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Topic Review
Indole Derivatives as Anti-Lung Cancer Agents
Indole scaffold is considered one of the most privileged scaffolds in heterocyclic chemistry. Indole may serve as an effective probe for the development of new drug candidates against challenging diseases, including lung cancer. 
  • 1.7K
  • 12 Nov 2021
Topic Review
Historical Perspective on Membrane Science and Technology
Over the last few decades, considerable effort has been devoted to developing better membranes and extending their range of applications to different areas. Membrane processes already have an established role in gas separation and water treatment, and their applications in the food, pharmaceutical, and health areas have been continuously increasing. In the last few years, membrane processes proved to have a key role in biorefinery and bioenergy production processes, namely for process intensification and the recovery and purification of valuable products. Membranes are also a crucial component of electrochemical energy conversion devices, including fuel cells and electrolysers. Moreover, the growing environmental concerns have drawn attention to the use of fossil-based polymers and toxic solvents for membrane fabrication. Therefore, the development of new membranes, using polymers from renewable sources and more sustainable fabrication methods, is being pursued.
  • 1.7K
  • 23 Feb 2022
Topic Review
A Lean-Led Design Approach
Lean-led Design is a  user-empowering approach that gained popularity in some countries such as the USA. It is proposed to be used during the project definition of healthcare projects in order to enhance quality of healthcare and optimize pathways that patients could follow.
  • 1.7K
  • 06 Apr 2022
Topic Review
Stock Selection Criterion
Stock selection criteria or stock picking is a multi-method technique for investing when specifically dealing with stocks (equity markets). The stock investment or position can be "long" (bought) (to benefit from a stock price increase) or "short" (sold) (to benefit from a decrease in a stock's price), depending on the investor or financial professional's expectation of how the stock price is going to move. The stock selection criteria may include systematic stock picking methods that utilize computer software and/or data.
  • 1.7K
  • 18 Oct 2022
Topic Review
Syslog
In computing, syslog /ˈsɪslɒɡ/ is a standard for message logging. It allows separation of the software that generates messages, the system that stores them, and the software that reports and analyzes them. Each message is labeled with a facility code, indicating the type of system generating the message, and is assigned a severity level. Computer system designers may use syslog for system management and security auditing as well as general informational, analysis, and debugging messages. A wide variety of devices, such as printers, routers, and message receivers across many platforms use the syslog standard. This permits the consolidation of logging data from different types of systems in a central repository. Implementations of syslog exist for many operating systems. When operating over a network, syslog uses a client-server architecture where a syslog server listens for and logs messages coming from clients.
  • 1.7K
  • 19 Oct 2022
Topic Review
Electrochemical Random-Access Memory
Electrochemical Random-Access Memory (ECRAM) is a type of non-volatile memory (NVM) with multiple levels per cell (MLC) designed for deep learning analog acceleration. An ECRAM cell is a three-terminal device composed of a conductive channel, an insulating electrolyte, an ionic reservoir, and metal contacts. The resistance of the channel is modulated by ionic exchange at the interface between the channel and the electrolyte upon application of an electric field. The charge-transfer process allows both for state retention in the absence of applied power, and for programming of multiple distinct levels, both differentiating ECRAM operation from the one of a field-effect transistor (FET). The write operation is deterministic and can result in symmetrical potentiation and depression, making ECRAM arrays attractive for acting as artificial synaptic weights in physical implementations of artificial neural networks (ANN). The technology challenges include open circuit potential (OCP) and semiconductor foundry compatibility associated with energy materials. Universities, government laboratories, and corporate research teams have contributed to the development of ECRAM for analog computing. Notably, Sandia National Laboratories designed a lithium-based cell inspired by solid-state battery materials, Stanford University built an organic proton-based cell, and International Business Machines (IBM) demonstrated in-memory selector-free parallel programming for a logistic regression task in an array of metal-oxide ECRAM designed for insertion in the back end of line (BEOL).
  • 1.7K
  • 17 Nov 2022
Topic Review
Evolutionary Psychology of Religion
The evolutionary psychology of religion is the study of religious belief using evolutionary psychology principles. It is one approach to the psychology of religion. As with all other organs and organ functions, the brain's functional structure is argued to have a genetic basis, and is therefore subject to the effects of natural selection and evolution. Evolutionary psychologists seek to understand cognitive processes, religion in this case, by understanding the survival and reproductive functions they might serve.
  • 1.7K
  • 21 Nov 2022
Topic Review
Thyroid Eye Disease
Thyroid eye disease (TED) is an inflammatory disease of orbital tissue characterized by infiltration of lymphocytic cells, orbital fat expansion, and extraocular muscle swelling. The gravity of thyroid eye disease lies in its sight-threatening, debilitating, and disfiguring potential. Despite extensive ongoing research about TED, the disorder remains elusive in its exact pathophysiology, prevention, and ideal treatment.
  • 1.7K
  • 22 Dec 2022
Topic Review
The Interplay between Plants and Microbial Communities
Plant-microbe interactions are critical for ecosystem functioning and driving rhizosphere processes. To fully understand the communication pathways between plants and rhizosphere microbes, it is crucial to measure the numerous processes that occur in the plant and the rhizosphere. Plants can host a wide range of microbes, collectively known as the plant microbiome, in the rhizosphere (i.e., the region of soil in the vicinity of plant roots), endosphere (i.e., plant internal tissues), and phyllosphere (i.e., stem, leaves, or flowers). These microbiomes form long-lasting interactions with the host plant, leading to positive, neutral, or negative impacts on crop performance and microbe-mediated biogeochemical processes.
  • 1.7K
  • 08 Feb 2023
Topic Review
Power Line Failures/Faults and Wildfire Initiation Mechanisms
Wildfires are one of the most hazardous natural disasters in Australia in terms of fatalities, property damage and financial losses. Events of catastrophic wildfires are recorded across the world including in the United States and Canada. Failures along power distribution infrastructure and network faults have been identified as some of the causes for the initiation of wildfires. Thus, it is critical to better understand the mechanisms and the potential prevention strategies for wildfires caused by power distribution system faults.
  • 1.7K
  • 15 Jun 2023
Topic Review
Attitudes towards Plastic Pollution
Plastic pollution has received unprecedented attention globally, and there are increasing calls to control it. Despite this, the uptrends of plastic consumption and mismanaged plastic waste show little sign of reversal. It is imperative to understand the attitudes of various societal groups towards plastics to identify the barriers to behavioral changes to reduce plastic pollution and synthesize effective countermeasures. Generally, there are negative attitudes towards plastic pollution and people are willing to act against it by supporting campaigns, paying for environmentally friendly alternatives, and supporting solution-based interventions from governments including policies, regulations and guidelines. Inconvenience due to limited options for plastic items and habits are two main barriers to behavioral changes. Governments play crucial roles to tap into these attitudes to lead and intensify control plastic pollution through a multi-pronged approach that facilitates systematic substitution of conventional plastics with environmentally friendly alternatives as well as the stepping-up of the circular plastic economy and industrial symbiosis. Progressively regulated capping of conventional plastic production and consumption could help the transition, and the public could complement government endeavors through education, mutual influence and awareness-raising which could also be driven by governmental policies and programs.
  • 1.7K
  • 21 Jun 2023
Topic Review
COVID-19 and Sleep Disturbances
The need for adequate good quality sleep to optimally function is well known. Various physical, psychological, biological, and social factors have been investigated to understand their impact on sleep. However, understanding the etiological processes that are involved in causing sleep disturbances (SD) as impacted by stressful phases such as pandemics has not been well studied. Many such etiological and management strategies have surfaced during the “coronavirus disease of 2019 (COVID-19) pandemic. The occurrence of these SD in the infected and uninfected individuals poses a need to investigate factors linked to such occurrence during this phase. Some of such factors include stressful practices such as social distancing, masking, vaccines, and medications availability, changes in routines, and lifestyles. As the status of infection improved, a collective term for all the prolonged effects of COVID-19 after the resolution of the primary infection called the post-COVID-19 syndrome (PCS) surfaced. Apart from impacting sleep during the infectious phase, the aftereffects of this virus left an even greater impact during the PCS.
  • 1.7K
  • 05 Sep 2023
Topic Review
Development of Trichosanthin
Tian Hua Fen, a herbal powder extract that contains trichosanthin (TCS), was used as an abortifacient in traditional Chinese medicine. In 1972, TCS was purified to alleviate the side effects. Because of its clinical applications, TCS became one of the most active research areas in the 1960s to the 1980s in China. These include obtaining the sequence information in the 1980s and the crystal structure in 1995. The replication block of TCS on human immunodeficiency virus in lymphocytes and macrophages was found in 1989 and started a new chapter of its development.
  • 1.7K
  • 21 Mar 2022
Topic Review
Intracellular Lifestyle of Staphylococcus aureus
Staphylococcus aureus (S. aureus) is part of the normal skin and nasal microbiota, with approximately 30% of the healthy adult population colonized mainly in the nasopharyngeal cavity. While colonization is usually asymptomatic, a symptomatic infection can occur if there is a breach in the mucosal barrier or skin. The severity of symptomatic infections ranges from superficial skin and soft tissue infections, to devastating complications, such as necrotizing pneumonia, endocarditis, toxic shock syndrome, and sepsis. In the pre-antibiotic era, S. aureus bacteremia mortality rates were astonishingly high, ranging between 75% and 83%. Even though antibiotics have reduced this number significantly, S. aureus bloodstream infections still account for over 19,000 deaths annually in the United States. With every new antibiotic that is developed, S. aureus resistance has been quickly observed. MRSA strains that are resistant to all penicillin-like β-lactam antibiotics pose a particularly serious threat to the community. Two types of MRSA exist: hospital-acquired (HA-)MRSA and community-acquired (CA-)MRSA. CA-MRSA strains are typically regarded as more virulent and can cause infections in otherwise healthy individuals. This notion is further supported by experimental animal studies, whereas HA-MRSA strains are less virulent than CA-MRSA and cause fewer disseminating diseases. Although in animal models, mice are typically not treated with antibiotics, which is unlike a hospital setting.
  • 1.7K
  • 05 Sep 2022
Topic Review
Application of Hydrogels for Bone Regeneration
Hydrogels are versatile biomaterials characterized by three-dimensional, cross-linked, highly hydrated polymeric networks. These polymers exhibit a great variety of biochemical and biophysical properties, which allow for the diffusion of diverse molecules, such as drugs, active ingredients, growth factors, and nanoparticles. Meanwhile, these polymers can control chemical and molecular interactions at the cellular level. The polymeric network can be molded into different structures, imitating the structural characteristics of surrounding tissues and bone defects. Interestingly, the application of hydrogels in bone tissue engineering (BTE) has been gathering significant attention due to the beneficial bone improvement results that have been achieved.
  • 1.7K
  • 29 Jun 2023
Topic Review
Glioblastoma Organoids
Glioblastoma (GB) is the most lethal primary adult brain tumor. The great number of mutations involved and the aggressiveness of glioblastoma render this type of cancer especially difficult to investigate. Moreover, the lack of reliable GB models, together with its considerable clinical heterogeneity, has impaired a comprehensive investigation of the mechanisms that lead to tumorigenesis, cancer progression, and response to treatments. To address this problem, cerebral organoids have emerged as promising tools to investigate brain biology and to recapitulates the major steps involved in glioblastoma tumorigenesis. Here we exemplify relevant aspects of 3D models of glioblastoma, with a specific focus on organoids and their involvement in basic and translational research.
  • 1.7K
  • 25 Nov 2020
Topic Review
Hypertension
Hypertension is abnormally high blood pressure in the arteries, which are the blood vessels that carry blood from the heart to the rest of the body. As the heart beats, it forces blood through the arteries to deliver nutrients and oxygen to the rest of the body. The strength of the blood pushing against the artery walls is blood pressure, which is measured in units called millimeters of mercury (mmHg). The top number in a blood pressure reading is the pressure when the heart pumps (systolic blood pressure), and the bottom number is the pressure between heart beats (diastolic blood pressure). In adults, a normal blood pressure measurement is about 120/80 mmHg. Blood pressure is considered high when the measurement is 130/80 mmHg or greater.
  • 1.7K
  • 16 Jan 2022
Topic Review
Human Amnion-Derived Stem Cells
Human amnion-derived stem cells (hADSCs) are referred as the cells of possessing the abilities of self-renew and differentiation, which are isolated from human amnion and include human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs).
  • 1.7K
  • 28 Sep 2021
Topic Review
Biomedical Effects of Oregano
The term oregano refers to a group of several plant genera, including Thymbra, Thymus, Coridothymus, Satureja, and Origanum, containing a high amount of the phytochemicals carvacrol and thymol in their essential oils.
  • 1.7K
  • 03 Nov 2021
Topic Review
Biomineralization Forming Process
Biomineralization is a process in which organic matter and inorganic matter combine with each other under the regulation of living organisms. 
  • 1.7K
  • 23 Nov 2021
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