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Topic Review
Voltage-Gated K+ Channels
Voltage-gated K+ (Kv) channels are intrinsic plasma membrane proteins mediating the selective flow of potassium ions in response to depolarization of the transmembrane electric field. Their ionic selectivity and voltage dependence allow Kv channels to be central players in virtually all physiological functions, including the maintenance and modulation of neuronal and muscular (both cardiac and skeletal) excitability, regulation of calcium signaling cascades, control of cell volume, immune response, hormonal secretion, and others.
  • 1.7K
  • 29 Jan 2022
Topic Review
ToLCNDV
The tomato leaf curl New Delhi virus (ToLCNDV) is a bipartite, single-stranded begomovirus that was first identified in India in 1995 affecting solanaceous crops. A different strain, named ToLCNDV-ES, was introduced in Spain in 2012 and causes severe symptoms in zucchini crops. Virus transmission experiments with the whitefly Bemisia tabaci, were used to compare the transmission parameters in zucchini and tomato plants.
  • 1.7K
  • 28 Feb 2022
Topic Review
Cyberbullying and Mental Health among University Students
Bullying is an aggressive behavior that is intentionally and repeatedly directed at individuals who have less power than the attacker does. Bullying may take many forms, including physical, verbal, and social bullying. In its physical form, bullying includes hitting, pushing, spitting, and other physical acts. Bullying in the oral form includes mocking, name-calling, and threatening. In its social form, it consists of spreading rumors (slander), exclusion from peer groups, and other forms. When dealing with perpetrators, these three forms of bullying most commonly occur face to face.
  • 1.7K
  • 16 Jun 2022
Topic Review
Twelve Principles of Green Tribology
Sustainability has become of paramount importance, as evidenced by the increasing number of norms and regulations concerning various sectors. Due to its intrinsic trans-sectorial nature, tribology has drawn the attention of the supporters of sustainability. This discipline allows the environmental, economic, and social impacts to be decreased in a wide range of applications following the same strategies. In 2010, Nosonovsky and Bhushan drew up 12 approaches based on the 12 principles of green chemistry and the 12 principles of green engineering, defining the “12 principles of green tribology.”
  • 1.7K
  • 01 Jul 2022
Topic Review
Factors Affecting FIV in Internal Two-Phase Flow
Two-phase flow is commonly encountered in various engineering systems. Momentum fluctuation in two-phase flow can create undesirable and destructive vibrations. These vibrations have attracted considerable attention and are known as flow-induced vibrations (FIV). Different factors effecting FIV is two phase flow is discussed here in detail.
  • 1.7K
  • 13 Oct 2022
Topic Review
Diabetes Mellitus Type 2
Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. Symptoms may also include increased hunger, feeling tired, and sores that do not heal. Often symptoms come on slowly. Long-term complications from high blood sugar include heart disease, strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to amputations. The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon. Type 2 diabetes primarily occurs as a result of obesity and lack of exercise. Some people are more genetically at risk than others. Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to diabetes mellitus type 1 and gestational diabetes. In diabetes mellitus type 1 there is a lower total level of insulin to control blood glucose, due to an autoimmune induced loss of insulin-producing beta cells in the pancreas. Diagnosis of diabetes is by blood tests such as fasting plasma glucose, oral glucose tolerance test, or glycated hemoglobin (A1C). Type 2 diabetes is partly preventable by staying a normal weight, exercising regularly, and eating properly. Treatment involves exercise and dietary changes. If blood sugar levels are not adequately lowered, the medication metformin is typically recommended. Many people may eventually also require insulin injections. In those on insulin, routinely checking blood sugar levels is advised; however, this may not be needed in those taking pills. Bariatric surgery often improves diabetes in those who are obese. Rates of type 2 diabetes have increased markedly since 1960 in parallel with obesity. As of 2015 there were approximately 392 million people diagnosed with the disease compared to around 30 million in 1985. Typically it begins in middle or older age, although rates of type 2 diabetes are increasing in young people. Type 2 diabetes is associated with a ten-year-shorter life expectancy. Diabetes was one of the first diseases described. The importance of insulin in the disease was determined in the 1920s.
  • 1.7K
  • 28 Sep 2022
Topic Review
Health Tourism in China
Health tourism refers to domestic and international tourism for individuals to improve their health in order to achieve the purpose of treating individuals and protecting their well-being. The concept of health tourism evolved from medical tourism to health-care tourism, and to the concurrent health tourism.
  • 1.7K
  • 30 Sep 2022
Topic Review
Linguistic Intelligence
Linguistic Intelligence is a part of Howard Gardner's multiple intelligence theory that deals with individuals' ability to understand both spoken and written language, as well as their ability to speak and write themselves. In a practical sense, linguistic intelligence is the extent to which an individual can use language, both written and verbal, to achieve goals. In addition to this, high linguistic intelligence has been linked to improved problem solving, as well as to increased abstract reasoning. In many cases, only the verbal aspects are taken into consideration. This is usually referred to as verbal intelligence or verbal fluency, and is commonly a reflection of an individual's overall linguistic intelligence.
  • 1.7K
  • 14 Oct 2022
Topic Review
Tetraspanin CD81
Tetraspanin CD81 plays major roles in cell-cell interactions and the regulation of cellular trafficking. This cholesterol-embarking transmembrane protein is a co-receptor for several viruses, including HCV, HIV-1 and Chikungunya virus, which exploits the large extracellular loop (EC2) for cell entry. CD81 is also an anticancer target implicated in cancer cell proliferation and mobility, and in tumor metastasis. 
  • 1.7K
  • 14 Apr 2023
Topic Review
The Crossroads of Computer Science and Physics
The intersection of computer science and physics has opened up exciting new opportunities for research and innovation. The principles of physics have inspired the development of new computational models, and the ability to simulate complex physical systems using computer algorithms has been a critical tool for physicists to test their theories and hypotheses. Conversely, computer science has also had a significant impact on physics, providing tools and techniques for simulations and data analysis that have enabled physicists to explore complex physical systems. Machine learning and AI techniques are also increasingly being used to tackle some of the most challenging problems in physics. Despite the many potential benefits of interdisciplinary research between computer science and physics, there are also significant challenges that must be addressed. The synergy between these two fields and how interdisciplinary research is shaping their future was described. The research discusses the challenges and opportunities of interdisciplinary research, future directions for research, and the countries and scientists at the forefront of this field. By addressing the challenges of interdisciplinary research, researchers can unlock the full potential of interdisciplinary research and shape the future of both computer science and physics.
  • 1.7K
  • 22 May 2023
Topic Review
Crack Healing Technologies of Asphalt Pavement
Crack healing has been a key area of asphalt pavement research. Energy supply technologies (induction and microwave heating) have demonstrated significant efficacy in enhancing the crack healing capability of asphalt pavement, particularly in microcracks. Crack healing technologies can effectively prolong the service life of asphalt pavement, thereby further reducing the damage to the environment caused by road engineering, reducing energy consumption and CO2 emissions.
  • 1.7K
  • 20 Jun 2023
Topic Review
Heterologous Production of Crocins in Different Species
Crocin is one of the most valuable components of the Chinese medicinal plant Crocus sativus and is widely used in the food, cosmetics, and pharmaceutical industries. Traditional planting of C. sativus is unable to fulfill the increasing demand for crocin in the global market, however, such that researchers have turned their attention to the heterologous production of crocin in a variety of hosts. 
  • 1.7K
  • 08 Jan 2024
Topic Review
Banana Fusarium Wilt Disease Detection
Banana Fusarium wilt (BFW), which is a soilborne fungal disease caused by the fungus Fusarium oxysporum f. sp. cubense race 4 (Foc 4) is the most devastating disease of bananas. It can occur in the whole growth period and spread fast.
  • 1.7K
  • 09 Mar 2022
Topic Review
Type 2 Diabetes Mellitus
Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.
  • 1.7K
  • 31 Jul 2020
Topic Review
FNIRS application in Parkinson’s Disease
The management of people affected by neurological disorders, such as Parkinson's disease, requires the adoption of targeted and cost-effective interventions to cope with chronicity. Although therapy adaptation and rehabilitation represent major targets, affordable and reliable neurophysiological correlates of cerebral activity to be used throughout treatment stages are often lacking. The functional Near-Infrared Spectroscopy (fNIRS) represents a versatile optical neuroimaging technology for investigating cortical hemodynamic activity in the most common chronic neurological conditions, including Parkinson's disease, with the advantages of non-invasiveness and portability which make fNIRS suitable for carrying out multiple measurements in rehabilitation settings.
  • 1.7K
  • 21 Oct 2020
Topic Review
46,XX Testicular Disorder
46,XX testicular disorder of sex development is a condition in which individuals with two X chromosomes in each cell, the pattern normally found in females, have a male appearance. People with this disorder have male external genitalia. They generally have small testes and may also have abnormalities such as undescended testes (cryptorchidism) or the urethra opening on the underside of the penis (hypospadias). A small number of affected people have external genitalia that do not look clearly male or clearly female (ambiguous genitalia). Affected children are typically raised as males and have a male gender identity.
  • 1.7K
  • 04 Jan 2021
Topic Review
The Discovery and Function of Filaggrin
Keratohyalin granules were discovered in the mid-19th century in cells that terminally differentiate to form the outer, cornified layer of the epidermis.  The first indications of the composition of these structures emerged in the 1960’s from a histochemical stain for histidine, followed by radioauto-graphic evidence for a high incidence of histidine incorporation into newly synthesized proteins in cells containing the granules.  Research during the next three decades revealed the structure and function of the major protein in these granules, which was initially called the ‘histidine-rich pro-tein.’  Steinert and Dale named the protein ‘filaggrin’ in 1981 because of its ability to aggregate keratin intermediate filaments.  The human gene for the precursor ‘profilaggrin’ was reported in 1991 to encode 10, 11 or 12 nearly identical repeats.  Remarkably, the mouse and rat genes encode up to 20 repeats.  The lifetime of filaggrin is the time required for keratinocytes in the granular layer to move into the inner cornified layer.  During this transition, filaggrin facilitates the collapse of corneocytes into an impermeable surface barrier.  The subsequent degradation of filaggrin is as remarkable as its synthesis and the end-products aide in maintaining moisture in the cornified layer.  It became apparent that ichthyosis vulgaris and atopic dermatitis were associated with the absence of this protein.  McLean’s team in 2006 identified the cause of these diseases by discov-ering loss-of-function mutations in the profilaggrin gene that led to dysfunction of the epidermal surface barrier.  This story illustrates the complexity in maintaining a healthy, functional surface barrier.
  • 1.7K
  • 07 Mar 2022
Topic Review
Design of Gold Nanoparticle Vertical Flow Assays
Vertical flow assays (VFAs) or flow-through assays have emerged as an alternate type of paper-based assay due to their faster detection time, larger sample volume capacity, and significantly higher multiplexing capabilities compared to lateral flow assays (LFAs).  VFA can be used for detecting important biomarkers in diagnostic medicine, particularly when VFA is paired with gold nanoparticle conjugation.
  • 1.7K
  • 10 May 2022
Topic Review
Optimizing Use of RTKLIB for Smartphone-Based GNSS Measurements
The Google Smartphone Decimeter Challenge (GSDC) was a competition held in 2021, where data from a variety of instruments useful for determining a phone’s position (signals from GPS satellites, accelerometer readings, gyroscope readings, etc.) using Android smartphones were provided to be processed/assessed in regard to the most accurate determination of the longitude and latitude of user positions. One of the tools that can be utilized to process the GNSS measurements is RTKLIB. RTKLIB is an open-source GNSS processing software tool that can be used with the GNSS measurements, including code, carrier, and doppler measurements, to provide real-time kinematic (RTK), precise point positioning (PPP), and post-processed kinematic (PPK) solutions.
  • 1.7K
  • 30 May 2022
Topic Review
Muramyl Peptides of Bacterial Origin
Muramyl peptides (MPs) are part of the peptidoglycan that forms the backbone of the cell walls of bacteria—both Gram-positive and Gram-negative. MPs are formed during the degradation of bacteria and are pathogen-associated molecular patterns (PAMPs) that are recognized by innate immune receptors.
  • 1.7K
  • 02 Aug 2022
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