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Topic Review
Pathogenesis and Treatment of Neuropsychiatric Lupus Erythematosus
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a broad spectrum of sub-types with diverse severities and prognoses. Ischemic and inflammatory mechanisms, including autoantibodies and cytokine-mediated pathological processes, are key components of the pathogenesis of NPSLE. Additional brain-intrinsic elements (such as the brain barrier and resident microglia) are also important facilitators of NPSLE. An improved understanding of NPSLE may provide further options for managing this disease. The attenuation of neuropsychiatric disease in mouse models demonstrates the potential for novel targeted therapies. Conventional therapeutic algorithms include symptomatic, anti-thrombotic, and immunosuppressive agents that are only supported by observational cohort studies, therefore performing controlled clinical trials to guide further management is essential and urgent. The latest pathogenetic mechanisms of NPSLE are presented, and the progress in its management is discussed.
  • 1.7K
  • 09 Sep 2022
Topic Review
Cascade Lake (Microarchitecture)
Cascade Lake is an Intel codename for a 14 nanometer server, workstation and enthusiast processor microarchitecture, launched in April 2019. In Intel's Process-Architecture-Optimization model, Cascade Lake is an optimization of Skylake. Intel states that this will be their first microarchitecture to support 3D XPoint-based memory modules. It also features Deep Learning Boost instructions and mitigations for Meltdown and Spectre. Intel officially launched new Xeon Scalable SKUs on February 24, 2020.
  • 1.7K
  • 23 Nov 2022
Topic Review
Clinical Application of Botulinum Toxin in Laryngeal Dystonia
Laryngeal dystonia (LD), or spasmodic dysphonia (SD), is a chronic, task-specific, focal movement disorder affecting the larynx. It interferes primarily with the essential functions of phonation and speech. LD affects patients’ ability to communicate effectively and significantly diminishes their quality of life. Botulinum neurotoxin was first used as a therapeutic agent in the treatment of LD four decades ago and remains the standard of care for the treatment of LD. 
  • 1.7K
  • 09 Dec 2022
Topic Review
Synthesis of Porous Composite Metal Oxides
Porous transition-metal oxides with good intrinsic activities can be used to disperse and stabilize the active noble metal phases, thus promoting improvements in selectivity and activity of the supported noble metal catalysts and in the meanwhile reinforcing the optimized utilization of noble metals.
  • 1.7K
  • 27 Feb 2023
Topic Review
Clinical Presentations of Human Anthrax
Anthrax is one of the most important zoonotic diseases which primarily infects herbivores and occasionally humans. The etiological agent is Bacillus anthracis which is a Gram-positive, aerobic, spore-forming, nonmotile, rod-shaped bacillus. The spores are resistant to environmental conditions and remain viable for a long time in contaminated soil, which is the main reservoir for wild and domestic mammals. Infections still occur in low-income countries where they cause suffering and economic hardship. Humans are infected by contact with ill or dead animals, contaminated animal products, directly exposed to the spores in the environment or spores released as a consequence of a bioterrorist event. Three classical clinical forms of the disease, cutaneous, gastrointestinal and inhalation, are seen, all of which can potentially lead to sepsis or meningitis.
  • 1.7K
  • 20 Mar 2023
Topic Review
Ultrasound and HPP to Control Fruit Enzymatic Browning
Polyphenoloxidase (PPO) is an endogenous enzyme, which is naturally present in plant tissues, and it has also been referred to as polyphenol oxidase, catechol oxidase, tyrosinase, phenolase, catecholase, and o-diphenol oxidase. It is an oxidoreductase-copper-containing metalloprotein, which catalyses the degradation of phenolic fruit constituents to o-quinones in the presence of oxygen. The combination of ultrasound with temperature, and high pressure processing (HPP) with temperature to inactivate polyphenoloxidase enzyme in three fruits (pear, apple and strawberry) was investigated and compared with PPO inactivation exclusively by a thermal process. 
  • 1.7K
  • 12 Jul 2022
Topic Review
Chinese Mountain Cat
The Chinese Mountain Cat (Felis bieti) is a small wild felid species native to the high-altitude regions of central China. Characterized by its distinctive grayish-brown fur, black-spotted coat, and bushy tail, this elusive feline is adapted to the harsh mountainous environments of the Tibetan Plateau and adjacent areas. Despite its status as one of the least studied wild cats, the Chinese Mountain Cat plays a crucial role in its ecosystem as a predator of small mammals and birds, highlighting the importance of conservation efforts to protect its fragile habitat.
  • 1.7K
  • 28 Feb 2024
Topic Review
PTEN in different TME compartments
Mounting preclinical and clinical evidence indicates that rewiring the host immune system in favor of an antitumor microenvironment achieves remarkable clinical efficacy in the treatment of many hematological and solid cancer patients. Nevertheless, despite the promising development of many new and interesting therapeutic strategies, many of these still fail from a clinical point of view, probably due to the lack of prognostic and predictive biomarkers. In that respect, several data shed new light on the role of the tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) in affecting the composition and function of the tumor microenvironment (TME) as well as resistance/sensitivity to immunotherapy. In this review, we summarize current knowledge on PTEN functions in different TME compartments (immune and stromal cells) and how they can modulate sensitivity/resistance to different immunological manipulations and ultimately influence clinical response to cancer immunotherapy
  • 1.7K
  • 04 Aug 2020
Topic Review
TGFB3 Gene
Transforming growth factor beta 3: The TGFB3 gene provides instructions for producing a protein called transforming growth factor beta-3 (TGFβ-3).
  • 1.7K
  • 25 Dec 2020
Topic Review
Ion-Imprinted Polymers
Growing concern over the hazardous effect of radionuclides on the environment is driving research on mitigation and deposition strategies for radioactive waste management. Currently, there are many techniques used for radionuclides separation from the environment such as ion exchange, solvent extraction, chemical precipitation and adsorption. Adsorbents are the leading area of research and many useful materials are being discovered in this category of radionuclide ion separation. The adsorption technologies lack the ability of selective removal of metal ions from solution. This drawback is eliminated by the use of ion-imprinted polymers, these materials having targeted binding sites for specific ions in the media.
  • 1.7K
  • 28 Sep 2021
Topic Review
CCL21/CCR7 in Breast Cancer
Breast cancer is a leading cause of cancer-related deaths worldwide, predominantly caused by metastasis. It is generally accepted that the pattern of breast cancer metastasis is largely determined by the interaction between the chemokine receptors on cancer cells and the chemokines expressed at the sites of metastatic disease. Chemokine receptors belong to the G-protein-coupled receptors (GPCRs) family that appear to be implicated in inflammatory diseases, tumor growth and metastasis. One of its members, C-C Chemokine receptor 7 (CCR7), binds chemokines CCL19 and CCL21, which are important for tissue homeostasis, immune surveillance and tumorigenesis. These receptors have been shown to induce the pathobiology of breast cancer due to their ability to induce cellular proliferation and migration upon the binding of the cognate chemokine receptors. The underlying signaling pathways and exact cellular interactions within this biological system are not fully understood and need further insights.
  • 1.7K
  • 25 May 2021
Topic Review
Wines' Volatile and Non-Volatile Characterization
Phenolic and volatile compounds have been the most common variables studied in wines due to their importance in chemical, physical and sensory properties. Phenolic compounds come from grapes and oak wood of the barrels where wines are aged and affect color and gustatory properties of wines, such as astringency, bitterness and structure.
  • 1.7K
  • 13 Aug 2021
Topic Review
Chelidonium majus L.
The effect of cultivation practises on both the phytochemical profile and biological activity of aqueous ethanol extracts of Chelidonium majus L. was studied. Extracts were prepared from aerial parts of the same plant population collected in the wild and grown under organic farming conditions. Both qualitative and quantitative analyses of alkaloids and flavonoid derivatives were performed by LC/MS methods, and the cytotoxicity of lyophilised extracts was studied in B16-F10, HepG2, and CaCo-2 cells. Coptisine was the dominant alkaloid of extracts prepared from wild-grown plants, whereas after cultivation, chelidonine was the most abundant alkaloid. The total alkaloid content was significantly increased by cultivation. Ten flavonol glycoconjugates were identified in C. majus extracts, and quantitative analysis did not reveal significant differences between extracts prepared from wild-grown and cultivated specimens. Treatment with C. majus extracts resulted in a dose-dependent increase in cytotoxicity in all three cell lines. The extracts prepared from cultivated specimens showed higher cytotoxicity than the extracts prepared from wild-grown plants. The strongest cytotoxic effect of cultivated C. majus was observed in B16-F10 cells (IC50 = 174.98 ± 1.12 µg/mL). Cultivation-induced differences in the phytochemical composition of C. majus extracts resulted in significant increases in the cytotoxic activities of the preparations.
  • 1.7K
  • 27 Sep 2021
Topic Review
CXCL1 as Gene, Promoter and Regulation of Expression
CXCL1 is one of the most important chemokines, part of a group of chemotactic cytokines involved in the development of many inflammatory diseases. It activates CXCR2 and, at high levels, CXCR1. The expression of CXCL1 is elevated in inflammatory reactions and also has important functions in physiology, including the induction of angiogenesis and recruitment of neutrophils.
  • 1.7K
  • 15 Feb 2022
Topic Review
Health, Economic and Social Challenges in COVID-19 Pandemic
The COVID-19-pandemic-related health, economic and social crises are leading to huge challenges for all spheres of human life across the globe. Various challenges highlighted by this pandemic include, but are not limited to, the need for global health cooperation and security, better crisis management, coordinated funding in public health emergencies, and access to measures related to prevention, treatment, and control. 
  • 1.7K
  • 10 May 2022
Topic Review
TI MSP432
The MSP432 is a mixed-signal microcontroller family from Texas Instruments. It is based on a 32-bit ARM Cortex-M4F CPU, and extends their 16-bit MSP430 line, with a larger address space for code and data, and faster integer and floating point calculation than the MSP430. Like the MSP430, it has a number of built-in peripheral devices, and is designed for low power requirements.
  • 1.7K
  • 04 Nov 2022
Topic Review
Secondary Metabolites from Trichoderma harzianum
The biocontrol fungus Trichoderma harzianum, from both marine and terrestrial environments, has attracted considerable attention. T. harzianum has a tremendous potential to produce a variety of bioactive secondary metabolites (SMs), which are an important source of new herbicides and antibiotics.
  • 1.7K
  • 05 Dec 2022
Topic Review
Application of Prime Editing to Liver Hereditary Diseases
Gene therapy holds tremendous potential in the treatment of inherited diseases. Unlike traditional medicines, which only treat the symptoms, gene therapy has the potential to cure the disease by addressing the root of the problem: genetic mutations. The discovery of CRISPR/Cas9 in 2012 paved the way for the development of those therapies. Improvement of this system led to the recent development of an outstanding technology called prime editing. This system can introduce targeted insertions, deletions, and all 12 possible base-to-base conversions in the human genome. Since the first publication on prime editing in 2019, groups all around the world have worked on this promising technology to develop a treatment for genetic diseases. Liver diseases are currently the most studied field for human gene therapy by prime editing. To date, prime editing has been attempted in preclinical studies for tyrosinemia type 1, alpha-1-antitrypsin deficiency, phenylketonuria, DGAT1-deficiency, bile salt export pump deficiency, liver cancer, and for a liver disease caused by a mutation in the DNMT1 gene.
  • 1.7K
  • 21 Feb 2023
Topic Review
Lynch Syndrome (LS)
Lynch syndrome (LS), also known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC), is an autosomal dominant cancer syndrome which causes about 2–3% of cases of colorectal carcinoma. The development of LS is due to the genetic and epigenetic inactivation of genes involved in the DNA mismatch repair (MMR) system, causing an epiphenomenon known as microsatellite instability (MSI). 
  • 1.7K
  • 22 Aug 2023
Topic Review
Cisplatin-Induced Ototoxicity
Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck, and lung cancer. Cisplatin is also used to treat tumors in children, such as neuroblastoma, osteosarcoma, and hepatoblastoma.
  • 1.7K
  • 30 Nov 2023
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