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Topic Review
Wild Edible Native Plants of Chile
Locally available WEPs edible plants; plant genetic resources; traditional knowledge(Wild Edible Native Plants) can provide consumers with a more diverse range of nutritionally high-quality compounds. They can be a source of energy, fibre and micronutrients and offer a large spectrum of phytochemicals such as phenols, tannins, flavones, terpenoids, polysaccharides, steroids, saponins and alkaloids.
  • 1.5K
  • 08 Apr 2022
Topic Review
Photosynthesis and Rubisco: An Evolutionary Perspective
When oxygenic photosynthesis evolved around 2.4 billion years ago, it is believed that all the oxygen-evolving organisms used the ribulose bisphosphate carboxylase-oxygenase (Rubisco)- photosynthetic carbon reduction cycle (PCRC) despite there being five other major CO2 assimilation pathways. Rubisco-PCRC was dominant, with the highest specific activity in presence of carbon dioxide at high concentrations without the presence of oxygen. 
  • 1.5K
  • 13 Apr 2022
Topic Review
Optical Coherence Tomography in Myopia and Pathologic Myopia
Myopia represents a growing and significantly global public health problem, with a prevalence of over two billion people (28.3% of the global population), including 277 million individuals (4.0%) with high myopia. Pathologic myopia is defined by the presence of myopic lesions in the posterior segment of the eye (posterior staphyloma or myopic maculopathy equal to or more serious than diffuse choroidal atrophy). Advances in imaging with optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) technology, including the development of swept source OCT/OCTA, widefield or ultra-widefield systems, have greatly improved the understanding, diagnosis, and treatment of myopia and myopia-related complications.
  • 1.5K
  • 17 Jun 2022
Topic Review
Hybrid Blockchains
A hybrid blockchain is often advocated where multiple parties, trust, data access management and sharing, friction, regulations and a combination of centralization and decentralization is involved. A hybrid blockchain is also used by entities that need the benefits of both the public and private characteristics, which can be achieved using Interchain, bridges or other interoperability solutions between legacy systems and blockchains, both public or private. Private, public, consortium and permissioned blockchains all have their own setbacks and benefits. Entities that do not want to expose sensitive business data to the internet are limited to private blockchains. Entities looking for no access restrictions at all can leverage public blockchains like Bitcoin or Ethereum. The hybrid blockchain ensures sensitive business data stays private on business nodes unless permitted. It also validates the hash of the private transactions through consensus algorithms and even public checkpoints such as Bitcoin and Ethereum. Through Interchain, the hash of a private transaction can be placed on the Bitcoin network or any other public blockchain such as Ethereum, making an immutable record of the event with the benefit of a public blockchain’s hash power.
  • 1.5K
  • 11 Oct 2022
Topic Review
Progressive Utilization Theory
Progressive Utilization Theory (PROUT) is a socioeconomic and political theory created by the Indian philosopher and spiritual leader Prabhat Ranjan Sarkar. Sarkar conceived of PROUT in 1959. Supporters of PROUT (Proutists) claim that the theory exposes and overcomes the limitations of both capitalism and communism. It aims to be economically progressive and improve social development. The theory is in line with Sarkar's Neohumanist values which aim to provide "proper care" to every being on the planet, including humans, animals and plants.
  • 1.5K
  • 20 Nov 2022
Topic Review Video Peer Reviewed
Employment Effect of Minimum Wages
The effect of minimum wages on employment is a mature, continuously researched topic. This study discusses the core theoretical approaches on the relationship between the minimum wage and employment, which is reflected by the empirical results from the international literature. Moreover, it presents the findings of the most recent research and the results of meta-analyses of this issue. While the theoretical approaches and outcomes of empirical studies vary, the meta-analysis demonstrates the lack of a significant correlation between minimum wages and employment. In light of the latest developments and meta-regressions, the literature does not provide a clear and definite sign of the relationship, but the trend seems to be driven towards a negative direction of the impact for the more sensitive groups. Therefore, further light needs to be shed onto this issue.
  • 1.5K
  • 30 Nov 2022
Topic Review
Polyphenols against Dry Eye Disease
Dry eye disease is a multifactorial pathology compromising the quality of life of patients, resulting in significant damage of the ocular surface and discomfort. The current therapeutical strategies are not able to definitively resolve the underlying causes and stop the symptoms. Polyphenols are promising natural molecules that are receiving increasing attention for their activity/effects in counteracting the main pathologic mechanisms of dry eye disease and reducing its symptoms.
  • 1.5K
  • 27 Feb 2021
Topic Review
Iron Oxide Nanoparticles in Biomedicine
Iron oxides are common natural compounds and can also easily be synthesized in the laboratory. There are 16 iron oxides, including oxides, hydroxides and oxide-hydroxides. These minerals are a result of aqueous reactions under various redox and pH conditions. They have the basic composition of Fe,O, and/or OH, but differ in the valency of iron and overall crystal structure. Some of the important iron oxides are goethite, akaganeite, lepidocrocite, magnetite and hematite.  Iron oxide (IO) nanoparticles consist of maghemite (y-Fe2O3) and/or magnetite (Fe3O4) particles with diameters ranging from 1 and 100 nanometer and find applications in magnetic data storage, biosensing, drug-delivery, etc. In nanoparticles (NPs), the surface area to volume ratio increases significantly. This allows a considerably higher binding capacity and excelent dispersibility of NPs in solutions. Magnetic NPs, with sizes between 2 and 20 nm display superparamagnetism, i.e. their magnetization is zero, in the absence of an external magnetic field and they can be magnetized by an extermal magnetic source. This property provides additional stability for magnetic nanparticles in solutions.  Because of their magnetic and superparamagnetic properties, iron oxide nanoparticles (IONPs) have many potential applications for medical use. The synthesis of these NPs has been the basis of many studies, each proposing different synthesis methods yielding nanostructures of different properties. The chemical, physical and magnetic properties of these nanostructures are examined to determine their possible application in mgnetic resonance imaging (MRI), contrast enhancement and thermal activation therapy. NPs characterization and demonstration of their potential uses pave  the way to the development of smart magnetic IONPs for targeted diagnostics and therapeutics of human diseases, including cancer and Alzheimer’s disease. Using the proprietary monoloyer polymer coating strategy, hydrophobic, organic ligand-coated IONPs have successfully been converted into water soluble, bio-accessible IONPs. Recent enhancement in the quality of both organic and water soluble IONPs opens avenues of opportunities for development of IO nanoparticles based applications, for example:  ·         As contrast agents for magnetic resonance imaging (MRI)  ·         As drug carriers for target specific drug delivery  ·         As gene carriers for gene therapy ·         As therapeutic agents for hyperthermia based cancer treatments ·         As magnetic sensing probes for in-vitro diagnostics (IVD) ·         As nanoadjuvant for vaccine and antibody production.  This growing portfolio of magnetic NPs excited us to offer a brief review on the biologically compatible IONPs synthesized by electrochemical deposition, and their potential use in biomedical application. 
  • 1.5K
  • 21 Jan 2021
Topic Review
Developing Edible Starch Film Used for Packaging Seasonings
Edible starch-based film was developed for packaging seasoning applied in instant noodles. The edible film can quickly dissolve into hot water so that the seasoning bag can mix in the soup of instant noodles during preparation.
  • 1.5K
  • 11 Jan 2022
Topic Review
Sentinel Lymph Node Biopsy Techniques in Endometrial Cancer
Lymph node status is important in predicting the prognosis and guiding adjuvant treatment in endometrial cancer. However, previous studies showed that systematic lymphadenectomy conferred no therapeutic values in clinically early-stage endometrial cancer but might lead to substantial morbidity and impact on the quality of life of the patients. The sentinel lymph node is the first lymph node that tumor cells drain to, and sentinel lymph node biopsy has emerged as an acceptable alternative to full lymphadenectomy in both low-risk and high-risk endometrial cancer.
  • 1.5K
  • 23 Nov 2022
Topic Review
Development of Schwann Cells
Schwann cells are glial cells of the peripheral nervous system. They exist in several subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are interesting for applications ranging from disease modeling to tissue engineering. Since primary human Schwann cells are challenging to obtain in large quantities, in vitro differentiation from other cell types presents an alternative. To achieve differentiation of Schwann cells from stem cell sources in vitro, cultures are manipulated using molecular factors to emulate developmental signaling events which lead to development of Schwann cells in vivo. Therefore, knowledge of molecular determinants in embryonal development of the Schwann cell fate is key to develop and refine in vitro differentiation protocols.
  • 1.5K
  • 05 Dec 2022
Topic Review
Verticillium Dahliae MAT1-1&MAT1-2
Verticillium dahliae is a soil-borne plant pathogenic fungus that causes Verticillium wilt on hundreds of dicotyledonous plant species. V. dahliae is considered an asexually (clonal) reproducing fungus, although both mating type idiomorphs (MAT1-1 and MAT1-2) are present, and is heterothallic. Most of the available information on V. dahliae strains, including their biology, pathology, and genomics comes from studies on isolates with the MAT1-2 idiomorph, and thus little information is available on the MAT1-1 V. dahliae strains in the literature. We therefore evaluated the growth responses of MAT1-1 and MAT1-2 V. dahliae strains to various stimuli. Growth rates and melanin production in response to increased temperature, alkaline pH, light, and H2O2 stress were higher in the MAT1-2 strains than in the MAT1-1 strains. In addition, the MAT1-2 strains showed an enhanced ability to degrade complex polysaccharides, especially starch, pectin, and cellulose. Furthermore, several MAT1-2 strains from both potato and sunflower showed increased virulence on their original hosts, relative to their MAT1-1 counterparts. Thus, compared to MAT1-1 strains, MAT1-2 strains derive their potentially greater fitness from an increased capacity to adapt to their environment and exhibit higher virulence. These competitive advantages might explain the current abundance of MAT1-2 strains relative to MAT1-1 strains in the agricultural and sylvicultural ecosystems, and this study provides the baseline information on the two mating idiomorphs to study sexual reproduction in V. dahliae under natural and laboratory conditions. 
  • 1.5K
  • 21 Jul 2021
Topic Review
Healthy Residential Buildings
Healthy residential buildings represent the future of construction concerned with the environment, which is increasingly emphasized. This is directly related to the research and development of environmentally friendly building materials, which on the one hand meet the specific requirements of the builder, and on the other hand do not harm the environment. It has possibility of achieving increased variability in healthy residential buildings via the customization of recycled polyvinyl butyral using smart technologies for sustainable design. 
  • 1.5K
  • 09 Sep 2021
Topic Review
Berberis lycium
Study of reproductive biology and pollination ecology helps in understanding the life history patterns of species. Such a study brings to light the bottlenecks, if any, on account of which the individuals of the species are not able to reproduce in nature and ultimately helps in planning appropriate conservation strategies for the species under threat. The present study was aimed at examining the morphological and reproductive variance in Berberis lycium, a threatened ecological specialist growing within shrubberies and open hillsides of the North-Western Himalayas in India. B. lycium displays three different variants. Flowering period ranges from February to September. Pollen viability as reported on fluorescein diacetate and acetocarmine treatments was highest for variant I, while maximum pollen output was obtained for variant III. Pollen pistil interaction is brought by the movement of anther towards stigma. Fluorescence microscopy of hand pollinated club shaped stigma shows that the germinating pollen form a ring over the receptive adaxial surface. Pollination syndrome is entomophily. Variant II attracts a significantly large number of pollinators from diverse insect families. Breeding experiments reflect that plants are self-compatible and cross fertile. Reproductive output (% fruit set) was highest for variant II followed by III and I, respectively. 
  • 1.5K
  • 15 Sep 2021
Topic Review
Thermochemical Cycle
Thermochemical cycles combine solely heat sources (thermo) with chemical reactions to split water into its hydrogen and oxygen components. The term cycle is used because aside of water, hydrogen and oxygen, the chemical compounds used in these processes are continuously recycled. If work is partially used as an input, the resulting thermochemical cycle is defined as a hybrid one.
  • 1.5K
  • 14 Oct 2022
Topic Review
Cosmetic Container
A cosmetic container is a fully enclosed object used to contain, store, and transport cosmetics. Cosmetics or cosmetic products are substances intended to enhance or preserve the human body's physical appearance or scent. Cosmetic containers are a deeper topic of cosmetic packaging, relating to ISO 22715. According to ISO, cosmetic containers are primary packaging. The container houses the actual product, while the outermost package is considered secondary packaging. These containers play important roles in both marketing and protecting the product.
  • 1.5K
  • 17 Oct 2022
Topic Review
Medical Entomology
The discipline of medical entomology, or public health entomology, and also veterinary entomology is focused upon insects and arthropods that impact human health. Veterinary entomology is included in this category, because many animal diseases can "jump species" and become a human health threat, for example, bovine encephalitis. Medical entomology also includes scientific research on the behavior, ecology, and epidemiology of arthropod disease vectors, and involves a tremendous outreach to the public, including local and state officials and other stake holders in the interest of public safety. Public health entomology has seen a huge surge in interest since 2005, due to the resurgence of the bed bug, Cimex lectularius.
  • 1.5K
  • 04 Nov 2022
Topic Review
Solar Compass
The solar compass, a surveying instrument that makes use of the sun's direction, was first invented and made by William Austin Burt. He patented it on February 25, 1836, in the United States Patent Office as No 9428X. It received a medal at the Great Exhibition of 1851.
  • 1.5K
  • 14 Nov 2022
Topic Review
Relationship of Human Endogenous Retroviruses and Human Cancers
Human endogenous retroviruses (HERVs), once external pathogens, now occupy more than 8% of the human genome and represent the merge of genomic and external factors leading to the development of cancers. Certain HERVs have perfectly assimilated into the cellular environment preventing oncogenesis, while others maintain their pathogenic potential and remain undercover until a time of cellular dysregulation. In particular, HERV genes such as gag, env, pol, np9, and rec have been discovered to carry central roles in immune regulation, checkpoint blockade, cell differentiation, cell fusion, proliferation, metastasis, and cell transformation in tumor environments. In addition, HERV long terminal repeat (LTR) regions have been shown to be involved in transcriptional regulation, creation of fusion proteins, expression of long non-coding RNAs (lncRNAs), and promotion of genome instability through recombination influencing oncogenesis.
  • 1.5K
  • 27 Mar 2023
Topic Review
Neurotensin and Neurotensin Receptors
The tridecapeptide neurotensin (NT) was isolated from the bovine hypothalamus. It is involved in gut motility and belongs to a family of bioactive peptides, including contulakin, xenopsin, LANT-6, and neuromedin, showing similar amino acid sequences at the C-terminal region; this sequence is essential for the physiological effects mediated by these peptides. Neurotensin is relevant in brain reward mechanisms. Its role in substance abuse needs to be explored in depth to open new therapeutic strategies.
  • 1.5K
  • 17 May 2023
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