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Topic Review
Physiological Function of Alpha-Synuclein
Synucleinopathy underlies a wide spectrum of clinical syndromes, including Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA), and pure autonomic failure (PAF). A common feature of these syndromes is alpha-synuclein (aS) aggregation and cellular inclusions.  In synucleinopathies, the formation of the distinct αS species is determined by the nature of the self-assembly processes, which is influenced by many factors including the SNCA mutation or multiplication, epigenetic regulation, post-translational modification, micro-environments, etc.  Both the oligomeric and fibrillar forms of αS are toxic to cells.  The detrimental effects of αS continue to grow as αS fibrils start to form LBs, which can cause mitochondrial disassembly, mitophagy, mitochondrial depolarization, and synaptic dysfunction that result in progressive neurodegeneration.  
  • 1.6K
  • 16 Sep 2023
Topic Review
Molecular Hybrids Targeting Tubulin Polymerization
Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an important target for cancer drug action because of their critical role in mitosis. Several microtubule-targeting agents with vast therapeutic advantages have been developed, but they often lead to multidrug resistance and adverse side effects. Thus, single-target therapy has drawbacks in the effective control of tubulin polymerization. Molecular hybridization, based on the amalgamation of two or more pharmacophores of bioactive conjugates to engender a single molecular structure with enhanced pharmacokinetics and biological activity, compared to their parent molecules, has recently become a promising approach in drug development. The practical application of combined active scaffolds targeting tubulin polymerization inhibitors has been corroborated in the past few years
  • 1.6K
  • 12 Apr 2022
Topic Review
Gravity Field and Steady-State Ocean Circulation Explorer
The Gravity Field and Steady-State Ocean Circulation Explorer (GOCE) was the first of ESA's Living Planet Programme satellites intended to map in unprecedented detail the Earth's gravity field. The spacecraft's primary instrumentation was a highly sensitive gravity gradiometer consisting of three pairs of accelerometers which measured gravitational gradients along three orthogonal axes. Launched on 17 March 2009, GOCE mapped the deep structure of the Earth's mantle and probed hazardous volcanic regions. It brought new insight into ocean behaviour; this in particular, was a major driver for the mission. By combining the gravity data with information about sea surface height gathered by other satellite altimeters, scientists were able to track the direction and speed of geostrophic ocean currents. The low orbit and high accuracy of the system greatly improved the known accuracy and spatial resolution of the geoid (the theoretical surface of equal gravitational potential on the Earth). The satellite's unique arrow shape and fins helped keep GOCE stable as it flew through the thermosphere at a comparatively low altitude of 255 kilometres (158 mi). Additionally, an ion propulsion system continuously compensated for the variable deceleration due to air drag without the vibration of a conventional chemically powered rocket engine, thus limiting the errors in gravity gradient measurements caused by non-gravitational forces and restoring the path of the craft as closely as possible to a purely inertial trajectory. After running out of propellant, the satellite began dropping out of orbit and made an uncontrolled reentry on 11 November 2013.
  • 1.6K
  • 02 Nov 2022
Topic Review
MOGUL Framework
The MOGUL framework is a research framework aiming to provide a theoretical perspective on the nature of language. MOGUL (Modular On-line Growth and Use of Language) draws on the common ground underlying various related areas of cognitive science including psycholinguistics, theoretical linguistics, first- and second-language acquisition, neurolinguistics and cognitive psychology; it is designed to be applicable to all these fields of research. The MOGUL framework's background assumption is that the mind is composed of expert systems which have evolved over time, one of which is responsible for human linguistic ability. Historically, scientific studies of language have been divided between many sub-disciplines; theoretical linguists focus on the abstract properties of language and researchers in other fields investigate how language is used and processed in real time: either in psychological terms or (in the case of neurolinguistics) through a study of the physical systems of neurons in the brain. Each field of study has developed its own research traditions and technical vocabulary, making it difficult to integrate insights across disciplines. The MOGUL Framework represents an attempt to identify common themes and compatible approaches in different (but related fields), and hence to facilitate integration.
  • 1.6K
  • 30 Nov 2022
Topic Review
Derivatization Strategies in Flavor Analysis
Wine and beer are the most appreciated and consumed beverages in the world. This success is mainly due to their characteristic taste, smell, and aroma, which can delight consumer’s palates. These olfactory characteristics are produced from specific classes of volatile compounds called “volatile odor-active compounds” linked to different factors such as age and production. Given the vast market of drinking beverages, the characterization of these odor compounds is increasingly important. However, the chemical complexity of these beverages has led the scientific community to develop several analytical techniques for extracting and quantifying these molecules. Even though the recent “green-oriented” trend is directed towards direct preparation-free procedures, for some class of analytes a conventional step like derivatization is unavoidable.
  • 1.6K
  • 16 Dec 2022
Biography
Bhasker Sharma
He is an acclaimed doctor not only in India but across the world. He holds the Guiness World record for hosting the Largest Homeopathy Lesson at Rajkot, Gujarat in August 2018. Dr Sharma was recently awarded two Presidential Awards by Donald Trump, the former president of the USA. These included the Presidential Active Lifestyle Award and Presidential Youth Fitness Award. Recently, Dr Sharma
  • 1.6K
  • 31 Jan 2023
Topic Review
The Circadian Clock from Birth to Death
The circadian clock is a prominent regulator of physiology. Most lifeforms on earth use endogenous, so-called circadian clocks to adapt to 24-h cycles in environmental demands driven by the planet’s rotation around its axis. Interactions with the environment change over the course of a lifetime, and so does regulation of the circadian clock system.
  • 1.6K
  • 10 Mar 2023
Topic Review
HPMCAS-Based Amorphous Solid Dispersions in Clinic
Therapeutic candidates with low solubility have become increasingly common in pharmaceutical research pipelines. Several techniques such as hot melt extrusion, spray drying, supercritical fluid technology, electrospinning, KinetiSol, etc., have been devised to improve either or both the solubility and dissolution to enhance the bioavailability of these active substances belonging to BCS Class II and IV.
  • 1.6K
  • 19 Dec 2023
Topic Review
ABC Transporters in the Innate Immune System
The ATP-binding cassette transporters (ABC transporters) are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes. It is of interest to note that many ABC transporters are involved in the transport of various lipids. In addition, this function may be related to the innate immune system. 
  • 1.6K
  • 22 Dec 2022
Topic Review
Copper Homeostasis in Mammals
One of the hallmarks of Cu metabolism in mammals is that tissue and fluid levels are normally maintained within a very narrow range of concentrations.  This results from the ability of the organism to respond to variations in intake from food and drink by balancing excretion, which occurs mainly via the bile and feces.  Although this sounds straightforward and we have already learned a great deal about aspects of this process, the balance between overall intake and excretion occurs over a high background of Cu recycling, which has generally been ignored.  In fact, most of the Cu absorbed from the GI tract actually comes from digestive fluids and is constantly “re-used”.  A great deal more recycling of Cu probably occurs in the interior, between cells of individual tissues and the fluid of the blood and interstitium.  This review presents what is known that is pertinent to understanding these complexities of mammalian Cu homeostasis and indicates where further studies are needed.
  • 1.6K
  • 10 Nov 2020
Topic Review
Long-Chain Polyunsaturated Fatty Acids
The effects of long-chain polyunsaturated fatty acids (LC PUFAs) have been frequently investigated in sows because the profitability of pig production depends mainly on reproduction performance. According to the results of the previous studies, n-3 fatty acids can postpone the time of parturition, decreasing the synthesis of prostaglandins, which are necessary for uterus contraction during labour. These effects could also be useful during the post-weaning period when low prostaglandin levels are indispensable for embryo survival. The n-3 fatty acids fed during the lactation period secreted in milk, may improve piglet performance. Despite the numerous previous field trials, there are no current feeding recommendations available for PUFAs in swine nutrition. In finding the appropriate dose of n-3 PUFAs in terms of sow nutrition, the n-6 PUFAs levels in the given feeds must be taken into account to ensure that there are no significant reductions in the final n-6/n-3 ratio.
  • 1.6K
  • 27 Oct 2020
Topic Review
Whole Ovary Cryopreservation and Transplantation
The aim of this systematic review is to shed light on the challenges of whole ovary cryopreservation and transplantation and to summarize the solutions that have been proposed so far in animal experiments and humans in order to stimulate further research in the field.
  • 1.6K
  • 16 Oct 2020
Topic Review
Cause-Related Marketing
This entry aims to examine the influence of cause–brand fit on consumer attitudes, attributed company motives, and the moderating role of corporate reputation.
  • 1.6K
  • 22 Oct 2020
Topic Review
Esophageal and Gastric Tumors
Gastric and esophageal tumors are diverse neoplasms that involve mucosal and submucosal tissue layers and include squamous cell carcinomas, adenocarcinomas, spindle cell neoplasms, neuroendocrine tumors, marginal B cell lymphomas, along with less common tumors. The worldwide burden of esophageal and gastric malignancies is significant, with esophageal and gastric cancer representing the ninth and fifth most common cancers, respectively. The approach to diagnosis and staging of these lesions is multimodal and includes a combination of gastrointestinal endoscopy, endoscopic ultrasound, and cross-sectional imaging. Likewise, therapy is multidisciplinary and combines therapeutic endoscopy, surgery, radiotherapy, and systemic chemotherapeutic tools. Future directions for diagnosis of esophageal and gastric malignancies are evolving rapidly and will involve advances in endoscopic and endosonographic techniques including tethered capsules, optical coherence tomography, along with targeted cytologic and serological analyses. 
  • 1.6K
  • 23 Feb 2021
Topic Review
Human–Machine Interface in Transport Systems
MAN PLATOONING by MAN and DB Schenker is a technical system that turns multiple vehicles into a convoy of trucks
  • 1.6K
  • 04 Mar 2021
Topic Review
DNA-Repair Pathways: Links to Neurodegeneration
Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). A possible causative role for DNA damage and DNA repair in the pathogenesis of common, late-onset NDDs is less well established, although DDR defects are emerging as possible culprits in diseases like AD, PD, and ALS. Whether targeting DNA repair or the DDR may be developed into therapeutic options against NDDs remains to be clarified.
  • 1.6K
  • 18 Jun 2021
Topic Review
Micromachined Accelerometers with Non-noise Floor
This paper reviews the research and development of micromachined accelerometers with a noise floor lower than 1 µg/√Hz. Firstly, the basic working principle of micromachined accelerometers is introduced. Then, different methods of reducing the noise floor of micromachined accelerometers are analyzed. Different types of micromachined accelerometers with a noise floor below 1 µg/√Hz are discussed. 
  • 1.6K
  • 09 Jul 2021
Topic Review
Antifungal Metabolites as Food Bio-Preservative
Perishable food spoilage caused by fungi is a major cause of discomfort for food producers. Food sensory abnormalities range from aesthetic degeneration to significant aroma, color, or consistency alterations due to this spoilage. Bio-preservation is the use of natural or controlled bacteria or antimicrobials to enhance the quality and safety of food. It has the ability to harmonize and rationalize the required safety requirements with conventional preservation methods and food production safety and quality demands. Even though synthetic preservatives could fix such issues, there is indeed a significant social need for “clean label” foods. As a result, consumers are now seeking foods that are healthier, less processed, and safer. The implementation of antifungal compounds has gotten a lot of attention in recent decades. As a result, the identification and characterization of such antifungal agents has made promising advances.
  • 1.6K
  • 29 Mar 2022
Topic Review
Ly6c as New Marker of Mouse Blood Vessels
During our research we have observed that Ly6c, which is traditionally only used as a classic and non-classical monocyte / macrophage differentiating antigen, can be used as a new specific marker of the mouse vasculature and to assess qualitatively and quantitatively vascular changes in health and disease. Researchers believe that this innovative application of Ly6c immunodetection, which has shown three advantages (brighter signal, homogeneous staining and greater selectivity) compared to traditional vessel markers such as IB4 isolectin, will be of high interest to researchers in this field.
  • 1.6K
  • 28 Mar 2022
Topic Review
Unravelling Formaldehyde Metabolism in Bacteria
Formaldehyde metabolism is prevalent in all organisms, where the accumulation of formaldehyde can be prevented through the activity of dissimilation pathways. Furthermore, formaldehyde assimilatory pathways play a fundamental role in many methylotrophs, which are microorganisms able to build biomass and obtain energy from single- and multicarbon compounds with no carbon–carbon bonds. 
  • 1.6K
  • 26 Jan 2022
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