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Topic Review
Capella (Engineering)
Capella is an open-source solution for model-based systems engineering (MBSE). Hosted at polarsys.org, this solution provides a process and tooling for graphical modeling of systems, hardware or software architectures, in accordance with the principles and recommendations defined by the Arcadia method. Capella is an initiative of PolarSys, one of several Eclipse Foundation working groups.
  • 1.6K
  • 23 Nov 2022
Topic Review
Unmanned Aerial Vehicles Implementations in Urban Planning
The rapid growth of urban populations and the need for sustainable urban planning and development has made Unmanned Aerial Vehicles (UAVs) a valuable tool for data collection, mapping, and monitoring.
  • 1.6K
  • 12 Jun 2023
Topic Review
Time-Sensitive Networking Standards and Applications for Intelligent Driving
The time-sensitive networking (TSN) family of standards is a tool set that offers reliability, determinism and time synchronization for safety-critical automotive communications over Ethernet links. The TSN standards leverage the previous work conducted within the IEEE 802.1 Working Group on IEEE audio video bridging (AVB). TSN is a set of specifications standardized by the Institute of Electrical and Electronics Engineers (IEEE) 802.1 work group (WG), the predecessor of which is audio video bridging (AVB).
  • 1.6K
  • 27 Jul 2023
Topic Review
Public–Private Partnerships Model Applied to Hospitals
When the public–private partnership (PPP) model is applied to healthcare (hospitals), it is possible to discover the path to success by developing a critical assessment and deriving a clear model. Most PPP model implementations in hospitals around the world have produced favorable outcomes, both in terms of the performance of healthcare units and in terms of cost-effectiveness. 
  • 1.6K
  • 25 Jun 2023
Topic Review
Adipogenic Transcription Factors
Adipogenic transcription factors including CCAAT/enhancer binding protein alpha (C/EBPα), C/EBP beta (C/EBPβ) and peroxisome proliferator-associated receptor gamma (PPARγ) are also expressed by osteoclastogenic cells. However, in contrast to MSCs, activation of these adipogenic transcription factors in HSCs promotes the differentiation of osteoclast precursors into mature osteoclasts. Herein, we discuss the molecular mechanisms that link adipogenic transcription factors to the osteoclast differentiation program.
  • 1.6K
  • 28 Oct 2020
Topic Review
DOG1
DOG1 (Delay of Germination-1), is a master regulator of primary seed dormancy that acts in concert with ABA to delay germination. The strongly regulated expression of DOG1 increases during seed maturation, and the DOG1-mRNA disappears quickly after seed imbibition, although the DOG1 protein is more stable. DOG1 expression is notably induced by abscisic acid (ABA) and low temperature during seed maturation. The DOG1 action involves the suppression of the ABA HYPERSENSITIVE GERMINATION (AHG1/AHG3) activity to enhance ABA sensitivity and finally impose the primary dormancy (PD). This suppression needs the formation of DOG1-heme complex. Together, DOG1 function is not restricted to PD process, but that it is also required for other facets of seed maturation and plant development (e.g. flowering and drought tolerance), in part by also interfering with the ethylene signaling components.  
  • 1.6K
  • 29 Oct 2020
Topic Review
Minerals in Inflammatory Bowel Diseases
The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral density is multifactorial and includes both diet and nutritional status. Calcium is the most often discussed minerals with regard to bone mineral density. Moreover, phosphorus; magnesium and sodium are also involved in the formation of bone mass. Patients suffering from inflammatory bowel diseases frequently consume inadequate amounts of the aforementioned minerals  or their absorption is disturbed, resulting innutritional deficiency and an increased risk of osteoporosis. 
  • 1.6K
  • 06 Nov 2020
Topic Review
KIT Gene
KIT proto-oncogene receptor tyrosine kinase
  • 1.6K
  • 23 Dec 2020
Topic Review
Enteric Nervous System
The gastrointestinal tract has the function of digesting food, absorbing the nutrients, and forming a barrier against harmful agents, but it is also an immune-hormonal system. Functional aspects of this system, such as peristaltic movements, substance transport, and local blood flow, are regulated by an intrinsic network of neuronal ganglia known as the enteric nervous system (ENS). The ENS provides motor excitatory neurons, innervate muscle layers, secretory glands, and the lymphatic vascular system. It is the largest and most complex part of the peripheral nervous system, being organized into distinct neuron networks within the gut wall, where individual small ganglia are interconnected by dense fiber bundles. These nerve plexuses are organized into two layers of neuronal ganglia and enteroglial cells that are interconnected: The myenteric plexus (Auerbach plexus) and the submucosa plexus (Meissner plexus). The ENS forms a complete sensory-motor reflex composed of intrinsic primary afferent neurons (IPANs), interneurons, and motor neurons.
  • 1.6K
  • 14 Jan 2021
Topic Review
Dairy Products through the Addition of Microalgae
Microalgae are prokaryotic or eukaryotic photosynthetic microorganisms which have the ability to grow fast and to live under conditions not favorable to other species. They are attracting increasing attention, as their incorporation in foods and beverages can be a promising strategy to develop sustainable foods with improved nutritional profiles and a strong positive impacts on health. Despite the increasing market demand in plant-based foods, the popularity of fermented dairy foods has increased in the recent years since they are a source of microorganisms with health-promoting effects. In this context, the incorporation of microalgae in cheeses, fermented milks and other dairy products represents an interesting approach towards the development of innovative and added-value hybrid products based on animal proteins and enriched with vegetable origin ingredients recognized as extremely valuable sources of bioactive compounds.
  • 1.6K
  • 21 Mar 2022
Topic Review
Attachment and Health
Attachment and Health is psychological model which considers how attachment theory pertains to people’s preferences and expectations for the proximity of others when faced with stress, threat, danger or pain. In 1982 the American Psychiatrist, Lawrence Kolb, noticed that patients with chronic pain displayed behaviours with their healthcare providers akin to what children might display with an attachment figure, thus marking one of the first applications of attachment theory to physical health. Development of adult attachment theory and adult attachment measures in the 1990s provided researchers with the means to apply attachment theory to health in a more systematic way. Since that time it has been used to understand variation in stress response, health outcomes and health behaviour. Ultimately, the application of attachment theory to health care may enable health care practitioners to provide more personalized medicine by creating a deeper understanding of patient distress and allowing clinicians to better meet their needs and expectations.
  • 1.6K
  • 27 Sep 2022
Topic Review
Synaptotagmin Isoforms and SYT1 Function
Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. Synaptotagmin-1 (SYT1), an identified synaptotagmin protein, plays an essential role in mediating the release of calcium-triggered neurotransmitters (NT) involved in regular synaptic vesicle exocytosis. 
  • 1.6K
  • 19 Oct 2022
Topic Review
Circular Economy at Global and Energy Markets
Sustainability is a strategic approach to develop a more sustainable economy to support the environment and socio-economic development. Literature on sustainability has been concerned mainly with global warming and environmental degradation issues, whereas the Circular Economy (CE) concept has recently been suggested as an alternative solution to support market sustainability and deal with both environmental and socio-economic challenges. In order to tackle these challenges, countries must switch from linear economies that follow the “take-make-dispose” principle to circular and sustainable economies. This research applies a structural and conceptual literature review to elucidate the most decisive determinants in the formation of circular strategies, particularly in the context of the energy sector. This research examines obstacles that hinder CE adoption and formulates drivers and measures to overcome them. The research shows that the circular approach is critical in achieving sustainable development. Circularity can be considered a novel and innovative approach to alleviating the contradiction between rapid economic growth and energy and raw materials shortages. The CE structure must be considered as a sustainable foundation to enhance economic growth by avoiding waste, preserving natural capital, managing resource scarcity, recycling materials, maximizing energy efficiency, and recirculating them into the economy. Analysis reveals that the circular system is a key pillar of sustainability, security, and efficiency in the energy sector. The sustainable energy transition requires incorporating the CE principles in the design process. It also revealed that both public and private sectors must move away from the linear paradigm towards circularity to achieve CE implementation.
  • 1.6K
  • 21 Feb 2023
Topic Review
Gallium Nitride Epitaxy
Gallium nitride (GaN) is a wide-bandgap semiconductor material with excellent electrical and optical properties, making it a promising candidate for various electronic and optoelectronic devices. In particular, the unique characteristics of GaN make it a popular choice for high-power and high-frequency applications, such as power electronics, RF amplifiers, and light-emitting diodes (LEDs).
  • 1.6K
  • 25 Apr 2023
Topic Review
Nanotechnology for Precision Agriculture
By adopting nanotechnology-based precision agricultural practices, the farming community can reduce agrochemicals while maintaining high crop productivity, protecting soil and water health, and contributing to a cleaner environment.
  • 1.6K
  • 14 Jun 2023
Topic Review
Micro-Irrigation Technologies in India and Africa
Water is an essential resource for the realization of the United Nations’ 2030 Sustainable Development Goals. The increasing global food insecurity, hunger, human population, and uneconomical extraction and use of non-renewable resources require, among other things, a substantial intensification of agricultural production. In this context, there has been a need to adopt irrigation technologies, especially in developing countries where agriculture and its allied sectors employ more than 50% of the total population but account for up to 90% of the total freshwater consumptive use. India and Africa are at the crux of this conundrum, where there is an urgent need to build resilience with the already excessively allotted water resources. Innovative and water-efficient irrigation technologies could be one of the windows of opportunity to overcome water scarcity and enhance food security in these regions. 
  • 1.6K
  • 08 Dec 2023
Topic Review
Sialic Acids
This article gives a very short overview on sialic acids and is an excerpt of the introduction from the publication ‘Control of Innate Immunity by Sialic Acids in the Nervous Tissue’ by Liao H, Klaus C, Neumann H. in the Int J Mol Sci. 2020 Jul 31;21(15):E5494. doi: 10.3390/ijms21155494
  • 1.6K
  • 13 Aug 2020
Topic Review
Forward Osmosis in Wastewater Treatment
Forward osmosis (FO), driven by the osmotic pressure difference between solutions divided by a semi-permeable membrane, has been recognised as a potential energy-efficient filtration process with a low tendency for fouling and a strong ability to filtrate highly polluted wastewater.
  • 1.6K
  • 02 Jul 2021
Topic Review
Activated Hepatic Stellate Cells
Hepatic stellate cells (HSC) are the major cellular drivers of liver fibrosis. Upon liver inflammation caused by a broad range of insults including non-alcoholic fatty liver, HSC transform from a quiescent into a proliferating, fibrotic phenotype.
  • 1.6K
  • 03 Dec 2021
Topic Review
Alkaline Phosphatase on Health
Alkaline phosphatase (ALP) is abundant in raw milk. Because of its high heat resistance, ALP negative is used as an indicator of successful sterilization. However, pasteurized milk loses its immune protection against allergies. Clinically, ALP is also used as an indicator of organ diseases. When the activity of ALP in blood increases, it is considered that diseases occur in the viscera and organs. Oral administration or injection of ALP will not cause harm to the body and has a variety of probiotic effects. For infants with low immunity, ALP intake is a good prebiotic, which can protect the infant's intestine from potential pathogens. In addition, ALP has a variety of probiotic effects on any age group, including the prevention and treatment of intestinal diseases, allergies, hepatitis, acute kidney injury (AKI), diabetes, and even the prevention of aging.
  • 1.6K
  • 23 May 2022
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