of drug development, along with molecular modelling methods, which provide a way to explain how these molecules interact with the ABC transporter. 
  • 1.0K
  • 21 Feb 2023
Topic Review
Indirect Type Electrochemical Glycated Hemoglobin Sensors
Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. Indirect type electrochemical HbA1c sensors work based on the measurement of fructosyl valine/fructosyl valine histidine (FV or FVH), which is a form of enzymatic determination. According to the type of enzymes, indirect sensors are divided into fructosyl amino acid oxidase (FAO) type, fructosyl peptide oxidase (FPOX) type, and molecularly imprinted catalyst (MIC) type sensors. These enzymes usually need to be processed with nanotechnology or imprinting technology to immobilize them on the electrode surface. 
  • 1.0K
  • 21 Apr 2022
Topic Review
Neuroprotective Diets
Nutrition and rehabilitation are crucial in post-stroke recovery, especially in the elderly. Since stroke is the leading cause of long-term disability, there is a need to promote special, individually tailored nutrition strategies targeting older patients with low motor ability. Chronic stroke survivors have higher risk of developing nutrition-related chronic diseases, such as sarcopenia, anemia, type 2 diabetes mellitus and osteoporosis.
  • 1.0K
  • 10 Aug 2021
Topic Review
Nanotechnology-Based Techniques for Sensing Amino Acids/Peptides/Proteins
Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance.
  • 1.0K
  • 13 Dec 2021
Topic Review
Polyphenols in Dental Applications
Polyphenols are a broad class of molecules extracted from plants and have a large repertoire of biological activities. Biomimetic inspiration from the effects of tea or red wine on the surface of cups or glass lead to the emergence of versatile surface chemistry with polyphenols. Owing to their hydrogen bonding abilities, coordination chemistry with metallic cations and redox properties, polyphenols are able to interact, covalently or not, with a large repertoire of chemical moieties, and can hence be used to modify the surface chemistry of almost all classes of materials.
  • 1.0K
  • 29 Mar 2022
Topic Review
Biomaterials for Drugs Nose–Brain Transport
Recently, the intranasal route has emerged as a promising administration site for central nervous system therapeutics since it provides a direct connection to the central nervous system, avoiding the passage through the blood–brain barrier, consequently increasing drug cerebral bioavailability.
  • 1.0K
  • 13 Apr 2021
Topic Review
Polyethyleneimine-Based Lipopolyplexes
Lipopolyplexes based on poliethylenimine are an interesting platform for future anti-cancer gene therapies. The carrier consists of nucleic acids condensed with poliethylenimine chains and enclosed in lipid vesicles. Lipopolyplexes could be very versatile, what enables tailoring the carrier for specific thereapeutic needs, however the preparation process is a multistage and fairly sensitive one, which additionally requires a specific balance to be maintained between its stability in the body, which would allow the appropriate dose of the preparation to reach the target site, and the ability to release nucleic acid at the right place and time.
  • 1.0K
  • 10 Jan 2022
Topic Review
MS-Based Metabolomic Workflows in Marine Natural Products Analysis
Marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention.
  • 998
  • 20 May 2022
Topic Review
Polyphenols in Ruminant Nutrition
Free radical oxygen molecules are formed during aerobic cellular metabolism, containing one or more unpaired electrons. Free radicals can bind to various molecules and damage membranes, nucleic acids, and proteins. In recent years, the plants used in feed have served as sources of different bioactive compounds for animals. In addition, nutrient compounds play a very important role in protecting against the effects of free radicals.
  • 982
  • 20 May 2022
Topic Review
HDAC Inhibitors
Histone deacetylase inhibitors (HDIs) are a class of prominent epigenetic drugs that are currently being tested in hundreds of clinical trials against a variety of diseases. A few compounds have already been approved for treating lymphoma or myeloma. HDIs bind to the zinc-containing catalytic domain of the histone deacetylase (HDACs) and they repress the deacetylase enzymatic activity. 
  • 966
  • 10 Jan 2022
Topic Review
Pseudomonas Lipopeptides
The Pseudomonas genus is ubiquitous and comprises species which are well known phytopathogens, such as P. syringae, or opportunistic human pathogens, such as P. aeruginosa, but also host members associated with water, soil and plant surfaces. Pseudomonas spp. are well adapted to growing in the rhizosphere and are well suited for biocontrol and growth promotion. Pseudomonas lipopeptides (Ps-LPs) play crucial roles in bacterial physiology, host–microbe interactions and plant disease control.
  • 952
  • 09 Feb 2022
Topic Review
Silver Cluster Interactions with Tyrosine
Tyrosine (Tyr) is involved in the synthesis of neurotransmitters, catecholamines, thyroid hormones, etc. Multiple pathologies are associated with impaired Tyr metabolism. Silver nanoclusters (Ag NCs) can be applied for colorimetric, fluorescent, and surface-enhanced Raman spectroscopy (SERS) detection of Tyr.
  • 941
  • 14 Mar 2022
Topic Review
SPR Biosensing of SARS-CoV-2 Entry Inhibitors
This work compiles recent advancements on the discovery of SARS-CoV2 inhibitors by SPR analysis. One of the major benefits of SPR biosensing is the possibility of easily investigating molecular interactions. Owing to this quality, SPR biosensor technology has become a first-line tool for analyzing the binding properties of potential drug candidates against COVID-19. Overall, SPR biosensors seem to offer a single methodology for attaining full kinetic profiles while providing the screening of fragment libraries and the validation of fragment hits.
  • 932
  • 06 Dec 2021
Topic Review
Complexes with Antibiofilm Activity
Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3d ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. 
  • 931
  • 28 Mar 2022
Topic Review
Metal Nanoparticles against Viruses
This study is an actual review about of recent studies using metal nanocomposites as antivirals against coronavirus and structurally similar viruses. We wrote this review in a new perspective, within the scope of nanomaterials, the purpose of the review is to demonstrate the potential of nanoparticles in combating the COVID-19 pandemic.
  • 928
  • 28 Jan 2022
Topic Review
Structure and Immobilization of Aptamers
Aptamers are synthetically produced via a process known as systematic evolution of ligands by exponential enrichment (SELEX).
  • 927
  • 29 Apr 2022
Topic Review
Lung-Cancer-Related Exhaled Breath Biomarkers
Lung cancer has been studied for decades because of its high morbidity and high mortality. Traditional methods involving bronchoscopy and needle biopsy are invasive and expensive, which makes patients suffer more risks and costs. Various noninvasive lung cancer markers, such as medical imaging indices, volatile organic compounds (VOCs), and exhaled breath condensates (EBCs), have been discovered for application in screening, diagnosis, and prognosis. However, the detection of markers still relies on bulky and professional instruments, which are limited to training personnel or laboratories. This seriously hinders population screening for early diagnosis of lung cancer. Advanced smartphones integrated with powerful applications can provide easy operation and real-time monitoring for healthcare, which demonstrates tremendous application scenarios in the biomedical analysis region from medical institutions or laboratories to personalized medicine.
  • 922
  • 21 Apr 2022
Topic Review
Random Path Routing Network Using Colored Petri Nets
Wireless sensor networks (WSNs) have been applied in networking devices, and a new problem has emerged called source-location privacy (SLP) in critical security systems. In wireless sensor networks, hiding the location of the source node from the hackers is known as SLP. The WSNs have limited battery capacity and low computational ability. Many state-of-the-art protocols have been proposed to address the SLP problems and other problems such as limited battery capacity and low computational power. One of the popular protocols is random path routing (RPR), and in random path routing, the system keeps sending the message randomly along all the possible paths from a source node to a sink node irrespective of the path’s distance. The problem arises when the system keeps sending a message via the longest route, resulting because of high battery usage and computational costs. 
  • 914
  • 08 Feb 2022
Topic Review
Copper Nanocluster and Pollutant Analysis
Copper nanoclusters (Cu NCs) with their inherent optical and chemical advantages have gained increasing attention as a kind of novel material that possesses great potential, primarily in the use of contaminants sensing and bio-imaging. With a focus on environmental safety, this article comprehensively reviews the recent advances of Cu NCs in the application of various contaminants, including pesticide residues, heavy metal ions, sulfide ions and nitroaromatics. The common preparation methods and sensing mechanisms are summarized.
  • 911
  • 12 Nov 2021
Topic Review
Artificial Super-Wettable Surfaces
Inspired by nature, significant research efforts have been made to discover the diverse range of biomaterials for various biomedical applications such as drug development, disease diagnosis, biomedical testing, therapy, etc. Polymers as bioinspired materials with extreme wettable properties, such as superhydrophilic and superhydrophobic surfaces, have received considerable interest in the past due to their multiple applications in anti-fogging, anti-icing, self-cleaning, oil–water separation, biosensing, and effective transportation of water. Apart from the numerous technological applications for extreme wetting and self-cleaning products, recently, super-wettable surfaces based on polymeric materials have also emerged as excellent candidates in studying biological processes. 
  • 909
  • 17 Jan 2022
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