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Topic Review
Anaerobic Fungi
Anaerobic fungi, though low in abundance in rumen, play an important role in the degradation of forage for herbivores. Anaerobic fungi have been found in almost all animals that ferment in the predigestive tract, including ruminants (e.g., Bovidae, Cervidae), pseudoruminants (e.g., hippos, camels, llamas, alpacas), and nonruminants (e.g., wallabies). They are also found in many postdigestive tract fermenters that digest plant tissues in the cecum and large intestine (e.g., elephants, horses, and rhinoceroses) and in some large herbivore rodents (e.g., long-eared guinea pigs). It appears that the establishment of anaerobic fungi in the alimentary canal of herbivores may be attributed to the complex and distinct chamber with a relatively neutral pH in the digestive tract and a long lag time in the digestive process for the ingested plant tissue, which is conducive to the growth and activity of anaerobic fungi. Therefore, anaerobic fungi, which appear in the digestive tract of these herbivores, especially in those that take in a lot of roughage, must have some unique reasons and advantages to exist in such a complex environment. 
  • 1.6K
  • 06 Apr 2022
Topic Review
Types of Micellar Assemblies
Amphiphilic block copolymers (with a variety of hydrophobic blocks and hydrophilic blocks; often polyethylene oxide) self-assemble in water to micelles/niosomes similar to conventional nonionic surfactants with high drug loading capacity.
  • 1.6K
  • 08 Nov 2022
Topic Review
Acid-Resistant Thin-Film Composite Nanofiltration Membrane
Membrane filtration technology has attracted extensive attention in academia and industry due to its advantages of eco-friendliness related to environmental protection and high efficiency. Polyamide thin-film composite nanofiltration (PA TFC NF) membranes have been widely used due to their high separation performance. Non-acid-resistant PA TFC NF membranes face tremendous challenges in an acidic environment. Novel and relatively acid-resistant polysulfonamide-based and triazine-based TFC NF membranes have been developed, but these have a serious trade-off in terms of permeability and selectivity. Hence, how to improve acid resistance of TFC NF membranes and their separation performance in acidic environments is a pivotal issue for the design and preparation of these membranes.
  • 1.6K
  • 12 Jan 2023
Topic Review
Construction Information Classification System
In the field of infrastructure construction, progress in digital transformation remains limited; this is particularly true in road construction, an infrastructure facility involving design, construction, and operation stages. Many construction subjects are involved at each stage of this cycle, generating substantial construction information. To drive the digital transformation of the construction industry, a construction information classification system is necessary for the development of a systematic construction information model. 
  • 1.6K
  • 22 Sep 2023
Topic Review
PRISMA Statement
The bioethanol sector is an extremely complex set of actors, technologies and market structures, influenced simultaneously by di erent natural, economic, social and political processes. That is why it lends itself to the application of system dynamics modelling. In last five years a relatively high level of experience and knowledge has accumulated related to the application of computer-aided system modelling for the analysis and forecasting of the bioethanol sector. The goal of the current paper is to o er a systematic review of the application of system dynamics models in order to better understand the structure, conduct and performance of the bioethanol sector. Our method has been the preferred reporting items for systematic reviews and meta-analyses (PRISMA), based on English-language materials published between 2015 and 2020. The results highlight that system dynamic models have become more and more complex, but as a consequence of the improvement in information technology and statistical systems, as well as the increasing experience gained they o er an ecient tool for decision makers in the business and political spheres. In the future, the combination of traditional system dynamics modelling and agent-based models will o er new perspectives for the preparation of more sophisticated description and forecasting.
  • 1.6K
  • 28 Oct 2020
Topic Review
Proteoglycans in the hormone-dependent cancers
The tumor microenvironment (TME) exhibits unique characteristics that differ among various tumor types. It is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded and supported by components of the extracellular matrix (ECM). Therefore, the interactions among cancer cells, stromal cells, and components of the ECM determine cancer progression and response to therapy. Proteoglycans (PGs), hybrid molecules consisting of a protein core to which sulfated glycosaminoglycan chains are bound, are significant components of the ECM that are implicated in all phases of tumorigenesis. These molecules, secreted by both the stroma and cancer cells, are crucial signaling mediators that modulate the vital cellular pathways implicated in gene expression, phenotypic versatility, and response to therapy in specific tumor types. Specific inputs from the endocrine and immune systems are some of the characteristics of hormone-dependent cancer pathogenesis. Notably, the mechanisms involved in various aspects of cancer progression are executed in the ECM niche of the TME, and its' PG components crucially mediate these processes including cancer metastasis, angiogenesis, immunobiology, autophagy, and response to therapy. Hormone-dependent cancers exhibit high morbidity and mortality. In spite of advances in therapy, the treatment  of hormone-dependent cancers remains an unmet health need. The tumor microenvironment (TME) exhibits unique characteristics that differ among various tumor types. It is composed of cancerous, non-cancerous, stromal, and immune cells that are surrounded and supported by components of the extracellular matrix (ECM). Therefore, the interactions among cancer cells, stromal cells, and components of the ECM determine cancer progression and response to therapy. Proteoglycans (PGs), hybrid molecules consisting of a protein core to which sulfated glycosaminoglycan chains are bound, are significant components of the ECM that are implicated in all phases of tumorigenesis. These molecules, secreted by both the stroma and cancer cells, are crucial signaling mediators that modulate the vital cellular pathways implicated in gene expression, phenotypic versatility, and response to therapy in specific tumor types. A plethora of deregulated signaling pathways contributes to the growth, dissemination, and angiogenesis of hormone-dependent cancers. Specific inputs from the endocrine and immune systems are some of the characteristics of hormone-dependent cancer pathogenesis. Importantly, the mechanisms involved in various aspects of cancer progression are executed in the ECM niche of the TME, and the PG components crucially mediate these processes.
  • 1.6K
  • 31 Aug 2020
Topic Review
Membranes Used as Separators in Microbial Fuel Cells
Microbial fuel cells (MFCs) are electrochemical devices focused on bioenergy generation and organic matter removal carried out by microorganisms under anoxic environments. In these types of systems, the anodic oxidation reaction is catalyzed by anaerobic microorganisms, while the cathodic reduction reaction can be carried out biotically or abiotically. Membranes as separators in MFCs are the primary requirements for optimal electrochemical and microbiological performance.
  • 1.6K
  • 29 Nov 2021
Topic Review
Nano-Drug Delivery to Target Macrophages
Macrophages are the most important innate immune cells that participate in various inflammation-related diseases. Therefore, macrophage-related pathological processes are essential targets in the diagnosis and treatment of diseases. Since nanoparticles (NPs) can be preferentially taken up by macrophages, NPs have attracted most attention for specific macrophage-targeting. 
  • 1.6K
  • 10 Jun 2022
Topic Review
Development of Robotic Arm Harvesters
Promotion of research and development in advanced technology must be implemented in agriculture to increase production in the current challenging environment where the demand for manual farming is decreasing due to the unavailability of skilled labor, high cost, and shortage of labor. The demand for fruit harvester technologies, i.e., mechanized harvesting, manned and unmanned aerial systems, and robotics, has increased. However, several industries are working on the development of industrial-scale production of advanced harvesting technologies at low cost, no commercial robotic arm has been developed for selective harvesting of valuable fruits and vegetables, especially within controlled strictures, i.e., greenhouse and hydroponic contexts. 
  • 1.6K
  • 28 Nov 2023
Topic Review
Tea/Tree Intercropping Plantations on Soil Ecological Service Function
The benefits of intercropping tea plantations exceeded those of monocropping tea plantations in terms of soil ecosystem service functions, such as water retention capacity, mineral contents, effects on energy transformation, and regulating environmental conditions. Intercropping tea plantations were more sustainable than regular tea plantations because of the different degrees of variability and benefits in all three aspects mentioned above. However, tea and tree intercropping plantations often require careful planning and preliminary experimentation to determine the type of intercropping that will have positive impacts, especially in the long term.
  • 1.6K
  • 09 Jun 2023
Topic Review
The Gut Microbiome in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease in which environmental and genetic factors are involved. Although the molecular mechanisms involved in NAFLD onset and progression are not completely understood, the gut microbiome (GM) is thought to play a key role in the process, influencing multiple physiological functions. 
  • 1.6K
  • 30 Oct 2020
Topic Review
Selective Autophagy
Autophagy is a “self-eating” process that engulfs cellular contents for their subsequent digestion in lysosomes to engage the metabolic need in response to starvation or environmental insults. According to the contents of degradation, autophagy can be divided into bulk autophagy (non-selective autophagy) and selective autophagy. Bulk autophagy degrades non-specific cytoplasmic materials in response to nutrient starvation while selective autophagy targets specific cargoes, such as damaged organelles, protein aggregates, and intracellular pathogens. Selective autophagy has been documented to relate to the reproductive processes, especially for the spermatogenesis, fertilization, and biosynthesis of testosterone.
  • 1.6K
  • 01 Dec 2020
Topic Review
γ-Glutamyltransferase in Urologic Neoplasms
γ-Glutamyltransferase (GGT), a membrane-bound enzyme, contributes to the metabolism of glutathione (GSH), which plays a critical physiological role in protecting cells against oxidative stress. GGT has been proposed as a biomarker of carcinogenesis and tumor progression given that GGT activity is important during both the promotion and invasion phases in cancer cells.
  • 1.6K
  • 14 Apr 2021
Topic Review
Small Molecule Natural Products Targeting Nrf2-HO-1 Signaling
The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney protection by regulating antioxidants during OS. Heme oxygenase-1 (HO-1), one of the targets of Nrf2-ARE, plays an important role in regulating OS and is protective in a variety of human and animal models of kidney disease. Thus, activation of Nrf2-HO-1 signaling may offer a potential approach to the design of novel therapeutic agents for kidney diseases.
  • 1.6K
  • 06 Jun 2022
Topic Review
Wila (Lichen)
Wila (Bryoria fremontii) is a dark brown, hair-like lichen that grows hanging from trees in western North America, and northern Europe and Asia. Wila grows abundantly in some areas, and is an important traditional food for many First Nations in North America.
  • 1.6K
  • 27 Oct 2022
Topic Review
CAPM and Fama and French Three-Five Factor Models
Entitled the Fama and French three-factor (hereafter, FF3F) model (1993), it embraces others risk factors in addition to the CAPM beta, such as the mimicking returns for the size factor and the mimicking returns for the book-to-market factor.
  • 1.6K
  • 02 Jan 2024
Topic Review
AhR, inflammation and breast cancer
AhR, an environmentally sensitive transcription factor, is one of the more evolutionary conserved molecules in living cells.
  • 1.6K
  • 21 Feb 2022
Topic Review
LAMM Syndrome
Congenital deafness with labyrinthine aplasia, microtia, and microdontia (also called LAMM syndrome) is a condition that affects development of the ears and teeth.
  • 1.6K
  • 04 Jan 2021
Topic Review
Protein Structure Fluctuation
Proteins are indispensable to cellular communication and metabolism. The structure on which cells and tissues are developed is deciphered from proteins. To perform functions, proteins fold into a three-dimensional structural design, which is specific and fundamentally determined by their characteristic sequence of amino acids.
  • 1.6K
  • 19 Apr 2022
Topic Review
Production of Ultra-High-Performance Concrete
Ultra-high-performance concrete (UHPC) is defined as a type of concrete that exhibits compressive strength greater than 120 MPa, a nominal maximum aggregate size of less than 5 mm, and flowability between 200 mm and 250 mm. UHPC exhibits a tensile strength greater than 5 MPa. According to the Federal Highway Administration (FHWA), USA, UHPC is characterized by the use of a combination of Portland cement and supplementary cementitious materials, an optimised gradation of granular materials, a high volume of discontinuous internal fibres, and a low water-to-cementitious materials ratio of less than 0.25. The microstructure of UHPC is characterized irregular pores, which control liquid evaporation and enhance durability in comparison to conventional and high-performance concretes.
  • 1.6K
  • 08 Feb 2024
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