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Topic Review
Anticancer Mechanisms of Natural and Synthetic Chalcones
ATP-binding cassette subfamily G and tubulin pharmacological mechanisms decrease the effectiveness of anticancer drugs by modulating drug absorption and by creating tubulin assembly through polymerization. A series of natural and synthetic chalcones have been reported to have very good anticancer activity, with a half-maximal inhibitory concentration lower than 1 µM. By modulation, it is observed in case of the first mechanism that methoxy substituents on the aromatic cycle of acetophenone residue and substitution of phenyl nucleus by a heterocycle and by methoxy or hydroxyl groups have a positive impact. To inhibit tubulin, compounds bind to colchicine binding site. Presence of methoxy groups, amino groups or heterocyclic substituents increase activity.
  • 1.0K
  • 14 Oct 2022
Topic Review
Biomedical Applications of Polyoxometalates Environmental
Polyoxometalates (POMs) are clusters of units of oxoanions of transition metals, such as Mo, W, V and Nb, that can be formed upon acidification of neutral solutions. Once formed, some POMs have shown to persist in solution, even in the neutral and basic pH range. These inorganic clusters, amenable of a variety of structures, have been studied in environmental, chemical, and industrial fields, having applications in catalysis and macromolecular crystallography, as well as applications in biomedicine, such as cancer, bacterial and viral infections, among others.
  • 1.0K
  • 14 Jan 2022
Topic Review
Mammary Stem Cell
Normal mammary epithelial cells are heterogeneous and organized in hierarchical fashion, in which the mammary stem cells (MaSC) lie at the apex with regenerative capacity as well as plasticity.
  • 1.0K
  • 31 Mar 2021
Topic Review
Monitoring Glucose Uptake and Metabolism in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common age-related dementia. The alteration in metabolic characteristics determines the prognosis. Patients at risk show reduced glucose uptake in the brain. Additionally, type 2 diabetes mellitus increases the risk of AD with increasing age. Therefore, changes in glucose uptake in the cerebral cortex may predict the histopathological diagnosis of AD.
  • 1.0K
  • 06 Sep 2022
Topic Review
Urease Inhibitory Activity
In our work, both Et-OH and Me-OH extracts of H. rhamnoides (91.69%±1.21) and C. fistula (79.44%±0.55) showed stronger action against urease activity. An overview on the medicinal uses of H. rhamnoides and C. fistula showing anti-urease activity may predict their possible alternative use for stomach problems. 
  • 1.0K
  • 28 Dec 2020
Topic Review
Cytotoxic Alkaloids from Marine Sponges
Marine sponges (porifera) have proved to be a prolific source of unique bioactive secondary metabolites, among which the alkaloids occupy a special place in terms of unprecedented structures and outstanding biological activities. Identification of active cytotoxic alkaloids extracted from marine animals, particularly sponges, is an important strive, due to lack of knowledge on traditional experiential and ethnopharmacology investigations. In this report, a comprehensive survey of demospongian bioactive alkaloids in the range 1987–2020 had been performed with a special emphasis on the potent cytotoxic activity. Different resources and databases had been investigated, including Scifinder (database for the chemical literature) CAS (Chemical Abstract Service) search, web of science, Marin Lit (marine natural products research) database. More than 230 representatives of different classes of alkaloids had been reviewed and classified, different genera belonging to the phylum porifera had been shown to be a prolific source of alkaloidal molecules, including Agelas sp., Suberea sp., Mycale sp., Haliclona sp., Epipolasis sp., Monanchora sp., Crambe sp., Reniera sp., and Xestospongia sp., among others. The sufficient production of alkaloids derived from sponges is a prosperous approach that requires more attention in future studies to consider the constraints regarding the supply of drugs, attained from marine organisms.
  • 1.0K
  • 04 Mar 2021
Topic Review
A Promiscuous Bacterial P450
CYP102A1 (BM3) is a catalytically self-sufficient flavocytochrome fusion protein isolated from Bacillus megaterium, which displays similar metabolic capabilities to many drug-metabolizing human P450 isoforms. BM3′s high catalytic efficiency, ease of production and malleable active site makes the enzyme a desirable tool in the production of small molecule metabolites, especially for compounds that exhibit drug-like chemical properties. The engineering of select key residues within the BM3 active site vastly expands the catalytic repertoire, generating variants which can perform a range of modifications. This provides an attractive alternative route to the production of valuable compounds that are often laborious to synthesize via traditional organic means. 
  • 1.0K
  • 03 Nov 2021
Topic Review
Structural Characteristics, Classification, and Nomenclature of Glycosphingolipids
Glycosphingolipids (GSLs) are a glycolipid subtype which plays vital roles in numerous biological processes, cell–cell interactions, as well as oncogenesis and ontogenesis. They are ubiquitous molecules found mostly in cell membranes.
  • 1.0K
  • 11 Sep 2023
Topic Review
Amino Acid Transporters and Stress Responses in Plants
Plants can absorb inorganic and organic nitrogen from the environment via the root system. In soil, inorganic nitrogen is usually found in the forms of nitrate and ammonium, while organic nitrogen usually exists in the forms of free amino acids, urea, and short peptides. The uptake of nitrogen-containing molecules by plants is mediated by the respective transporters of these molecules, especially amino acid transporters, which have been known to play a major role in distributing nitrogen throughout the whole plant. Amino acid accumulation and signaling have been suggested to play important roles in stress responses.
  • 1.0K
  • 17 Mar 2022
Topic Review
Circadian Rhythm Influences Insulin Secretion
In the intestine, the expression of sodium-glucose transport protein 1 (SGLT-1) has a rhythmic cycle, which is increased when the glucose intake is anticipated. Similar mechanisms regulate insulin secretion. Besides being regulated by glucose levels and incretins, its exocytosis also has a circadian regulation, possibly because incretins also have a circadian rhythm themselves.
  • 1.0K
  • 13 Dec 2022
Topic Review
The Proteomics Toolbox to Study Compartmentalized cAMP Signalling
cAMP is a second messenger that regulates a myriad of cellular functions in response to multiple extracellular stimuli. New developments in the field have provided exciting insights into how cAMP utilizes compartmentalization to ensure specificity when the message conveyed to the cell by an extracellular stimulus is translated into the appropriate functional outcome. cAMP signaling uses different mechanisms, including protein–protein interactions (PPIs) and protein phosphorylation, to relay, process, and translate signals into cellular responses. cAMP signaling compartmentalization heavily relies on the formation of local signaling domains where cAMP signaling components involved in a specific cellular response cluster together. Within such domains, cAMP signals are translated into specific cellular responses via the phosphorylation of target proteins. As such, mapping the domain interaction landscape and defining the downstream phosphorylation events are the key aspects of compartmentalized signaling studies.
  • 1.0K
  • 30 Mar 2023
Topic Review
Stress-associated Plant Acyl-CoA-binding Proteins
Plants are constantly exposed to environmental stresses during their growth and development. Owing to their immobility, plants possess stress-sensing abilities and adaptive responses to cope with the abiotic and biotic stresses caused by extreme temperatures, drought, flooding, salinity, heavy metals and pathogens. Acyl-CoA-binding proteins (ACBPs), a family of conserved proteins among prokaryotes and eukaryotes, bind to a variety of acyl-CoA esters with different affinities and play a role in the transport and maintenance of subcellular acyl-CoA pools. In plants, studies have revealed ACBP functions in development and stress responses through their interactions with lipids and protein partners.
  • 1.0K
  • 03 Jun 2021
Topic Review
Autophagy and Flavonoids
Autophagy, which is a conserved biological process and essential mechanism in maintaining homeostasis and metabolic balance, enables cells to degrade cytoplasmic constituents through lysosomes, recycle nutrients, and survive during starvation. Autophagy exerts an anticarcinogenic role in normal cells and inhibits the malignant transformation of cells. On the other hand, aberrations in autophagy are involved in gene derangements, cell metabolism, the process of tumor immune surveillance, invasion and metastasis, and tumor drug-resistance. Therefore, autophagy-targeted drugs may function as anti-tumor agents. Accumulating evidence suggests that flavonoids have anticarcinogenic properties, including those relating to cellular proliferation inhibition, the induction of apoptosis, autophagy, necrosis, cell cycle arrest, senescence, the impairment of cell migration, invasion, tumor angiogenesis, and the reduction of multidrug resistance in tumor cells. Flavonoids, which are a group of natural polyphenolic compounds characterized by multiple targets that participate in multiple pathways, have been widely studied in different models for autophagy modulation. However, flavonoid-induced autophagy commonly interacts with other mechanisms, comprehensively influencing the anticancer effect. Accordingly, targeted autophagy may become the core mechanism of flavonoids in the treatment of tumors.
  • 1.0K
  • 05 Feb 2021
Topic Review
MiRNAs in Pregnant Corpus Luteum
Recent scientific developments in understanding the lifespan of the corpus luteum provided new insights into dynamic molecular changes occurring during transition of this fascinating endocrine gland into the organ supporting pregnancy. Processes such as oocyte-sperm interaction, preparation of the uterus for implantation, blastocyst attachment, and successful gestation are mainly driven by progesterone, a steroid hormone produced by the corpus luteum. Inadequate production of progesterone has been described in several mammals, including humans, as luteal phase deficiency, a condition in which endogenous progesterone is insufficient to support pregnancy. Thus, it is essential to extend knowledge about the molecular mechanisms controlling the function of the corpus luteum. Unfortunately, still there is a lack of data explaining the regulation of core molecules responsible for the maintenance of luteal function. Recent studies shed a new light on the molecular mechanisms supporting luteal function, involving microRNAs.
  • 1.0K
  • 29 Oct 2020
Topic Review
Histone Deacetylases and Their Inhibitors in Ischemic Stroke
Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4. Histone deacetylases inhibitors have been shown to be effective in protecting the brain from ischemic damage. Histone deacetylases inhibitors induce neurogenesis and angiogenesis in damaged brain areas promoting functional recovery after cerebral ischemia.
  • 1.0K
  • 29 Oct 2021
Topic Review
Physicochemical Characteristics of Exosomes
Exosomes have been proposed as prospective “Trojan horse” nanocarriers of anticancer theranostics owing to their biocompatibility, increased stability, permeability, negligible immunogenicity, prolonged circulation time, and high loading capacity.
  • 1.0K
  • 26 May 2023
Topic Review
Hydroxytyrosol and Arginine
Phytochemicals from plant extracts are becoming increasingly popular in the world of food science and technology because they have positive effects on human health. In particular, several bioactive foods and dietary supplements are being investigated as potential treatments for chronic COVID. Hydroxytyrosol (HXT) is a natural antioxidant, found in olive oil, with antioxidant anti-inflammatory properties that has been consumed by humans for centuries without reported adverse effects.
  • 1.0K
  • 18 May 2023
Topic Review
Dietary Phytochemicals in Skin Cancer
Human skin is continuously subjected to environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin adopts various molecular mechanisms to maintain homeostasis, excessive and repeated stresses can overwhelm these systems, leading to serious cutaneous damage, including both melanoma and non-melanoma skin cancers. Phytochemicals present in the diet possess the desirable effects of protecting the skin from damaging free radicals as well as other benefits. Dietary phytochemicals appear to be effective in preventing skin cancer and are inexpensive, widely available, and well tolerated. Multiple in vitro and in vivo studies have demonstrated the significant anti-inflammatory, antioxidant, and anti-angiogenic characteristics of dietary phytochemicals against skin malignancy. Moreover, dietary phytochemicals affect multiple important cellular processes including cell cycle, angiogenesis, and metastasis to control skin cancer progression. Herein, we discuss the advantages of key dietary phytochemicals in whole fruits and vegetables, their bioavailability, and underlying molecular mechanisms for preventing skin cancer. Current challenges and future prospects for research are also reviewed. To date, most of the chemoprevention investigations have been conducted preclinically, and additional clinical trials are required to conform and validate the preclinical results in humans.
  • 1.0K
  • 27 May 2021
Topic Review
Nuclear Magnetic Resonance and Metabolomics
The use of nuclear magnetic resonance spectroscopy (NMR) for structure determination and the quantification of small molecules has a long history in successfully characterizing the chemical composition of biological systems. One of the earliest applications of NMR included the use of 31P and 13C NMR to monitor the energetic and redox status of cells and tissues. While these studies demonstrated the value of NMR for metabolism, a renaissance occurred with the emergence of metabolomics in the early 2000s. Metabolomics is defined as the broad range analysis of measurable small molecules in biological samples. 
  • 1.0K
  • 26 Aug 2022
Topic Review
Gastrointestinal Disorders Involving ICCs and the ENS
The enteric nervous system (ENS) is organized into two plexuses—submucosal and myenteric—which regulate smooth muscle contraction, secretion, and blood flow along the gastrointestinal tract under the influence of the rest of the autonomic nervous system (ANS). Interstitial cells of Cajal (ICCs) are mainly located in the submucosa between the two muscle layers and at the intramuscular level. They communicate with neurons of the enteric nerve plexuses and smooth muscle fibers and generate slow waves that contribute to the control of gastrointestinal motility. They are also involved in enteric neurotransmission and exhibit mechanoreceptor activity. A close relationship appears to exist between oxidative stress and gastrointestinal diseases, in which ICCs can play a prominent role. Thus, gastrointestinal motility disorders in patients with neurological diseases may have a common ENS and central nervous system (CNS) nexus. In fact, the deleterious effects of free radicals could affect the fine interactions between ICCs and the ENS, as well as between the ENS and the CNS.
  • 1.0K
  • 25 Apr 2023
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