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Topic Review
SIRT1-NF-κB Axis
Inflammation is an adaptive response triggered by harmful conditions or stimuli, such as an infection or tissue damage pursuing homeostasis reestablishment. Liver diseases cause approximately 2 million deaths per year worldwide and hepatic inflammation is a common factor to all of them, being the main driver of hepatic tissue damage and causing progression from NAFLD (non-alcoholic fatty liver disease) to NASH (non-alcoholic steatohepatitis), cirrhosis and, ultimately, HCC (hepatocellular carcinoma). The metabolic sensor SIRT1, a class III histone deacetylase with strong expression in metabolic tissues such as liver, and transcription factor NF-κB, a master regulator of inflammatory response, show an antagonistic relationship in controlling inflammation. For this reason, SIRT1 targeting is emerging as a potential strategy to improve different metabolic and/or inflammatory pathologies. In this review, we explore diverse upstream regulators and some natural/synthetic activators of SIRT1 as possible therapeutic treatment for liver diseases.
  • 1.8K
  • 27 Oct 2020
Topic Review
Spherical Nucleic Acids
Spherical nucleic acids (SNAs) are nanostructures consisting of nucleic acids in a spherical configuration, often around a nanoparticle core. SNAs are advantageous as gene-regulating agents compared to conventional gene therapy owing to their low toxicity, enhanced stability, uptake by virtually any cell, and ability to penetrate the epidermal barrier. 
  • 1.8K
  • 25 Nov 2020
Topic Review
Rippling Muscle Disease
Rippling muscle disease is a condition in which the muscles are unusually sensitive to movement or pressure (irritable).
  • 1.8K
  • 24 Dec 2020
Topic Review
Histone Acetyltransferase GCN5
Transcription of protein-encoding genes starts with forming a pre-initiation complex comprised of RNA polymerase II and several general transcription factors. To activate gene expression, transcription factors must overcome the repressive chromatin structure, which is accomplished with multiprotein complexes. Histone Acetyl Transferases (HAT) catalyze acetylation of specific lysine residues in histone N-tails, which are involved in transcriptional regulation and other nuclear processes. HATs are parts of large multiprotein complexes, like the SAGA complex, where their activity is enhanced, and their substrate specificity is altered. The whole complex is recruited to target sequences on the genome with other components involved in protein-protein interactions. A prototypical HAT which acts as a transcriptional adaptor is known as General Control Nonrepressed protein 5 (GCN5), first identified in Saccharomyces cerevisiae. GCN5 was defined biochemically as the first transcription-linked HAT with specificity for histone H3 lysine 14 (H3K14). However, GCN5 could also acetylate additional histone lysine residues, such as H3K9, H3K18, H3K23, H3K27, H3K36, other histones such as H4 and H2B and non-histone nuclear proteins.  In Arabidopsis, GCN5 is required for many developmental processes such as leaf development, apical dominance, root meristem activity, inflorescence, floral meristem function and flower fertility. 
  • 1.8K
  • 10 Feb 2021
Topic Review
Thermosets with Flame Retardants
Epoxy and unsaturated polyester resins are the most used thermosetting polymers.They are commonly used in electronics, construction, marine, automotive and aircraft industries.Moreover, reinforcing both epoxy and unsaturated polyester resins with carbon or glass fibre in a fabric form has enabled them to be used in high-performance applications. However, their organic nature as any other polymeric materials made them highly lammable materials. Enhancing the flame retardancy performance of thermosetting polymers and their composites can be improved by the addition of flame-retardant materials, but this comes at the expense of their mechanical properties. In this regard, a comprehensive review on the recent research articles that studied the flame retardancy of epoxy resin, unsaturated polyester resin and their composites were covered. Flame retardancy performance of different flame retardant/polymer systems was evaluated in terms of Flame Retardancy index (FRI) that was calculated based on the data extracted from the cone calorimeter test. Furthermore, lame retardant selection charts that relate between the flame retardancy level with mechanical properties in the aspects of tensile and lexural strength were presented. This review paper is also dedicated to providing the reader with a brief overview on the combustion mechanism of polymeric materials, their flammability behaviour and the commonly used flammability testing techniques and the mechanism of action of flame retardants.
  • 1.8K
  • 29 Mar 2021
Topic Review
Electrostatic Repulsion Reversed-Phase Liquid Chromatography
Electrostatic Repulsion Reversed-Phase Liquid Chromatography (ERRP) allows the elution of bases in protonated form without peak distorsion (as commonly happen in reversed phase) due to the presence of positive charges in the chromatographic system. 
  • 1.8K
  • 05 Aug 2021
Topic Review
AB5 Derivatives of Cyclotriphosphazene
AB5 compounds issued from the reactivity of hexachlorocyclotriphosphazene are relatively easy to obtain using two ways: either first the reaction of one chloride with one reagent, followed by the reaction of the five remaining Cl with another reagent, or first the reaction of five chlorides with one reagent, followed by the reaction of the single remaining Cl with another reagent. This particular property led to the use of such compounds as core for the synthesis of dendrons (dendritic wedges), using the five functions for growing the dendritic branches. The single function can be used for the synthesis of diverse types of dendrimers (onion peel, dumbbell-shape, Janus), for covalent or non-covalent grafting to solid surfaces, providing nanomaterials, for grafting a fluorophore, especially for studying biological mechanisms, or for self-associations to get micelles.
  • 1.8K
  • 04 Aug 2021
Topic Review
HDAC3 Complex and Nuclear Hormone Receptors
Histone deacetylase 3 is the core component of the nuclear receptor corepressor complex, and plays a central role in transcriptional repression mediated by nuclear hormone receptors. 
  • 1.8K
  • 08 Oct 2021
Topic Review
3D Printed Electromagnetic Vibration Harvesters
Energy harvesting is the utilisation of ambient energy in order to power electronics such as wireless sensor nodes (WSN) or wearables without the need of batteries. This allows to operate the node over a much longer time period compared to battery-powered devices along with lower maintenance efforts. Furthermore, the low-maintenance requirements allow to operate these WSNs in environments with limited or no accessibility.
  • 1.8K
  • 05 Nov 2021
Topic Review
High-Value Bioactive Primary Metabolites of Microalgae
Microalgae is an aquatic microorganism with a plethora of diverse bioactive compounds including phenolics, carotenoids, vitamin B12 and peptides. Microalgal bioactive compounds have been shown to possess positive health effects such as antihypertensive, anti-obesity, antioxidative, anticancer and cardiovascular protection.
  • 1.8K
  • 08 Jul 2023
Topic Review
Devil Facial Tumour Disease
Devil facial tumour disease (DFTD) is an aggressive non-viral clonally transmissible cancer which affects Tasmanian devils, a marsupial native to Australia . DFTD was first described in 1996. In the subsequent decade the disease ravaged Tasmania's wild devils. Affected high-density populations suffered up to 100% mortality in 12–18 months. Between 1996 and 2015, DFTD wiped out 95% of affected colonies.
  • 1.8K
  • 21 Oct 2022
Topic Review
Green and Blue Hydrogen Production in Colombia
Hydrogen is the most abundant element in nature, but it cannot be considered an energy source by itself because it is impossible to find it in its elemental form in nature. Colombia, a privileged country in terms of diversity, availability of natural resources, and geographical location, has set a roadmap for hydrogen as part of the energy transition plan proposed in 2021. To reduce its emissions in the mid-term and foster its economy, hydrogen production should be green and blue, with specific targets set for 2030 for the hydrogen costs and produced quantities. A comparison is made concerning the state-of-the-art production of blue and green hydrogen and how Colombia performs in each pathway.
  • 1.8K
  • 30 Nov 2022
Topic Review
Protein-Based Targeting Self-Assembling Nanoparticles for Biomedical Applications
Targeted nanoparticles of different origins are considered as new-generation diagnostic and therapeutic tools. Targeted protein self-assembling nanoparticles circumvent this problem since proteins are encoded in DNA and the final protein product is produced in only one possible way. The combination of the endless biomedical potential of protein carriers as nanoparticles and the standardized protein purification protocols will make significant progress in “magic bullet” creation possible, bringing modern biomedicine to a new level. The entry focused on the currently existing platforms for targeted self-assembling protein nanoparticles based on transferrin, lactoferrin, casein, lumazine synthase, albumin, ferritin, and encapsulin proteins, as well as on proteins from magnetosomes and virus-like particles. The applications of these self-assembling proteins for targeted delivery in vitro and in vivo are thoroughly discussed, including bioimaging applications and different therapeutic approaches, such as chemotherapy, gene delivery, and photodynamic and photothermal therapy. 
  • 1.8K
  • 08 Mar 2023
Topic Review
Alopecia Associated with Antiseizure Medication
The mainstay of treatment for epilepsy is antiseizure medications (ASMs). Approximately 70% of individuals with epilepsy obtain seizure freedom with adequate ASMs therapy. Adverse effects of antiseizure medications (ASMs) remain one of the major causes of non-adherence. Cosmetic side effects (CSEs) are among the most commonly reported side effects of ASMs. Alopecia is one of the CSEs that has a high intolerance rate leading to poor therapeutical compliance. 
  • 1.8K
  • 04 Sep 2023
Topic Review
Membrane-Based Technologies for Post-Combustion CO2 Capture
Carbon dioxide (CO2), which results from fossil fuel combustion and industrial processes, accounts for a substantial part of the total anthropogenic greenhouse gases (GHGs). As a result, several carbon capture, utilization and storage (CCUS) technologies have been developed during the last decade. Chemical absorption, adsorption, cryogenic separation and membrane separation are the most widely used post-combustion CO2 capture technologies. 
  • 1.8K
  • 29 Dec 2023
Topic Review
Subsurface Landslide Monitoring Techniques
Landslides are a common and challenging geohazard that may be caused by earthquakes, rainfall, or manmade activity. Various monitoring strategies are used to safeguard populations at risk from landslides. This task frequently depends on the utilization of remote sensing methods, which include the observation of Earth from space, laser scanning, and ground-based interferometry. In recent years, there have been notable advancements in technologies utilized for monitoring landslides (i.e., subsurface systems). 
  • 1.8K
  • 06 Jun 2024
Topic Review
Curcumin in Metastatic Colorectal Cancer
Curcumin (diferuloylmethane)—the “golden spice”—has been widely studied because of its pleiotropic effects in cancer. Curcumin, a hydrophobic polyphenol, is derived from the rhizome of the herb Curcuma longa and constitutes the major curcuminoid in the spice turmeric (77% curcumin, 17% demethoxycurcumin, 3% bis-demethoxycurcumin). Curcumin is “generally recognized as safe” (GRAS) as a dietary supplement by the U.S Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA) and has been catalogued with the E100 code of the European Union. 
  • 1.8K
  • 09 Dec 2022
Topic Review
Leaching
Leaching is the process of a solute becoming detached or extracted from its carrier substance by way of a solvent. Leaching is a naturally occurring process which scientists have adapted for a variety of applications with a variety of methods. Specific extraction methods depend on the soluble characteristics relative to the sorbent material such as concentration, distribution, nature, and size. Leaching can occur naturally seen from plant substances (inorganic and organic), solute leaching in soil, and in the decomposition of organic materials. Leaching can also be applied affectedly to enhance water quality and contaminant removal, as well as for disposal of hazardous waste products such as fly ash, or rare earth elements (REEs). Understanding leaching characteristics is important in preventing or encouraging the leaching process and preparing for it in the case where it is inevitable. In an ideal leaching equilibrium stage, all the solute is dissolved by the solvent, leaving the carrier of the solute unchanged. The process of leaching however is not always ideal, and can be quite complex to understand and replicate, and often different methodologies will produce different results.
  • 1.8K
  • 15 Nov 2022
Topic Review
NeWS
NeWS (Network extensible Window System) is a discontinued windowing system developed by Sun Microsystems in the mid-1980s. Originally known as "SunDew", its primary authors were James Gosling and David S. H. Rosenthal. The NeWS interpreter was based on PostScript (as was the later Display PostScript, although the two projects were otherwise unrelated) extending it to allow interaction and multiple "contexts" to support windows. Like PostScript, NeWS could be used as a complete programming language, but unlike PostScript, NeWS could be used to make complete interactive programs with mouse support and a GUI.
  • 1.8K
  • 14 Nov 2022
Topic Review
COVID-19 Spread Faster with HVAC
Droplets and aerosolized viral particles expelling from the body through coughing or sneezing and it is spreading to nearby surroundings. CFD model has been developed to simulate the air flow and the transport and dispersion of the aerosolized viral particles and fine droplets suspended in the air particles through the office. The study presents two cases involving the spreading limits and pathways of the aerosolized viral particles and fine droplets suspended in the air in a place; without and with air conditioning unit. The results showed that the use of air conditioning systems can increase the chances of spreading COVID-19 virus infection. The air-conditioning unit recirculates the same air inside a room, and this has the potential to create a virus-laden environment. Air circulation indoors such as using air conditioning units should be avoided in closed places. Existing ventilation systems should be expanded to include extraction and air filtration systems and/or germicidal, ultraviolet light. Also, opening a window can help bring in fresh air from the outside and disperse stale air inside, and that could help reduce the possibility of the spread of the virus particles in the closed place. Lastly, crowds of people in closed public places should be avoided (HVAC: Heating, ventilation, and air conditioning).
  • 1.8K
  • 17 Feb 2021
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