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Topic Review
Carbon Mineralization Technologies
Carbon dioxide is a byproduct of the industrial society. It is released into the atmosphere, which has an adverse effect on the environment. Carbon dioxide management is necessary to limit the global average temperature increase to 1.5 degrees Celsius and mitigate the effects of climate change, as outlined in the Paris Agreement. 
  • 1.8K
  • 29 Jun 2022
Topic Review
Gold Nanoparticles
Nanomaterials are popularly used in drug delivery, disease diagnosis and therapy. Among a number of functionalized nanomaterials such as carbon nanotubes, peptide nanostructures, liposomes and polymers, gold nanoparticles (Au NPs) make excellent drug and anticancer agent carriers in biomedical and cancer therapy application. Recent advances of synthetic technique improved the surface coating of Au NPs with accurate control of particle size, shape and surface chemistry. These make the gold nanomaterials a much easier and safer cancer agent and drug to be applied to the patient’s tumor. Although many studies on Au NPs have been published, more results are in the pipeline due to the rapid development of nanotechnology. The purpose of this review is to assess how the novel nanomaterials fabricated by Au NPs can impact biomedical applications such as drug delivery and cancer therapy. Moreover, this review explores the viability, property and cytotoxicity of various Au NPs.
  • 1.8K
  • 27 Oct 2020
Topic Review
Nanomedicine in NSCLC
The hard diagnosis and treatment of NSCLC, together with its late diagnosis and lack of therapies during the early stages of the disease,  so far explain its high mortality rate. The reformulation of conventional therapies as nanomedicines, has led to a new generation of treatments for NSCLC. However, the deepening of the relationship between the tumor and the patient's immune system encompasses the most promising strategies today. From immune checkpoint inhibitors, identified in 2018, to the development of vaccines based on genetic material, immunotherapies represent the best of options. The use of nanometric vehicles for the release of genetic material, protein or drug allows reducing doses and increasing efficiency. These, together with delivery systems based on nanomedicines, promise to increase the specificity and efficacy of treatments, reducing the extremely harmful side effects of conventional therapies. Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances in research aiming to understand its intricate nature. Consequently, the retrospective analysis of conventional therapies has allowed the introduction of novel tools provided by nanotechnology, leading to considerable improvements in clinical outcomes. Furthermore, the development of novel immunotherapies based on the recently understood interaction of the immune system with the tumor highlights the real possibility of definitively treating NSCLC from its early stages. Novel engineering approaches in nanomedicine will enable to overcome the intrinsic limits of conventional and emerging therapies regarding off-site cytotoxicity, specificity, resistance mechanisms, and administration issues. The convergence point of these therapies with nanotechnology lays the foundation for achieving currently unmet needs.
  • 1.8K
  • 17 Sep 2020
Topic Review
Low-Temperature Hot Stamping Technologies
Improvement of the hot stamping process is important for reducing processing costs and improving the productivity and tensile properties of final components. One major approach to this has been to conduct all or part of the process at lower temperatures.
  • 1.8K
  • 23 Dec 2020
Topic Review
Biowastes on Soil Remediation
Biowastes refer to the biodegradable food residues from private household and food industry, garden industry, municipal wastes, and sewage sludge.
  • 1.8K
  • 29 Jul 2021
Topic Review
O-GlcNAcylation
O-GlcNAcylation is a posttranslational modification that occurs at serine and threonine residues of protein substrates by the addition of O-linked β-d-N-acetylglucosamine (GlcNAc) moiety. Two enzymes are involved in this modification: O-GlcNac transferase (OGT), which attaches the GlcNAc residue to the protein substrate, and O-GlcNAcase (OGA), which removes it. This biological balance is important for many biological processes, such as protein expression, cell apoptosis, and regulation of enzyme activity.
  • 1.8K
  • 04 Mar 2021
Topic Review
NRF2 Regulation
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription.
  • 1.8K
  • 11 Jun 2021
Topic Review
Downy Mildew Detection and Diagnostics
Downy mildews affect important crops and cause severe losses in production worldwide. Accurate identification and monitoring of these plant pathogens, especially at early stages of the disease, is fundamental in achieving effective disease control. The rapid development of molecular methods for diagnosis has provided more specific, fast, reliable, sensitive, and portable alternatives for plant pathogen detection and quantification than traditional approaches. 
  • 1.8K
  • 11 Jun 2021
Topic Review
Role of Retinal Pigment Epithelium
The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). 
  • 1.8K
  • 24 Nov 2021
Topic Review
The History of Blood Vessel Anastomosis
Surgical technique and technology frequently coevolve. The brief history of blood vessel anastomosis is full of famous names. While the techniques pioneered by these surgeons have been well described, the technology that facilitated their advancements and their inventors deserve recognition. The mass production of laboratory microscopes in the mid-1800s allowed for an explosion of interest in tissue histology. This improved understanding of vascular physiology and thrombosis laid the groundwork for Carrel and Guthrie to report some of the first successful vascular anastomoses. In 1916, McLean discovered heparin. Twenty-four years later, Gordon Murray found that it could prevent thrombosis when performing end-to-end anastomosis. These discoveries paved the way for the first-in-human kidney transplantations. Otolaryngologists Nylen and Holmgren were the first to bring the laboratory microscope into the operating room, but Jacobson was the first to apply these techniques to microvascular anastomosis. His first successful attempt in 1960 and the subsequent development of microsurgical tools allowed for an explosion of interest in microsurgery, and several decades of innovation followed.
  • 1.8K
  • 15 Mar 2022
Topic Review
Pathophysiology of Autosomal Dominant Polycystic Kidney Disease
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder that typically presents in adults. Both kidneys are affected by cysts, leading to end stage renal disease in adulthood. Prevalence of ADPKD was estimated to be 1:400 to 1:1000 live births.
  • 1.8K
  • 14 Apr 2022
Topic Review
Combined Finite–Discrete Element Method
The continuum–discontinuum method (CDM) is a promising tool for the study of the rock fracture and fragmentation process under static or dynamic loading conditions, e.g., blasting. The hybrid/combined finite element method (FDEM) might be the most widely used continuum–discontinuum method. Based on the FDEM, many tools are developed for modelling the entire rock fracture process, e.g., Y-2D, Y-GUI, Y-GEO, Y-Slope, Y2D/3D IDE, and the commercial software ELFEN.
  • 1.8K
  • 09 May 2022
Topic Review
Models for Evaluation Intrusion Detection Systems in IoT
Using the Internet of Things (IoT) for various applications, such as home and wearables devices, network applications, and even self-driven vehicles, detecting abnormal traffic is one of the problematic areas for researchers to protect network infrastructure from adversary activities. Several network systems suffer from drawbacks that allow intruders to use malicious traffic to obtain unauthorized access. Attacks such as Distributed Denial of Service attacks (DDoS), Denial of Service attacks (DoS), and Service Scans demand a unique automatic system capable of identifying traffic abnormality at the earliest stage to avoid system damage. Numerous automatic approaches can detect abnormal traffic. However, accuracy is not only the issue with current Intrusion Detection Systems (IDS), but the efficiency, flexibility, and scalability need to be enhanced to detect attack traffic from various IoT networks. 
  • 1.8K
  • 27 May 2022
Topic Review
Pretreatment of Lignocellulosic Biomass
Biohydrogen fermentation using lignocellulosic biomass (LCB) materials as feedstocks is better alternative to petroleum-based fuels due to its ecofriendly nature since there is no greenhouse gas (GHG) emissions during combustion. The recalcitrant nature of LCB waste materials is mainly attributed to the rigid cell wall structure, crystalline cellular machinery, and lignin component, which makes lignocellulosic materials resistant toward chemical and biological actions. Hence, the pretreatment process is an obligatory step to make LCB materials accessible for the generation of sugar fractions after disintegration of biomass.
  • 1.8K
  • 13 Dec 2022
Topic Review
Cerebrovascular and Neurological Dysfunction
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to a standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are mild or no symptoms of this virus. However, a selection of patients is suffering from large artery ischemic strokes. Although the pathophysiology of the SARS-CoV-2 virus affecting the cerebrovascular system has not been elucidated yet, researchers have identified several pathogenic mechanisms, including a role for the ACE2 receptor. Therefore, it is extremely crucial to identify the risk factors related to the progression and adverse outcome of cerebrovascular-neurological dysfunction in COVID-19 patients. Since many articles have reported the effect of smoking (tobacco and cannabis) and vaping in cerebrovascular and neurological systems, and considering that smokers are more prone to viral and bacterial infection compared to non-smokers, it is high time to explore the probable correlation of smoking in COVID-19 patients. Herein, we have reviewed the possible role of smoking and vaping on cerebrovascular and neurological dysfunction in COVID-19 patients, along with potential pathogenic mechanisms associated with it.
  • 1.8K
  • 01 Apr 2021
Topic Review
Food Losses and Waste
Food losses and waste (FLW) refers to "a decrease, at all stages of the food chain, from harvest to consumption in mass, of food that was originally intended for human consumption, regardless of the cause". Food waste (FW) is a critical challenge in the Gulf Cooperation Council (GCC). This paper analyzes research dealing with food waste in the GCC countries (viz. Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, United Arab Emirates). It draws upon a systematic review performed on Scopus in January 2020. The paper covers both bibliometrics (e.g., authors, affliations, journals) and research topics (e.g., causes, food supply chain stages, extent and quantity, food security, economic impacts, environmental implications, management strategies). A main finding of the review is the scarcity of data onFWin the GCC in general and in Kuwait, Oman, and Bahrain in particular. Most of the selected articles address FW reuse and recycling (e.g., waste-to-energy conversion, compost production). Indeed, other FW management strategies, such as reduction/prevention and redistribution, are overlooked. The systematic review highlights that further research on FW in the GCC is highly needed with a focus on the identified research gaps such as causes and drivers, trends, magnitude and extent, environmental and economic impacts, along with implications of food wastage in terms of food security. Since food wastage is a common issue for all GCC countries, these research gaps should be addressed in a shared regional research agenda.
  • 1.8K
  • 27 Oct 2020
Topic Review
Precision Agriculture
According to a recent definition of Precision Agriculture (PA), developed by the International Society of Precision Agriculture, the term refers to a management strategy, which uses acquisition, processing, analysis, and combination with other information of temporal, spatial, and other data in order to facilitate decision-making based on the estimated variability. 
  • 1.8K
  • 08 Feb 2021
Topic Review
Food Loss in Meat Sector
Food losses and wastage are one of the most important problems of the modern world. The scale of this phenomenon is so large that it should be treated as a global problem. Food losses occur at every stage of the agri-food chain, from primary production (ag-riculture), through storage, processing, transport, distribution and consumption.
  • 1.8K
  • 25 Jun 2021
Topic Review
Anatomy of the Human Nose
The visible part of the human nose is the protruding part of the face that bears the nostrils. The shape of the nose is determined by the ethmoid bone and the nasal septum, which consists mostly of cartilage and which separates the nostrils. On average the nose of a male is larger than that of a female. The nasal root is the top of the nose, forming an indentation at the suture where the nasal bones meet the nasal part of the frontal bone. The anterior nasal spine is the thin projection of bone at the midline on the lower nasal margin, holding the cartilaginous center of the nose. Adult humans have nasal hair in the nostrils.
  • 1.8K
  • 01 Nov 2022
Topic Review
Animal Behaviorist
Ethology is the scientific study of animal behaviour, usually with a focus on behaviour under natural conditions, and viewing behaviour as an evolutionarily adaptive trait. Behaviourism as a term also describes the scientific and objective study of animal behaviour, usually referring to measured responses to stimuli or to trained behavioural responses in a laboratory context, without a particular emphasis on evolutionary adaptivity. Throughout history, different naturalists have studied aspects of animal behaviour. Ethology has its scientific roots in the work of Charles Darwin and of American and German ornithologists of the late 19th and early 20th century, including Charles O. Whitman, Oskar Heinroth, and Wallace Craig. The modern discipline of ethology is generally considered to have begun during the 1930s with the work of Dutch biologist Nikolaas Tinbergen and Austrian biologists Konrad Lorenz and Karl von Frisch, the three recipients of the 1973 Nobel Prize in Physiology or Medicine. Ethology combines laboratory and field science, with a strong relation to some other disciplines such as neuroanatomy, ecology, and evolutionary biology. Ethologists typically show interest in a behavioural process rather than in a particular animal group, and often study one type of behaviour, such as aggression, in a number of unrelated species. Ethology is a rapidly growing field. Since the dawn of the 21st century researchers have re-examined and reached new conclusions in many aspects of animal communication, emotions, culture, learning and sexuality that the scientific community long thought it understood. New fields, such as neuroethology, have developed. Understanding ethology or animal behaviour can be important in animal training. Considering the natural behaviours of different species or breeds enables trainers to select the individuals best suited to perform the required task. It also enables trainers to encourage the performance of naturally occurring behaviours and the discontinuance of undesirable behaviours.
  • 1.8K
  • 02 Nov 2022
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