Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Mathematical Modeling and Computational Tools in Drug Design
The conventional drug discovery approach is an expensive and time-consuming process, but its limitations have been overcome with the help of mathematical modeling and computational drug design approaches. Previously, finding a small molecular candidate as a drug against a disease was very costly and required a long time to screen a compound against a specific target. The development of novel targets and small molecular candidates against different diseases including emerging and reemerging diseases remains a major concern and necessitates the development of novel therapeutic targets as well as drug candidates as early as possible. In this regard, computational and mathematical modeling approaches for drug development are advantageous due to their fastest predictive ability and cost-effectiveness features. Computer-aided drug design (CADD) techniques utilize different computer programs as well as mathematics formulas to comprehend the interaction of a target and drugs. Traditional methods to determine small-molecule candidates as a drug have several limitations, but CADD utilizes novel methods that require little time and accurately predict a compound against a specific disease with minimal cost.
  • 6.6K
  • 01 Aug 2022
Topic Review
Congregation for the Doctrine of the Faith
The Congregation for the Doctrine of the Faith (Latin: Congregatio pro Doctrina Fidei; CDF) is the oldest among the nine congregations of the Roman Curia. It was founded to defend the church from heresy; today, it is the body responsible for promulgating and defending Catholic doctrine. Formerly known as the Supreme Sacred Congregation of the Roman and Universal Inquisition, it is informally known in many Catholic countries as the Holy Office, and between 1908 and 1965 was officially known as the Supreme Sacred Congregation of the Holy Office. Founded by Pope Paul III in 1542, the congregation's sole objective is to "spread sound Catholic doctrine and defend those points of Christian tradition which seem in danger because of new and unacceptable doctrines." Its headquarters are at the Palace of the Holy Office, just outside Vatican City. The congregation employs an advisory board including cardinals, bishops, priests, lay theologians, and canon lawyers. The current Prefect is Archbishop Luis Ladaria Ferrer, who was appointed by Pope Francis for a five-year term beginning July 2017.
  • 6.6K
  • 29 Sep 2022
Topic Review
Sulfate-Reducing Microorganisms
Sulfate-reducing microorganisms (SRM) or sulfate-reducing prokaryotes (SRP) are a group composed of sulfate-reducing bacteria (SRB) and sulfate-reducing archaea (SRA), both of which can perform anaerobic respiration utilizing sulfate (SO42–) as terminal electron acceptor, reducing it to hydrogen sulfide (H2S). Therefore, these sulfidogenic microorganisms "breathe" sulfate rather than molecular oxygen (O2), which is the terminal electron acceptor reduced to water (H2O) in aerobic respiration. Most sulfate-reducing microorganisms can also reduce some other oxidized inorganic sulfur compounds, such as sulfite (SO32–), dithionite (S2O42–), thiosulfate (S2O32–), trithionate (S3O62–), tetrathionate (S4O62−), elemental sulfur (S8), and polysulfides (Sn2−). Depending on the context, "sulfate-reducing microorganisms" can be used in a broader sense (including all species that can reduce any of these sulfur compounds) or in a narrower sense (including only species that reduce sulfate, and excluding strict thiosulfate and sulfur reducers, for example). Sulfate-reducing microorganisms can be traced back to 3.5 billion years ago and are considered to be among the oldest forms of microbes, having contributed to the sulfur cycle soon after life emerged on Earth. Many organisms reduce small amounts of sulfates in order to synthesize sulfur-containing cell components; this is known as assimilatory sulfate reduction. By contrast, the sulfate-reducing microorganisms considered here reduce sulfate in large amounts to obtain energy and expel the resulting sulfide as waste; this is known as dissimilatory sulfate reduction. They use sulfate as the terminal electron acceptor of their electron transport chain. Most of them are anaerobes; however, there are examples of sulfate-reducing microorganisms that are tolerant of oxygen, and some of them can even perform aerobic respiration. No growth is observed when oxygen is used as the electron acceptor. In addition, there are sulfate-reducing microorganisms that can also reduce other electron acceptors, such as fumarate, nitrate (NO3−), nitrite (NO2−), ferric iron [Fe(III)], and dimethyl sulfoxide. In terms of electron donor, this group contains both organotrophs and lithotrophs. The organotrophs oxidize organic compounds, such as carbohydrates, organic acids (e.g., formate, lactate, acetate, propionate, and butyrate), alcohols (methanol and ethanol), aliphatic hydrocarbons (including methane), and aromatic hydrocarbons (benzene, toluene, ethylbenzene, and xylene). The lithotrophs oxidize molecular hydrogen (H2), for which they compete with methanogens and acetogens in anaerobic conditions. Some sulfate-reducing microorganisms can directly utilize metallic iron [Fe(0)] as electron donor, oxidizing it to ferrous iron [Fe(II)].
  • 6.6K
  • 04 Nov 2022
Topic Review
Cost–Benefit Analysis for Road Infrastructure Projects
Cost–benefit analysis (CBA) is considered an effective evaluation method for fostering optimal decision-making and ranking of road infrastructures over decades. Eight distinct modelling categories used for CBA implementation were determined, each encompassing three different modelling approaches for capturing the data risk assessment (deterministic or probabilistic), CBA’s parameters interactive behavior (static or dynamic) and the considered economies (microeconomic or macroeconomic). In-depth content analysis led to the interpretation of the current status of extant models and the identification of three main knowledge gaps: the absence of the CBA’s inputs updating into a probabilistic environment, the deficiency of a dynamic interdependent framework and the necessity of homogenous cost datasets for road projects. Future research directions and a conceptual framework for modelling CBA into a microeconomic, probabilistic and dynamic environment are proposed providing decision-makers with new avenues for more reliable CBA modelling.
  • 6.6K
  • 29 Jan 2023
Topic Review
Brassicaceae Family
Brassicaceae family vegetables have an ample worldwide distribution, which can be found in all continents except Antarctica. One of the most striking features of this botanical family is the presence of several kinds of secondary metabolites with a distinctive taste, and also interesting bioactivities. The most deeply studied are the glucosinolates (GSL) and from their bioactive breakdown products, the isothiocyanates and the indoles. Moreover, these species are also rich and possess unique profiles of phenolic compounds, carotenoids, and other groups of less studied compounds such as phytoalexins, terpenes, phytosteroids, and tocopherols, here reviewed.
  • 6.6K
  • 29 Oct 2020
Topic Review
Visual Appearance of Oil
The visual appearance of oil spills at sea is often used as an indicator of spilled oil properties, state and slick thickness. These appearances and the oil properties that are associated with them are reviewed in this entry. The appearance of oil spills is an estimator of thickness of thin oil slicks, thinner than a rainbow sheen (<3 µm). Rainbow sheens have a strong physical explanation. Thicker oil slicks (e.g., >3 µm) are not correlated with a given oil appearance. At one time, the appearance of surface discharges from ships was thought to be correlated with discharge rate and vessel speed; however, this approach is now known to be incorrect. Oil on the sea can sometimes form water-in-oil emulsions, dependent on the properties of the oil, and these are often reddish in color. These can be detected visually, providing useful information on the state of the oil. Oil-in-water emulsions can be seen as a coffee-colored cloud below the water surface. Other information gleaned from the oil appearance includes coverage and distribution on the surface.
  • 6.6K
  • 27 Jan 2021
Topic Review
Mini-LED and Micro-LED
The mini-LEDs with chip sizes ranging from 100 to 200 μm have already been commercialized for backlight sources in consumer electronics applications. The realized local diming can greatly improve the contrast ratio at relatively low energy consumptions. The micro-LEDs with chip size less than 100 μm, still remain in the laboratory.
  • 6.6K
  • 24 Jun 2021
Topic Review
Music Psychology
Music psychology, or the psychology of music, may be regarded as a branch of both psychology and musicology. It aims to explain and understand musical behaviour and experience, including the processes through which music is perceived, created, responded to, and incorporated into everyday life. Modern music psychology is primarily empirical; its knowledge tends to advance on the basis of interpretations of data collected by systematic observation of and interaction with human participants. Music psychology is a field of research with practical relevance for many areas, including music performance, composition, education, criticism, and therapy, as well as investigations of human attitude, skill, performance, intelligence, creativity, and social behavior. Music psychology can shed light on non-psychological aspects of musicology and musical practice. For example, it contributes to music theory through investigations of the perception and computational modelling of musical structures such as melody, harmony, tonality, rhythm, meter, and form. Research in music history can benefit from systematic study of the history of musical syntax, or from psychological analyses of composers and compositions in relation to perceptual, affective, and social responses to their music.
  • 6.6K
  • 03 Nov 2022
Topic Review
Short-Faced Bear
The short-faced bear (Arctodus sp.) is an extinct bear genus that inhabited North America during the Pleistocene epoch from about 1.8 Mya until 11,000 years ago. It was the most common tremarctine bear in North America and many of its fossils have been found in the La Brea tar pits in southern California . There are two recognized species: the lesser short-faced bear (Arctodus pristinus) and the giant short-faced bear (Arctodus simus), with the latter considered to be one of the largest known terrestrial mammalian carnivores that has ever existed. It has been hypothesized that their extinction coincides with the Younger Dryas period of global cooling commencing around 10,900 BC.
  • 6.6K
  • 05 Nov 2022
Topic Review
Lithium-Ion Battery Fire Suppression
Lithium-ion Batteries (LiBs) hazards, techniques for mitigating risks, the suppression of LiB fires and identification of shortcomings for future improvement were thoroughly reviewed. Water is identified as an efficient cooling and suppressing agent and water mist is considered the most promising technique to extinguish LiBs fire. 
  • 6.6K
  • 29 Apr 2021
Topic Review
Herfindahl–Hirschman Index
The Herfindahl index (also known as Herfindahl–Hirschman Index, HHI, or sometimes HHI-score) is a measure of the size of firms in relation to the industry they are in and an indicator of the amount of competition among them. Named after economists Orris C. Herfindahl and Albert O. Hirschman, it is an economic concept widely applied in competition law, antitrust and also technology management. HHI is calculated by squaring the market share of each competing firm in the industry and then summing the resulting numbers,(sometimes limited to the 50 largest firms), where the market shares are expressed as fractions or points. The result is proportional to the average market share, weighted by market share. As such, it can range from 0 to 1.0, moving from a huge number of very small firms to a single monopolistic producer. Increases in the Herfindahl index generally indicate a decrease in competition and an increase of market power, whereas decreases indicate the opposite. Alternatively, if whole percentages are used, the index ranges from 0 to 10,000 "points". For example, an index of .25 is the same as 2,500 points. The major benefit of the Herfindahl index in relationship to such measures as the concentration ratio is that it gives more weight to larger firms. Other benefits of the Herfindahl index includes its simple calculation method and the small amount of easily obtainable data required for the calculation. The measure is essentially equivalent to the Simpson diversity index, which is a diversity index used in ecology; the inverse participation ratio (IPR) in physics; and the effective number of parties index in politics.
  • 6.6K
  • 24 Oct 2022
Topic Review
Science, Technology, Society and Environment Education
Science, technology, society and environment (STSE) education, originates from the science technology and society (STS) movement in science education. This is an outlook on science education that emphasizes the teaching of scientific and technological developments in their cultural, economic, social and political contexts. In this view of science education, students are encouraged to engage in issues pertaining to the impact of science on everyday life and make responsible decisions about how to address such issues (Solomon, 1993 and Aikenhead, 1994)
  • 6.6K
  • 20 Oct 2022
Topic Review
siRNA Structure, Function and Delivery
siRNA is a double-stranded RNA molecule with 21- and 22-nucleotide generated by ribonuclease III cleavage from longer double-stranded RNA (dsRNAs). After binding to the RNA-induced silencing complex (RISC) in the cytoplasm, the sense strand of siRNA undergoes ejection, while the antisense strand of siRNA targets the complementary messenger RNA (mRNA). 
  • 6.6K
  • 20 May 2022
Topic Review
Li7La3Zr2O12 (LLZO): An Overview
Li7La3Zr2O12 (LLZO) is an inorganic garnet type solid electrolyte which has proven to be one of the most promising electrolytes because of its high ionic conductivity at room temperature, low activation energy, good chemical and electrochemical stability, and wide potential window.
  • 6.6K
  • 03 Aug 2021
Topic Review Peer Reviewed
Solar Chimney Applications in Buildings
A solar chimney is a renewable energy system used to enhance the natural ventilation in a building based on solar and wind energy. It is one of the most representative solar-assisted passive ventilation systems attached to the building envelope. It performs exceptionally in enhancing natural ventilation and improving thermal comfort under certain climate conditions. The ventilation enhancement of solar chimneys has been widely studied numerically and experimentally. The assessment of solar chimney systems based on buoyancy ventilation relies heavily on the natural environment, experimental environment, and performance prediction methods, bringing great difficulties to quantitative analysis and parameterization research. With the increase in volume and complexity of modern building structures, current studies of solar chimneys have not yet obtained a unified design strategy and corresponding guidance. Meanwhile, combining a solar chimney with other passive ventilation systems has attracted much attention. The solar chimney-based integrated passive-assisted ventilation systems prolong the service life of an independent system and strengthen the ventilation ability for indoor cooling and heating. However, the progress is still slow regarding expanded applications and related research of solar chimneys in large volume and multi-layer buildings, and contradictory conclusions appear due to the inherent complexity of the system.
  • 6.6K
  • 13 Apr 2022
Topic Review
Hydrothermal Liquefaction of Biomass
Hydrothermal liquefaction is a high-temperature high-pressure thermochemical conversion method adapted to convert high-water content biomass feedstocks to biofuels and many other valuable industrial chemicals. The hydrothermal process is broadly classified into carbonization, liquefaction, and gasification with hydrothermal liquefaction conducted in the intermediate temperature range of 250–374 °C and pressure of 4–25 MPa. Over the years, various solvents and co-solvents have been used as conversion mediums to promote easy decomposition of the lignocellulosic components in biomass. To obtain the final products, the product separation process typically involves multiple extraction and evaporation steps, which greatly depend on the type of extractive solvents and process parameters. In general, the main aim of the hydrothermal process is to produce a primary product, such as bio-oil, biochar, gases, or industrial chemicals, such as adhesives, benzene, toluene, and xylene.
  • 6.6K
  • 19 Aug 2021
Topic Review
Gaia Hypothesis
The Gaia hypothesis (/ˈɡaɪ.ə/), also known as the Gaia theory, Gaia paradigm, or the Gaia principle, proposes that living organisms interact with their inorganic surroundings on Earth to form a synergistic and self-regulating, complex system that helps to maintain and perpetuate the conditions for life on the planet. The hypothesis was formulated by the chemist James Lovelock and co-developed by the microbiologist Lynn Margulis in the 1970s. Lovelock named the idea after Gaia, the primordial goddess who personified the Earth in Greek mythology. The suggestion that the theory should be called "the Gaia hypothesis" came from Lovelock's neighbour, William Golding. In 2006, the Geological Society of London awarded Lovelock the Wollaston Medal in part for his work on the Gaia hypothesis. Topics related to the hypothesis include how the biosphere and the evolution of organisms affect the stability of global temperature, salinity of seawater, atmospheric oxygen levels, the maintenance of a hydrosphere of liquid water and other environmental variables that affect the habitability of Earth. The Gaia hypothesis was initially criticized for being teleological and against the principles of natural selection, but later refinements aligned the Gaia hypothesis with ideas from fields such as Earth system science, biogeochemistry and systems ecology. Even so, the Gaia hypothesis continues to attract criticism, and today many scientists consider it to be only weakly supported by, or at odds with, the available evidence.
  • 6.6K
  • 07 Nov 2022
Topic Review Peer Reviewed
Cuteness and Its Emotional Responses
Cuteness is commonly associated with visual features such as large eyes, a disproportionately large head, round body shapes, and small size. While these traits are most often observed in infants and young animals, they also appear in inanimate objects and digital representations intentionally designed to evoke emotional appeal. Drawing on developmental psychology, behavioral science, neuroscience, and cultural studies, this paper examines five core emotional responses to cute stimuli: caretaking, socializing, whimsical, cute aggression, and kama muta (the feeling of being emotionally moved). These responses emerge from an interplay between evolutionary mechanisms, such as caregiving instincts, and cultural frameworks that shape how cuteness is perceived, expressed, and valued. The analysis highlights not only biological foundations but also cultural moderators, with particular attention to gender differences and the pervasive role of kawaii aesthetics in Japan’s popular culture, communication, and everyday life. This paper provides an overview of these emotional responses, situates them within their theoretical foundations and broader psychological and social implications, and proposes a framework for future research.
  • 6.6K
  • 17 Sep 2025
Topic Review
Transmission Dynamics of COVID-19
COVID-19 is pneumonia caused by a novel coronavirus which is an emerging infectious disease, and outbreaks in more than 200 countries around the world. Consequently, the spread principles and prevention and control measures of COVID-19 have become a global problem to be solved. Here, we pose a series of dynamical models to reveal the transmission mechanisms of COVID-19. Based on these mathematical models, data fitting and spread trend of COVID-19 are explored to show the propagation law between human populations. We hope that our work may provide some useful insights for effective control of the COVID-19.
  • 6.6K
  • 28 Oct 2020
Biography
Guru Nanak
Gurū Nānak (15 April 1469 – 22 September 1539), also referred to as Bābā Nānak ('father Nānak'),[1] was the founder of Sikhism and is the first of the ten Sikh Gurus. His birth is celebrated worldwide as Guru Nanak Gurpurab on Katak Pooranmashi ('full-moon of Kattak'), i.e. October–November. Nanak is said to have travelled far and wide across Asia teaching people the message of ik onk
  • 6.6K
  • 09 Dec 2022
  • Page
  • of
  • 2798
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback