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Sosa-Gutierrez, C.G. The Genus Porophyllum. Encyclopedia. Available online: https://encyclopedia.pub/entry/7309 (accessed on 16 November 2024).
Sosa-Gutierrez CG. The Genus Porophyllum. Encyclopedia. Available at: https://encyclopedia.pub/entry/7309. Accessed November 16, 2024.
Sosa-Gutierrez, Carolina G.. "The Genus Porophyllum" Encyclopedia, https://encyclopedia.pub/entry/7309 (accessed November 16, 2024).
Sosa-Gutierrez, C.G. (2021, February 16). The Genus Porophyllum. In Encyclopedia. https://encyclopedia.pub/entry/7309
Sosa-Gutierrez, Carolina G.. "The Genus Porophyllum." Encyclopedia. Web. 16 February, 2021.
The Genus Porophyllum
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This entry is adapted from the peer-reviewed paper 10.3390/scipharm89010007

The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities.

Porophyllum phytochemical studies

1. Introduction

A growing world-wide interest in the use of phytopharmaceuticals as complementary or alternative medicine, either to prevent or to ameliorate many diseases, has been noted in recent years. Furthermore, a great portion of the world’s population uses plants as their primary source of medicinal agents [1]. Nowadays, medicinal plant’s importance relies not only on their cultural richness but also on the scientific knowledge generated from ecological, geographical, cultural, pharmacological, and chemical analysis, which constitutes the current research context of traditional medicine.

Plants of the genus Porophyllum (family Asteraceae) are native to the western hemisphere, growing in tropical and subtropical areas from North and South America [2][3][4][5][6][7]. It consists of 25 species [8], 17 of which are found in Mexico, with Guerrero, Morelos, Puebla, and Hidalgo, the main states of large-scale production [2].

These are annual or perennial plants that possess developed green leaves with aromatic glands and a strong flavour. Some of these species are grown in family gardens and are sometimes associated with tropical deciduous, sub-deciduous, sub-evergreen, evergreen, thorn, mesophyll mountain, oak, and pine forests [9][10][11].

Due to the strong flavour of its leaves, they are consumed in a fresh state or to spice some dishes, as well as being used as pesticides [1][12]. Mexican species, Porophyllum linaria (Cav.) DC. and Porophyllum ruderale (Jacq.) Cass. var. macrocephalum (DC.) R.R. Johnson. Known as ‘papalos’ or ‘papaloquelites’, particularly in central Mexico. Moreover, the infusions of some species of Porophyllum are used in traditional medicine because of activity against cramps and venereal diseases, as well as their antispasmodic, antibacterial, anti-inflammatory, antifungal, and insecticide properties, especially Porophyllum gracile Bent, P. linaria, Porophyllum obscurum (Spreng.) D.C., P. ruderale, Porophyllum tagetoides, Porophyllum scoparia A. Gray, and Porophyllum riedelli Baker [2][12].

2. Porophyllum Genus Compounds and Pharmacological Activities

Although current ethnopharmacological investigations of traditional medicines have achieved important contributions to plant-derived medicines, as well as the advancement of pharmacology, drug discovery from medicinal flora is more complex than is generally recognized because plants are applied for different therapeutic indications within and between cultures [13][14][15][16][17][18][19][20][21].

Many plants of the genus Porophyllum have been used in folk medicine as remedies to treat a wide variety of human pathologies, particularly those related to digestive disorders. Of all the known species of this genus, the specie P. ruderale is the most investigated, however, there are few studies focused on the pharmacological activity of its compounds.

In vitro and in vivo studies performed with the purified extracts and compounds of these plants support most of their reported uses in folk medicine for the treatment of a wide variety of pathological conditions, including its use as an antifungal agent and insecticide [4][22][23][24][25][26]. In addition, some studies in animals have shown antinociceptive properties for some of the pure constituents of these plants [4]. It is important to mention that there are very few studies on its toxicity, which indicates that plants of this genus are well tolerated for human consumption.

The compounds of the Porophyllum genus have been of great interest due to the large number of biological activities they present [27]. In plants, these compounds fulfil chemical defence functions against environmental stress, as well as wound and injury repair mechanisms. The compounds present in the genus have been evaluated for their antibacterial and insecticidal activities [22][28][24][25][26][29][30][31][32]. This effects could be mediated by the activation of the Mucosal-associated invariant T (MAIT) cells in charge of recognizing the antigens sent by non-polymorphic MR1, MAIT cells are activated by a metabolic precursor of riboflavin (present in the genus Porophyllum) synthesis presented by MR1 and, therefore, respond to many bacteria and some fungi. Despite their broad antibacterial properties, their functional role in persistent viral infections is poorly understood, and several studies have reported that MAIT cells recognize only bacterial- and yeast-derived antigens presented via MR1 and that they do not have antiviral specificity [2][33][34]. There is accumulating evidence suggesting that terpene compounds like myrcene, limonene, linalool and caryophyllene are a promising target for use as real alternatives that can be applied in vector-borne disease control programs, for their considerable potential as repellents and larvicides, their low level of toxicity to mammals, and their limited environmental impact [26]. In the study carried out by Fontes-Jr et al. [24], it was found that the larvae of A. aegypti were susceptible to the composition of essential oil from the flowers and leaves of P. ruderale; the main compounds identified in the oil were (E)-β-ocimeno (93.95%), myrcene (3.37%), (Z)-β-ocimeno (1.38%), and β-pinene (0.27%). The responsibility of this biological activity has been studied, showing that the lipophilicity of monoterpene compounds is related to the production of neurotoxic intoxication, in addition to the fact that components of essential oils act to block octopamine receptors, producing serious neurological alterations with harmful effects on insects [31] octopamine and tyramine are distinguished by the presence or absence of a hydroxyl group at the β position [32]. These structurally closely-related amines regulate intracellular cAMP levels in opposite directions, i.e., up and down regulation, by acting on different G protein-coupled receptors. Based on the evaluation of compounds for endocrine disruptor activity using a reporter gene assay, three-dimensional quantitative structure activity relationships were analysed to elicit responses through androgen receptors [35]. Therefore, findings regarding the structures of the binding sites of natural biomolecules, such as terpene compounds found in the Porophyllum genus, would be useful to design new insecticidal molecules with a novel mode of action in addition to lower production cost and effective insecticidal activity.

Other monoterpenic compound of pharmacological importance is α-terpineol, whose antihypertensive activity has been studied, mainly mediated by the release of Nitric Oxide (NO) and the subsequent activation of the NO-cGMP pathway (cyclic guanosine 3′,5′-monophosphate). This activity is linked to a reduction in calcium influx that occurs through voltage sensitive CavL channels, resulting in a decrease in vascular resistance attributed to α-terpineol that leads to the induction of hypotension [36].

Regarding antinociceptive activity, monoterpenic compounds have been identified to produce significant analgesic effects in formalin and writhing tests, which are related to the inhibition of PGE2 and PGF2α levels in the peritoneal fluid and to the inhibition of the release of substance P and other inflammatory molecules. However, the activity of these compounds has also been linked to a selective inhibition of COX-2 (0.69 mM), so this type of compound could potentially be used in the development of new drugs for the treatment of diseases painful and/or inflammatory [37]. Thiophenes are a class of heterocyclic compounds that contain sulphur and are found in both natural and synthetic products, displaying several different pharmacological properties, including anti-inflammatory, antiulcer [38], antimicrobial [39], antifungal [40], and anticancer [41] effects. Natural thiophenes are characteristic secondary metabolites of plants belonging to the Asteraceae family, among which Porophyllum is a genus [42]. The interest in the bioactivity of these compounds is due to their properties that can be developed synthetically or used naturally for the design of new drugs, using thiophenes as raw material.

These compounds have not yet been thoroughly studied, specifically the mechanisms of action of the pharmacological activities attributed to them, however, some authors such as Takahashi et al. [28][43] have shown that the extract in dichloromethane from aerial parts of P. ruderale exhibit strong activity against L. amazonensis, making it a potent antileishmanial compound. Those responsible for these pharmacological activities were bithiophenes and terthiophenes, whose biocidal activities were attributed primarily to the decrease in mitochondrial membrane potential in promastigotes [44].

Conversely, it was observed that treatment with a hexane extract of the aerial parts of P. obscurum (PoHex) showed photosensitive activity against a panel of twenty-five Candida strains isolated from patients with head and neck cancer undergoing radiotherapy with MFC values between 0.98 and 1.95 µg/mL, which were resistant to multiple drugs [11]. The mechanism of the antifungal activity of the thiophenes contained in PoHex can be classified as photodynamic, considering that thiophenes are excellent producers of singlet oxygen but are not precursors in electron transfer reactions, understanding that oxygen singlets have high chemical reactivity, which leads to rapid death in microorganisms and in lower concentrations than other biocides, in addition to not affecting nearby cells or organs [45].

Terthiophenes present in this genus have also been associated with HIV-1 protease inhibitory activities with an IC50 value of 58 µM, but did not show any activity towards HIV-1 integrase [46].

Among these effects, its anticancer activity has been highlighted, which has been linked to the induction of cell death by apoptosis, through an increase in the activity of caspase 3 and in the expression levels of the apoptotic proteins Bak and Bim, as well as a decrease in the antiapoptotic proteins Bcl-2 and Bcl-xL. On the other hand, it has been seen that these compounds cause a blockage of the cell cycle in the G2/M phase, decreasing the expression of the regulatory proteins of this phase, cyclins A and b1 and the kinase Cdk1 [47].

3. Conclusions

The genus Porophyllum represents one of the most widely used pre-Hispanic species in traditional medicine for the treatment of various diseases. The data presented here show the great potential represented by the compounds contained in their different species. Important pharmacological activities of isolated Porophyllum compounds has been found. Those compounds can be used in the synthesis of some phytopharmaceuticals, including terpenic and azufraid compounds, such as thiophenes, which may even develop synergism among the compounds containing these plants and increase their pharmacological potency. However, a great deal of information remains to be discovered about the mechanisms of action of these molecules, as well as preclinical studies that check these gender and its compounds could be safely used as treatments for different pathologies.

 

References

  1. Alonso-Castro, A.J.; Domínguez, F.; Maldonado-Miranda, J.J.; Castillo-Pérez, L.J.; Carranza-Álvarez, C.; Solano, E.; Isiordia-Espinoza, M.A.; Juárez-Vázquez, M.C.; Zapata-Morales, J.R.; Argueta-Fuertes, M.A.; et al. Use of medicinal plants by health professionals in Mexico. J. Ethnopharmacol. 2017, 198.
  2. Castro Lara, D.; Bye Boettler, R.A.; Mera Ovando, L.M. Diagnóstico del pápaloquelite en México, 1st ed.; Universidad Autónoma Chapingo: Chapingo, Mexico, 2011; pp. 1–47. ISBN 978-607-12-0199-7.
  3. Moreno-Salazar, S.F.; Robles-Zepeda, R.E.; Johnson, D.E. Plant folk medicines for gastrointestinal disorders among the main tribes of Sonora, Mexico. Fitoterapia 2008, 79, 132–141.
  4. Lima, G.M.; Silva, M.R.; Bonfim, R.R.; Thomazzi, S.M.; Santos, M.R.V.; Quintans-Júnior, L.J.; Bonjardim, L.R.; Araújo, A.A.S. Assessment of antinociceptive and anti- inflammatory activities of Porophyllum ruderale aqueous extract. Braz. J. Pharm. 2011, 21, 486–490.
  5. Juárez, Z.N.; Hernández, L.R.; Bach, H.; Sánchez-Arreola, E.; Bach, H. Antifungal activity of essential oils extracted from Agastache mexicana ssp. xolocotziana and Porophyllum linaria against post-harvest pathogens. Ind. Crop. Prod. 2015, 74, 178–182.
  6. García de Alba García, J.E.; Ramírez Hernández, B.C.; Robles Arellano, G.; Zañudo Hernández, J.; Salcedo Rocha, A.L.; García de Alba Verduzco, J.E. Conocimiento y uso de las plantas medicinales en la zona metropolitana de Guadalajara. RAS 2012, 39, 29–44.
  7. Urióstegui-Flores, A. Hierbas medicinales utilizadas en la atención de enfermedades del sistema digestivo en la ciudad de Taxco, Guerrero, México. Rev. Salud Pública 2015, 17, 85–96.
  8. Strother, J.L. Porophyllum. In Flora of North America, North of Mexico; Editorial Committee, Ed.; Oxford University Press: New York, NY, USA, 2007; p. 233235.
  9. Milan, P.; Hayashi, A.H.; Appezzato-da-Glória, B. Appezzato-da-Glória, B. Comparative leaf morphology and anatomy of three Asteraceae species. Braz. Arch. Biol. Technol. 2006, 49, 135–144.
  10. Mattana, C.; Satorres, S.; Alcaráz, L.; Petenatti, E.; del Vitto, L.; Petenatti, M.; Laciar, A. Evaluation of the antibacterial properties of extracts obtained from native Porophyllum lanceolatum in San Luis, Argentina. PhOL 2012, 3, 162–166.
  11. Postigo, A.; Funes, M.; Petenatti, E.; Bottai, H.; Pacciaroni, A.; Sortino, M. Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity. Photodiagnosis Photodyn. Ther. 2017, 20, 263–272.
  12. Estrada, A.S.; Ortiz, E.; Villaseñor, J.L.; Espinosa-García, F.J. The distribution of cultivated species of Porophyllum (Asteraceae) and their wild relatives under climate change. Syst. Biodivers. 2016, 14, 1–11.
  13. Andrade-Cetto, A. Ethnobotanical study of the medicinal plants from Tlanchinol, Hidalgo, México. J. Ethnopharmacol. 2009, 122, 163–171.
  14. Clement, Y.N.; Williams, A.F.; Khan, K.; Bernard, T.; Bhola, S.; Fortuné, M.; Medupe, O.; Nagee, K.; Seaforth, C.E. A gap between acceptance and knowledge of herbal remedies by physicians: The need for educational intervention. BMC Complement. Altern. Med. 2005, 5, 1–9.
  15. Chen, S.L.; Yu, H.; Luo, H.M.; Wu, Q.; Li, C.F.; Steinmetz, A. Conservation and sustainable use of medicinal plants: Problems, progress, and prospects. Chin. Med. 2016, 11, 1–10.
  16. Uniyal, S.K.; Singh, K.N.; Jamwal, P.; Lal, B. Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya. J. Ethnobiol. Ethnomed. 2006, 2, 1–8.
  17. Alves, R.R.N.; Rosa, I.M.L. Biodiversity, traditional medicine and public health: Where do they meet? J. Ethnobiol. Ethnomed. 2007, 3, 1–9.
  18. Maroyi, A. Traditional use of medicinal plants in south-central Zimbabwe: Review and perspectives. J. Ethnobiol. Ethnomed. 2013, 31, 1–18.
  19. Soria, N.; Ramos, P. Uso de plantas medicinales en la atención primaria de salud en Paraguay: Algunas consideraciones para su uso seguro y eficaz. Mem. Inst. Investig. Cienc. Salud 2015, 13, 8–17.
  20. Soria, N. Las Plantas Medicinales y su aplicación en la Salud Pública. Rev. Salud Publica Parag. 2018, 8, 7–8.
  21. Gallegos-Zurita, M. Las plantas medicinales: Principal alternativa para el cuidado de la salud, en la población rural de Babahoyo, Ecuador. Anales de la Facultad de Medicina 2016, 77, 327–332.
  22. Guillet, G.; Bélanger, A.; Arnason, J.T. Volatile monoterpenes in Porophyllum gracile and P. ruderale (Asteraceae): Identification, localization and insecticidal synergism with α-Terthienyl. Phytochemistry 1998, 49, 423–429.
  23. Hernández-Cruz, J.; Luna-Cruz, A.; Loera-Alvarado, E.; Villanueva-Sánchez, E.; Landero-Valenzuela, N.; Zárate-Nicolás, B.H.; Diego-Nava, F.; Granados-Echegoyen, C.A. Effiiency of the essential oil of Porophyllum linaria (Asteraceae) a Mexican Endemic Plant Against Sitophilus zeamais (Coleoptera: Curculionidae). J. Insect Sci. 2019, 20, 1–9.
  24. Fontes, U.R., Jr.; Ramos, C.S.; Serafini, M.R.; Cavalcanti, S.C.H.; Alves, P.B.; Lima, G.M.; Andrade, P.H.S.; Bonjardim, L.R.; Quintans, L.J., Jr.; Araújo, A.A.S. Evaluation of the lethality of Porophyllum ruderale essential oil against Biomphalaria glabrata, Aedes aegypti and Artemia salina. Afr. J. Biotechnol. 2012, 11, 3169–3172.
  25. Chantraine, J.M.; Dominique, L.; Ballivian, C.; Saavedra, G.; Ibañez, R.; Vilaseca, L.A. Insecticidal Activity of Essential Oils on Aedes aegypti Larvae. Phytother. Res. 1998, 12, 350–354.
  26. Andrade-Ochoa, S.; Sánchez-Torres, L.E.; Nevárez-Moorillón, G.V.; Camacho, A.D.; Nogueda-Torres, B. Aceites esenciales y sus componentes como una alternativa en el control de mosquitos vectores de enfermedades. Biomédica 2017, 37, 224–243.
  27. Sultana, N.; Saify, Z.S. Enzymatic biotransformation of terpenes as bioactive agents. J. Enzym. Inhib. Med. Chem. 2012, 28, 1113–1128.
  28. Takahashi, H.T.; Novello, C.R.; Ueda-Nakamura, T.; Filho, B.P.; Palazzo de Mello, J.C.; Nakamura, C.V. Thiophene derivatives with antileishmanial activity isolated from aerial parts of Porophyllum ruderale (Jacq.) Cass. Molecules 2011, 16, 3469–3478.
  29. Isman, M.B. Botanical insecticides, deterrents, and repellents in modern agriculture and an increasingly regulated world. Annu. Rev. Entomol. 2006, 51, 45–66.
  30. Dambolena, J.S.; Zunino, M.P.; Herrera, J.M.; Pizzolitto, R.P.; Areco, V.A.; Zygadlo, J.A. Terpenes: Natural Products for Controlling Insects of Importance to Human health—A Structure-Activity Relationship Study. Psyche J. Entomol. 2016, 2, 1–17.
  31. Rattan, R.S. Mechanism of action of insecticidal secondary metabolites of plant origin. Crop Prot. 2010, 29, 913–920.
  32. Huang, J.; Hamasaki, T.; Ozoe, F.; Ohta, H.; Enomoto, K.; Kataoka, H.; Sawa, Y.; Hirota, A.; Ozoe, Y. Identification of Critical Structural Determinants Responsible or Octopamine Binding to the α-Adrenergic-like Bombyx mori Octopamine Receptor. Biochemistry 2007, 46, 5896–5903.
  33. Le Bourhis, L.; Martin, E.; Péguillet, I.; Guihot, A.; Froux, N.; Coré, M.; Lévy, E.; Dusseaux, M.; Meyssonier, V.; Premel, V.; et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat. Immunol. 2010, 11, 701–708.
  34. Gold, M.; Cerri, S.; Smyk-Pearson, S.; Cansler, M.; Vogt, T.; Delepine, J.; Winata, E.; Swarbrick, G.; Chua, W.; Yu, Y.; et al. Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells. PLoS Biol. 2010, 8, e1000407.
  35. Mniff, W.; Hassine, A.I.; Bouaziz, A.; Bartegi, A.; Thomas, O.; Roig, B. Effect of endocrine disruptor pesticides: A review. Int. J. Environ. Res. Public Health 2011, 8, 2265–2303.
  36. Sabino, C.K.; Fereira-Filho, E.S.; Mendes, M.; da Silva-Filho, J.C.; Ponte, M.; Moura, L.; Oliveira, E.; Quintans-Junior, L.J.; dos Santos, M.; Oliveira, R.; et al. Cardiovascular effects induced by α-terpineol in hypertensive rats. Flavour Fragr. J. 2013, 28, 333–339.
  37. Quintans-Junior, L.; Oliveira, M.; Santana, M.; Santana, M.; Guimaraes, A.; Siqueira, J.; de Sousa, P.; Almeida, R. α-Terpineol reduces nociceptive behavior in mice. Pharm. Biol. 2011, 49, 583–586.
  38. Mohareb, R.M.; Zaki, M.Y.; Abbas, N.S. Synthesis, anti-inflammatory and anti-ulcer evaluations of thiazole, thiophene, pyridine and pyran derivatives derived from androstenedione. Steroids 2015, 98, 80–91.
  39. Mabkhot, Y.N.; Alatibi, F.; El-Sayed, N.N.E.; Al-Showiman, S.; Kheder, N.A.; Wadood, A.; Rauf, A.; Bawazeer, S.; Hadda, T.B. Antimicrobial Activity of Some Novel Armed Thiophene Derivatives and Petra/Osiris/Molinspiration (POM) Analyses. Molecules 2016, 21, 222.
  40. Mendonça Junior, F.J.B.; Lima-Neto, R.G.; Oliveira, T.B.; Lima, M.; Pitta, I.; Galdino, S.L.; Cruz, R.M.D.; Neves, R.P. Synthesis and Evaluation of the Antifungal Activity of 2-(Substituted-Amino)-4,5-Dialkyl-Thiophene-3-Carbonitrile Derivatives. Lat. Am. J. Pharm. 2011, 30, 1492–1499.
  41. Romagnoli, R.; Baraldi, P.G.; Salvador, M.K.; Preti, D.; Tabrizi, M.A.; Bassetto, M.; Brancale, A.; Hamel, E.; Castagliuolo, I.; Bortolozzi, R.; et al. Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno [2,3-b]pyridines as New Potent Anticancer Agents. J. Med. Chem. 2013, 56, 2606–2618.
  42. Gil, A.; Ghersa, C.M.; Perelman, S. Root thiophenes in Tagetes minuta L. accessions from Argentina: Genetic and Environmental contribution to changes in concentration and composition. Biochem. Syst. Ecol. 2002, 30, 1–13.
  43. Melo, M.S.; Sena, L.C.S.; Barreto, F.J.N.; Bonjardim, L.R.; Almeida, J.R.G.S.; Lima, J.T.; de Sousa, D.P.; Quintans-Júnior, L.J. Antinociceptive effects of citronellal in mice. Pharm. Biol. 2010, 48, 411–416.
  44. Van Hellemond, J.J.; Opperdoes, F.R.; Tielens, A.G. The extraordinary mitochondrion and unusual citric acid cycle in Trypanosoma brucei. Biochem. Soc. Trans. 2005, 33, 967–971.
  45. Wainwright, M.; Maisch, T.; Nonell, S.; Plaetzer, K.; Almeida, A.; Tegos, G.P.; Hamblin, M.R. Photoantimicrobials—Are we afraid of the light? Lancet Infect. Dis. 2016, 17, e49–e55.
  46. Tewtrakul, S.; Subhadhirasakul, S.; Cheenpracha, S.; Karalai, C. HIV-1 Protease and HIV-1 Integrase inhibitory substances from Eclipta prostrata. Phytother. Res. 2007, 21, 1092–1095.
  47. Pistritto, G.; Trisciuoglio, D.; Ceci, C.; Garufi, A.; D’Orazi, G. Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging 2016, 8, 603–619.
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