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Topic Review
The Role of Cigarette Smoking on Bone Metabolism
Cigarette smoking (CS) is recognized as an independent risk factor for the development of osteoporosis. Clinical studies have illustrated that smokers have significantly lower bone mineral density (BMD) than non-smokers, and cumulative bone loss can increase their lifetime risk of hip fracture by 50%. It has been shown that long-term CS can lead to an imbalance of bone turnover, further contributing to the reduction in bone mass and bone length and increased risk of fractures. Furthermore, chronic consumption of cigarettes has been increasingly linked to impaired muscle function.
  • 1.6K
  • 11 May 2022
Topic Review
APT (Debian)
Advanced Package Tool, or APT, is a free software user interface that works with core libraries to handle the installation and removal of software on Debian, Ubuntu and other Linux distributions. APT simplifies the process of managing software on Unix-like computer systems by automating the retrieval, configuration and installation of software packages, either from precompiled files or by compiling source code.
  • 1.6K
  • 27 Oct 2022
Topic Review
Universal Flu Vaccine
A universal flu vaccine is a flu vaccine that is effective against all influenza strains regardless of the virus sub type, antigenic drift or antigenic shift. Hence it should not require modification from year to year. As of 2021 no universal flu vaccine had been approved for general use, several were in development, and one was in clinical trial.
  • 1.6K
  • 27 Oct 2022
Topic Review
Precursor
Precursors are characteristic wave patterns caused by dispersion of an impulse's frequency components as it propagates through a medium. Classically, precursors precede the main signal, although in certain situations they may also follow it. Precursor phenomena exist for all types of waves, as their appearance is only predicated on the prominence of dispersion effects in a given mode of wave propagation. This non-specificity has been confirmed by the observation of precursor patterns in different types of electromagnetic radiation (microwaves, visible light, and terahertz radiation) as well as in fluid surface waves and seismic waves.
  • 1.6K
  • 02 Dec 2022
Topic Review
Skeletal Imaging Features in Osteopetrosis
Osteopetrosis (from the Greek “osteo”: bone; “petrosis”: stone) is a clinically and genetically heterogeneous group of rare diseases of the skeleton, sharing the same main characteristic of an abnormally increased bone density. Dense bones in radiological studies are considered the hallmark of these diseases, and the reason for the common term used: “Marble bone disease”.
  • 1.6K
  • 18 Jan 2023
Topic Review
Euclidean Graphs as Curvilinear Feature Descriptors
Euclidean graphs are an ideal data structure for the functional description of line-shaped features in digital images such as cracks as they convey both geometrical and topological information about the object path in a compact and integrated format, enabling the development of autonomous, highly tuned algorithms for identification, selection, analysis, comparison and archiving of the identified objects.
  • 1.6K
  • 06 Apr 2023
Topic Review
Forest Bathing
Forest bathing was proposed in Japan in 1982 for the purpose of reducing stress and health management, and research on the health promotion and disease prevention effects of forest bathing began in Japan in 2004. Since then, many papers were published and, in 2012, Forest Medicine was established as a new preventive medicine. Imagine a new medical science that could let you know how to be more active, more relaxed, healthier, and happier, with reduced stress and a reduced risk of lifestyle-related diseases. This new medical science is Forest Medicine. Forest Medicine studies the effects of forest environments on human health and is a new interdisciplinary science that belongs to the categories of environmental and preventive medicine.
  • 1.6K
  • 05 Jun 2023
Topic Review
Xishuangbanna Cucumber: Current Status and Future Prospects
The Xishuangbanna (XIS) cucumber is an important botanical variety, accumulating high levels of β-carotene (700 μg/100 g) in the endocarp of mature fruit compared with normal green/white flesh types (25–50 μg/100 g, fresh weight). β-carotene is an essential precursor of provitamin A synthesis required for human health, thus XIS cucumber is an appealing germplasm for vitamin A breeding programs.
  • 1.6K
  • 17 Feb 2022
Topic Review
Linoleic Acid
The purpose of this entry was to summarize human intervention trials that investigated the effects of linoleic acid consumption on lipid risk markers for cardiovascular disease (CVD) in healthy individuals. It also provided mechanistic details, and dietary recommendations for linoleic acid. Future research directions were also discussed. The findings from this entry demonstrated that linoleic acid consumption decreases CVD risk markers in healthy individuals.  
  • 1.6K
  • 09 Sep 2020
Topic Review
Electroplated Functional Materials
Electroplating has been favored to date as a surface treatment technology in various industries in the development of semiconductors, automobiles, ships, and steel due to its advantages of being a simple, solution-based process, with low cost and high throughput. Recently, classical electroplating has been reborn as an advanced manufacturing process for functional materials by combining it with unconventional optical three-dimensional (3D) nanofabrication techniques capable of generating polymer templates with high-resolution 3D periodic nanostructures.
  • 1.6K
  • 29 Dec 2020
Topic Review
Intravenous Immunoglobulins
Intravenous immunoglobulins (IVIG) are blood preparations pooled from the plasma of donors that have been first employed as replacement therapy in immunodeficiency. IVIG interact at multiple levels with the different components of the immune system and exert their activity against infections. Passive immunotherapy includes convalescent plasma from subjects who have recovered from infection, hyperimmune globulin formulations with a high titer of neutralizing antibodies, and monoclonal antibodies (mAbs). IVIG are used for the prevention and treatment of several infections, especially in immunocompromised patients, or in case of a poorly responsive immune system. The evolution of IVIG from a source of passive immunity to a powerful immunomodulatory/anti-inflammatory agent results in extensive applications in autoimmune diseases. IVIG composition depends on the antibodies of the donor population and the alterations of protein structure due to the processing of plasma.
  • 1.6K
  • 23 Feb 2021
Topic Review
Wind Speed Analysis of Hurricane Sandy
The database of the HWind project sponsored by the National Oceanic and Atmospheric Administration (NOAA) for hurricanes between 1994 and 2013 is analysed. Moreover, the wind speed of Hurricane Sandy is studied.
  • 1.6K
  • 18 Nov 2021
Topic Review
Lee-Style T'ai Chi Ch'uan
The Lee style of t'ai chi ch'uan (李氏太極拳) is closely related to a range of disciplines of Taoist Arts taught within the Lee style including Qigong, Tao Yin, Ch'ang Ming, Traditional Chinese Medicine, Taoist alchemy, Feng Shou Kung Fu, and weapons practice. According to practitioners, it was first brought to the West in the 1930s by Chan Kam Lee and was subsequently popularized by Chee Soo who was the President of the International Taoist Society from 1958 until his death in 1994. The Lee style of t'ai chi ch'uan comprises two forms known as 'the dance' or Tiào wǔ 跳舞, and 'the form'. Other exercises include I Fu Shou or 'sticky hands', Whirling Hands, Whirling Arms, and various qi and Li development exercises. Lee style t'ai chi is related to Martial Arts training, and there are five distinct areas of development that comprise the whole Art:
  • 1.6K
  • 12 Oct 2022
Topic Review
Eurasian Economic Community
The Eurasian Economic Community (EAEC or EurAsEC) was a regional organisation between 2000 and 2014 which aimed for the economic integration of its member states. The organisation originated from the Commonwealth of Independent States (CIS) on 29 March 1996, with the treaty on the establishment of the Eurasian Economic Community signed on 10 October 2000 in Kazakhstan's capital Astana by Presidents Alexander Lukashenko of Belarus, Nursultan Nazarbayev of Kazakhstan, Askar Akayev of Kyrgyzstan, Vladimir Putin of Russia, and Emomali Rahmon of Tajikistan. Uzbekistan joined the community on 7 October 2005, however later withdrew on 16 October 2008. During the 14 years, the EAEC implemented a number of economic policies to unify the community. The Customs Union of Belarus, Kazakhstan, and Russia was formed on 1 January 2010, and later renamed the Eurasian Customs Union. The four freedoms of movement modelled after the European Union (goods, capital, services, and people) were fully implemented by 25 January 2012, with the formation of the Eurasian Economic Space. On 10 October 2014, an agreement on the termination of the Eurasian Economic Community was signed in Minsk after a session of the Interstate Council of the EAEC. The Eurasian Economic Community was terminated from 1 January 2015 in connection with the launch of the Eurasian Economic Union. While the Eurasian Economic Union effectively replaces the community, membership negotiations with Tajikistan are still ongoing. All other EAEC members have joined the new union.
  • 1.6K
  • 04 Nov 2022
Topic Review
Sound Reduction Index
The sound reduction index is used to measure the level of sound insulation provided by a structure such as a wall, window, door, or ventilator. It is defined in the series of international standards ISO 16283 (parts 1-3) and the older ISO 140 (parts 1-14), or the regional or national variants on these standards. In the United States, the sound transmission class rating is generally used instead. The basic method for both the actual measurements and the mathematical calculations behind both standards is similar, however they diverge to a significant degree in the detail, and in the numerical results produced. Standardized methods exist for measuring the sound insulation produced by various structures in both laboratory and field (actual functional buildings and building sites) environments. A number of indexes are defined which each offer various benefits for different situations.
  • 1.6K
  • 07 Nov 2022
Topic Review
Biological Properties of Flavonoid Quercetin
Quercetin is a dietary flavonoid present in vegetables, fruits, and beverages, such as onions, apples, broccoli, berries, citrus fruits, tea, and red wine. Flavonoids have antioxidant and anti-inflammatory effects, acting in the prevention of several diseases. 
  • 1.6K
  • 27 Feb 2023
Topic Review
Zonulin Pathway as a Therapeutic Target
The integrity and thus the function of blood–brain barrier (BBB) TJs play a crucial role in the pathomechanism of neuroinflammatory and neurodegenerative diseases. Previously, it has been suggested that targeting different elements of the zonulin pathway, including actin filaments, TJs, or NF-κB, have potential therapeutic effects on CNS diseases. Indeed, encouraging results are accumulating from a recent preclinical study, using myosin light chain kinase (MLCK) inhibitor ML-7, which attenuates BBB disruption by preventing the disintegration of actin cytoskeletal microfilaments. Similarly, blocking the cleavage of TJ proteins by matrix metalloproteases (MMP) inhibitors, using either direct (broad-spectrum or selective MMP-2 and MMP-9) or indirect inhibitors (COX) has been shown to protect BBB. Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, such as rosiglitazone, pioglitazone, or D-allose, also prevented BBB integrity by inhibiting NF-κB activation. Therefore, the use of zonulin inhibitors seems to be justified in the treatment of CNS diseases.
  • 1.6K
  • 04 May 2023
Topic Review
Dihydrocaffeic Acid
Dihydrocaffeic acid (DHCA) is a phenolic acid bearing a catechol ring and three-carbon side chain. Despite its being found in minor amounts in numerous plants and fungi of different origins, it has attracted the interest of various research groups in many fields of science, from food to biomedical applications.
  • 1.6K
  • 24 May 2023
Topic Review
5-Aminolevulinic Acid Photodynamic Therapy in Cancer Treatment
5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) is a therapeutic option for a variety of cutaneous and internal malignancies. PDT uses a photosensitizer that, activated by light in the presence of molecule oxygen, forms ROS, which are responsible for the apoptotic activity of the malignant tissues. 5-ALA is usually used as an endogenous pro-photosensitizer because it is converted to Protoporphyrin IX (PpIX), which enters into the process of heme synthesis and contextually becomes a photosensitizer, radiating a red fluorescent light. PDT has the benefit of being administered before or after chemotherapy, radiation, or surgery, without impairing the efficacy of these treatment techniques. Furthermore, sensitivity to PDT is unaffected by the negative effects of chemotherapy or radiation. 
  • 1.6K
  • 30 May 2023
Topic Review
Zinc Oxide Nanoparticles and Their Physiochemical Properties
Zinc oxide nanomaterials have been the cynosure of this decade because of their immense potential in different biomedical applications. It includes their usage in the prognosis and treatment of different infectious and cellular diseases, owing to their peculiar physiochemical properties such as variable shape, size, and surface charge etc. Increasing demand and usage of the ZnO nanomaterials raise concerns about their cellular and molecular toxicity and their biocompatibility with human cells.
  • 1.6K
  • 12 Jul 2023
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