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Topic Review
Nanocarriers Used in Co-Delivery Systems
The concept of the co-delivery approach first occurred from merging two research fields: drug delivery and gene therapy. Co-delivery systems combine at least two therapeutic agents with different physiological and physicochemical properties; thus, achieving clinical combination chemotherapy. Taking into consideration the co-delivery strategy, combination therapy via nanotechnology approaches has progressively become a desirable technique and one of the leading frontiers in research to find an efficient drug delivery system (DDS).
  • 1.6K
  • 29 Aug 2022
Topic Review
Renewable Energy and Economic Growth
The clean development mechanism entails a vast deployment of renewable energy technologies to enhance sustainable development. Energy security is quickly becoming a reality as various renewable energy supplies are exploited because of their potential for mitigating GHG emissions. As part of the UNFCCC (United Nations Framework Convention on Climate Change), the Kyoto Protocol incorporates the idea of a “clean development framework”. Developed nations would contribute to emission reduction measures, which would then fund renewable energy programs in the developing world. Increasing the usage of green technology and renewable energy sources can help address this problem. However, mass sustainable energy development faces a few obstacles, including unpredictability, input–output cost analysis, higher manufacturing costs, and a lack of knowledge and financial resources. Renewable energy sources are critical to a country’s overall growth. Developing countries must increase their reliance on renewable energy sources.
  • 1.6K
  • 13 Sep 2022
Topic Review
Prognostic Factors in Spica Cast MRI
Closed reduction followed by spica casting is a conservative treatment for developmental dysplasia of the hip (DDH). Magnetic resonance imaging (MRI) can verify proper closed reduction of the dysplastic hip. The abduction angle is the only influencing factor for improved development of the DDH. No other prognostic factors in MRI measurements, such as gender, age at time of the first spica cast, or treatment involving overhead extension were found to be predictive of mid-term outcome. Mild residual dysplasia in the first follow-up X-ray warrants further observation.
  • 1.6K
  • 26 Sep 2022
Topic Review
Eurobonds
European bonds are proposed government bonds issued in euros jointly by the 19 eurozone nations. The idea was first raised by the European Commission in 2011. Eurobonds would be debt investments whereby an investor loans a certain amount of money, for a certain amount of time, with a certain interest rate, to the eurozone bloc altogether, which then forwards the money to individual governments. Eurobonds have been suggested as a way to tackle the European sovereign debt crisis as the indebted states could borrow new funds at better conditions as they are supported by the rating of the non-crisis states. Because Eurobonds would allow already highly indebted states access to cheaper credit thanks to the strength of other eurozone economies, they are controversial, and may suffer from the free rider problem.
  • 1.6K
  • 14 Nov 2022
Topic Review
Diphyllobothriasis
Diphyllobothriasis is the infection caused by tapeworms of the genus Diphyllobothrium (commonly D. latum and D. nihonkaiense). Diphyllobothriasis mostly occurs in regions where raw fish is regularly consumed; those who consume raw fish are at risk of infection. The infection is often asymptomatic and usually presents only with mild symptoms, which may include gastrointestinal complaints, weight loss, and fatigue. Rarely, vitamin B12 deficiency (possibly leading to anaemia) and gastrointestinal obstructions may occur. Infection may be long-lasting in absence of treatment. Diphyllobothriasis is generally diagnosed by looking for eggs or tapeworm segments in passed stool. Treatment with antiparasitic medications is straightforward, effective, and safe.
  • 1.6K
  • 18 Nov 2022
Topic Review
Bacterial Cellulose for Wound Dressing Application
Chronic ulcers are among the main causes of morbidity and mortality due to the high probability of infection and sepsis and therefore exert a significant impact on public health resources. Numerous types of dressings are used for the treatment of skin ulcers-each with different advantages and disadvantages. Bacterial cellulose (BC) has received enormous interest in the cosmetic, pharmaceutical, and medical fields due to its biological, physical, and mechanical characteristics, which enable the creation of polymer composites and blends with broad applications. In the medical field, BC was at first used in wound dressings, tissue regeneration, and artificial blood vessels. This material is suitable for treating various skin diseases due its considerable fluid retention and medication loading properties. BC membranes are used as a temporary dressing for skin treatments due to their excellent fit to the body, reduction in pain, and acceleration of epithelial regeneration. BC-based composites and blends have been evaluated and synthesized both in vitro and in vivo to create an ideal microenvironment for wound healing.
  • 1.6K
  • 21 Nov 2022
Topic Review
Mechanisms of CLL Cell Stimulation via BcR
The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and expansion of the neoplastic clone. This notion was initially suggested by observations of the CLL BcR repertoire and of correlations existing between certain BcR features and the clinical outcomes of single patients. Based on these observations, tyrosine kinase inhibitors (TKIs), which block BcR signaling, have been introduced in therapy with the aim of inhibiting CLL cell clonal expansion and of controlling the disease. Indeed, the impressive results obtained with these compounds provided further proof of the role of BcR in CLL.
  • 1.6K
  • 01 Dec 2022
Topic Review
Relationship between Critical Thinking and the Halo Effect
During the process of recruiting suitable job candidates for a corporation, HR managers play a pivotal role. However, several factors influence HR managers when making these crucial hiring decisions. One such factor is the halo effect. However, the halo effect can be reduced through deliberate and systematic cognitive processing. 
  • 1.6K
  • 05 Jul 2023
Topic Review
Mitochondrial-Derived Vesicles
Mitophagy is crucial for maintaining mitochondrial quality. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles, which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into extracellular vesicles occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles, cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity.
  • 1.6K
  • 17 Nov 2023
Topic Review
Mitotane Lipid Nanocarriers and Enantiomers
Emerging studies suggested that the S-(-)-mitotane is more potent than the R-(+)-mitotane for AdrenoCortical Carcinoma (ACC) treatment. Currently, mitotane is the only FDA-approved drug . Therefore, we suggest that the production of pure and active S-(-)-mitotane might offer synergic or additive benefits for ACC patients, and even better if combined to solid lipid-based nanocarriers, and smart/advanced nanocarriers. 
  • 1.6K
  • 08 Dec 2020
Topic Review
Food Loss and Waste Prevention
Preventing food losses and waste is a potential strategy for better balance food supply and demand and is essential to improve food security while reducing environmental impact and providing economic benefits to the different actors in the food supply chain.
  • 1.6K
  • 27 May 2021
Topic Review
Antimicrobial Resistance Assessment in Aquacultures
Aquaculture is a new food production sector that has been increasing dramatically over the last two decades due to the high demand for a healthy protein source. The aquaculture production figures indicate a substantial increase in the relative contribution of aquaculture to total fish consumption from 5% in 1962 to 49% in 2002. The use of antimicrobials in aquaculture, even at subinhibitory concentrations, has been promoting antimicrobial resistance in bacteria from the aquatic environment. New omics tools and approaches pave the way for the assessment of antimicrobial resistance in these environments.
  • 1.6K
  • 19 Jul 2021
Topic Review
On-Site Medical Management of Avalanche Victims
Avalanche accidents are common in mountain regions and approximately 100 fatalities are counted in Europe each year. The average mortality rate is about 25% and survival chances are mainly determined by the degree and duration of avalanche burial, the patency of the airway, the presence of an air pocket, snow characteristics, and the severity of traumatic injuries. The most common cause of death in completely buried avalanche victims is asphyxia followed by trauma. Hypothermia accounts for a minority of deaths; however, hypothermic cardiac arrest has a favorable prognosis and prolonged resuscitation and extracorporeal rewarming are indicated.
  • 1.6K
  • 13 Oct 2021
Topic Review
Field Measurement Studies on Indoor Air Quality
The Indoor Air Quality (IAQ) is one of the key factors that influence the quality of the indoor environment, as well as the human health.
  • 1.6K
  • 16 Feb 2022
Topic Review
Biofilm Prevention and Therapy: Alternatives to Standard Antibiotics
In order to combat the global health crisis of escalating antibacterial resistance, guidelines on responsible antimicrobial stewardship are urgently required. Yet, currently there is no international consensus. Tackling discrepancies that may arise when implementing novel antibiotics is critical to their longevity of use. A wide range of antibiotics previously heavily used is no longer effective due to elevated minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) doses for treatment. Thus, there is a pressing need to develop effective way to prevent biofilm from forming as well as to carefully apply alternative therapies to standard antibiotic treatments.
  • 1.6K
  • 11 May 2022
Topic Review Peer Reviewed
The Applications of Microphysiological Systems in Biomedicine: Impact on Urologic and Orthopaedic Research
Microphysiological systems (MPSs) are in vitro models that can incorporate dynamic stimuli such as flow, pressure and contraction in cell culture, enabling the formation of cellular architectures and retrieving physiological function often absent in conventional 2D-cell culture. MPS applications saw a substantial growth in recent years, drawing attention from industry as a strategy to optimize pre-clinical drug-development purposes, as well as from biomedical research, to fill a gap between in vivo and in vitro models. Several MPS platforms are now available and are employed in the development of bone and kidney complex systems for urologic and orthopaedic research. These advances have enabled, for example, the in vitro modelling of bone regeneration and renal drug secretion, and have dramatic potential to improve research into both orthopaedic and urology cancers. 
  • 1.6K
  • 16 Jun 2022
Topic Review
Structure and Functions of Aβ and Tau Proteins
The amyloid hypothesis, i.e., the abnormal accumulation of toxic Aβ assemblies in the brain, has been considered the mainstream concept sustaining research in Alzheimer’s Disease (AD). However, the course of cognitive decline and AD development better correlates with tau accumulation rather than amyloid peptide deposition. Moreover, all clinical trials of amyloid-targeting drug candidates have been unsuccessful, implicitly suggesting that the amyloid hypothesis needs significant amendments. Accumulating evidence supports the existence of a series of potentially dangerous relationships between Aβ oligomeric species and tau protein in AD.
  • 1.6K
  • 29 Aug 2022
Topic Review
Rhina (Genus)
The bowmouth guitarfish (Rhina ancylostoma), also called the shark ray or mud skate, is a species of ray and a member of the family Rhinidae. Its evolutionary affinities are not fully resolved, though it may be related to true guitarfishes and skates. This rare species occurs widely in the tropical coastal waters of the western Indo-Pacific, at depths of up to 90 m (300 ft). Highly distinctive in appearance, the bowmouth guitarfish has a wide and thick body with a rounded snout and large shark-like dorsal and tail fins. Its mouth forms a W-shaped undulating line, and there are multiple thorny ridges over its head and back. It has a dorsal color pattern of many white spots over a bluish gray to brown background, with a pair of prominent black markings over the pectoral fins. This large species can reach a length of 2.7 m (8.9 ft) and weight of 135 kg (298 lb). Usually found near the sea floor, the bowmouth guitarfish prefers sandy or muddy areas near underwater structures. It is a strong-swimming predator of bony fishes, crustaceans, and molluscs. This species gives live birth to litters of two to eleven pups, which are nourished during gestation by yolk. The International Union for Conservation of Nature (IUCN) has assessed the bowmouth guitarfish as Vulnerable because it is widely caught by artisanal and commercial fisheries for its valuable fins and meat. It is viewed as a nuisance by trawlers, however, because its bulk and thorny skin cause it to damage netted catches. Habitat degradation and destruction pose an additional, significant challenge to this ray's survival. The bowmouth guitarfish adapts well to captivity and is displayed in public aquariums.
  • 1.6K
  • 18 Oct 2022
Topic Review
Regulation of Gastric Function
The nervous system, and endocrine system collaborate in the digestive system to control gastric secretions, and motility associated with the movement of food throughout the gastrointestinal tract, including peristalsis, and segmentation contractions. Gastric activity involved in digestion is divided into three stages known as the cephalic phase, the gastric phase, and the intestinal phase. These phases overlap and all three can occur simultaneously. A fourth phase of acid secretion is known as the basal state which occurs in the times between meals (interdigestive phase). The level of acid secretion during these times is regulated by body weight, individual, number of parietal cells, and time of day. Acid secretion is lowest in the morning before awakening and highest at night.
  • 1.6K
  • 26 Oct 2022
Topic Review
Neoabolitionism
Neoabolitionist (or neo-abolitionist or new abolitionism) is a term used in historiography to characterize historians of race relations motivated by the spirit of racial equality typified by the abolitionists who fought to abolish slavery in the mid-19th century. They write especially about African-American history, slavery, the American Civil War and the Reconstruction Era. As abolitionists had worked in the 19th century to end slavery and provide equal rights under the US Constitution to blacks, the new activists worked to enforce constitutional rights for all citizens and restore equality under the law for African Americans, including suffrage and civil rights. In the late 20th century some historians emphasized the worlds of African Americans in their own words, in their own communities, to recognize them as agents, not victims. Publishing in the mid-1960s and through the 20th century, a new generation of historians began to revise traditional accounts of slavery in the United States, reconstruction, racial segregation and Jim Crow laws. Some major historians began to apply the term "neoabolitionist" to such historians, and some of this group identified as such.
  • 1.6K
  • 03 Nov 2022
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