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Topic Review
Endocannabinoid System Present in the Glioblastoma Tumour Microenvironment
The highly aggressive and invasive glioblastoma (GBM) tumour is the most malignant lesion among adult-type diffuse gliomas, representing the most common primary brain tumour in the neuro-oncology practice of adults. With a poor overall prognosis and strong resistance to treatment, this nervous system tumour requires new, innovative treatment. GBM is a polymorphic tumour consisting of an array of stromal cells and various malignant cells contributing to tumour initiation, progression, and treatment response. Cannabinoids possess anti-cancer potencies against glioma cell lines and in animal models. To improve existing treatment, cannabinoids as functionalised ligands on nanocarriers were investigated as potential anti-cancer agents. The GBM tumour microenvironment is a multifaceted system consisting of resident or recruited immune cells, extracellular matrix components, tissue-resident cells, and soluble factors. 
  • 1.6K
  • 31 Jan 2024
Topic Review
Metformin and Polycystic Ovary Syndrome
Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in combination with other drugs, restores the ovarian function in women with polycystic ovary syndrome (PCOS) and improves fetal development, pregnancy outcomes and offspring health in gestational diabetes mellitus (GDM) and T2DM.
  • 1.6K
  • 23 Aug 2023
Topic Review
Cytokinins in Plant
Cytokinins (CKs) are key phytohormones that not only regulate plant growth and development but also mediate plant tolerance to drought stress. Recent advances in genome-wide association studies coupled with in planta characterization have opened new avenues to investigate the drought-responsive expression of CK metabolic and signaling genes, as well as their functions in plant adaptation to drought. Under water deficit, CK signaling has evolved as an inter-cellular communication network which is essential to crosstalk with other types of phytohormones and their regulating pathways in mediating plant stress response. In this review, we revise the current understanding of CK involvement in drought stress tolerance. Particularly, a genetic framework for CK signaling and CK crosstalk with abscisic acid (ABA) in the precise monitoring of drought responses is proposed. In addition, the potential of endogenous CK alteration in crops towards developing drought-tolerant crops is also discussed.
  • 1.6K
  • 28 Oct 2020
Topic Review
Sol Rezza
Sol Rezza (born April 7, 1982, Buenos Aires, Argentina ) is a composer, audio engineer and radio producer; specialist in sound design and composition in the field of experimental music and radio art for various media, theater, festivals and installations. Her main works of sound experimentation are the creation of immersive sound environments through the transformation of field recordings, effects and surround sound. Owner of an atypical professional tour, Sol Rezza works in different areas related to sound; from live performances, experimental compositions for radio to the realization of atmospheres / environments and / or sound effects for digital media, video games, films as well as for installations. All her works have two main axes of analysis: the way we perceive time and space through our senses and how sounds influence that perception.
  • 1.6K
  • 29 Sep 2022
Topic Review
Barriers to Industrial Heritage Reconstruction and Reuse
The reconstruction and reuse of industrial heritage has constituted important means for the protection of that heritage, and has played a crucial role in promoting urban renewal and sustainable urban development. Based on time limits imposed on the completion of any reconstruction and reuse project, the obstacles can be divided into financial and systemic barriers in the early stage of a project and into secondary problems in the latter stage of a project. 
  • 1.6K
  • 05 Dec 2022
Topic Review
Stabilization of Essential Oil
Essential oils (EOs) have stability problems, including volatility, oxidation, photosensitivity, heat sensitivity, humidity sensitivity, pH sensitivity, and ion sensitivity. A drug delivery system is an effective way to stabilize EOs, especially due to the protective effect of polymeric drug carriers. Polysaccharides are frequently employed as drug carrier materials because they are highly safe, come in a variety of forms, and have plentiful sources.
  • 1.6K
  • 24 Aug 2023
Topic Review
History of Web Syndication Technology
Web syndication technologies were preceded by metadata standards such as the Meta Content Framework (MCF) and the Resource Description Framework (RDF), as well as by 'push' specifications such as Channel Definition Format (CDF). Early web syndication standards included Information and Content Exchange (ICE) and RSS. More recent specifications include Atom and GData.
  • 1.6K
  • 09 Nov 2022
Topic Review
CO2 Pneumoperitoneum
Laparoscopy (LS) has been shown to decrease the inflammatory sequelae of endotoxemia. β-arrestin 2 plays an important function in signal transduction pathway of TLR4. High mobility group box-1 (HMGB-1) is involved in the delayed systemic inflammatory response. We investigated the effects of CO2 insufflation on liver, lung, and kidney expression of both β-arrestin 2 and HMGB-1 during sepsis. Cecal ligation and puncture (CLP) was performed in male rats and 6 h later the animals were randomly assigned to receive a CO2 pneumoperitoneum or laparotomy. Animals were euthanized; liver, lung, and kidney were removed for the evaluation of β-arrestin 2 and HMGB-1 expression. Immunohistochemical detection of myeloperoxidase (MPO) was investigated in lung and liver and bacterial load was determined in the peritoneal fluid. CO2 pneumoperitoneum reduced peritoneal bacterial load, increased the expression of β-arrestin 2, and blunted the expression of the potent proinflammatory HMGB-1 in liver, lung, and kidney compared with laparotomy. Liver and lung MPO was markedly reduced in rats subjected to LS compared with laparotomy. We believe that CO2 exerts an early protective effect by reducing bacterial load and likely toll-like receptor activation which in turn leads to a preserved β-arrestin 2 expression and a reduced HMGB-1 expression.
  • 1.6K
  • 02 Nov 2020
Topic Review
Capillary-Driven Flow Device
The capillary flow device works on the principle of capillary-driven flow microfluidics and allows detection by multiple microchannels in a single microchip via smartphone imaging/portable detectors. Compared to other types of devices such as dipsticks and paper microfluidic devices, this device is fabricated with cheaper materials, coated with minute amounts of reagents and offers multiplexity on a single microchip. The sample is loaded into the microchannels via capillary force, which eliminates the requirement of external/internal fluidic mechanisms or controls. A capillary-driven flow device was developed in this study which is simple to operate and allows loading multiple samples in a single device.
  • 1.6K
  • 30 Oct 2020
Topic Review
Electric Vehicle Batteries
In electric and hybrid vehicles Life Cycle Assessments (LCAs), batteries play a central role and are in the spotlight of scientific community and public opinion. Automotive batteries constitute, together with the powertrain, the main differences between electric vehicles and internal combustion engine vehicles. For this reason, many decision makers and researchers wondered whether energy and environmental impacts from batteries production, can exceed the benefits generated during the vehicle’s use phase. In this framework, the purpose of the present literature review is to understand how large and variable the main impacts are due to automotive batteries’ life cycle, with particular attention to climate change impacts, and to support researchers with some methodological suggestions in the field of automotive batteries’ LCA. The results show that there is high variability in environmental impact assessment; CO2eq emissions per kWh of battery capacity range from 50 to 313 g CO2eq/kWh. Nevertheless, either using the lower or upper bounds of this range, electric vehicles result less carbon-intensive in their life cycle than corresponding diesel or petrol vehicles.
  • 1.6K
  • 27 Oct 2020
Topic Review
Magnetic Iron Oxide Nanoparticle Synthesis
Iron oxides are chemical compounds which havedifferent polymorphic forms, including γ-Fe2O3 (maghemite), Fe3O4(magnetite), and FeO (wustite). Among them, the most studiedare γ-Fe2O3 and Fe3O4,as they possess extraordinary properties at the nanoscale (such as superparamagnetism, high specific surface area, biocompatible etc.),because at this size scale, the quantum effectsaffect matter behavior and optical, electrical and magnetic properties.Therefore, in the nanoscale, these materials become ideal for surface functionalization and modification in various applications such as separation techniques, magnetic sorting (cells and other biomolecules etc.), drug delivery, cancer hyperthermia, sensing etc., and also for increased surface area-to-volume ratio, which allows for excellent dispersibility in the solution form.The current methods used are partially and passively mixed reactants, and,thus, every reaction has a different proportion of all factors which causes further difficulties in reproducibility.Direct active and complete mixing and automated approaches could be solutions to thissize- and shape-controlled synthesis, playing a key role in its exploitation for scientific or technological purposes. An ideal synthesis method should be able to allow reliable adjustment of parameters andcontrol over the following: fluctuation in temperature;pH, stirring rate;particle distribution; size control;concentration; and control over nanoparticle shape andcomposition i.e., crystallinity, purity, and rapid screening. Iron oxide nanoparticle (IONP)-based available clinical applications are RNA/DNAextraction and detection of infectious bacteria andviruses. Such technologies are important at POC (point of care) diagnosis.IONPs can play a key role in these perspectives.Although there are various methods for synthesis of IONPs,one of the most crucial goals is to control size and properties with high reproducibility to accomplish successful applications.Using multiple characterization techniques to identify and confirm the oxide phase of iron can provide better characterization capability. It is very important to understand the in-depth IONP formation mechanism, enabling better control over parameters and overall reaction and, by extension, properties of IONPs.This workprovides an in-depth overview ofdifferent properties, synthesis methods, and mechanisms of iron oxide nanoparticles (IONPs) formation, and the diverse range of theirapplications. Differentcharacterization factors and strategiesto confirm phase purity in the IONP synthesis field are reviewed.First, properties of IONPs and various synthesis routes with their merits and demerits are described. We also describe different synthesis strategies and formation mechanisms for IONPs such as for: wustite (FeO), hematite(α-Fe2O3), maghemite(ɤ-Fe2O3) and magnetite(Fe3O4). We also describe characterization of these nanoparticles and various applications in detail. In conclusion, we present a detailed overview on the properties, size-controlled synthesis, formation mechanisms and applications of IONPs.
  • 1.6K
  • 30 Oct 2020
Topic Review
Phytochemicals in Prostate Cancer
Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. 
  • 1.6K
  • 14 Sep 2021
Topic Review
The Effect of Music on Livestock
The welfare of animals, especially those kept in intensive production systems, is a priority for modern agriculture. This stems from the desire to keep animals healthy, to obtain a good-quality final product, and to meet the demands of today’s consumers, who have been increasingly persuaded to buy organic products. As a result, new sound-based methods have been pursued to reduce external stress in livestock. Music therapy has been known for thousands of years, and sounds were believed to improve both body and spirit. Today, they are mostly used to distract patients from their pain, as well as to treat depression and cardiovascular disorders. However, recent studies have suggested that appropriately selected music can confer some health benefits, e.g., by increasing the level and activity of natural killer cells. For use in livestock, the choice of genre, the loudness of the music and the tempo are all important factors. Some music tracks promote relaxation (thus improving yields), while others have the opposite effect. 
  • 1.6K
  • 11 Jan 2022
Topic Review
Orientation of the Kofun Tombs
The Kofun period of the history of Japan—between the 3rd and the 7th century AD—bears its name from the construction of huge, earth mound tombs called Kofun. Among them, the largest have a keyhole shape and are attributed to the first, semi-legendary emperors. 
  • 1.6K
  • 17 Feb 2022
Topic Review
Stability of Cu-Based Catalysts for Methanol Reforming
The stability of copper-based catalysts is an important property that affects the catalytic efficiency, which determines the service life of the catalytic base in the methanol steam reforming (MSR) reaction, and plays an important role in the sustainable production of hydrogen.
  • 1.6K
  • 21 Jul 2022
Topic Review
Internet Taxes
In 1996, several U.S. states and municipalities began to see Internet services as a potential source of tax revenue. The 1998 Internet Tax Freedom Act halted the expansion of direct taxation of the Internet, grandfathering existing taxes in ten states. In the United States alone, some 30,000 taxing jurisdictions could otherwise have laid claim to taxes on a piece of the Internet. The law, however, did not affect sales taxes applied to online purchases. These continue to be taxed at varying rates depending on the jurisdiction, in the same way that phone and mail orders are taxed.
  • 1.6K
  • 26 Oct 2022
Topic Review
Ground Deicing of Aircraft
Ground deicing of aircraft is commonly performed in both commercial and general aviation. The fluids used in this operation are called deicing or anti-icing fluids. The initials ADF (Aircraft Deicing Fluid), ADAF (Aircraft Deicer and Anti-icer Fluid) or AAF (Aircraft Anti-icing Fluid) are commonly used.
  • 1.6K
  • 23 Nov 2022
Topic Review
Health Effects of Red Wine Consumption
A strong controversy persists regarding the effect of red wine (RW) consumption and health. Guidelines for the prevention of cardiovascular diseases (CVD) and cancers discourage alcohol consumption in any form, but several studies have demonstrated that low RW intake may have positive effects on CVD risk. 
  • 1.6K
  • 27 Apr 2023
Topic Review
The Effects of Dietary on Tumor Metabolism
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells. Novel dietary interventions such as amino acid restriction and periodic fasting mimicking diets can prevent or dampen the formation of an immunosuppressive microenvironment by acting systemically on the release of hormones and growth factors, inhibiting the release of proinflammatory cytokines, and remodeling the tumor vasculature and extracellular matrix.
  • 1.6K
  • 10 Aug 2023
Topic Review
Factors Influencing Employees’ Intrapreneurial Behavior
Effectively promoting employees’ intrapreneurial behavior has become the focus of enterprises. This study takes the middle and grassroots employees in enterprises as subjects and explores the configuration effect of multiple influencing factors on employees’ intrapreneurial behavior. Based on employee expectation theory and individual-environment matching theory, this study collates six influencing factors: entrepreneurial self-efficacy, entrepreneurial competence, task school level,perceived value, management support, and reward mechanism. A total of 163 samples were obtained, and the qualitative comparative analysis method based on fuzzy set was used to analyze the influence mechanism and result path of employees’ intrapreneurial behavior from the perspective of the interaction between individual factors and organizational factors. Six influencing paths of employees’ high intrapreneurial behavior were found, which can be divided into ability-driven and value-driven factors, revealing that the six factors can produce equivalent results in different configurations. Furthermore, five influencing paths of employees’ non-high intrapreneurial behavior were divided into three types: ability obstacle type, perception obstacle type, and value obstacle type.These have an asymmetric causal relationship with employees’ high intrapreneurial behavior. This study provides management support for effectively stimulating employees’ intrapreneurial behavior.
  • 1.6K
  • 26 Sep 2023
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