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Topic Review
Enzyme Crosslinking Approaches for Bone Tissue Engineering
Crosslinking strategies have been extensively explored in order to design novel hydrogels for bone tissue engineering. Lately, the fabrication of hydrogels with the help of enzyme-mediated crosslinking approaches has been extensively explored. This approach has resulted in promising outcomes with convincing prospects. Enzymes are required in minimal quantity and are very efficient in their actions, as they increase the reaction rate without being expended during the course of the reaction process. The efficiency of an enzyme is defined by the number of substrate molecules converted into products per unit of enzyme, which is also known as turnover number (k cat). The high efficiency of enzyme-based reactions comes from the precise specificity, which ensures the conversion of a particular type of substrate to products. Many enzymes have been explored in order to prepare biomimetic hydrogels for bone tissue engineering. The details of every enzyme-based crosslinking approach are discussed in the following sections.
  • 1.5K
  • 11 Oct 2022
Topic Review
Soyuz TMA-19
Soyuz TMA-19 was a crewed spaceflight to the International Space Station (ISS) and is part of the Soyuz programme. It was launched on 15 June 2010 carrying three members of the Expedition 24 crew to the International Space Station, who remained aboard the station for around six months. Soyuz TMA-19 was the 106th crewed flight of a Soyuz spacecraft, since the first mission which was launched in 1967. The spacecraft remained docked to the space station for the remainder of Expedition 24, and for Expedition 25, to serve as an emergency escape vehicle. It undocked from ISS and landed in Kazakhstan on 26 November 2010. It was the 100th mission to be conducted as part of the International Space Station programme since assembly began in 1998.
  • 1.5K
  • 25 Nov 2022
Topic Review
Assessment of Nanomaterials’ Hemotoxicity
The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch of science, named nanotoxicology, which aims to study the dangerous effects of nanomaterials on human health and on the environment, has recently emerged. However, the toxicity and risk associated with nanomaterials are unclear or not completely understood. The development of an adequate experimental strategy for assessing the toxicity of nanomaterials may include a rapid/express method that will reliably, quickly, and cheaply make an initial assessment. One possibility is the characterization of the hemocompatibility of nanomaterials, which includes their hemolytic activity as a marker.
  • 1.5K
  • 13 Dec 2022
Topic Review
Methods for Protein Crystallization
Proteins are biopolymers consisting of amino acids linked by peptide bonds. A peptide bond is a type of amide bond that occurs during the formation of proteins and peptides as a result of the interaction of the α-amino group (-NH2) of one amino acid with the α-carboxyl group (-COOH) of another amino acid. The main method for determining the spatial structure of a protein is X-ray structural analysis of protein crystals. The main difficulty in applying this method is in obtaining a perfect protein-crystal. 
  • 1.5K
  • 28 Jan 2023
Topic Review
Lactic Acidosis’ Effect on Energy Metabolism
Lactic acidosis, a hallmark of solid tumour microenvironment, originates from lactate hyperproduction and its co-secretion with protons by cancer cells displaying the Warburg effect. Long considered a side effect of cancer metabolism, lactic acidosis is now known to play a major role in tumour physiology, aggressiveness and treatment efficiency. 
  • 1.5K
  • 07 Mar 2023
Topic Review
By-Products for the Agri-Food Industry
In Europe, around 31 million tonnes of food by-products are generated during primary production and trade. The management of these by-products may cause a negative impact, both at the economic and environmental levels, for both industry and society. In this regard, taking into consideration that these by-products retain the dietary fibre compositions and the bioactive compounds of the starting materials, plant food agro-industries have an interest in taking advantage of them, from a nutritional point of view. Using different extraction techniques they can be used as the source of insoluble and soluble dietary fibre, polyphenols, carotenoids, and other bioactive compounds.
  • 1.5K
  • 06 May 2023
Topic Review
Generating Interior Design from Text
Because interior design is subject to inefficiency, more creativity is imperative. Due to the development of artificial intelligence diffusion models, the utilization of text descriptions for the generation of creative designs has become a novel method for solving the aforementioned problem.
  • 1.5K
  • 15 Aug 2023
Topic Review
Air Cargo Logistics Industry in South Africa
The air cargo logistics industry is part of the services offered in the aviation sector. The industry fulfils a segment of the supply chain system for the seamless distribution of goods to meet consumers’ demands.
  • 1.5K
  • 04 Dec 2023
Topic Review
Therapeutic Antibodies Targeting Glycosylation
We generated a platform for designing optimized functional therapeutic antibodies against cancer glycans. The target tumor-associated carbohydrate antigen is commonly expressed in colon and pancreatic cancers. We developed a system for selection of potent antibodies by yeast surface display against this carbohydrate antigen, then showed that elite clones have potent affinity, specificity, cancer cell binding, and therapeutic efficacy. These tools have broad utility for manipulating and engineering antibodies against carbohydrate antigens, and provide major innovative avenues of research in the field of cancer therapy and diagnostics.
  • 1.5K
  • 20 Oct 2020
Topic Review
Gluten-Free Diet
The gluten-free diet (GFD) has gained increasing popularity in recent years, supported by marketing campaigns, media messages and social networks. Nevertheless, real knowledge of gluten and GF-related implications for health is still poor among the general population. The GFD has also been suggested for non-celiac gluten/wheat sensitivity (NCG/WS), a clinical entity characterized by intestinal and extraintestinal symptoms induced by gluten ingestion in the absence of celiac disease (CD) or wheat allergy (WA).
  • 1.5K
  • 29 Dec 2020
Topic Review
Bone Resorption
Bone resorption, the process by which bone is broken down to liberate products needed by the body’s metabolism, most prominently, but not exclusively, calcium, is incompletely understood.
  • 1.5K
  • 29 Jan 2022
Topic Review
Printed Humidity Sensors
Printing technologies have been attracting increasing interest in the manufacture of electronic devices and sensors. They offer a unique set of advantages such as additive material deposition and low to no material waste, digitally-controlled design and printing, elimination of multiple steps for device manufacturing, wide material compatibility and large scale production to name but a few.
  • 1.5K
  • 24 Feb 2021
Topic Review
Thermophotovoltaic Cell
Generally, waste heat is redundantly released into the surrounding by anthropogenic activities without strategized planning. Consequently, urban heat islands and global warming chronically increases over time. Thermophotovoltaic (TPV) systems can be potentially deployed to harvest waste heat and recuperate energy to tackle this global issue with supplementary generation of electrical energy.
  • 1.5K
  • 29 Nov 2021
Topic Review
Urban Ecosystem Models
Urban ecosystem services provide many benefits for human beings. Given the dramatic increase of urbanization, maintaining sustainability of cities relies heavily on ecosystem services, and it is crucial for quantifying, managing, and optimizing urban ecosystem services to promote social and ecological sustainable development. 
  • 1.5K
  • 22 Apr 2022
Topic Review
Tesla Turbine
The Tesla turbine is a bladeless centripetal flow turbine patented by Nikola Tesla in 1913. It is referred to as a bladeless turbine. The Tesla turbine is also known as the boundary-layer turbine, cohesion-type turbine, and Prandtl-layer turbine (after Ludwig Prandtl) because it uses the boundary-layer effect and not a fluid impinging upon the blades as in a conventional turbine. Bioengineering researchers have referred to it as a multiple-disk centrifugal pump. One of Tesla's desires for implementation of this turbine was for geothermal power, which was described in Our Future Motive Power.
  • 1.5K
  • 10 Oct 2022
Topic Review
Cancellation (Television)
In television, cancellation refers to the termination of a program by a network, typically because of low viewership, financial losses, low ratings, or unfavourable critical reviews. Other potential reasons for canceling television programs include controversies involving the program's cast, conflicts among the show's staff members or to make room for new programming. Shows whose runs end due to a mutual creative decision by its creators, producers, cast, and the network it airs on (such as Seinfeld, The Sopranos, or The Cosby Show) are not considered to be "cancelled" but rather "concluded" or "ended", with a special last episode called its series finale. Even so, programs that end their runs in this manner are sometimes incorrectly stated to have been cancelled, even if the program was renewed for a final season (such as with American Idol, by which the term was incorrectly applied upon the announcement of Fox, Fremantle Media and 19 Entertainment's decision to renew the show for a 15th and final season in May 2015 to air in 2016); shows that are cancelled traditionally end their runs during the television season in which the program airs first-run episodes at the time, either effective immediately after the announcement is made by the network or until all remaining episodes are broadcast. The Friday night death slot is a perceived graveyard slot in United States television, referring to the idea that a television program in the United States scheduled on Friday evenings is destined for imminent cancellation.
  • 1.5K
  • 14 Oct 2022
Topic Review
BlackBerry Enterprise Server
BlackBerry Enterprise Server designates the middleware software package that is part of the BlackBerry wireless platform supplied by BlackBerry Limited. The software and service connects to messaging and collaboration software (MDaemon Messaging Server, Microsoft Exchange, Lotus Domino, Novell GroupWise) on enterprise networks and redirects emails and synchronizes contacts and calendaring information between servers, desktop workstations, and mobile devices. Some third-party connectors exist, including Scalix, Zarafa, Zimbra, and the Google Apps BES Connector, although these are not supported by BlackBerry Limited. As of June 2018, BlackBerry Enterprise Server has been renamed to BlackBerry Unified Endpoint Manager (UEM).
  • 1.5K
  • 23 Nov 2022
Topic Review
Emotional Dysregulation
Emotional dysregulation is a term used in the mental health community that refers to emotional responses that are poorly modulated and do not lie within the accepted range of emotive response. Emotional dysregulation can be associated with an experience of early psychological trauma, brain injury, or chronic maltreatment (such as child abuse, child neglect, or institutional neglect/abuse), and associated disorders such as reactive attachment disorder. Emotional dysregulation may be present in people with psychiatric disorders such as attention deficit hyperactivity disorder, autism spectrum disorders, bipolar disorder, borderline personality disorder, complex post-traumatic stress disorder, and fetal alcohol spectrum disorders. In such cases as borderline personality disorder and complex post-traumatic stress disorder, hypersensitivity to emotional stimuli causes a slower return to a normal emotional state. This is manifested biologically by deficits in the frontal cortices of the brain. Possible manifestations of emotional dysregulation include extreme tearfulness, angry outbursts or behavioral outbursts such as destroying or throwing objects, aggression towards self or others, and threats to kill oneself. Emotional dysregulation can lead to behavioral problems and can interfere with a person's social interactions and relationships at home, in school, or at place of employment.
  • 1.5K
  • 25 Nov 2022
Topic Review
Phytoestrogens Definition and Origin
Phytoestrogens are literally estrogenic substances of plant origin. Although these substances are useful for plants in many aspects, their estrogenic properties are essentially relevant to their predators. As such, phytoestrogens can be considered to be substances potentially dedicated to plant–predator interaction.
  • 1.5K
  • 30 Jan 2023
Topic Review
Technology Transfer in the Industry 4.0 Era
Modern innovative models have the possibility of transferring research and development (R&D) output through technology transfer from scientific and research institutions or other enterprises. The complex process of technology transfer is significantly dependent on cooperation among academia, industry, and governments in response to the technological developments driven together through Industry 4.0 (I4.0). As a result, numerous technology transfer factors must be addressed for I4.0 to become a reality. However, the abundance of literature on I4.0 and associated technologies, the key ingredients, and insights for effectively executing I4.0 technology transfer are fairly limited.
  • 1.5K
  • 31 Jan 2023
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