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Topic Review
Thermoresponsive Polypeptoids
Thermoresponsive polypeptoids exhibiting a reversible phase transition in a controlled manner to temperature are a promising class of smart polymers that have drawn growing interest because of its excellent biocompatibility, biodegradability, and bioactivity. The phase transition behavior of these polymers can be tuned by polymer architectures, chain-end, and various functional groups. 
  • 1.5K
  • 29 Dec 2020
Topic Review
The Genus Porophyllum
The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities.
  • 1.5K
  • 28 Sep 2021
Topic Review
Klotho
Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly reduces lifespan, and its overexpression extends it and protects against various pathological phenotypes, especially renal disease. It was shown to regulate phosphate and calcium metabolism, protect against oxidative stress, downregulate apoptosis, and have antiinflammatory and antifibrotic properties.
  • 1.5K
  • 05 Mar 2021
Topic Review
Ameliorate Concanavalin A-Induced Liver Injury
Liver diseases represent a threat to human health and are a significant cause of mortality and morbidity worldwide. Autoimmune hepatitis (AIH) is a progressive and chronic hepatic inflammatory disease, which may lead to severe complications. Concanavalin A (Con A)-induced hepatic injury is regarded as an appropriate experimental model for investigating the pathology and mechanisms involved in liver injury mediated by immune cells as well as T cell-related liver disease. Despite the advances in modern medicine, the only available strategies to treat AIH, include the use of steroids either solely or with immunosuppressant drugs. Unfortunately, this currently available treatment is associated with significant side-effects. Therefore, there is an urgent need for safe and effective drugs to replace and/or supplement those in current use. Natural products have been utilized for treating liver disorders and have become a promising therapy for various liver disorders.
  • 1.5K
  • 23 Feb 2021
Topic Review
Luminescent Ln-Ionic Liquids beyond Europium
What is called an ionic liquid (IL) has a very broad definition, comprising multiple substances possessing a wide diversity of structures and properties. An IL consists of both organic and inorganic ions, and may contain more than one cation or anion. Normally, a substance is considered to be an IL if completely composed of ions, with a melting point below 100 °C. Ionic liquids containing lanthanides or lanthanide compounds in ionic liquids are very important in the field of soft luminescent materials. 
  • 1.5K
  • 27 Aug 2021
Topic Review
Oleanolic Acid
Oleanolic acid (OA) is a pentacyclic triterpenoid, abundantly found in plants of the Oleaceae family, and is well known for its beneficial pharmacological activities. 
  • 1.5K
  • 11 Nov 2021
Topic Review
Polyurea Aerogels
The term “aerogel” describes a certain class of low-density solid materials with a high open porosity. Aerogels can be considered to be a subclass of the much broader domain of porous materials; however, they are distinguished from, for example, blown foams, because they are prepared in a completely different manner—namely, by drying wet gels in a way that preserves nearly all of their volume in the final dry form.
  • 1.5K
  • 02 Apr 2022
Topic Review
Adopting Modular Integrated Construction for Affordable Sustainable Housing
The rise of offsite construction (OSC) techniques, especially modular integrated construction (MiC), has been evident. MiC’s adoption in affordable sustainable housing (ASH) is still underdeveloped; however, due to various benefits of MiC over conventional construction methods, it is envisioned to be a significant emerging approach for tackling growing housing demand, and ASH in particular.
  • 1.5K
  • 15 Jun 2022
Topic Review
Nutrition and Supplementation in Ulcerative Colitis
Wrzodziejące zapalenie jelita grubego (UC) należy do grupy nieswoistych zapaleń jelit (IBD). WZJG jest nieuleczalnym, rozlanym i przewlekłym procesem zapalnym błony śluzowej okrężnicy z naprzemiennymi okresami zaostrzenia i remisji. 
  • 1.5K
  • 30 Jun 2022
Topic Review
Vice News
Vice News (stylized as VICE News) is Vice Media's current affairs channel, producing daily documentary essays and video through its website and YouTube channel. It promotes itself on its coverage of "under-reported stories". Vice News was created in December 2013 and is based in New York City , though it has bureaus worldwide.
  • 1.5K
  • 14 Oct 2022
Topic Review
Military Sexual Trauma
As defined by the United States Department of Veterans Affairs, military sexual trauma (MST) are experiences of sexual assault, or repeated threatening sexual harassment that occurred while a person was in the United States Armed Forces.
  • 1.5K
  • 14 Oct 2022
Topic Review
Xenopus Oocytes to Study Fully-Processed Membrane Proteins
The use of Xenopus oocytes in electrophysiological and biophysical research constitutes a long and successful story, providing major advances to the knowledge of the function and modulation of membrane proteins, mostly receptors, ion channels, and transporters. These cells are capable of correctly expressing heterologous proteins after injecting the corresponding mRNA or cDNA. The Xenopus oocyte has become an outstanding host–cell model to carry out detailed studies on the function of fully-processed foreign membrane proteins after their microtransplantation to the oocyte. 
  • 1.5K
  • 24 Oct 2022
Topic Review
GSK-3 Inhibitor
Glycogen synthase, an enzyme that is responsible in glycogen synthesis, is activated by glucose 6-phosphate (G6P), and inhibited by glycogen synthase kinases (GSK3). Those two mechanisms play an important role in glycogen metabolism. Glycogen synthase kinase (GSK-3) is a serine/threonine kinase that phosphorylate either threonine or serine, and this phosphorylation permits a variety of biological activities as glycogen metabolism, cell signaling, cellular transport, and others. GS inhibition by GSK-3β leads to a decrease in glycogen synthesis in the liver and muscles, along with increased blood glucose or hyperglycemia. This is why GSK-3β is associated with the pathogenesis and progression of many diseases, such as diabetes, obesity, and cancer. Human GSK-3 has two isoforms, α and β. It is active in resting cells and is inhibited by several hormones such as insulin, endothelial growth factor, and platelet-derived growth factor. Insulin inactivates it by phosphorylation of the specific serine residues Ser21 and Ser9 in GSK-3 isoforms α and β, respectively. In a phosphatidylinositol 3-kinase-dependent way. Glycogen synthase kinase inhibitors are different chemotypes and have variable mechanisms of action; they may be cations, from natural sources, synthetic ATP and non-ATP competitive inhibitors and substrate-competitive inhibitors. GSK3 is a bi-lobar architecture with N-terminal and C-terminal, the N-terminal is responsible for ATP binding and C-terminal which is called as activation loop mediates the kinase activity, Tyrosine located at the C-terminal it essential for full GSK3 activity.
  • 1.5K
  • 02 Nov 2022
Topic Review
Terpenoid Transport in Plants
Contrary to the biosynthetic pathways of many terpenoids, which are well characterized and elucidated, their transport inside subcellular compartments and the secretion of reaction intermediates and final products at the short- (cell-to-cell), medium- (tissue-to-tissue), and long-distance (organ-to-organ) levels are still poorly understood, with some limited exceptions.
  • 1.5K
  • 15 Feb 2023
Topic Review
Biochar for Remediation of Polluted Soils
Soil contamination with organic contaminants and various heavy metals has become a global environmental concern. Biochar application for the remediation of polluted soils may render a novel solution to soil contamination issues.
  • 1.5K
  • 06 Apr 2023
Topic Review
Acoustic Technology in Food Processing
Acoustic technology is characterized as environmentally friendly and is considered an alternative method due to its sustainability and economic efficiency. This technology provides advantages such as the intensification of processes, increasing the efficiency of processes and eliminating inefficient ones, improving product quality, maintaining the product’s texture, organoleptic properties, and nutritional value, and ensuring the microbiological safety of the product.
  • 1.5K
  • 10 Oct 2023
Topic Review
Open BOK Context
A Body of Knowledge (BOK) is a concept used to represent concepts, terms, and activities that make up a professional domain. In addition, an Open BOK is necessary because it allows us to develop the abilities and talents of professionals in different Knowledge Areas (KAs).
  • 1.5K
  • 02 Nov 2020
Topic Review
Astaxanthin as a Novel Mitochondrial Regulator
Astaxanthin is a member of the carotenoid family that is found abundantly in marine organisms. It has been reported that astaxanthin functions both as a pigment, and as an antioxidant with superior free radical quenching capacity.
  • 1.5K
  • 29 Mar 2022
Topic Review
Dental Fiber-Post Systems
The field of dental medicine is constantly evolving and advancing toward minimally invasive techniques. Several studies have demonstrated that bonding to the tooth structure, particularly enamel, yields the most predictable results. In some instances, however, significant tooth loss, pulpal necrosis, or irreversible pulpitis may limit the options available to the restorative dentist. In these cases, placement of a post and core followed by a crown is the preferred treatment option, provided all requirements are met.
  • 1.5K
  • 19 May 2023
Topic Review
In Vitro Embryogenesis and Gastrulation Using Stem Cells
During early mammalian embryonic development, fertilized one-cell embryos develop into pre-implantation blastocysts and subsequently establish three germ layers through gastrulation during post-implantation development. Stem cells have emerged as a powerful tool to study embryogenesis and gastrulation without the need for eggs, allowing for the generation of embryo-like structures known as synthetic embryos or embryoids. These in vitro models closely resemble early embryos in terms of morphology and gene expression and provide a faithful recapitulation of early pre- and post-implantation embryonic development. Synthetic embryos can be generated through a combinatorial culture of three blastocyst-derived stem cell types, such as embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm cells, or totipotent-like stem cells alone. 
  • 1.5K
  • 26 Sep 2023
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